WO2019085342A1 - Tissue sample collection and separation device - Google Patents

Abstract

A tissue sample collection and separation device, comprising: a bottle body (5) having an upper part with a first volume and a lower part with a second volume; a bottle cap (2) suitable for the upper part and having porous channels (6) for receiving tissue samples; an annular filter net (8) installed at the center of a bottom surface of the lower part of the bottle body (5) and having a support column (4) which can extend upwards from the lower part of the bottle body (5); and at least one inner core (3) detachably installed on the upper part of the bottle body (5) and having a plurality of side walls (21, 22, 23, 24) and a porous bottom surface (25). The porous bottom surface (25) of the inner core (3) can filter the tissue samples, so that the tissue samples are kept on the upper part of the bottle body (5), and fluid flows into the lower part of the bottle body (5).

Description

Tissue sample collection and separation device Technical field

The present invention relates to a tissue sample collection and separation device, and more particularly to a tissue sample collection and separation device with dual filtration function.

technical background

With the wide use of endoscopes, clinicians can perform biopsy sampling under direct vision through endoscopic forceps for pathological testing, providing the most direct evidence for disease diagnosis; clinicians can also use endoscopic forceps The road underwent various minimally invasive procedures under direct vision. A variety of dexterous instruments can be used to perform various types of surgery directly through the endoscopic forceps, which not only provides patients with safer micro-trauma surgery opportunities, but also reduces the pain of patients. With the development of science and technology, in order to alleviate the suffering of patients, the outer diameter of the endoscope is developing in a smaller and smaller direction, and the clamp for the minimally invasive surgical endoscope is developing in an increasingly larger direction.

Tissue sample collection and separation devices are currently in clinical use. The working principle is: connecting the suction tube of the tissue sample collection and separation device with the suction device, and the collection hole is connected with the endoscope clamp, and under the direct vision of the endoscope, through the work of the suction device, Samples such as polyps in the body are absorbed into the sample collection and separation device through the collection hole for pathological analysis. The traditional sample collection and separation device adopts the bottle body and the bottle cap to be buckled up and down, and adopts single layer filtration, which is easy to cause misoperation. When the collection hole is not aligned with the collection basket, it is not drawn into the collection basket. The polyp sample may be directly sucked out from the suction tube and directly enter the waste collection bottle, so that no biopsy is taken, and the serious situation may Delaying the treatment of the patient, the present invention provides a tissue sample collection and separation device with dual filtration, which can provide a safe and reliable polyp sample even if the collection hole is not aligned with the collection basket. Tissue sample collection and separation device.

Summary of the invention

In order to solve the deficiencies in the prior art, the present invention provides a tissue sample collection and separation device with double filtration, which enables the user to take out the specimen more conveniently, avoids the loss of the specimen, and provides the safety and reliability of the biopsy.

The present invention provides a tissue sample collection and separation device comprising: a bottle body having an upper portion of a first volume and a lower portion of a second volume; a cap adapted for the upper portion a bottle cap having a channel for receiving a tissue sample; an annular filter mesh mounted at a center of a bottom surface of the lower portion of the bottle body, the annular filter mesh having a hollow support column extending upward from a lower portion of the bottle body, the support column and the bottle Between the inner surface of the body, at least one inner core is detachably mounted on the upper portion of the bottle body, the inner core has a plurality of side walls and a porous bottom surface, and the porous bottom surface of the inner core can filter the tissue sample to keep the tissue sample At the upper portion of the first volume of the bottle, fluid flows into the lower portion of the second volume of the bottle.

In one embodiment, the inner surface of the bottle body further has a stepped protrusion on which the inner core can be placed.

In one embodiment, the inner core may also have two recesses that are respectively fixed to the convex portions of the inner surface of the inner surface of the bottle and the convex portions of the outer surface of the support post.

In one embodiment, the porous bottom surface of the inner core and the annular filter screen can also be designed with different pore sizes to achieve different sample separation capabilities. Preferably, the porous bottom surface structure of the inner core has a larger diameter than the annular filter.

In one embodiment, the inner cores may be one or more and independent of one another. Preferably, the inner cores may also be four and independent of one another.

In one embodiment, the cap further has a suction tube that extends downwardly from the surface of the cap into the body to form a suction channel.

In one embodiment, the cap further has a positioning indication. On the one hand, the positioning indication may be located on the edge of the cap, that is, the cap edge has a protruding positioning indication, and the protruding positioning indication may be A colored triangular indication, on the other hand, the positioning indication may be located below the cap, ie a scalloped positioning structure beneath the cap.

Beneficial effects:

The tissue sample collecting and separating device provided by the invention has the porous bottom surface and the annular filter mesh of the inner core functioning as double filtration, thereby better separating the tissue sample from the fluid, and when the tissue sample enters the inner core, at this time The inner layer of the porous bottom surface is subjected to the first layer of filtration. Normally, the tissue sample is stored in the inner core, and the fluid is filtered through the second layer of the annular filter and then sucked out through the suction channel, even in special cases, the tissue sample. Without entering the inner core and directly entering the bottle body, due to the presence of the annular filter, the tissue sample can be prevented from being sucked away by mistake, thereby reducing the risk of surgery.

The tissue sample collecting and separating device provided by the invention has the inner core detachably mounted on the upper part of the bottle body, and the annular filter net is installed at the center of the bottom surface of the lower part of the bottle body, and the two have a large space spacing, thereby greatly reducing the space. The problem that the inner porous bottom surface and the filter hole of the annular filter are clogged due to too close a distance to the dirt.

DRAWINGS

Figure 1 is a perspective view of the overall section of the tissue sample collection and separation device

Figure 2 is an exploded view of the tissue sample collection and separation device

Figure 3 is a cross-sectional view showing the assembly structure of the tissue sample collection and separation device

Figure 4A is a bottle diagram with an inner core mounted

Figure 4B is a core structure diagram

Figure 5 is a top view of the inner core and the bottle body fixed

Figure 6A is a schematic view of the structure of the cap having a prominent positioning indication at the edge

6B is a schematic view showing the structure of a bottle cap having a scalloped protrusion positioning structure at the bottom.

1, hose, 2, cap, 3, inner core, 4, support column, 5, bottle body, 6, collecting holes, 7, suction tube, 8, ring filter, 9, step-like protrusion, 10, Protruding positioning indication, 11, scalloped locating structure, 21, inner core side wall, 22, inner core side wall, 23, outer curved wall, 24, inner curved wall, 25, porous bottom surface, 31, inner curved a recess 32 on the wall, a convex portion on the outer surface of the support column, 33, a recess on the outer curved wall, 34, a convex portion on the inner surface of the bottle, 35, a recess

Detailed ways

The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

As shown in Figure 1, the tissue sample collection and separation device of the present invention can be used to collect a tissue sample comprising a body 5 and a cap 2 that is removably and rotatably capped to the bottle 5. Preferably, the bottle body 5 may be a hollow cylinder and has a circular bottom surface, the bottle body 5 has an upper portion of the first volume and a lower portion of the second volume, and the upper portion of the bottle body 5 and the lower portion of the bottle body 5 may Having the same diameter or different diameters, preferably, the diameter of the upper portion of the bottle body 5 is larger than the lower portion of the bottle body 5. Preferably, the cap 2 can be covered with the bottle body 5 in a suitable manner such as a friction fastener or a screwing. The cooperation between the bottle cap 2 and the bottle body 5 requires a certain airtightness requirement, when the suction is closed. At least a negative pressure of 20 Kpa can be achieved, and under this negative pressure, the bottle 5 can still rotate relative to the cap 2.

As shown in Figures 2-5, the cap 2 has a suction tube 7 which extends downwardly from the upper surface of the cap 2 into the body 5 to form a suction channel. The cap 2 also has a collecting hole 6 through which the hose 1 can be connected by pipe connection to the endoscope to form a collecting passage.

The annular filter screen 8 is mounted at the center of the circular bottom surface of the lower portion of the bottle body 5. The plurality of holes of the annular filter screen serve to filter the tissue sample, and have a hollow support column extending upward from the lower portion of the bottle body 5 to below the bottle cap 2. 4, forming a fluid circulation channel, the support column 4 may be a hollow cylinder, when the bottle cap 2 is covered on the upper part of the bottle body 5, the suction pipe 7 is located in the support column in the bottle body 5 and is fixed from the bottom of the bottle body 5 The distance, so when the suction is performed by the external suction device, the fluid located in the bottle body 5 is sucked out through the annular filter 8 and then into the suction passage formed by the suction pipe 7, thereby achieving the purpose of filtration.

As shown in FIGS. 2-5, the inner surface of the upper portion of the bottle body 5 may have a stepped projection 9, and between the support post 4 and the inner surface of the upper portion of the bottle body 5, one or more inner cores 3 are detachably mounted independently of each other. On the stepped projection 9 of the upper inner surface of the bottle body 5, preferably all of the inner cores 3 accommodated in the bottle body 5 may have the same size and volume or different sizes and volumes, preferably all the inner cores 3 have the same Size and volume. The inner core 3 can have a plurality of side walls 21, 22, 23, 24 and a porous bottom surface 25, and the porous bottom surface of the inner core 3 can filter the tissue sample, keeping the tissue sample in the upper portion of the bottle body 5, and the fluid flows into the bottle body 5 The lower part. Specifically, the inner core 3 includes two relatively angled side walls 21, 22, an outer curved wall 23 extending between the outer edges of the two side walls 21, 22, and at the two side walls 21, An inner curved wall 24 extending between the inner edges of 22, the outer curved wall 23 abutting the inner surface of the body 5, and the outer curved wall 23 is shaped to match the inner surface of the body 5, the inner curved wall 24 is adjacent to the outer surface of the support column 4, the shape of the inner curved wall 24 is matched with the outer surface of the support column 4, and the angle between the two side walls 21, 22 of the inner core 3 can be according to the inner core 3 of the bottle body 5 In quantitative adjustment, the two side walls 21, 22 extend vertically upward from the bottom of the upper portion of the bottle 5 to a position adjacent to the cap 2, the bottoms of the two side walls 21, 22, and the outer curved wall 23 and the inner curved wall 24 The bottom portions are connected to form a hollow inner bottom surface 25, and the porous bottom surface 25 has filtering holes for filtering. When the bottle cap 2 is rotated relative to the bottle body 5, the collecting hole 6 on the bottle cap 2 can be placed above an inner core 3, and the external suction device is suctioned through the suction pipe 7, in the closed container system. The tissue sample is directly aspirated from the biopsy channel, passes through the hose, and then falls into the inner core 3 through the collecting hole 6. Since the porous bottom surface 25 of the inner core 3 has a filtering hole, the fluid will be sucked directly through the suction channel. The tissue sample is left in an inner core 3. When a tissue sample aspiration process is completed, the cap 2 can be rotated to align the collection hole 6 with the other inner core 3 to perform the next tissue sample aspiration process. Preferably, four inner cores 3 can be placed in the bottle body 5, and the four inner cores 3 are independent of each other. The size and volume of the four inner cores 3 can be designed as needed, and the four inner cores 3 can have the same The size and volume or the different size and volume, the spacing between the four inner cores 3 may be uniform or different, preferably, the cross-sectional areas of the four inner cores 3 are the same, four inner cores 3 has the same size, and the spacing between the cores 3 is uniform.

When the inner core 3 is housed in the bottle body 5, the porous bottom surface 25 of the inner core 3 and the annular filter screen 8 can function as a double filter to better separate the tissue sample from the fluid, and the porous bottom surface of the inner core 3 is 25 And the annular filter 8 can be designed to have different pore sizes as needed to achieve different sample separation capabilities. For example, the aperture of the porous bottom surface 25 of the inner core 3 may be larger than the aperture of the annular filter 8, and larger tissue samples may remain in the inner core 3, while smaller tissue samples may remain in the presence of the annular filter 8 The lower part of the bottle body 5 so as not to enter the suction channel, under normal circumstances, the tissue sample can be stored in the inner core 3, and the smaller tissue sample will remain in the lower part of the bottle body 5; even in special cases, That is, the tissue sample does not enter the inner core 3 and directly enters the bottle body 5. At this time, due to the presence of the annular filter screen 8, the tissue sample can be prevented from being sucked away during the suction process, thereby reducing the risk of surgery. In addition, the aperture of the porous bottom surface 25 of the inner core 3 may also be the same as the aperture of the annular filter screen 8. Under normal circumstances, the tissue sample may be stored in the inner core 3; even in special cases, the tissue sample does not enter the inner core 3 And directly into the bottle body 5, at this time due to the presence of the annular filter 8, can also avoid the tissue sample is sucked away during the suction process, thereby reducing the risk of surgery. Since the porous bottom surface 25 of the inner core 3 is located at the upper portion of the bottle body 5, and the annular filter screen 8 is installed at the center of the lower bottom surface of the bottle body 5, the two have a large spatial spacing, thereby greatly reducing the porosity of the inner core 3 There is a problem that the bottom surface 25 and the filter holes of the annular filter 8 are clogged due to too close a distance to adhere to dirt.

As shown in Figures 4-5, in order to ensure proper installation and positioning of the inner core 3, the tissue collecting and separating device also has an inner core 3 positioning structure so that the inner core 3 can be located in the correct area during installation. The inner core 3 has a simple positioning structure and is easy to operate, so that the mounting positions of the respective inner cores 3 are correct and movement does not occur during use. Preferably, the inner core 3 positioning structure may have one or more sets of corresponding protrusions 32, 34 and recesses 31, 33, wherein a corresponding set of protrusions 32, 34 and recesses 31, 33 may be located The inner surface of the bottle body 5 and the outer curved wall 23 of the inner core 3, and the other set of corresponding convex portions 32, 34 and recesses 31, 33 may be located on the outer surface of the support column 4 and the inner curved shape of the inner core 3. Wall 24. Preferably, the inner core 3 positioning structure may include a projection 32 on the outer surface of the support post 4 and a recess 31 on the inner curved wall 24 of the inner core 3 corresponding thereto, the outer surface of the support post 4 The convex portion 32 extends upward from the bottom of the support column 4 to be flush with the upper surface of the support column 4, and at a position horizontally flush with the stepped projection 9 of the bottle body 5, the convex portion 32 faces the passage of the support column 4. Slightly recessed 35 such that the projection 32 extends downwardly from the upper surface of the support post 4 into an L shape, and in the process of placing the inner core 3, the recess 31 of the inner curved wall 24 corresponds to The projections 32 on the outer surface of the support column 4 are snap-fitted to prevent the inner core from rotating, and the porous bottom surface 25 in the direction of the inner curved wall 24 can be placed on the recess 35, the recess on the inner curved wall 24. 31 matches the convex portion 32. Preferably, the inner core 3 positioning structure may include a projection 33 on the inner surface of the bottle body 5 and a recess 33 on the outer curved wall 23 of the inner core 3 corresponding thereto, the convex portion 34 from the bottle body 5 The stepped protrusion 9 of the inner surface extends upwards by about 2 mm to 5 mm, in any shape that can be disposed as needed. Preferably, the protrusion 34 can be an inverted trapezoid, and the recess 33 of the outer curved wall 23 of the inner core 3 can be The projections 34 match. The inner core 3 and the bottle body 5 and the support column 4 are fixed by the concave-convex manner, and the inner core 3 and the bottle body 5 and the support column 4 are matched by the gap card, so that the inner core 3 can be easily taken out, and the operation is simple and convenient. .

As shown in Figure 6A, the cap 2 can include a positioning indication to indicate the relative position of the cap 2 and the inner core 3, which can be indicative of a structural indication or visibility. Preferably, the edge of the cap 2 may have a protruding positioning indicator 10 that may indicate the relative position of the collection aperture 6 to the inner core 3, which may be a colored triangular indication. In addition, the inner core 3 may also carry a number or letter mark to indicate the relative position of the collecting hole 6 and the inner core 3.

As shown in FIG. 6B, the bottle cap 2 may have a structural positioning indication below, and may be at least one protrusion, and the protrusion may be a fan-shaped protrusion positioning structure 11 which is larger than the porous bottom surface 25 of the inner core 3. The area is slightly smaller, and it can be completely dropped into the inner core 3. When the cap 2 is rotated relative to the bottle body 5, the scalloped positioning structure 11 can interact with the inner core 3 to produce a slight click. The person has a tactile sensation, thereby prompting the user to rotate to the correct position of the collecting hole 6 corresponding to one of the inner cores 3.

As shown in Figures 1-6, the assembly process of the tissue collecting and separating device: an annular filter screen 8 with a hollow support column 4 is installed at the center of the bottom surface of the lower portion of the bottle body 5, in the upper portion of the support column 4 and the bottle body 5 Between the surfaces, a desired number of inner cores 3 are independently and detachably mounted on the stepped projections 9 on the inner surface of the upper portion of the bottle body 5, and are respectively fixed to the bottle body 5 and the support column 4 by a series of convex recessed structures. In order to prevent the inner core 3 from rotating, the bottle cap 2 can be attached to the bottle body 5. The bottle cap 2 has a suction tube 7 and a collecting hole 6, and the hose 1 can be connected to the collecting hole 6 by a pipe. Thereby the cap 2 is connected to the endoscope to form a collecting channel, and the suction tube 7 can be connected to the suction system to achieve the suction effect.

In order to collect tissue samples from the patient, the user may choose to use one of the cores 3 for tissue collection, and the cap 2 may be rotated such that the collection holes 6 are located above an inner core 3, when suction is performed by the suction system, The fluid and tissue samples can enter the collection well 6 through the collection channel and fall into the inner core 3, after which the fluid passes through the annular filter 8 at the lower portion of the bottle 5 and is sucked away from the suction channel formed by the suction tube. When a tissue sample suction is completed, the bottle cap 2 is rotated so that the collection hole 6 is positioned above the other inner core 3, and the second suction can be continued.

The above description is only a preferred embodiment of the present application, so that those skilled in the art can understand or implement the invention of the present application. Various modifications and combinations of these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the application. . Therefore, the present application is not limited to the embodiments shown herein, but the broadest scope consistent with the principles and novel features disclosed herein.

Claims (11)

A tissue sample collection and separation device, characterized in that the tissue sample collection and separation device comprises: a bottle body having an upper portion of a first volume and a lower portion of a second volume; a bottle adapted to the upper portion a cap having a channel for receiving a tissue sample; an annular filter meshing at a center of a bottom surface of the lower portion of the bottle body, the annular filter mesh having a hollow support column extending upward from a lower portion of the bottle body, the support column and the support column Between the inner surfaces of the bottle, at least one inner core is detachably mounted on the upper portion of the bottle body, the inner core has a plurality of side walls and a porous bottom surface, and the porous bottom surface of the inner core can filter the tissue sample to make the tissue sample Maintained in the upper portion of the first volume of the bottle, and fluid flows into the lower portion of the second volume of the bottle. The tissue sample collecting and separating device according to claim 1, wherein an inner surface of the bottle body has a stepped projection, and the inner core can be placed on the stepped projection. The tissue sample collecting and separating device according to claim 1 or 2, wherein the inner core has two recesses, which are respectively fixed to the convex portion of the inner surface of the bottle body and the convex portion of the outer surface of the support column. . The tissue sample collection and separation device according to claim 1 or 2, wherein the porous bottom surface of the inner core and the annular filter have the same or different pore sizes. The tissue sample collection and separation device according to claim 4, wherein the porous bottom surface of the inner core has a larger diameter than the annular filter. The tissue sample collection and separation device according to claim 1 or 2, wherein the inner core is one or more and independent of each other. The tissue sample collection and separation device according to claim 6, wherein the inner cores are four and independent of each other. The tissue sample collection and separation device of claim 1 wherein said cap has a suction tube that extends downwardly from the surface of the cap into the body to form a pump Suction channel. The tissue sample collection and separation device of claim 8 wherein said cap has a positioning indication thereon. The tissue sample collection and separation device of claim 9 wherein said cap opening has an indexing indication thereon. The tissue sample collection and separation device according to claim 9, wherein the cap has a scalloped projection positioning structure underneath.

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