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WO2019087209A1 - Dispositif d'ophtalmoscope portable et procédé de capture d'image de fond d'œil - Google Patents

Dispositif d'ophtalmoscope portable et procédé de capture d'image de fond d'œil Download PDF

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Publication number
WO2019087209A1
WO2019087209A1 PCT/IN2018/050704 IN2018050704W WO2019087209A1 WO 2019087209 A1 WO2019087209 A1 WO 2019087209A1 IN 2018050704 W IN2018050704 W IN 2018050704W WO 2019087209 A1 WO2019087209 A1 WO 2019087209A1
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WIPO (PCT)
Prior art keywords
captured
eye
image capturing
image
user
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Ceased
Application number
PCT/IN2018/050704
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English (en)
Inventor
Mohammed IMRAN AKTHAR
Theenathayalan PARTHASARATHY
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Individual
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Individual
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Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes

Definitions

  • the present invention generally relates to an ophthalmoscopy.
  • the present invention relates to a wearable ophthalmoscope device, which can monitor fundus image captured in real time. More particularly, the present invention relates to a wearable ophthalmoscope device, which can be detachably interconnected for examining user's one eye or both eyes. Further, the present invention relates to a method of capturing fundus images, auto diagnosing and generating diagnostic report in real time.
  • the present invention is configured to locally grade the captured fundus images conditions.
  • ophthalmoscopy also called funduscopy
  • funduscopy is a test that allows a health professional to see inside the fundus of the eye and other structures using an ophthalmoscope, which is done as part of an eye examination and done as part of a routine physical examination.
  • An ophthalmoscope is device used to image the fundus or eye fundus and other structures of the eye. This imaging is used to determine the health of the retina and vitreous humor and to evaluate conditions such as hypertension, diabetic retinopathy, glaucoma, diabetic macular edima, age related macualar degeneration and papilledema and other eye conditions which causes preventable blindness.
  • the ophthalmoscope device may include a camera that is used to capture the images and a display used to display the images obtained by the ophthalmoscope device. The eye must be aligned properly with the device to capture fundus images.
  • US9237847 discloses an ophthalmoscope device which includes a support structure, an image capture device, and a display device.
  • the support structure is configured to be worn by a subject.
  • the image capture device is configured to capture images of the eye fundus of the subject.
  • the display device is configured to overlay images in the field of view of the subject. The overlaid images are used to align the pupil/fovea orientation axis with the optical axis of the image capture device.
  • US20170010470 discloses a user-wearable diagnostic health system comprising a frame, an augmented reality display attached to the frame, a light detector attached to the frame and a processor configured to conduct a health analysis of the user based on light detected by the light detector.
  • US9060718 discloses an apparatus for retinal self-imaging.
  • Visual stimuli help the user self-align his eye with a camera.
  • Bi-ocular coupling induces the test eye to rotate into different positions. As the test eye rotates, a video is captured of different areas of the retina.
  • US20160135675 discloses a system and a method for detecting an optical parameter of an eye, which are used to determine an optical parameter of an eye and particularly a position of a focusing point of the eye.
  • WO2010051304 discloses an indirect ophthalmoscope which includes a wearable headset, and the wearable headset includes a light source, a beam splitter reflecting infrared radiation from the light source to an eye, a camera collecting radiation reflected by the eye through the beam splitter, an analog to digital convertor receiving a raw signal from the camera based on the collected radiation, the analog to digital convertor converting the raw signal to a digital signal; a black and white to color converter converting the digital signal into a color signal, a streaming video converter processing the color signal into a video signal, and a pair of video monitors displaying an image of the eye based on the video signal, the wearable headset also including a video transmitter, the video transmitter transmitting the video signal to a computer over a network, the computer extracting a plurality of images from the video signal.
  • KR 1020170048072 discloses a device communication unit receiving the visual material for inspecting the eye ball state of the user using the wearable device and provides the related contents the check result to the natural disposition from the server, the display section which it outputs so that the user examines the visual material, and the photographing unit surveying the eyeball state of the user examining the visual material.
  • the conventional devices fail to detect the presence of eyes and automatically align and focus on the eye. Further, the conventional devices could not grade or categorizes the image based on the disease and further requires manual alignment of the camera for viewing the fundus. Accordingly, there exists a need for a wearable ophthalmoscope device, which can monitor the fundus image captured in real time. Further, there exists a need for a wearable ophthalmoscope device, which can locally grade the captured fundus images for eye conditions.
  • a wearable ophthalmoscope device comprising of:
  • a support frame configured to be worn by a user
  • one side of the support frame is provided with at least two inner cavities, wherein each of the inner cavities is configured to detachably hold at least two image capturing devices, actuators, and light sources,
  • image capturing devices, actuators, light sources, and display screen are connected to the wired or wireless transceiver module through the processor,
  • the image capturing device is connected to the processor through the respective actuator to host said image capturing device for their automatic detection and alignment with user's retina
  • optical assembly is located in optical path between the user's eye and the image capturing device to scale the images captured for viewing
  • the display device is mounted on other side of the support frame for operator to monitor the image captured by the images capturing devices in real time.
  • the wearable ophthalmoscope device includes one or more switches connected to the processor for manual operation of the wearable ophthalmoscope device in one or more operating modes.
  • the support frame is detachably interconnected for examining the user's one eye or both eyes.
  • the light sources are configured to provide illumination towards the user eye to assist the image capturing devices to capture images in zero light condition for non-mydriatic fundus scan.
  • the light source includes infrared based LED and white LED.
  • the wearable ophthalmoscope device includes at least two view finders mounted on other side of the support frame for the operator to view the image captured by the image capturing devices in real time. It is another aspect of the present invention, wherein the wearable ophthalmoscope device is remotely or locally controlled from a portable device connected to the wired or wireless transceiver module or remotely through a cloud server for teleconsultation.
  • the portable device includes mobile phone, tablet, laptop, personal computer, headphone, and microphone.
  • the support frame includes a headset and a supporting headband.
  • the display device is a touch screen display.
  • the wearable ophthalmoscope device is self- operated using visual guidance visible in the display screen positioned inward facing towards the user along with audio instructions.
  • Yet another aspect of the present invention there is provided a method of capturing fundus images and auto diagnosing using the wearable ophthalmoscope device, comprising steps of: entering user's demographics;
  • the fundus image is captured in two dimensional (2D) or three dimensional (3D) according to the operator control.
  • the captured fundus images are automatically analyzed and diagnosed for diabetic retinopathy; identify the stage of diabetic retinopathy; identify the stage of diabetic macular edema; segmentation of retinal blood vessels; lesions in the retina; the stage of glaucoma and the stage of age related macular degeneration.
  • Figure 1 illustrates wearable ophthalmoscope device according to the present invention.
  • Figure 2 illustrates wearable ophthalmoscope device worn by user according to the present invention.
  • Figure 3 is a block diagram illustrating method of capturing fundus image, auto diagnosing and generating diagnostic report according to the present invention.
  • the present invention as herein described relates to a wearable ophthalmoscope device, which can monitor and diagnose the fundus image of a user captured in real time.
  • the wearable ophthalmoscope device comprises of a support frame [1] configured to be worn by a user; at least four 2D/3D image capturing devices [2]; at least four actuators [3]; at least two light sources [4]; at least two optical assemblies [5]; at least two display screens [6a and 6b]; processor; wired or wireless transceiver module; storage device and power source.
  • One side of the support frame [1] is provided with at least two distinct inner cavities [lb] for left and right eye. Each of the inner cavities [lb] is configured to detachably hold at least two image capturing devices [2], actuators [3], and light sources [4].
  • the image capturing devices [2], actuators [3], light sources [4], and display screen [6a] are connected to the wired or wireless transceiver module through the processor.
  • the light sources [4] are configured to provide illumination towards the user eye to assist the image capturing devices [2] to capture images in zero light condition for non-mydriatic fundus scan, said light source [4] includes infrared based LED and White LED.
  • the image capturing device [2] is connected to the processor through the respective actuator [3] to host said image capturing device [2] for their automatic detection and alignment with user's retina as shown in Figure 2.
  • the actuators [3] assist the movement of camera in three dimensional directional inside the cavity for example x, y and z directions per cavity [lb].
  • the optical assembly [5] is located in optical path between the user's eye and the image capturing device [2] to scale the images captured for viewing.
  • the display screen [6a] is mounted on other side of the support frame for operator to monitor the image captured by the images capturing devices [2] in real time.
  • the display screen [6a] is a touch screen display.
  • the support frame [1] is detachably interconnected using one or more control buttons [11] as shown in Figure 2 for examining the user's one eye or both eyes, said support frame [1] includes a headset and a supporting headband [la].
  • the support frame [1] is positioned such that it remains stable on user's eye during medical examination.
  • the headset creates complete darkness when the user wear it which causes pupil to dilate.
  • the infrared based LED aligns and focuses on the fundus to get black and white image. Once focussed, infrared based white LED is used to get color image of the fundus.
  • the wearable ophthalmoscope device includes at least two view finders [8] mounted on other side of the support frame [1] for operator to view the image captured by the image capturing devices [2] in real time.
  • the wearable ophthalmoscope device could be remotely or locally controlled from a portable device connected to the wired or wireless transceiver module through a cloud server, said portable device includes mobile phone, tablet, laptop, personal computer, headphone [12], and microphone [9].
  • the wearable ophthalmoscope device is self-operated using visual guidance visible in the display device [6b] positioned inward facing towards the user and using audio instructions.
  • the wearable ophthalmoscope device optionally includes one or more switches [7a and 7b] connected to the processor for manual operation to operate said wearable ophthalmoscope device in one or more operating modes.
  • the wearable ophthalmoscope device includes protective glass [10] positioned above the optical assembly [5], said protective glass [10] includes toughened or tempered glass.
  • the wearable ophthalmoscope device includes USB port to connect with the portable device for charging or data transfer.
  • the wearable ophthalmoscope device can also be functioned and controlled using a software application installed in a portable device such as mobile phone, tablet, laptop, and personal computer.
  • the touch screen display device performs various operations that includes but not limited to taking fundus images of retina or other portion of the eye; recording video of the patient eye; local processing of the diagnosis for the retina image captured using deep machine learning; sharing the images to remote server for tele-consultation; updating the embedded software; managing patient details; pairing head-set with other portable devices over WiFi or Bluetooth; adjusting the image capturing device for their proper alignment with eyes for examination; to firmly position the support frame.
  • the device of the present invention is powered by either AC or DC power source.
  • the present invention is directed to a method of capturing fundus images, activating auto diagnosing and generating diagnostic report.
  • the operator enters user's or patient's demographics that include but not limited to name, unique id number, date of birth, gender, left or right eye, mobile number and address.
  • the operator initiates the image capturing process through the image capturing device, said initiation is through press of a button or via the mobile application.
  • the image capturing device scans for the presence of the retina in the view along with blinks of the eye which thereby determines the presence of human being and is ready for retina fundus scan.
  • the image capturing devices is adjusted for their detection and alignment with user's eye for examination automatically using the actuators.
  • the light sources are switched on which allows the retina to be visible in the darkness.
  • the image is now visible in grey scale.
  • the image capturing device performs auto focussing on the retina image for better visibility.
  • the light sources are automatically adjusted for optimum exposure.
  • Fundus images of retina or other portion of user's eye is captured using the image capturing devices, said fundus image is captured in two dimensional (2D) or three dimensional (3D) according to the operator control.
  • the images captured are checked for quality by activating auto detection of the images. If the images captured are not satisfactory, a message is displayed about the issue with image quality and request for the new image to be captured to the user or operator.
  • the captured fundus images are processed to auto detection, if the scan was taken for left or right eye.
  • the captured fundus images are automatic analyzed, diagnosed and a diagnostic report is generated.
  • the captured fundus images are transmitted to the portable device locally or through cloud server for remote examination.
  • the captured fundus images are graded by the portable device connected through the cloud server.
  • the fundus image captured are locally graded and the diagnostic report are shown for further consultation with physicians.
  • the captured fundus images or video are displayed in the display device in real time to the operator.
  • the images or video captured by the image capturing devices are viewed in real time using the view finders.
  • the captured fundus images are automatically analysed and diagnosed for the following.
  • the captured fundus images are automatically analysed for the presence of diabetic retinopathy and identify the stage of diabetic retinopathy.
  • the captured fundus images are automatically analysed for determining the stage of diabetic macular edema.
  • Further the captured fundus images are analysed for automatically segmentation of retinal blood vessels. Diabetic retinopathy causes blood vessel proliferation.
  • Further the captured fundus images are analysed for auto detection for lesions in the retina. The regions detected with lesions are marked with labels. Further the captured fundus images are analysed for auto detection of the stage of Glaucoma.
  • the captured fundus images are analysed for auto detection of the stage of age related macular degeneration.
  • a comprehensive diagnostic report is generated with patient's name, the retina image for left and right eye. For each eye, the report list the presence of diabetic retinopathy, stage of diabetic retinopathy, stage of diabetic macular edema, image of retina with blood vessels segmented, image of retina with presence of lesions and their location with labels, presence of glaucoma with cup and disc highlighted, presence of stage of age related macular degeneration. This report is downloadable.
  • the wearable ophthalmoscope device is operated in one or more modes using one or more switches as per requirements.
  • the physician can connect the "Patient Only” mode head-set and visualise the retinal scan in his "Physician Mode” device.
  • the Physician can be connected locally to the "Patient Only” mode head-set or remotely for tele consultation.
  • 2D/3D Mode In this mode of operation, the operator can select, if the diagnosis is needed for scanning the eye in 2D or 3D mode.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

La présente invention concerne un dispositif d'ophtalmoscope pouvant être porté, qui peut surveiller l'image de fond de l'œil capturée en temps réel. Plus particulièrement, la présente invention concerne un dispositif d'ophtalmoscope pouvant être porté, qui peut être interconnecté de façon détachable pour examiner un œil ou les deux yeux de l'utilisateur. Le dispositif peut détecter et s'aligner automatiquement avec l'œil de l'utilisateur pour un examen. Le fonctionnement de dispositif d'ophtalmoscope portable est commandé à distance à partir d'un dispositif mobile portable connecté à un module d'émetteur-récepteur filaire ou sans fil localement ou à distance via un serveur cloud pour la téléconsultation. En outre, la présente invention concerne un procédé de capture d'images de fond d'œil, de diagnostic automatique et de génération de rapport de diagnostic en temps réel. De manière avantageuse, la présente invention est configurée pour classer localement les conditions d'images de fond d'œil capturées.
PCT/IN2018/050704 2017-11-03 2018-10-31 Dispositif d'ophtalmoscope portable et procédé de capture d'image de fond d'œil Ceased WO2019087209A1 (fr)

Applications Claiming Priority (2)

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IN201741039185 2017-11-03
IN201741039185 2017-11-03

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3751581A1 (fr) * 2019-06-07 2020-12-16 Welch Allyn, Inc. Criblage d'images numériques et/ou diagnostic utilisant l'intelligence artificielle
CN114222520A (zh) * 2019-07-31 2022-03-22 克森农-虚拟现实公司 眼科测试系统和方法
WO2022129591A1 (fr) * 2020-12-17 2022-06-23 Delphinium Clinic Ltd. Système de détermination d'une ou plusieurs caractéristiques d'un utilisateur sur la base d'une image de son œil à l'aide d'un casque de ra/rv
ES2933226A1 (es) * 2021-07-30 2023-02-02 Share Global Health S L Dispositivo para control de retinopatías diabéticas u otras afecciones detectables a través del estudio ocular
USD1005289S1 (en) 2022-03-03 2023-11-21 Xenon Ophthalmics Inc. Headset
USD1005288S1 (en) 2022-03-03 2023-11-21 Xenon Ophthalmics Inc. Module for head mounted display
USD1019641S1 (en) 2022-03-03 2024-03-26 Xenon Ophthalmics Inc. Headset
USD1021898S1 (en) 2022-03-03 2024-04-09 Xenon Ophthalmics Inc. Module for head mounted display
EP4356818A4 (fr) * 2021-06-17 2025-06-11 Kowa Company, Ltd. Programme médical et système d'examen médical

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US20160135675A1 (en) * 2013-07-31 2016-05-19 Beijing Zhigu Rui Tuo Tech Co., Ltd System for detecting optical parameter of eye, and method for detecting optical parameter of eye

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US20160135675A1 (en) * 2013-07-31 2016-05-19 Beijing Zhigu Rui Tuo Tech Co., Ltd System for detecting optical parameter of eye, and method for detecting optical parameter of eye

Non-Patent Citations (1)

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Title
MICHAEL D. ABRMOFF ET AL.: "Retinal Imaging and Image Analysis", IEEE REV BIOMED ENG., vol. 3, 1 January 2010 (2010-01-01), pages 169 - 208, XP011339903 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3751581A1 (fr) * 2019-06-07 2020-12-16 Welch Allyn, Inc. Criblage d'images numériques et/ou diagnostic utilisant l'intelligence artificielle
US11915826B2 (en) 2019-06-07 2024-02-27 Welch Allyn, Inc. Digital image screening and/or diagnosis using artificial intelligence
CN114222520A (zh) * 2019-07-31 2022-03-22 克森农-虚拟现实公司 眼科测试系统和方法
EP4003142A4 (fr) * 2019-07-31 2023-08-23 Xenon-VR, Inc. Systèmes et procédés de test ophtalmique
CN114222520B (zh) * 2019-07-31 2025-10-14 克森农-虚拟现实公司 眼科测试系统和方法
US12376745B2 (en) 2019-07-31 2025-08-05 Xenon Ophthalmics Inc. Ophthalmologic testing systems and methods
WO2022129591A1 (fr) * 2020-12-17 2022-06-23 Delphinium Clinic Ltd. Système de détermination d'une ou plusieurs caractéristiques d'un utilisateur sur la base d'une image de son œil à l'aide d'un casque de ra/rv
EP4356818A4 (fr) * 2021-06-17 2025-06-11 Kowa Company, Ltd. Programme médical et système d'examen médical
ES2933226A1 (es) * 2021-07-30 2023-02-02 Share Global Health S L Dispositivo para control de retinopatías diabéticas u otras afecciones detectables a través del estudio ocular
USD1005288S1 (en) 2022-03-03 2023-11-21 Xenon Ophthalmics Inc. Module for head mounted display
USD1021898S1 (en) 2022-03-03 2024-04-09 Xenon Ophthalmics Inc. Module for head mounted display
USD1019641S1 (en) 2022-03-03 2024-03-26 Xenon Ophthalmics Inc. Headset
USD1095527S1 (en) 2022-03-03 2025-09-30 Xenon Ophthalmics I Nc. Headset
USD1005289S1 (en) 2022-03-03 2023-11-21 Xenon Ophthalmics Inc. Headset

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