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WO2019073286A1 - Dispositif améliorant la circulation sanguine au niveau des extrémités à l'aide d'eau saturée en dioxyde de carbone comprimée - Google Patents

Dispositif améliorant la circulation sanguine au niveau des extrémités à l'aide d'eau saturée en dioxyde de carbone comprimée Download PDF

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Publication number
WO2019073286A1
WO2019073286A1 PCT/IB2017/056294 IB2017056294W WO2019073286A1 WO 2019073286 A1 WO2019073286 A1 WO 2019073286A1 IB 2017056294 W IB2017056294 W IB 2017056294W WO 2019073286 A1 WO2019073286 A1 WO 2019073286A1
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WIPO (PCT)
Prior art keywords
carbon dioxide
fluid
saturated water
water
pressure
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Ceased
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PCT/IB2017/056294
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English (en)
Inventor
Mohamed FAGEIR
Maisa MOHAMMED
Mohammed KHAIRY
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Priority to PCT/IB2017/056294 priority Critical patent/WO2019073286A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/02—Bathing devices for use with gas-containing liquid, or liquid in which gas is led or generated, e.g. carbon dioxide baths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H35/00—Baths for specific parts of the body
    • A61H35/006—Baths for specific parts of the body for the feet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
    • A61H2033/145—Devices for gas baths with ozone, hydrogen, or the like with CO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/02—Characteristics of apparatus not provided for in the preceding codes heated or cooled
    • A61H2201/0207—Characteristics of apparatus not provided for in the preceding codes heated or cooled heated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
    • A61H2201/105—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy with means for delivering media, e.g. drugs or cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/164—Feet or leg, e.g. pedal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/1654—Layer between the skin and massage elements, e.g. fluid or ball
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2205/00—Devices for specific parts of the body
    • A61H2205/10—Leg
    • A61H2205/106—Leg for the lower legs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00—Pneumatic or hydraulic massage
    • A61H9/005—Pneumatic massage
    • A61H9/0078—Pneumatic massage with intermittent or alternately inflated bladders or cuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00—Pneumatic or hydraulic massage
    • A61H9/005—Pneumatic massage
    • A61H9/0078—Pneumatic massage with intermittent or alternately inflated bladders or cuffs
    • A61H9/0092—Cuffs therefor

Definitions

  • Diabetes is a chronic condition that occurs when the body cannot produce enough insulin or cannot use insulin, and is diagnosed by observing raised levels of glucose in the blood. Insulin is required to transport glucose from the bloodstream into the body's cells where it is used as energy. The lack, or ineffectiveness, of insulin in a person with diabetes means that glucose remains circulating in the blood. Over time, the resulting high levels of glucose in the blood (known as hyperglycemia) causes damage to many tissues in the body, leading to the development of disabling and life-threatening health complications[l].
  • hyperglycemia causes damage to many tissues in the body, leading to the development of disabling and life-threatening health complications[l].
  • Diabetes is one of the largest global health emergencies of the 21st century. Each year more and more people live with this condition, which can result in life-changing complications. In addition to the 415 million adults who are estimated to currently have diabetes, there are 318 million adults with impaired glucose tolerance, which puts them at high risk of developing the disease in the future, in 2015 One out of every eleven adults has diabetes (9.09% of world population)and the ratio will rise to one out of every ten adults in 2040 (10% of world population)[l].
  • Diabetic foot is an infection, ulceration, or destruction of deep tissues of the foot associated with neuropathy and/or peripheral arterial disease in the lower extremity of people with diabetes[3].
  • the diabetes affects 15% of people with diabetes that That means 1.4% of the world's population (more than 11 million people around the world). Amputation
  • the end stage of the diabetic foot syndrome is the requirement for amputation as many as 6 - 10% of all patients with diabetes will undergo amputation for treatment of infection, accounting for 57% of no traumatic lower extremity amputations[4], patients with diabetes have a 15 times increased risk of amputation relative to the normal population[5].
  • Carboxytherapy is the use of C02-rich water bathing which was developed in France in 1930. It was found that C02 helped in wound healing and fat accumulation in arteries[9].
  • Carbon dioxide is easily absorbed percutaneously. Consequently, it is inherently the end product of metabolism, can be artificially increased in the tissues by absorbing carbon dioxide percutaneously from a carbonated water bath. As a result, blood vessels can be dilated and blood flow volume can be increased. As a result of this action, blood vessels are temporarily dilated. Alternatively, dysfunctional finer vessels can be opened again to increase blood flow volume or allow blood to enter peripheral tissues. This technique for alleviating symptoms is actively used in the form of carbonated springs therapy[ll]
  • Artificial C02-enriched water has been prepared by various methods, for example by dissolving tablets containing sodium bicarbonate and succinic acid in hot fresh water or by bubbling C02 gas into ordinary bath water[12] Or through mechanical pressure as in the manufacture of soft drinks.
  • Carbon dioxide (C02) therapy refers to the transcutaneous or subcutaneous administration of C02 for therapeutic purposes.
  • One example of this is the use of spa therapy that emerged as an important treatment in Europe during the 1800s, another example is the use of artificial C02 enriched water for bathing, which has been clinically applied to improve ischemic limb symptom.
  • These therapeutic effects of C02 are caused by an increase in blood flow and microcirculation assessed by Laser Doppler, and an increase of tcP02 in ischemic tissues, which is explained by the Bohr effect[13].
  • a vascularization therapy that increases the number of newly formed blood vessels of an affected site by immersing in carbonated warm water having a carbon dioxide concentration of 700 ppm or more and a water temperature of 33 to 42° C[ll].
  • a vascularization therapy that increases the number of vascular endothelial cells in tissue of an affected site by 1.5 times or more and that increases the number of endothelial precursor cells in the peripheral blood at an affected site by 1.1 times or more by immersing the affected site of a peripheral blood vessel in the aforementioned carbonated warm water[ll]
  • hemoglobin For hemoglobin to carry the required oxygen molecules to cells from the lungs, hemoglobin carries two final products of cellular respiration H+ and C02 from the tissues to the lungs and kidneys, The C02 produced by oxidation of organic fuels in mitochondria, is hydrated to form bicarbonate:
  • This reaction is catalyzed by carbonic anhydrase, an enzyme particularly abundant in erythrocytes. Carbon dioxide is not very soluble in aqueous solution, and bubbles of C02 would form in the tissues and blood if it were not converted to bicarbonate. As you can see from the reaction catalyzed by carbonic anhydrase, the hydration of C02 results in an increase in the H+ concentration (a decrease in pH) in the tissues. The binding of oxygen by hemoglobin is profoundly influenced by pH and C02 concentration, so the inter conversion of C02 and bicarbonate is of great importance to the regulation of oxygen binding and release in the blood [15].
  • the binding of H+ and C02 is inversely related to the binding of oxygen.
  • the affinity of hemoglobin for oxygen decreases as Hland C02 are bound, and 02 is released to the tissues.
  • the affinity of hemoglobin for oxygen increases and the protein binds more 02 for transport to the peripheral tissues.
  • This effect of pH and C02 concentration on the binding and release of oxygen by hemoglobin is called the Bohr effect, after Christian Bohr, the Danish physiologist (and father of physicist Niels Bohr) who discovered it in 1904[15].
  • the binding equilibrium for hemoglobin and one molecule of oxygen can be designated by the reaction:
  • HHb+ + 02 Hb02 + H+ (3)
  • HHb+ denotes a protonated form of hemoglobin. This equation tells us that the 02- saturation curve of hemoglobin is influenced by the H+ concentration.
  • Both 02 and H+ are bound by hemoglobin, but with inverse affinity.
  • hemoglobin binds 02 and releases protons.
  • H+ is bound and 02 is released.
  • the pH of blood is 7.6 in the lungs and 7.2 in the tissues. Experimental measurements on hemoglobin binding are often performed at pH 7.4 as in the figure 3 in the drawings file[15].
  • Hemoglobin also binds C02, again in a manner inversely related to the binding of oxygen. Carbon dioxide binds as a carbonate group to thect- amino group at the amino-terminal end of each globin chain, forming Carbaminohemoglobin.
  • the CDT required carbonated warm water having a carbon dioxide concentration higher than700 ppm and a water temperature of 33 to 42° C (more preferably from 35 to 39° C near body temperature).
  • the amount of carbon dioxide percutaneous absorption from a carbonated warm water bath increases proportionately to the concentration of carbon dioxide dissolved in the carbonated warm water.
  • the frequency of immersion is preferably at least once every 24 hours. Moreover, if the frequency of immersion is from 1 to 2 times every 24 hours, adequate effects are obtained and the load on the patient is not excessively large, thereby making this preferable[ll].
  • the immersion time of a single treatment is preferably at least 10 minutes. Moreover, if the duration of a single immersion is within the range of 10 to 30 minutes, adequate effects are obtained and the burden on the patient is not excessively large[ll].
  • the CDT performed by the highly concentrated carbonated warm water is associated with a high degree of safety, and can be performed easily without requiring any special complicated apparatuses or equipment[ll].
  • a Hydro-thermo- Mechanical system has been designed to deliver a carbon dioxide saturated water with a concentration higher than 700 parts per million, a temperature between 35-39 ° C and applied contact pressure between the solution and the surface of the skin around 100 millimeters of mercury.
  • our invented system works on compressing the C02 saturated water on the skin to increase both the amount of absorbed gas and the bohr effect to enhance the blood flow and circulation in the extremities and heal diabetic foot ulcers.
  • the effectiveness of the therapy can also be greatly increased by compressing the C02 saturated water on the skin of the extremities which will increase the amount of transcutaneous absorbed gas, in turn increasing the positive effect on the blood circulation according to the bohr effect law (as explained in the background).
  • Figures 1 and 2 show the simple system mechanism which depends on the compression of C02 saturated water on the skin either by an external air inflatable membrane as shown in figure 1, or by pumping a suitable amount of C02 saturated water in the enclosed environment of the system which in turn compresses the fluid on the skin as shown in Figure 2.
  • the system will be used by both diabetic patients who already has diabetic foot ulcers for therapeutic purposes, and diabetic patients who doesn't have diabetic foot issues for preventive purposes.
  • the system can also be used as a physiotherapy to enhance blood circulation for people who has blood flow issues.
  • the figure shows the systems mechanism in case of depending on applying extra pressure on the fluid and the extremity together.
  • a device enhancing the blood circulation at the extremities using compressed C02 saturated water is provided.
  • Figures 1 and 2 show the simple system mechanism which depends on the compression of C02 saturated water on the skin either by an external air inflatable membrane as shown in figure 1, or by pumping a suitable amount of C02 saturated water in the enclosed environment of the system which in turn compresses the fluid on the skin as shown in Figure 2.
  • the invention consists of two main units:
  • 1- carbon dioxide saturated water production unit which is responsible for the compressing of the gas and it's dissolving, and controlling its temperature.
  • this unit transfers it to the second unit (containment and compression unit through the carbon dioxide saturated water inlet shown as element number 9 in the attached figures.
  • 2- containment and compression unit shown in figure 1 and figure 2, it consists of a plastic bag shown as element number 5 in the figures, connected to a carbon dioxide saturated water inlet shown as element 9, the bag contains the carbon dioxide saturated water (element 4) and the patient inserts the affected limb (element 1) inside the bag and seal it near the knee.
  • the bag (element 5) is surrounded by a two layers sock shaped rubber, the inner layer is inflatable (element 3) and the external layer is a hard and static (shown as element 6 in the figures).
  • the compressed air (shown as element 7 in the figures) is pumped between the two layers of the rubber sock. Which will get the inflatable layer (element 3) to expand and towards the plastic bag (element 5) Which will in turn compress the bag and the carbon dioxide saturated water against the skin. Compressed air will come through the inlet a shown as element 2, increasing the pressure of the fluid against the skin, and exits through the outlet shown as element 8 causing the pressure to decrease on the internal components (the plastic bag and the affected limb).
  • compressing the C02 saturated water on the skin depends on air compression, using less amount of the fluid as shown in (figure 1).
  • compressing the C02 saturated water on the skin depends on the amount of carbon dioxide saturated water compressed in the plastic bag.
  • fluid pressure in limited space will lead to fluid pressure on the surface of the skin.

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Les ulcères du pied du diabétique sont l'un des préoccupations les plus importantes de patients diabétiques et le plus dangereux. D'autre part, la carboxythérapie est considérée comme une méthode efficace de prévention et de guérison des ulcères du pied du diabétique. Bien que la nécessité soit grande, la technologie ne propose pas de solution jusqu'à présent pour résoudre le problème, toutes les technologies de carboxythérapie communes sont focalisées sur la production d'eau saturée en CO2 elle-même au lieu de l'opération de traitement. L'absence de méthode d'utilisation claire et efficace de carboxythérapie est un obstacle le maintenant de l'étalement dans le monde, notre invention est destinée à augmenter l'efficacité de la carboxythérapie par compression de l'eau saturée en CO2 sur la peau de l'extrémité, qui, en retour, augmente l'efficacité du traitement (compression augmente la quantité de gaz absorbé à travers la peau). Notre invention se distingue des autres systèmes en concentrant sur l'augmentation de la quantité de gaz absorbé par les tissus des zones ciblées.
PCT/IB2017/056294 2017-10-11 2017-10-11 Dispositif améliorant la circulation sanguine au niveau des extrémités à l'aide d'eau saturée en dioxyde de carbone comprimée Ceased WO2019073286A1 (fr)

Priority Applications (1)

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PCT/IB2017/056294 WO2019073286A1 (fr) 2017-10-11 2017-10-11 Dispositif améliorant la circulation sanguine au niveau des extrémités à l'aide d'eau saturée en dioxyde de carbone comprimée

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PCT/IB2017/056294 WO2019073286A1 (fr) 2017-10-11 2017-10-11 Dispositif améliorant la circulation sanguine au niveau des extrémités à l'aide d'eau saturée en dioxyde de carbone comprimée

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220249318A1 (en) * 2021-02-08 2022-08-11 Zachary Wood Lyon System and Method of Applied Contrasting Therapy to Pelvic Regions and Human Distal Anatomy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037092A1 (en) 2003-04-01 2005-02-17 Mitsubishi Rayon Co., Ltd. Vascularization therapy by highly concentrated carbonated warm water bath
JP2009022710A (ja) * 2007-07-19 2009-02-05 Viita Kk 炭酸泉浴の方法および用具
EP2172179A1 (fr) * 2007-07-09 2010-04-07 ACP Japan Co. Ltd. Système de bain au dioxyde de carbone sous pression
EP2689765A1 (fr) * 2011-11-04 2014-01-29 ACP Japan Co., Ltd. Procédé de bain sous pression de brume gazeuse et système de bain sous pression de brume gazeuse

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037092A1 (en) 2003-04-01 2005-02-17 Mitsubishi Rayon Co., Ltd. Vascularization therapy by highly concentrated carbonated warm water bath
EP2172179A1 (fr) * 2007-07-09 2010-04-07 ACP Japan Co. Ltd. Système de bain au dioxyde de carbone sous pression
JP2009022710A (ja) * 2007-07-19 2009-02-05 Viita Kk 炭酸泉浴の方法および用具
EP2689765A1 (fr) * 2011-11-04 2014-01-29 ACP Japan Co., Ltd. Procédé de bain sous pression de brume gazeuse et système de bain sous pression de brume gazeuse

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"Diabetes in America", 1995, NATIONAL INSTITUTES OF HEALTH, article "Lower Extremity Foot Ulcers and Amputations in Diabetes"
"napo estimates", NAPO, 2015
A. J. M. BOULTON; L. VILEIKYTE; D. ARMSTRONG; I. D. FEDERATION: "The global burden of diabetic foot disease", LANCET, vol. 366, no. 9498, November 2005 (2005-11-01), pages 1719 - 1724, XP025277276, DOI: doi:10.1016/S0140-6736(05)67698-2
D. L. NELSON; M. M. COX: "Lehninger Principles of Biochemistry. 6th ed.", 2013
E. J. G. PETERS: "The infected diabetic foot", HIGH RISK DIABETIC FOOT: TREATMENT AND PREVENTION, 2010, pages 92 - 126
F. AGUIREE; A. BROWN; N. H. CHO; G. DAHLQUIST; S. DODD; T. DUNNING; M. HIRST; C. HWANG; D. MAGLIANO; C. PATTERSON: "IDF diabetes atlas", 2015
H. HAYASHI; S. YAMADA; Y. KUMADA; H. MATSUO; T. TORIYAMA; H. KAWAHARA: "Immersing Feet in Carbon Dioxide-enriched Water Prevents Expansion and Formation of Ischemic Ulcers after Surgical Revascularization in Diabetic Patients with Critical Limb Ischemia", ANN. VASE. DIS., vol. 1, no. 2, 2008, pages 111 - 117
M. G. HOCHMAN; Y. CHEUNG; D. P. BROPHY; J. A. PARKER: "The Diabetic Foot", 2006, SPRINGER, article "Imaging of the Diabetic Foot", pages: 227 - 253
N. KOUTNA: "Carboxytherapy - new, non-invasive method of aesthetic medicine", CASOPIS LEKARU CESKYCH, vol. 145, no. 11, 2006, pages 841 - 843
N. NISHIMURA; J. SUGENOYA; T. MATSUMOTO; M. KATO; H. SAKAKIBARA; T. NISHIYAMA; Y. INUKAI; T. OKAGAWA; A. OGATA: "Effects of repeated carbon dioxide-rich water bathing on core temperature, cutaneous blood flow and thermal sensation", EUR. J. APPL. PHYSIOL., vol. 87, no. 4-5, January 2002 (2002-01-01), pages 337 - 342
N. SHALAN; A. AI-BAZZAZ; I. AL-ANI; F. NAJEM; M. AI-MASRI: "Effect of Carbon Dioxide Therapy on Diabetic Foot Ulcer", J. DIABETES MELLIT., November 2015 (2015-11-01), pages 284 - 289, XP055283936, DOI: doi:10.4236/jdm.2015.54035
N. SINGH; D. G. ARMSTRONG; B. A. LIPSKY: "Preventing foot ulcers in patients with diabetes", JAMA, vol. 293, no. 2, January 2005 (2005-01-01), pages 217 - 228
SAMEER ALKHAWAJA: "CARBAL THERAPY FOR TREATMENT OF DIABETIC FOOT ( C02 WATER BATH", KUFA MED.JOURNAL, vol. 15, no. 1, 2012, pages 211 - 222
Y. SAKAI; M. MIWA; K. OE; T. UEHA; A. KOH; T. NIIKURA; T. IWAKURA; S. Y. LEE; M. TANAKA; M. KUROSAKA: "A Novel System for Transcutaneous Application of Carbon Dioxide Causing an 'Artificial Bohr Effect' in the Human Body", PLOS ONE, vol. 6, no. 9, September 2011 (2011-09-01), pages e24137

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220249318A1 (en) * 2021-02-08 2022-08-11 Zachary Wood Lyon System and Method of Applied Contrasting Therapy to Pelvic Regions and Human Distal Anatomy
US12005025B2 (en) * 2021-02-08 2024-06-11 Zachary Wood Lyon System and method of applied contrasting therapy to pelvic regions and human distal anatomy

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