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WO2019039896A1 - Dispositif de stimulation cérébrale destiné à traiter la démence - Google Patents

Dispositif de stimulation cérébrale destiné à traiter la démence Download PDF

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Publication number
WO2019039896A1
WO2019039896A1 PCT/KR2018/009761 KR2018009761W WO2019039896A1 WO 2019039896 A1 WO2019039896 A1 WO 2019039896A1 KR 2018009761 W KR2018009761 W KR 2018009761W WO 2019039896 A1 WO2019039896 A1 WO 2019039896A1
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WIPO (PCT)
Prior art keywords
average value
user
time
acceleration sensor
gyro sensor
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Ceased
Application number
PCT/KR2018/009761
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English (en)
Korean (ko)
Inventor
나동석
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DABO Industry Co Ltd
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DABO Industry Co Ltd
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Publication date
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Publication of WO2019039896A1 publication Critical patent/WO2019039896A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense

Definitions

  • the present invention relates to a brain stimulation apparatus for treating dementia, and more particularly, to a device for stimulating human hearing and improving symptoms of dementia through activation of brain function.
  • Our bodies have five senses, and the brain that accepts various kinds of information and stimuli from the senses of these five senses performs various functions based on these stimuli and information.
  • the human brain is affected by external stimuli such as visual, auditory, and tactile.
  • external stimuli such as visual, auditory, and tactile.
  • the phenomenon of the brain that tries to match the frequency of external stimuli is called the frequency response (FFR: FREQUENCY FOLLOWING RESPONSE).
  • Electroencephalogram is an electrical phenomenon in which neurons of the cerebral cortex are generated in response to certain inputs and is fundamentally caused by the mechanism of the sodium potassium pump.
  • a gamma wave of 30 Hz or more is observed in an extreme anxiety or an excited state according to a psychological state of a human being.
  • a beta wave of 15 to 30 Hz is observed, and meditation, relaxation, , 8- to 14-Hz alpha waves are observed, and in the super-learning state, slightly sleepy state, and high creativity, a 4- to 7-Hz cetaphase is observed and 0.5 to 3 Hz delta waves are mainly observed in the deep sleep state .
  • the EEG induction technique uses the frequency-following response phenomenon to synchronize a human brain wave to a desired frequency artificially, thereby calming a user in an excited state or appropriately awakening And to improve the learning ability of the user.
  • a signal inducing an EEG is called an EEG signal.
  • ALPHA (8-14 Hz) appears in relaxed state like meditation, and helps to relieve stress and improve concentration.
  • the brain explosively produces alpha waves between 14 Hz and 8 Hz, and the brain becomes alpha state.
  • the brain waves that occur when the body and the mind are in harmony in a state of high consciousness are alpha-waves.
  • ALPAPA As the muscles are relaxed and the mind is relaxed and the consciousness is concentrated, the expression of ALPAPA means that the body and mind are in a very stable state.
  • the brain wave induction device is a device developed for the purpose of controlling the above-mentioned EEG, and electronically generates a signal similar to the frequency of an EEG such as an alpha wave or a seta wave or a delta wave, . ≪ / RTI >
  • the signal frequency signal useful for inducing EEG is mainly less than 20 Hz. However, most humans can not hear the induction frequency because the human audible tone is usually in the range of 20Hz to 20000Hz. Thus, in order to generate an electroencephalogram inducing signal for inducing an EEG, a binaural beat method using the difference between the two signals is used.
  • the binaural beat principle is that if a signal with a slight difference in frequency is heard at the same time in both ears of a human, the EEG with the frequency corresponding to the difference is induced. For example, if a signal of 400 Hz is transmitted to the left ear and a signal of 410 Hz is transmitted to the right ear simultaneously, a 10 Hz alfa wave corresponding to the difference is induced in the user's brain.
  • the brain stimulation device performs the function of stimulating the auditory sense of the user with the sound of the binaural beat as described above to improve or regenerate the weakened or degenerated brain function. As it can improve many problems associated with human life, it is effective in relieving stress, improving memory, improving concentration, treating insomnia, treating depression, and also treating dementia and ADHD.
  • the state of the user in using the above-described brain stimulation apparatus is various. Immediately after exercise, the user's pulse or EEG may be excited and the frequency of the whole may be high. In the case of a user who is in the house alone on the day when the whole day falls, the pulse may be low and the frequency of EEG may be relatively low.
  • a user in order to use the brain stimulation device, a user has to use any of various modes such as a stress relieving mode, a memory improvement mode, a concentration improvement mode, an insomnia treatment mode, a depression treatment mode, a dementia treatment mode, When one is selected, the user immediately gives the binaural bit of the mode to the user's hearing, which provides the sound to the user who is not ready to effectively accept the binaural bit of the selected mode, It is often difficult to expect the effect.
  • modes such as a stress relieving mode, a memory improvement mode, a concentration improvement mode, an insomnia treatment mode, a depression treatment mode, a dementia treatment mode
  • the state of a user who uses the brain stimulation apparatus is automatically determined, and the state of the user is automatically determined to change the state of the brain stimulation apparatus to maximize the effect.
  • the present invention provides a brain stimulation apparatus that can maximize the use effect by allowing brain stimulation to be performed in earnest.
  • a brain stimulation apparatus comprising:
  • An acceleration sensor and a gyro sensor installed in the body for sensing a movement of a body held in a user's hand;
  • a memory for repeatedly updating and storing a signal measured by the acceleration sensor and the gyro sensor in a first time unit
  • a first average value which is an average variation amount of the acceleration sensor and the gyro sensor signal during a second time before the power switch is turned on, is calculated based on the information stored in the memory when the power switch is turned on,
  • a second average value which is an average of variation amounts of the acceleration sensor and the gyro sensor signals until a time when an additional switch operation is performed after the power switch is turned on and a variation amount of the acceleration sensor and the gyro sensor signal
  • a control unit for preferentially generating a binaural bit for calibrating a user for a predetermined fourth time and then generating a binaural bit corresponding to a mode selected by the user;
  • a sound source generating unit for generating the binaural bit with a frequency sound source in an audible frequency under the control of the control unit.
  • controller adjusts the fourth time according to a difference between the third average value and the second average value
  • the binaural bits for calming the user may have frequencies in the range of 4 Hz to 8 Hz.
  • control unit is configured to control the acceleration sensor and the gyro sensor signal at a start time of the fourth time from a binaural bit having the same frequency as that of the acceleration sensor and the gyro sensor signal for the third time, And may be configured to progressively change accordingly.
  • the body After the fourth time for generating a binaural bit for calming the user, the body is provided with a function for selecting whether to use the function for switching to generate a binaural bit suitable for the mode selected by the user Further comprising a switch;
  • the control unit may be configured to perform or omit a function of generating a binaural bit for calming the user for the fourth time period before the mode selected by the user according to the signal of the function selection switch.
  • the state of a user who uses the brain stimulation apparatus is automatically determined, and the state of the user is automatically determined to change the state of the brain stimulation apparatus to maximize the effect.
  • FIG. 1 is a block diagram of a brain stimulation apparatus according to the present invention.
  • FIG. 2 is a state of use of the brain stimulation apparatus according to the present invention.
  • the brain stimulation apparatus of the present invention includes an acceleration sensor 3 and a gyro sensor 5 installed in the body 1 for sensing movement of a body 1 held in a user's hand, Wow;
  • a memory 7 for repeatedly updating and storing signals measured by the acceleration sensor 3 and the gyro sensor 5 in a first time unit;
  • the acceleration sensor 3 is provided in the body 1 so that when the power switch 9 is turned on, the acceleration sensor 3 for the second time before the power switch 9 is turned on, based on the information stored in the memory 7, And the average value of the fluctuation amount of the signals of the acceleration sensor 3 and the gyro sensor 5 until the time when additional switch operation is performed after the power switch 9 is turned on,
  • a posture variation calculation unit 11 for calculating a second mean value and calculating a third average value which is an average of the variation amount of the signals of the acceleration sensor 3 and the gyro sensor 5 during the third time after the additional switch operation; Comparing the first average value with a
  • the sound source generating unit 15 is connected to a user's earphone 19 to provide a binaural beat sound to the user.
  • the acceleration sensor 3 and the gyro sensor 5 are built in the body 1 of the brain stimulation device so that the change of the movement and posture of the user's hand and arm is measured It will be done.
  • the fluctuation amount of the signal measured by the acceleration sensor 3 and the gyro sensor 5 will be large, Or when the user whose mood is down has caught the body 1, the fluctuation amount of the measured signal will be very small.
  • the first time may be set, for example, to 5 seconds, and the second time may be set to a time within the first time, for example, 3 seconds or the like. Accordingly, the first average value is set to a value that is the reverse of the sensor signal for 5 seconds immediately before the power switch 9 is turned on by the user stored in the memory 7, And the acceleration sensor 3 and the gyro sensor 5 signals during a period of time t1.
  • the second average value is a variation average value of the signals of the acceleration sensor 3 and the gyro sensor 5 during the operation of the additional switch (e.g., mode selection switch, etc.) after the user turns on the power switch 9.
  • the additional switch e.g., mode selection switch, etc.
  • the first average value indicates a user state immediately before the user holds the body 1 and turns on the power switch 9
  • the second average value indicates the state of the user after the power switch 9 is turned on have.
  • the third time may be set to, for example, 2 seconds, and the third mean value may indicate that the user starts using the brain stimulation device in earnest.
  • the user is not at least calm in that the second average value and the third average value are similar to each other within a predetermined reference range and the third average value is equal to or greater than the predetermined reference value, as compared with the first average value.
  • the predetermined reference range may be set, for example, within the range of ⁇ 10% of the first average value, and the reference value for comparing the third average value may be set to a level that can indicate the excited state of the user It can be determined.
  • the first to third average values may be obtained by converting the average value of the fluctuation amount of the acceleration sensor 3 signal and the average value of the fluctuation amount of the gyro sensor 5 signal into one value by applying appropriate weights.
  • the first to third average values may be determined as signal fluctuation amounts of the installed sensors.
  • the fourth time may be set within a range of 30 seconds to several minutes, which is set in consideration of the time required for the user to switch to a state in which the effect of the brain stimulation apparatus can be maximally accommodated.
  • the controller 13 determines that the second average value and the third average value are similar to or larger than the first average value within the reference range, the user can select the operation mode By generating and providing a binaural bit for calming the user for the fourth time period prior to generating and providing the binaural bit, the binaural bit of the mode selected by the user can be well acted upon by the user And the binaural bit of the selected mode is provided to maximize the effect of the operation.
  • the controller 13 may adjust the fourth time according to the difference between the third average value and the second average value and may increase the fourth time as the value obtained by subtracting the second average value from the third average value is greater have.
  • the third average value is larger than the second mean value, it can be determined that the user has not been calmed down even though it is time to use the full brain stimulation device.
  • the third average value is smaller than the second average value, The length of the fourth time is adjusted so that the function of calming the user for a more appropriate time according to the state of the user can be performed.
  • the binaural bit for calming the user has a frequency in the range of 4 Hz to 8 Hz.
  • the above frequency range is almost the same as the frequency range of the ADHD treatment mode. In the case of a normal person, the above frequency range can be used to calmly induce it.
  • the control unit 13 may calm the user from the binaural bit having the same frequency as the variation frequency of the acceleration sensor 3 and the gyro sensor 5 signal for the third time at the start of the fourth time And may be configured to gradually change with the passage of time with a binaural beat for the time.
  • the binaural bit having the same frequency as the fluctuation frequency of the acceleration sensor 3 and the gyro sensor 5 signal during the third time period substantially coincides with the current state of the user, So that the user can adapt to the sound of the binaural beat and adapt quickly so that a quick adaptation of the user can be obtained and by switching to a binaural bit at a frequency for gradually calming the user, It is possible to shorten the time in terms of the total time required to calm the user and to prevent the occurrence of the sense of heterogeneity of the user.
  • the control unit 13 may be configured to perform or omit a function of generating a binaural bit for calming the user for the fourth time period before the mode selected by the user according to the signal of the function selection switch 17 It will be possible.
  • the device can be used for treating dementia.
  • the user can select and use stress relief mode, memory improvement mode, concentration improvement mode, insomnia treatment mode, depression treatment mode and ADHD treatment mode have.

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Abstract

La présente invention concerne un dispositif de stimulation cérébrale pour traiter la démence, comprenant : un capteur d'accélération et un capteur gyroscopique, qui sont logés dans un corps de façon à détecter un mouvement du corps tenu dans la main d'un utilisateur ; une mémoire, pour mettre à jour et mémoriser de manière répétée des signaux qui sont mesurés par le capteur d'accélération et le capteur gyroscopique dans une première unité de temps ; un commutateur de puissance du corps ; une unité de calcul de variation de position, disposée dans le corps, qui, si le commutateur de puissance est allumé, calcule une première valeur moyenne sur la base d'informations mémorisées dans la mémoire, la première valeur moyenne étant une moyenne des quantités de variation des signaux du capteur d'accélération et du capteur gyroscopique pendant une deuxième période de temps avant que le commutateur de puissance ne soit allumé, qui calcule une deuxième valeur moyenne, qui est une moyenne des quantités de variation des signaux du capteur d'accélération et du capteur gyroscopique pendant une période de temps après que le commutateur de puissance a été allumé, jusqu'à ce qu'une opération de commutation supplémentaire soit effectuée, et qui calcule une troisième valeur moyenne, qui est une moyenne des quantités de variation des signaux du capteur d'accélération et du capteur gyroscopique pendant une troisième période de temps après l'opération de commutation supplémentaire ; une unité de commande, pour comparer la première valeur moyenne, la deuxième valeur moyenne et la troisième valeur moyenne et effectuer une commande en vue de générer de préférence un battement binaural pour calmer l'utilisateur pour une quatrième période de temps prédéterminée, si la deuxième valeur moyenne et la troisième valeur moyenne sont supérieures à la première valeur moyenne ou similaires à la première valeur moyenne au sein d'une plage de référence prédéterminée, puis de générer un battement binaural approprié pour un mode sélectionné par l'utilisateur ; et une unité de génération de source sonore, pour générer le battement binaural avec une source sonore au sein d'une fréquence audible sous la commande de l'unité de commande.
PCT/KR2018/009761 2017-08-24 2018-08-24 Dispositif de stimulation cérébrale destiné à traiter la démence Ceased WO2019039896A1 (fr)

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KR1020170107327A KR101828954B1 (ko) 2017-08-24 2017-08-24 치매 치료용 두뇌 자극 장치
KR10-2017-0107327 2017-08-24

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KR102180929B1 (ko) * 2018-05-11 2020-11-19 서원대학교산학협력단 경도인지장애 진단 기구
KR102339346B1 (ko) 2020-05-11 2021-12-16 주식회사 볼드코퍼레이션 딥러닝 기반의 바이노럴 비트를 이용한 음원 제공 시스템 및 그 방법
KR20220033676A (ko) 2020-09-10 2022-03-17 가톨릭관동대학교산학협력단 경두개 자극 치료장치 및 이를 이용한 경두개 자극 치료방법
KR20220046123A (ko) 2020-10-07 2022-04-14 가톨릭관동대학교산학협력단 시변자기장을 이용한 경두개 자극 치료장치 및 이를 이용한 경두개 자극 치료방법
KR20220057155A (ko) 2020-10-29 2022-05-09 가톨릭관동대학교산학협력단 경두개 펄스 자극장치
KR20220140153A (ko) 2021-04-09 2022-10-18 (주)뉴로니어 치매 예방 및 개선을 위한 헤드 마운팅 장치
KR102370514B1 (ko) * 2021-10-06 2022-03-04 (주)디라직 바이노럴 음향 재생 제어 시스템 및 그 방법
KR102400319B1 (ko) 2021-12-31 2022-05-24 (주)리솔 객체의 복수의 뇌 영역에서 동기화된 진동을 동조시킴으로써, 뇌를 자극하는 장치 및 방법
KR102425066B1 (ko) 2022-03-25 2022-07-28 (주)리솔 실시간 eeg 신호 모니터링을 기초로, 뇌에서 동기화된 뇌파진동을 동조시키는 맞춤형 경두개교류전기자극 장치 및 방법
KR102753148B1 (ko) 2022-01-28 2025-01-21 (주)뉴로니어 눈과 뇌의 교차신경을 이용한 뇌 자극 장치

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