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WO2019088360A1 - Dispositif d'accès vasculaire pour hémodialyse - Google Patents

Dispositif d'accès vasculaire pour hémodialyse Download PDF

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Publication number
WO2019088360A1
WO2019088360A1 PCT/KR2017/015351 KR2017015351W WO2019088360A1 WO 2019088360 A1 WO2019088360 A1 WO 2019088360A1 KR 2017015351 W KR2017015351 W KR 2017015351W WO 2019088360 A1 WO2019088360 A1 WO 2019088360A1
Authority
WO
WIPO (PCT)
Prior art keywords
conduit
blood vessel
connection
blood flow
flow paths
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2017/015351
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English (en)
Korean (ko)
Inventor
진동찬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Catholic University of Korea
Original Assignee
Industry Academic Cooperation Foundation of Catholic University of Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of Catholic University of Korea filed Critical Industry Academic Cooperation Foundation of Catholic University of Korea
Publication of WO2019088360A1 publication Critical patent/WO2019088360A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3659—Cannulae pertaining to extracorporeal circulation
    • A61M1/3661—Cannulae pertaining to extracorporeal circulation for haemodialysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A61M2039/0258—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body for vascular access, e.g. blood stream access

Definitions

  • the present invention relates to a blood vessel connection apparatus for hemodialysis, and more particularly, it is possible to simultaneously connect a vein and an artery, so that a separate arteriovenous fistula is not required for hemodialysis,
  • the present invention relates to a blood vessel connection apparatus for hemodialysis,
  • the arteriovenous fistula has been used as an aneurysm, it has been used with a thick needle.
  • the arteriovenous fistula is difficult to be thickened after surgery. The risk of hemodynamic burden in the cardiovascular system as well as the shape of the fistula due to too much blood flow of the arteriovenous fistula.
  • arteriovenous fistula is difficult to treat due to the difficulty of needle puncture and pain, inconvenience of hemostasis, arteriovenous fistula lumen stenosis, infectious disease, and the like during each dialysis.
  • a plastic catheter for hemodialysis which is temporarily used, complications such as infectious diseases and thrombosis occur and there is a problem that can not be used for a long time.
  • a blood vessel connection apparatus for hemodialysis comprising: a main conduit in which a pair of blood flow paths partitioned from each other are formed; An arterial connection conduit having one side connected to one of the blood flow paths and the other side connected to an artery; A vein connection conduit having one side connected to the other of the blood flow paths and the other side connected to the vein; And a connection unit located on the opposite side of the arterial connection conduit and the vein connection conduit with respect to the main conduit and each having a pair of connection conduit sections connected to the blood flow paths and connected to the dialyzer .
  • At least one of the arterial connection conduit and the vein connection conduit has a sharp-tipped end portion for drilling the blood vessel; An engaging portion provided at a position adjacent to the tip end portion and hooked to the inner wall of the blood vessel through the blood vessel together with the tip end portion; And a locking part disposed to surround the one of the conduits and installed to be movable relative to the conduit and being engaged with the locking part in the process of approaching the locking part.
  • the locking part is a plurality of locking hooks provided on an outer surface of the one of the conduits at intervals along the circumferential direction, and the locking part is a ring member having a locking protrusion that is engaged with the locking hook.
  • the present invention further comprises a position fixing wire arranged so as to surround the collarbone so as to support the main catheter on the collarbone and having both ends connected to the main catheter.
  • the main conduit includes a pair of hooks to which both ends of the position fixing wire are hooked.
  • connection unit is detachably connected to the main conduit so that the connection unit is selectively connected to the main conduit and when the connection unit is not connected to the main conduit,
  • the cap member includes a pair of insertion portions to be inserted into the respective transfer paths and a pair of insertion portions formed integrally with the insertion portions, And a flange portion surrounding the outer circumferential surface of the flange portion.
  • the blood vessel connection apparatus for hemodialysis having the above-described configuration is characterized in that a pair of blood flow paths are formed in the main conduit (allowing the veins and the arteries to flow in a partitioned state)
  • the arterial blood flow and the venous blood flow are separately connected to the dialyzer through the connecting unit and thus the operation of the arteriovenous fistula operation is performed It is possible to promptly perform hemodialysis for reasons such as not being required, and since there is no blood flow other than dialysis, there is almost no cardiovascular burden, and thus it is possible to provide a high quality medical service.
  • the distal end portion, the engaging portion and the locking portion are included in the conduit connected to the blood vessel, only the tip portion is located in the blood vessel, and the connecting and holding force of the conduit to the blood vessel is stabilized It is possible to minimize the intra-vascular structure to prevent complications, and it is expected that the present embodiment can stably support the blood vessel.
  • FIG. 1 is an exploded perspective view of a blood vessel connection apparatus for hemodialysis according to an embodiment of the present invention
  • FIG. 2 is a plan view showing a configuration of an embodiment of the present invention.
  • 3 is a use state diagram of one embodiment of the present invention.
  • FIG. 4 is a sectional view taken along the line IV-IV in Fig. 3;
  • FIG. 5 is a diagram for explaining a stable connection state of an embodiment of the present invention.
  • FIG. 6 is a use state diagram different from FIG. 3 of the embodiment of the present invention.
  • FIG. 6 is a use state diagram different from FIG. 3 of the embodiment of the present invention.
  • FIG. 7 is a view for explaining the principle of hemodialysis in one embodiment of the present invention.
  • FIG. 8 is a view for explaining an installation process of an embodiment of the present invention.
  • FIG. 1 is a perspective view of an apparatus for connecting a blood vessel for hemodialysis according to an embodiment of the present invention.
  • FIG. 2 is a plan view of a blood vessel connection apparatus according to an embodiment of the present invention.
  • FIG. 4 is a cross-sectional view taken along the line IV-IV in FIG. 3,
  • FIG. 5 is a view for explaining a stable connection state of the embodiment of the present invention,
  • the blood vessel connection apparatus for hemodialysis includes a main conduit 1, an artery connection conduit 2, a vein connection conduit 3, And a connection unit (4).
  • the main conduit 1 is formed in a hollow tube shape.
  • the main conduit 1 may be formed of various materials without being limited to any one material as long as it can provide the blood transfer passages 11 and 12 , And a flexible and elastic synthetic resin material such as polyurethane.
  • the main conduit 1 is formed in a tubular shape similar to a conduit used in conventional hemodialysis, a pair of blood transfer passages 11 and 12 are formed instead of one transfer path, There is a structural difference from the conventional one.
  • the blood flow of the vein (R) flows to one of the pair of moving paths, and the blood flow of the artery (A) flows to the other.
  • the artery connecting conduit 2 has one side connected to one of the blood transfer passages 11 and 12 and the other side connected to the artery A.
  • 'connection' means not only a physical connection but also a line through which the vein R and the artery A can flow.
  • the artery connecting conduit 2 and the main conduit 1 are separately manufactured, and then the artery A is provided with a moving line by mutual physical connection, It is also possible to connect the moving passages 11 and 12 and the artery A with each other.
  • vein connection conduit 3 One side of the vein connection conduit 3 is connected to the other of the blood transfer passages 11 and 12 and the other side is connected to the vein R.
  • connection unit 4 is located on the opposite side of the arterial connection conduit 2 and the vein connection conduit 3 with respect to the main conduit 1 and the blood transfer passages 11, And a pair of connecting conduits 41 and 42 connected to the dialyzer, respectively.
  • One of the connecting conduits 41 and 42 is connected to one of the blood flow paths 11 and 12 and the other is connected to the other of the blood flow paths 11 and 12 Lt; / RTI > These connecting conduits 41 and 42 are connected to the dialyzer 8 so as to form a closed loop together with the dialyzer 8 to enable hemodialysis.
  • a blood connecting apparatus for hemodialysis having such a configuration is provided with a pair of blood transfer passages 11 and 12 formed in the main conduit 1 (a vein R and an artery A) And the blood flow paths 11 and 12 are connected to the artery A and the vein R through the artery connecting conduit 2 and the vein connecting conduit 3 respectively
  • the arterial blood flow and the venous blood flow can be flowed into the dialyzer 8 through the connecting unit 4 at the same time in a state in which the arterial blood flow and the venous blood flow are separately distinguished from each other, Therefore, it is possible to provide a high-quality medical service, since there is no blood flow other than dialysis, and there is almost no cardiovascular burden.
  • the present embodiment is structured such that it can securely maintain a connection holding force with respect to a blood vessel because it should not be separated from the blood vessel arbitrarily while the dialysis operation is performed as shown in Fig.
  • the artery connecting conduit 2 and the vein connecting conduit 3 adopted in the present embodiment are provided with the leading ends 21 and 31, the engaging portions 22 and 32, and the locking portion 23, (33).
  • the tip portions 21 and 31 are formed to have sharp ends so that they can easily pass through the blood vessel, and the fastening portions 22 and 32 4 (b), it is provided at a position adjacent to the tip ends 21 and 31 and is provided with the tip ends 21 and 31 and penetrates the blood vessels, Hang on the side wall.
  • the locking portions 23 and 33 are disposed in a manner to surround the respective conduits 2 and 3 and are provided so as to be movable relative to the conduits. In FIGS. 4A and 4B, And is engaged with the engaging portions 22 and 32 in the process of approaching the engaging portions 22 and 32 as shown in FIG.
  • the present embodiment having such a configuration allows the blood vessels to be easily pierced by the tip portions 21 and 31 of the respective conduits 2 and 3 and prevents the tip It is possible to secure the primary connection maintaining force between the conduit and the blood vessel by the portions 22 and 32.
  • the conduits 2 and 3 can be clamped to the blood vessels by the second and third portions 22 and 32 so that the conduits can be separated from the blood vessels due to strong blood flow or pressure generated during hemodialysis And the like.
  • the tip portions 21 and 31 are positioned in the blood vessel and the conduits 2 and 3 are fixed by using the locking portions 22 and 32 and the locking portions 23 and 33, It is expected that the intravenous structure can be minimized and the complication can be prevented.
  • latching portions 22 and 32 can be variously constructed as long as they can be hooked on the inner side wall of the blood vessel, the latching portions 22 and 32 may be formed on the outer surface of any one of the above- The hooking hooks being formed by a plurality of hooks.
  • the locking portions 23 and 33 are for forming a connection with the locking portions 22 and 32 so as to secure a greater connection holding force.
  • the locking portions 23 and 33 Member.
  • the present invention is characterized in that the main conduit 1 is arranged to surround the collarbone C so that the main conduit 1 can be supported on the collarbone C, And a position fixing wire (5) connected to the main conduit (1).
  • the vein R and the artery A to which the respective conduits 2 and 3 are connected in the present embodiment are the subclavian vein and subclavian artery formed at positions adjacent to the collarbone C respectively.
  • the position fixing wire 5 passes through the tissue in the body so as to cover the collarbone C and is connected to the main conduit 1 after passing through it so that the blood vessel connection holding force of the present embodiment is further secured I will.
  • the main conduit 1 is connected to the position fixing wire 5 so that both ends of the position fixing wire 5 are engaged with each other so that the connection operation with the position fixing wire 5 can be performed smoothly.
  • the main conduit 1 preferably includes a pair of rings 13.
  • FIG. 6 is a use state diagram different from FIG. 3 of the embodiment of the present invention.
  • connection unit 4 employed in the present embodiment is detachably connected to the main conduit 1, thereby being selectively connected or disconnected to the main conduit 1.
  • This embodiment is characterized in that when the connecting unit 4 is not connected to the main conduit 1 a cap member for closing the pair of blood transfer passages 11 and 12 of the main conduit 1 6).
  • the cap member 6 includes a pair of insertion portions 61 and 62 and a flange portion 63.
  • the flange portion 63 is formed integrally with the inserting portions 61 and 62, and the flange portion 63 is formed integrally with the inserting portions 61 and 62, The outer circumferential surface of the main conduit 1 is wrapped with each of the inserting portions 61 and 62 being inserted into the moving path.
  • the flange 63 seals the outer circumferential surface of the main conduit 1 in a state in which the pair of inserting portions 61 and 62 are in close contact with the respective passageways,
  • FIG. 7 is a view for explaining the principle of hemodialysis in one embodiment of the present invention.
  • the present embodiment allows the connector 7, which is a connection medium between the connecting unit 4 and the dialyzer 8, to be connected to the dialyzer 8 through the connecting unit 4,
  • the connector 7 and the connecting unit 4 can be rapidly and reliably connected to each other in the case where hemodialysis is not required by making detachable coupling (screwing) It has an advantage that it can be separated.
  • FIG. 8 is a view for explaining the installation process of the embodiment of the present invention.
  • the lower skin of the left collarbone (C) is disinfected and cut about 3-4 cm laterally (not shown). Thereafter, the subclavian vein (V) and the artery (A) are exposed to about 1 cm (not shown), and then the artery (A) and the vein (V) 91).
  • This embodiment with the expander 92 is then accessed through the safety wire 91 and then the venous connection conduit 3 is connected to the vein V and then the expander 92 is closed, The safety wire 91 is removed after the locking part 33 is moved toward the locking part 32 side to form a mold.
  • the artery connecting conduit 2 is connected to the portion of the artery A in the same manner and then the expander 92 is removed and then the locking portion 23 is made to approach the engaging portion 22 side , The safety wire 91 is removed.
  • the position fixing wire 5 surrounds the collarbone C using a curved mosquito hemostat or the like, thereby firmly securing the present embodiment to the underment.
  • the exposed part of the skin is exposed to the outside of the skin by connecting the trocar, and then the incised skin is sutured.
  • the connected trocar needle is removed and the hemodialysis is performed by connecting the present embodiment to the dialyzer 8 through the connector 7.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne un dispositif d'accès vasculaire pour hémodialyse. Le dispositif d'accès vasculaire pour hémodialyse selon la présente invention comprend : un conduit principal dans lequel une paire de trajets d'écoulement sanguin séparés les uns des autres sont formés; un conduit d'accès artériel ayant un côté relié à l'un quelconque des trajets d'écoulement sanguin et l'autre côté relié à une artère; un conduit d'accès veineux ayant un côté relié à l'autre des trajets d'écoulement sanguin et l'autre côté relié à une veine; et des unités de raccordement situées sur le côté opposé du conduit d'accès artériel et du conduit d'accès veineux par rapport au conduit principal et ayant chacune une paire de sections de conduit de raccordement reliées aux trajets d'écoulement sanguin et reliées à un hémodialyseur.
PCT/KR2017/015351 2017-11-03 2017-12-22 Dispositif d'accès vasculaire pour hémodialyse Ceased WO2019088360A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170145938A KR102004615B1 (ko) 2017-11-03 2017-11-03 혈액투석용 혈관 접속 장치
KR10-2017-0145938 2017-11-03

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WO2019088360A1 true WO2019088360A1 (fr) 2019-05-09

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PCT/KR2017/015351 Ceased WO2019088360A1 (fr) 2017-11-03 2017-12-22 Dispositif d'accès vasculaire pour hémodialyse

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110368543A (zh) * 2019-08-23 2019-10-25 曹瑞民 一种血液透析用外周血管导管组件
CN111760099A (zh) * 2020-06-28 2020-10-13 成都市青白江区人民医院 透析血流连接器及透析装置
CN115192892A (zh) * 2022-08-19 2022-10-18 普多邦兴达(天津)医疗科技有限公司 一种结合血管内瘘的体表接口系统
US20230044667A1 (en) * 2020-01-14 2023-02-09 Nicola Grandolfo External end device and method for its connection to flow lines

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772268A (en) * 1984-05-25 1988-09-20 Cook Incorporated Two lumen hemodialysis catheter
JPH11500031A (ja) * 1995-02-14 1999-01-06 セレックス・リミテッド・パートナーシップ 血液透析アクセス装置
KR20020091523A (ko) * 2001-05-31 2002-12-06 (주)에이치비메디컬스 혈관 문합 장치
JP2004526481A (ja) * 2001-01-24 2004-09-02 アロウ・インターナショナル・インコーポレイテッド 取付け可能なハブを有する多内腔カテーテル
JP2008136766A (ja) * 2006-12-05 2008-06-19 Yukio Horiguchi 血液透析用補助器具

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7198611B2 (en) * 2002-02-11 2007-04-03 Baxter International Inc. Dialysis connector and cap having an integral disinfectant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772268A (en) * 1984-05-25 1988-09-20 Cook Incorporated Two lumen hemodialysis catheter
JPH11500031A (ja) * 1995-02-14 1999-01-06 セレックス・リミテッド・パートナーシップ 血液透析アクセス装置
JP2004526481A (ja) * 2001-01-24 2004-09-02 アロウ・インターナショナル・インコーポレイテッド 取付け可能なハブを有する多内腔カテーテル
KR20020091523A (ko) * 2001-05-31 2002-12-06 (주)에이치비메디컬스 혈관 문합 장치
JP2008136766A (ja) * 2006-12-05 2008-06-19 Yukio Horiguchi 血液透析用補助器具

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110368543A (zh) * 2019-08-23 2019-10-25 曹瑞民 一种血液透析用外周血管导管组件
CN110368543B (zh) * 2019-08-23 2025-01-10 曹瑞民 一种血液透析用外周血管导管组件
US20230044667A1 (en) * 2020-01-14 2023-02-09 Nicola Grandolfo External end device and method for its connection to flow lines
CN111760099A (zh) * 2020-06-28 2020-10-13 成都市青白江区人民医院 透析血流连接器及透析装置
CN115192892A (zh) * 2022-08-19 2022-10-18 普多邦兴达(天津)医疗科技有限公司 一种结合血管内瘘的体表接口系统

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KR102004615B1 (ko) 2019-10-04
KR20190050486A (ko) 2019-05-13

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