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WO2019032945A9 - Cd40-binding agents and uses thereof - Google Patents

Cd40-binding agents and uses thereof Download PDF

Info

Publication number
WO2019032945A9
WO2019032945A9 PCT/US2018/046186 US2018046186W WO2019032945A9 WO 2019032945 A9 WO2019032945 A9 WO 2019032945A9 US 2018046186 W US2018046186 W US 2018046186W WO 2019032945 A9 WO2019032945 A9 WO 2019032945A9
Authority
WO
WIPO (PCT)
Prior art keywords
agents
polypeptides
cd40l
fragment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2018/046186
Other languages
French (fr)
Other versions
WO2019032945A1 (en
Inventor
Austin L. Gurney
Minu K. SRIVASTAVA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mereo Biopharma 5 Inc
Original Assignee
Oncomed Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharmaceuticals Inc filed Critical Oncomed Pharmaceuticals Inc
Publication of WO2019032945A1 publication Critical patent/WO2019032945A1/en
Publication of WO2019032945A9 publication Critical patent/WO2019032945A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des polypeptides et des agents qui se lient au CD40 humain. Les polypeptides ou les agents peuvent comprendre des polypeptides de fusion, en particulier des polypeptides comprenant le domaine extracellulaire de CD40L ou un fragment de celui-ci, le domaine extracellulaire de CD40L ou un fragment de celui-ci comprenant une mutation dans la région de liaison à l'intégrine. Les agents peuvent comprendre des agents bispécifiques et multispécifiques. L'invention concerne également des procédés d'utilisation de ces polypeptides ou agents pour induire et/ou améliorer la réponse immunitaire, ainsi que des procédés de traitement de maladies telles que le cancer.The invention provides polypeptides and agents that bind to human CD40. The polypeptides or agents may comprise fusion polypeptides, particularly polypeptides comprising the extracellular domain of CD40L or a fragment thereof, the extracellular domain of CD40L or a fragment thereof comprising a mutation in the binding region to integrin. The agents may include bispecific and multispecific agents. The invention also relates to methods of using these polypeptides or agents to induce and / or enhance the immune response, as well as methods of treating diseases such as cancer.

PCT/US2018/046186 2017-08-10 2018-08-10 Cd40-binding agents and uses thereof Ceased WO2019032945A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762543734P 2017-08-10 2017-08-10
US62/543,734 2017-08-10

Publications (2)

Publication Number Publication Date
WO2019032945A1 WO2019032945A1 (en) 2019-02-14
WO2019032945A9 true WO2019032945A9 (en) 2019-04-18

Family

ID=65272694

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2018/046186 Ceased WO2019032945A1 (en) 2017-08-10 2018-08-10 Cd40-binding agents and uses thereof

Country Status (1)

Country Link
WO (1) WO2019032945A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190263888A1 (en) 2010-10-19 2019-08-29 Op-T Llc Therapeutic peptides and methods for treating autoimmune related disease
US11793854B2 (en) 2019-03-21 2023-10-24 Op-T Llc Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction
CA3143752A1 (en) 2019-07-12 2021-01-21 Op-T Llc Peptides and methods for treating diseases
EP4135742A2 (en) 2020-04-17 2023-02-22 Op-T Llc Bioactive peptides and methods of use thereof
WO2022036495A1 (en) 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
KR20230156937A (en) * 2021-03-12 2023-11-15 얀센 바이오테크 인코포레이티드 Bio-engineered immunomodulatory fusion protein compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3103875A1 (en) * 2008-07-21 2016-12-14 Apogenix AG Tnfsf single chain molecules
MA41460A (en) * 2015-02-03 2017-12-12 Oncomed Pharm Inc TNFRSF LIAISON AGENTS AND THEIR USES

Also Published As

Publication number Publication date
WO2019032945A1 (en) 2019-02-14

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