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WO2018229551A3 - Methods to treat opioid use disorder - Google Patents

Methods to treat opioid use disorder Download PDF

Info

Publication number
WO2018229551A3
WO2018229551A3 PCT/IB2018/000770 IB2018000770W WO2018229551A3 WO 2018229551 A3 WO2018229551 A3 WO 2018229551A3 IB 2018000770 W IB2018000770 W IB 2018000770W WO 2018229551 A3 WO2018229551 A3 WO 2018229551A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
use disorder
opioid use
treat opioid
treat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/000770
Other languages
French (fr)
Other versions
WO2018229551A2 (en
Inventor
Celine M. LAFFONT
Malcolm A. YOUNG
Norma L. FOX
Barbara R. HAIGHT
Susan M. LEARNED
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indivior UK Ltd
Original Assignee
Indivior UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indivior UK Ltd filed Critical Indivior UK Ltd
Priority to NZ760033A priority Critical patent/NZ760033A/en
Priority to EP18762131.3A priority patent/EP3638240A2/en
Priority to AU2018283724A priority patent/AU2018283724B2/en
Publication of WO2018229551A2 publication Critical patent/WO2018229551A2/en
Publication of WO2018229551A3 publication Critical patent/WO2018229551A3/en
Priority to IL271430A priority patent/IL271430A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The disclosure provides sustained-release buprenorphine formulations that produce therapeutic plasma concentration levels of buprenorphine in patients to treat opioid use disorder.
PCT/IB2018/000770 2017-06-16 2018-06-15 Methods to treat opioid use disorder Ceased WO2018229551A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
NZ760033A NZ760033A (en) 2017-06-16 2018-06-15 Methods to treat opioid use disorder
EP18762131.3A EP3638240A2 (en) 2017-06-16 2018-06-15 Methods to treat opioid use disorder
AU2018283724A AU2018283724B2 (en) 2017-06-16 2018-06-15 Methods to treat opioid use disorder
IL271430A IL271430A (en) 2017-06-16 2019-12-15 Methods to treat opioid use disorder

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201762521121P 2017-06-16 2017-06-16
US62/521,121 2017-06-16
US201762572331P 2017-10-13 2017-10-13
US62/572,331 2017-10-13
US201762572996P 2017-10-16 2017-10-16
US62/572,996 2017-10-16
US201762598338P 2017-12-13 2017-12-13
US62/598,338 2017-12-13
US201862632995P 2018-02-20 2018-02-20
US62/632,995 2018-02-20
US201862656216P 2018-04-11 2018-04-11
US62/656,216 2018-04-11
US201862680935P 2018-06-05 2018-06-05
US62/680,935 2018-06-05

Publications (2)

Publication Number Publication Date
WO2018229551A2 WO2018229551A2 (en) 2018-12-20
WO2018229551A3 true WO2018229551A3 (en) 2019-02-14

Family

ID=63407480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/000770 Ceased WO2018229551A2 (en) 2017-06-16 2018-06-15 Methods to treat opioid use disorder

Country Status (5)

Country Link
EP (1) EP3638240A2 (en)
AU (1) AU2018283724B2 (en)
IL (1) IL271430A (en)
NZ (1) NZ760033A (en)
WO (1) WO2018229551A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11000520B2 (en) 2014-11-07 2021-05-11 Indivior Uk Limited Buprenorphine dosing regimens

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016071767A1 (en) * 2014-11-07 2016-05-12 Indivior Uk Limited Buprenorphine dosing regimens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1768650T3 (en) 2004-06-04 2008-09-29 Camurus Ab Liquid storage formulations
US9060935B2 (en) 2005-01-21 2015-06-23 Camurus Ab Pharmaceutical lipid compositions
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481018B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine
US8975270B2 (en) 2010-06-08 2015-03-10 Rb Pharmaceuticals Limited Injectable flowable composition comprising buprenorphine
CA3003650A1 (en) 2015-11-04 2017-05-11 Indivior Uk Limited Quantification of drugs in biological samples

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016071767A1 (en) * 2014-11-07 2016-05-12 Indivior Uk Limited Buprenorphine dosing regimens

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANON: "FDA Approves SUBLOCADE(TM) (Buprenorphine Extended-Release), the First and Only Once-Monthly Injectable Buprenorphine Formulation to Treat Moderate to Severe Opioid Use Disorder", 30 November 2017 (2017-11-30), XP055528322, Retrieved from the Internet <URL:https://web.archive.org/web/20171204174528/https://www.multivu.com/players/English/8221151-indivior-sublocade-buprenorphine-fda-approval/> [retrieved on 20181129] *
ANON: "HIGHLIGHTS OF PRESCRIBINGINFORMATION SUBLOCADE", 1 November 2017 (2017-11-01), XP055528072, Retrieved from the Internet <URL:http://indivior.com/wp-content/uploads/2017/11/SUBLOCADE-Prescribing-Information.pdf> [retrieved on 20181128] *
RICHARD C CRIST ET AL: "An Intronic Variant in OPRD1 Predicts Treatment Outcome for Opioid Dependence in African-Americans", NEUROPSYCHOPHARMACOLOGY., vol. 38, no. 10, 23 April 2013 (2013-04-23), US, pages 2003 - 2010, XP055528570, ISSN: 0893-133X, DOI: 10.1038/npp.2013.99 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11000520B2 (en) 2014-11-07 2021-05-11 Indivior Uk Limited Buprenorphine dosing regimens
US11839611B2 (en) 2014-11-07 2023-12-12 Indivior Uk Limited Buprenorphine dosing regimens

Also Published As

Publication number Publication date
EP3638240A2 (en) 2020-04-22
AU2018283724A2 (en) 2020-01-23
AU2018283724A1 (en) 2020-01-16
NZ760033A (en) 2023-02-24
IL271430A (en) 2020-01-30
AU2018283724B2 (en) 2021-08-19
WO2018229551A2 (en) 2018-12-20

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WO2018229551A3 (en) Methods to treat opioid use disorder

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