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WO2018103973A1 - Système de désinfection - Google Patents

Système de désinfection Download PDF

Info

Publication number
WO2018103973A1
WO2018103973A1 PCT/EP2017/078197 EP2017078197W WO2018103973A1 WO 2018103973 A1 WO2018103973 A1 WO 2018103973A1 EP 2017078197 W EP2017078197 W EP 2017078197W WO 2018103973 A1 WO2018103973 A1 WO 2018103973A1
Authority
WO
WIPO (PCT)
Prior art keywords
sanitising
foaming liquid
foaming
hypochlorite solution
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2017/078197
Other languages
English (en)
Inventor
Amitava Pramanik
Priyanka SARKAR
Nimish Harshadrai Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever NV
Conopco Inc
Original Assignee
Unilever NV
Conopco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever NV, Conopco Inc filed Critical Unilever NV
Priority to MX2019006653A priority Critical patent/MX2019006653A/es
Priority to PL17792091T priority patent/PL3551741T3/pl
Priority to BR112019011552-8A priority patent/BR112019011552B1/pt
Priority to EP17792091.5A priority patent/EP3551741B1/fr
Publication of WO2018103973A1 publication Critical patent/WO2018103973A1/fr
Priority to ZA2019/03270A priority patent/ZA201903270B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0094—High foaming compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/395—Bleaching agents
    • C11D3/3956—Liquid compositions

Definitions

  • the present invention relates to a sanitising system, a sanitizing kit and a method of sanitising hands using said system or kit.
  • the sanitising system comprises a first compartment comprising an alkaline aqueous hypochlorite solution containing 0.0010 to 2.0 wt.% of hypochlorite (CIO " ) and a second compartment comprising an acid aqueous foaming liquid, valve means operable to put both the first compartment and the second compartment in communication with an outlet, wherein, upon operation of the valve means, the hypochlorite solution is mixed with the foaming liquid to produce an aqueous hypochlorous acid (HOCI) solution having a pH in the range of 5 to 7, and the HOCI solution is discharged through the outlet to form a sanitising foam.
  • HOCI aqueous hypochlorous acid
  • the sanitising kit of the present invention comprises a first container comprising an alkaline aqueous hypochlorite solution containing 0.0010 to 2.0 wt.% of hypochlorite and valve means operable to dispense the hypochlorite solution from the first container; a second container comprising an acid aqueous foaming liquid and valve means operable to dispense the foaming liquid from the second container; and instructions for use instructing users to simultaneously or successively operate the valve means of the first and the second container to dispense the hypochlorite solution and the foaming liquid into a hand of a user.
  • Alcohol is typically used in antimicrobial sanitising formulations and can be used alone or in combination with antimicrobial agents such as triclosan or benzalkonium salts.
  • an antimicrobial agent can be generated in situ by mixing of components in a dispensing system.
  • US 2013/0202484 AA discloses a hand sanitizer that provides the benefits of an antibacterial alcohol hand wash and sanitizer with the sporicidal properties of chlorine dioxide (CIO2).
  • the hand sanitizer comprises:
  • a first part comprising a chlorite solution and contained in a first dispenser whereby it will be dispensed as a spray or jet of liquid;
  • the chlorine dioxide is generated in situ by mixing an aqueous sodium chlorite solution held in a container with an aqueous solution of one or more acids and surfactant, held in a second container. Repeated use of such a formulation can lead to skin irritation.
  • US 2010/0036305 AA discloses a dispensing system that generates CIO2 and that comprises two compartments.
  • the first dispenser chamber is filled with a liquid (first part) which comprises deionised water containing a first reagent (sodium chlorite) and foam promoter (cocamidopropyl betaine).
  • the second dispenser chamber is filled with an aqueous acid solution (second part) comprising deionised water containing citric acid, sorbic acid, boric acid, and foam promoter (cocamidopropyl betaine).
  • the solution also comprises a buffer (trisodium phosphate), trisodium citrate, glycerine, benzotriazole, sodium molybdate and sodium nitrate.
  • the first part and the second part are miscible as liquids and as foams to produce CIO2 on exiting the dispensing system.
  • US 2005/0282722 AA (SC Johnson) discloses a two part soap scum and mold/mildew stain removing composition, the composition comprising:
  • a combined composition having a pH from about 9 to about 1 1 .
  • the sanitizing system of the present invention comprises:
  • a first compartment comprising an alkaline aqueous hypochlorite solution, said hypochlorite solution containing 0.0010 to 2.0 wt.% of hypochlorite (CIO " ) and having a pH in the range of 8 to 13.5;
  • a second compartment comprising an acid aqueous foaming liquid, said foaming liquid containing 0.1 to 5.0 wt.% of a foaming agent and having a pH in the range of 2 to 6;
  • ⁇ valve means operable to put both the first compartment and the second
  • the hypochlorite solution is mixed with the foaming liquid in a ratio of from 0.8:1 to 1 .3:1 respectively to produce an aqueous hypochlorous acid (HOCI) solution having a pH in the range of 5 to 7, and the aqueous hypochlorous acid solution is discharged through the outlet to form a sanitising foam.
  • HOCI aqueous hypochlorous acid
  • the alkaline aqueous hypochlorite solution and the acid aqueous foaming liquid are mixed together an aqueous hypochlorous acid solution having a pH 5-7 is produced and is discharged in the form of a foam.
  • This foam has anti-microbial properties and is very effective as a small quantity (mass) of foam can cover a large surface area.
  • Another aspect of the present invention relates to a sanitising kit comprising
  • hypochlorite solution containing 0.0010 to 2.0 wt.% of hypochlorite and having a pH in the range of 8 to 13.5, said first container comprising valve means operable to dispense the hypochlorite solution from the first container;
  • a second container comprising an acid aqueous foaming liquid, said foaming liquid containing 0.1 to 5.0 wt.% of a foaming agent and having a pH in the range of 2 to
  • said second container comprising valve means operable to dispense the foaming liquid from the second container foam
  • the user can mix the alkaline aqueous hypochlorite solution and the acid aqueous foaming liquid to form sanitising foam in the form of a foamed aqueous hypochlorous acid solution having a pH 5 to 7.
  • the invention further provides a method of sanitising hands using a sanitising system or a sanitizing kit according to the present invention.
  • any particular upper value or amount can be associated with any particular lower value or amount.
  • a first aspect of the present invention relates to a sanitising system comprising:
  • a first compartment comprising an alkaline aqueous hypochlorite solution, said hypochlorite solution containing 0.0010 to 2.0 wt.% of hypochlorite (CIO " ) and having a pH in the range of 8 to 13.5;
  • a second compartment comprising an acid aqueous foaming liquid, said foaming liquid containing 0.1 to 5.0 wt.% of a foaming agent and having a pH in the range of 2 to 6;
  • valve means operable to put both the first compartment and the second
  • hypochlorite solution is mixed with the foaming liquid in a ratio of from 0.8:1 to 1 .3:1 respectively to produce an aqueous hypochlorous acid (HOCI) solution having a pH in the range of 5 to 7, and the aqueous hypochlorous acid solution is discharged through the outlet to form a sanitising foam.
  • HOCI aqueous hypochlorous acid
  • hypothalamic acid refers to the non-dissociated acid with chemical formula HOCI.
  • foaming agent refers to a substance that is capable of promoting the formation of an aqueous foam.
  • first and second compartments are housed in a single container, with both the first and second compartments having separate dip tubes.
  • the dip tubes extend to a mixing chamber comprising valve means wherein the alkaline aqueous hypochlorite solution and the acid aqueous foaming liquid are mixed together for discharge through the outlet.
  • the foaming agent employed in accordance with the present invention is preferably a surfactant.
  • Suitable surfactants that may be used in the composition according to the present invention are anionic, zwitterionic, non-ionic or amphoteric surfactants, and mixtures thereof. More preferably, the foaming agent is an anionic surfactant or zwitterionic surfactant. Most preferably, the foaming agent is an anionic surfactant.
  • the foaming liquid comprises at least 0.1 wt.% of a foaming anionic surfactant, more preferably at least 0.5 wt.% of a foaming anionic surfactant, even more preferably at least 1.0 wt.% of a foaming anionic surfactant.
  • the foaming liquid comprises at most 5 wt.% of a foaming anionic surfactant, more preferably at most 4 wt.% of a foaming anionic surfactant, even more preferably at most 3 wt.% of a foaming anionic surfactant.
  • the foaming anionic surfactant is selected from sodium lauryl ether sulfate (SLES), sodium lauryl sulfate (SLS), ammonium lauryl sulfate and combinations thereof.
  • the foaming liquid comprises 0.2 to 2 wt.%, more preferably 0.3 to 1.5 wt.% and most preferably 0.5 to 1.0 wt.% of organic acid selected from citric acid, lactic acid, malonic acid, malic acid and combinations thereof. Most preferably the organic acid is citric acid.
  • the foaming liquid preferably has a pH in the range of 5 to 7, more preferably between 5.2 and 6.8, even more preferably between 5.2 and 6.8.
  • the foaming liquid preferably contains at least 90 wt.% water, more preferably at least 92 wt.% water and most preferably at least 94 wt.% water.
  • the foaming liquid contains less than 5 wt.% ethanol, more preferably less than 3 wt.% ethanol, most preferably less than 1 wt.% ethanol.
  • the foaming liquid contains less than 1 wt.% hydrogen peroxide, more preferably less than 0.5 wt.% hydrogen peroxide, even more preferably less than 0.2 wt.% hydrogen peroxide.
  • the hypochlorite solution contains 0.001 to 2.0 wt.%, more preferably 0.005 to 1.5 wt.%, even more preferably 0.007 to 1.0 wt.% and most preferably 0.01 to 0.5 wt.% of hypochlorite.
  • the hypochlorite solution preferably has a pH in the range of 8 to 12, more preferably a pH in the range of 9 to 1 1 and even more preferably a pH in the range of 9 to 10.
  • the hypochlorite solution contains at least 90 wt.% water, more preferably at least 92 wt. % water and most preferably at least 94 wt. % water.
  • the hypochlorite solution contains less than 5 wt.% ethanol, more preferably less than 3 wt.% ethanol, more preferably less than 1 wt. % ethanol.
  • the first compartment is substantially free of a foaming agent.
  • substantially free of a foaming agent is meant that the foaming agent is present in less than 2%, preferably less than 1 %, more preferably less than 0.1 % by weight and optimally absent from the first compartment.
  • the sanitizing foam that is produced by operating the valve means of the sanitising system preferably has a density of 0.1 to 0.3 g/ml, more preferably of 0.16 to 0.23 g/ml.
  • Foam density can be determined by dispensing foam into a pre-weighed measuring cylinder, measuring the volume of the foam and weighing the measuring cylinder containing the foam. The measured weight to volume ratio corresponds to the density of foam.
  • the first compartment contains 25 to 2,000 ml, more preferably 50 to 1 ,200 ml of the hypochlorite solution liquid and the second
  • compartment contains 25 to 2,000 ml, more preferably 50 to 1 ,200 ml of the foaming liquid.
  • the present invention relates to a sanitising kit comprising
  • hypochlorite solution containing 0.0010 to 2.0 wt.% of hypochlorite and having a pH in the range of 8 to 13.5, said first container comprising valve means operable to dispense the hypochlorite solution from the first container;
  • a second container comprising an acid aqueous foaming liquid, said foaming liquid containing 0.1 to 5.0 wt.% of a foaming agent and having a pH in the range of 2 to 6, said second container comprising valve means operable to dispense the foaming liquid from the second container;
  • ⁇ instructions for use instructing users to simultaneously or successively (in random order) operate the valve means of the first and the second container to dispense the first the hypochlorite solution and the foaming liquid into a hand of a user.
  • the alkaline aqueous hypochlorite solution is dispensed in the form of a liquid and the acid aqueous foaming liquid is dispensed in the form of a foam.
  • the alkaline aqueous hypochlorite solution in the first container preferably is an alkaline aqueous hypochlorite solution as used in the sanitising system according to the present invention.
  • the acid aqueous foaming liquid in the second container preferably is an acid aqueous foaming liquid as used in the sanitising system.
  • the present invention relates to a method of sanitising hands using a sanitising system or a sanitizing kit according to the present invention, said method comprising operating the valve means of the sanitising system to dispense the sanitizing foam into a hand of a user or comprising operating in random order the valve means of the first and the second container to dispense the hypochlorite solution and the foaming liquid into a hand of a user.
  • liquid components of a two-component sanitising systems were prepared on the basis of the formulation shown in Table 1 (percentages are weight percentages).
  • Each compartment of the spraying device contained a dip tube that extended into the same mixing chamber.
  • the spraying device further contained a manually operated pump system that pumped the fluids from the compartments into the mixing chamber and that expelled the mixture from this mixing chamber through a dispensing nozzle. Upon operation of the pump system the two liquid components were combined in the mixing chamber in a weight ratio of approximately 1 :1.
  • a sanitising foam was produced by operating the pump system of the spraying device described in Example 1.
  • the foam had a density of approximately 0.2 g/ml.
  • the hypochlorous acid concentration and the pH of the foam are given in Table 2.
  • the antimicrobial efficacy of the sanitising foam was determined using a Microbial Contact Kill Assay.
  • the liquid components of the sanitising foam were carefully mixed to produce an unfoamed sanitising liquid to facilitate the testing of the antimicrobial efficacy.
  • E.coli ATCC 10536 and S. aureus ATCC 6538 strains were revived from glycerol stock.
  • a serial dilution was made from the neutralized samples of step 7 and 100 ⁇ of each dilution plated onto tryptic soy agar plates to give plates having dilutions of 10 ⁇ 10 "2 , 10 "3 ,10- 4 and 10 "5 .
  • Initial culture control was also done by performing serial dilutions of the initial control E.coli and S. aureus prepared in step 5, and by plating 100 ⁇ onto tryptic soy agar plates to give plates having dilutions of 10 "1 , 10 "2 , 10 3 ,10 “4 , 10 "5 ,10 “6 and 10 "7 .
  • Example 3 The stability of the hypochlorous acid in the foaming liquid post mixing was measured using iodometric titration. The results are shown in Table 4.
  • Table 4 shows that hypochlorous acid decomposes quickly after mixing meaning that the user's skin is not exposed to high concentration of active chlorine for a long time.
  • the sanitizing system according to the present invention is ideal for hand sanitizing applications.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un système de désinfection, un kit de désinfection et un procédé de désinfection des mains à l'aide dudit système ou dudit kit. Le système de désinfection comprend un premier compartiment comprenant une solution aqueuse alcaline d'hypochlorite contenant 0,0010 à 2,0 % en poids d'hypochlorite (ClO-) et un deuxième compartiment comprenant un liquide moussant aqueux acide, des moyens de vanne actionnables pour mettre à la fois le premier compartiment et le deuxième compartiment en communication avec un orifice de sortie, lors du fonctionnement du moyen de vanne, la solution d'hypochlorite étant mélangée avec le liquide moussant pour produire une solution aqueuse d'acide hypochloreux (HOCl) présentant un pH dans la plage de 5 à 7 et la solution de HOCl étant évacuée à travers la sortie pour former une mousse désinfectante.
PCT/EP2017/078197 2016-12-09 2017-11-03 Système de désinfection Ceased WO2018103973A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
MX2019006653A MX2019006653A (es) 2016-12-09 2017-11-03 Sistema sanitizante.
PL17792091T PL3551741T3 (pl) 2016-12-09 2017-11-03 Układ odkażający
BR112019011552-8A BR112019011552B1 (pt) 2016-12-09 2017-11-03 Sistema de desinfecção, kit de desinfecção e método de desinfecção das mãos
EP17792091.5A EP3551741B1 (fr) 2016-12-09 2017-11-03 Système d'assainissement
ZA2019/03270A ZA201903270B (en) 2016-12-09 2019-05-23 Sanitising system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16203298.1 2016-12-09
EP16203298 2016-12-09

Publications (1)

Publication Number Publication Date
WO2018103973A1 true WO2018103973A1 (fr) 2018-06-14

Family

ID=57542824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2017/078197 Ceased WO2018103973A1 (fr) 2016-12-09 2017-11-03 Système de désinfection

Country Status (6)

Country Link
EP (1) EP3551741B1 (fr)
BR (1) BR112019011552B1 (fr)
MX (1) MX2019006653A (fr)
PL (1) PL3551741T3 (fr)
WO (1) WO2018103973A1 (fr)
ZA (1) ZA201903270B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2911975A1 (es) * 2020-11-20 2022-05-23 Brill Engines S L Un producto para la limpieza de la piel sana

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046718A1 (fr) * 1997-04-16 1998-10-22 Unilever Plc Compositions de blanchiement comprenant de l'hypochlorite et systemes de distribution de ces compositions
WO2000012672A1 (fr) * 1998-08-31 2000-03-09 The Clorox Company Produit moussant pour deboucher les tuyaux d'ecoulement
US20050282722A1 (en) 2004-06-16 2005-12-22 Mcreynolds Kent B Two part cleaning composition
US20100036305A1 (en) 2005-01-28 2010-02-11 Tristel Plc. Sterilant system
WO2010133855A1 (fr) * 2009-05-22 2010-11-25 Tristel Plc Désinfectant pour les mains
GB2477597A (en) * 2010-02-03 2011-08-10 Mauve Technology Ltd Disinfectant materials and methods
US20130202484A1 (en) 2010-09-29 2013-08-08 Tristel Plc Hand sanitizer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046718A1 (fr) * 1997-04-16 1998-10-22 Unilever Plc Compositions de blanchiement comprenant de l'hypochlorite et systemes de distribution de ces compositions
WO2000012672A1 (fr) * 1998-08-31 2000-03-09 The Clorox Company Produit moussant pour deboucher les tuyaux d'ecoulement
US20050282722A1 (en) 2004-06-16 2005-12-22 Mcreynolds Kent B Two part cleaning composition
US20100036305A1 (en) 2005-01-28 2010-02-11 Tristel Plc. Sterilant system
WO2010133855A1 (fr) * 2009-05-22 2010-11-25 Tristel Plc Désinfectant pour les mains
GB2477597A (en) * 2010-02-03 2011-08-10 Mauve Technology Ltd Disinfectant materials and methods
US20130202484A1 (en) 2010-09-29 2013-08-08 Tristel Plc Hand sanitizer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2911975A1 (es) * 2020-11-20 2022-05-23 Brill Engines S L Un producto para la limpieza de la piel sana

Also Published As

Publication number Publication date
ZA201903270B (en) 2020-09-30
BR112019011552B1 (pt) 2022-12-27
EP3551741B1 (fr) 2022-02-09
PL3551741T3 (pl) 2022-06-06
BR112019011552A2 (pt) 2019-10-15
MX2019006653A (es) 2019-08-21
EP3551741A1 (fr) 2019-10-16

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