[go: up one dir, main page]

WO2018177182A1 - Dispositif thérapeutique portable destiné à être utilisé dans le traitement de la maladie d'alzheimer par stimulation lumineuse du nerf optique - Google Patents

Dispositif thérapeutique portable destiné à être utilisé dans le traitement de la maladie d'alzheimer par stimulation lumineuse du nerf optique Download PDF

Info

Publication number
WO2018177182A1
WO2018177182A1 PCT/CN2018/079879 CN2018079879W WO2018177182A1 WO 2018177182 A1 WO2018177182 A1 WO 2018177182A1 CN 2018079879 W CN2018079879 W CN 2018079879W WO 2018177182 A1 WO2018177182 A1 WO 2018177182A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
disease
light source
portable therapeutic
optic nerve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2018/079879
Other languages
English (en)
Chinese (zh)
Inventor
关一夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liaoning Zohnsun Care Medical Devices Co Ltd
Original Assignee
Liaoning Zohnsun Care Medical Devices Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liaoning Zohnsun Care Medical Devices Co Ltd filed Critical Liaoning Zohnsun Care Medical Devices Co Ltd
Priority to CN201880006540.7A priority Critical patent/CN111867676A/zh
Publication of WO2018177182A1 publication Critical patent/WO2018177182A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/04—Eye-masks ; Devices to be worn on the face, not intended for looking through; Eye-pads for sunbathing
    • A61F9/045—Eye-shades or visors; Shields beside, between or below the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes

Definitions

  • the invention relates to the fields of neurobiology, biochemistry, physiology, therapeutic instruments for degenerative diseases of the elderly and the like.
  • AD Alzheimer disease
  • AD also known as Alzheimer's disease
  • AD is a central nervous system degenerative disease, insidious onset, slow course, continuous, difficult to find early, is the most common one for senile dementia Types.
  • the clinical manifestations of AD are progressive mental state decay, including progressive mental memory disorders, cognitive dysfunction, personality changes, language disorders and other neuropsychiatric symptoms, behavioral disorders and even confusion. AD seriously affects people's social, professional and life functions [1].
  • AD Alzheimer's disease
  • AD Alzheimer's disease
  • the currently widely accepted doctrine has deposited plaques formed by the accumulation of A ⁇ -amyloid on the outer surface of brain nerve cells [4], neuronal fibrillation in neuronal cells formed by hyperphosphorylation of tau [5], and Neuronal loss with gliosis and so on.
  • the neurofibrils are entangled in the cytoplasm of the neurons. This neurofibrillary tangles develop to a certain extent, which can degenerate and destroy the neurons, leaving the spiral plaques of silver stains in the middle, and the middle is the amyloid core, ie the senile plaques.
  • a ⁇ -amyloid aggregation in the cerebral cortex and hippocampus is most prevalent, and A ⁇ deposits are also found in the striatum, amygdala and thalamus. Locally, A[beta]-amyloid deposits are a product of the development of neurofibrillary tangles to advanced stages. In addition, AD patients also have neuronal loss, cortical purple pigmentation and astrocytic hyperplasia.
  • AD Alzheimer's disease
  • AD model mice (5XFAD) were placed in a black test chamber, and the mice were stimulated with LED light for one hour: then A ⁇ -soluble protein and A ⁇ -amyloid deposit plaques in the visual cortex of AD mice were examined.
  • Six different stimulation methods were used in the experiment: 20 Hz regulated scintillation light, 40 Hz regulated scintillation light, 80 Hz regulated scintillation light, disordered scintillation light, continuous light, and no light.
  • the results of the assay showed that AD mice stimulated with 40 Hz-regulated LED scintillation light were significantly different.
  • the expression levels of soluble A 1-40 and soluble A 1-42 in the visual cortex of AD mice were reduced by 57.96% and 57.97%, respectively.
  • the same experiment was also validated in another AD model mouse (APP/PS1) experiment. Immunohistochemistry results also showed that there was no change in the number of microglia in the visual cortex of 5XFAD mice, but the diameter of microglia increased by 65.8%.
  • the other five stimulation methods did not change the soluble A 1-40 and soluble A 1-42 expression levels of the mice.
  • the present invention provides a portable therapeutic device that uses LED light to stimulate the eye to treat, ameliorate and prevent Alzheimer's disease.
  • a portable therapeutic device that uses an LED light source to stimulate the eye to treat, improve, and prevent Alzheimer's disease.
  • a portable therapeutic apparatus for treating Alzheimer's disease using light-stimulated optic nerve characterized in that:
  • the treatment device includes:
  • An eye mask that can be attached to a person's face and cover the eye
  • a power source that supplies energy to the light source
  • a control element that regulates changes in the light source.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulating optic nerve is characterized in that the eye mask is an eye mask made of an opaque material.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulation optic nerve is characterized in that the light source is fixed on one side of the eyecup contacting the face.
  • the light source is an annular light source array composed of a plurality of point light sources, and two annular light source arrays are arranged on the eye mask.
  • the two annular light source arrays cover the eyes.
  • the point light source is a light emitting diode, and the light emitting diode is circular or square.
  • the circular light-emitting diode has a diameter of 2 - 5 mm.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulation optic nerve is characterized in that: the annular array consisting of the point light sources is filled with other point light sources, and the arrangement is one at the center of the circle, at the center of the circle 6 between the ring and the ring.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulating optic nerve is characterized in that the light source has a wavelength of 400-800 nm and a brightness modulation frequency of 40 Hz, wherein the illumination time is 1 - 20 ms. Tune, illuminance is 20 – 2000 lux.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulation optic nerve is characterized in that the power source is a power supply device connected to a light source through a power line.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulating optic nerve is characterized in that the power source is a battery fixed to an eye mask.
  • the portable therapeutic device for treating Alzheimer's disease by using light stimulating optic nerve is characterized in that the control element is a controller for adjusting the brightness frequency of the light fixed on the power supply device.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulating optic nerve is characterized in that the control element is a controller fixed on the eye mask and regulating the frequency of the light brightness by receiving an instruction sent by the mobile communication device.
  • the portable therapeutic apparatus for treating Alzheimer's disease by using light stimulation optic nerve is characterized in that the annular light source array is composed of 12 point light sources.
  • the portable therapeutic device has the characteristics of simple operation, convenient application and high cost performance.
  • the portable therapeutic device is not only suitable for medical institutions at all levels (high-end top three hospitals, community hospitals, township hospitals), but also for various types of rehabilitation institutions, elderly health management institutions, and families.
  • the portable therapeutic device can be used not only in a fixed place, but also as a wearable therapeutic device, and the use is not limited by location and time. This portable therapeutic device will be mainly used for the treatment and improvement of patients with Alzheimer's disease, and for the prevention of Alzheimer's disease in the middle-aged and elderly population.
  • 1 and 2 are schematic views showing the distribution of the eye mask and the LED light source inside the eye mask
  • T2 is the LED light source lighting time.
  • the treatment device includes:
  • An eye mask that can be attached to a person's face and cover the eye
  • a power source that supplies energy to the light source
  • a control element that regulates changes in the light source.
  • the eye mask is an eye mask made of an opaque material.
  • the light source is fixed on one side of the eye contact contacting the face;
  • the light source is an annular light source array composed of a plurality of point light sources, and two annular light source arrays are arranged on the eye cover, and when the eye cover covers both eyes, the two annular light source arrays cover the eyes on.
  • the light source adopts a circular light-emitting diode with a diameter of 2 mm;
  • the annular array composed of the point light source is filled with other point light sources, and the arrangement is one at the center of the circle and six at the center of the circle and the ring.
  • the light source has a wavelength of 600 nm and a brightness modulation frequency of 40 Hz, with a bright time of 1 – 20 ms and an illumination of 1500 lux.
  • the invention relates to a portable therapeutic apparatus for treating Alzheimer's disease by using light stimulating optic nerve, and the technical idea thereof is to stimulate the eye of a patient by LED light to achieve the effect of treating, improving and preventing Alzheimer's disease.
  • a portable therapeutic apparatus for treating Alzheimer's disease using light-stimulated optic nerve characterized in that:
  • the treatment device includes:
  • An eye mask that can be attached to a person's face and cover the eye
  • a power source that supplies energy to the light source
  • a control element that adjusts the change in brightness of the source.
  • the eye shield is an eye mask made of an opaque material, preferably black.
  • the light source is fixed to the side of the eyecup that contacts the face.
  • the light source is an array of annular light sources composed of a plurality of point light sources, and two annular light source arrays are arranged on the eye mask. When the eye cover covers both eyes, the two annular light source arrays cover the eyes.
  • the light source is preferably arranged in a laterally elliptical ring shape.
  • the point source is a light-emitting diode
  • the light-emitting diode is circular or square, and for a circle, preferably has a diameter of 2 - 5 mm.
  • annular array of point sources is filled with other point sources, preferably one at the center of the circle and six between the center of the circle and the ring.
  • the focus of the invention to achieve therapeutic effects lies in the parameters of the light source, as shown in FIG. 3, specifically: the light source has a wavelength of 400-800 nm, the brightness modulation frequency is 40 Hz, and the illumination time is adjustable from 1 to 20 milliseconds. The illuminance is 20 – 2000 lux. After extensive experiments and research by the inventors, the above parameters of the light source can effectively treat and improve the patient's disease state.
  • the power source is a power supply device connected to the light source through a power line. Or a battery that is attached to the eye shield.
  • the control element is a controller that adjusts the brightness of the light on the power supply unit. Or a controller that is fixed to the eyecup to regulate the brightness frequency by receiving an instruction sent by the mobile communication device.
  • the annular light source array is composed of 12 point light sources, and the effect is better.
  • the mobile communication device includes a mobile phone, a wristwatch or a wearable device.
  • the method of use of the present invention is as follows:
  • an elastic strap to secure the eye shield to the face and cover the eye, adjusting the elastic strap to comfort.
  • the brightness can be adjusted by setting the T2 time according to personal comfort.
  • the setting range of T2 time is 1 - 20 ms (T1 time has been fixed to 25 ms).
  • one of the treatment options for light scintillation stimulation can be selected: (1) 15 minutes/time, 4 times/day; (2) 30 minutes/time, 2 times/day; (3) 60 minutes / time, 1 time / day. Every seven days is a course of treatment.
  • the treatment device includes:
  • An eye mask that can be attached to a person's face and cover the eye
  • a power source that supplies energy to the light source
  • a control element that regulates changes in the light source.
  • the eye mask is an eye mask made of an opaque material.
  • the light source is fixed on one side of the eye contact contacting the face;
  • the light source is an annular light source array composed of a plurality of point light sources, and two annular light source arrays are arranged on the eye cover, and when the eye cover covers both eyes, the two annular light source arrays cover the eyes on.
  • the light source adopts a circular light-emitting diode with a diameter of 2 mm;
  • the annular array composed of the point light source is filled with other point light sources, and the arrangement is one at the center of the circle and six at the center of the circle and the ring.
  • the light source has a wavelength of 600 nm and a brightness modulation frequency of 40 Hz, with a bright time of 1 – 20 ms and an illumination of 1500 lux.
  • the treatment device includes:
  • An eye mask that can be attached to a person's face and cover the eye
  • a power source that supplies energy to the light source
  • a control element that regulates changes in the light source.
  • the eye mask is an eye mask made of an opaque material.
  • the light source is fixed on one side of the eye contact contacting the face;
  • the light source is an annular light source array composed of a plurality of point light sources, and two annular light source arrays are arranged on the eye cover, and when the eye cover covers both eyes, the two annular light source arrays cover the eyes on.
  • the light source uses a circular light-emitting diode with a diameter of 5 mm; the light source has a wavelength of 600 nm and a brightness modulation frequency of 40 Hz, wherein the light-on time is adjustable from 1 to 20 milliseconds and the illumination is 20 lux.
  • the treatment device includes:
  • An eye mask that can be attached to a person's face and cover the eye
  • a power source that supplies energy to the light source
  • a control element that regulates changes in the light source.
  • the eye mask is an eye mask made of an opaque material.
  • the light source is fixed on one side of the eye contact contacting the face;
  • the light source is an annular light source array composed of a plurality of point light sources, and two annular light source arrays are arranged on the eye cover, and when the eye cover covers both eyes, the two annular light source arrays cover the eyes on.
  • the light source uses a circular light-emitting diode with a diameter of 5 mm; the light source has a wavelength of 600 nm and a brightness modulation frequency of 40 Hz, wherein the light-on time is adjustable from 1 to 20 milliseconds and the illumination is 2000 lux.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un dispositif thérapeutique portable qui utilise la lumière pour stimuler le nerf optique. Au moyen de la stimulation de l'œil(s) d'un sujet en utilisant une lumière de diode électroluminescente (DEL), les effets de traitement, d'amélioration et de prévention de la maladie d'Alzheimer sont obtenus. Le dispositif thérapeutique portable comprend : un masque oculaire qui peut être fixé au visage et qui recouvre les yeux; une source de lumière qui est fixée au masque oculaire; et une source d'alimentation électrique qui fournit de l'énergie à la source lumineuse émettant de la lumière. Le dispositif thérapeutique portable présente les caractéristiques d'un fonctionnement simple, d'une application pratique et est très rentable. Le dispositif thérapeutique portable est approprié non seulement pour divers niveaux d'institutions de traitement médical, mais également pour diverses institutions de rééducation, institutions de gestion de santé aux personnes âgées, et diverses utilisations à l'intérieur de la maison. Le dispositif thérapeutique portable peut non seulement être utilisé dans un lieu fixe et similaire, mais peut également être transporté en tant que dispositif pouvant être porté, et, par conséquent, l'utilisation n'est pas limitée par l'emplacement ou le temps.
PCT/CN2018/079879 2017-03-27 2018-03-21 Dispositif thérapeutique portable destiné à être utilisé dans le traitement de la maladie d'alzheimer par stimulation lumineuse du nerf optique Ceased WO2018177182A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201880006540.7A CN111867676A (zh) 2017-03-27 2018-03-21 利用光刺激视觉神经治疗阿尔茨海默病的便携式治疗仪

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710188035.6A CN107019849A (zh) 2017-03-27 2017-03-27 利用光刺激视觉神经治疗阿尔茨海默病的便携式治疗仪
CN201710188035.6 2017-03-27

Publications (1)

Publication Number Publication Date
WO2018177182A1 true WO2018177182A1 (fr) 2018-10-04

Family

ID=59525377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/079879 Ceased WO2018177182A1 (fr) 2017-03-27 2018-03-21 Dispositif thérapeutique portable destiné à être utilisé dans le traitement de la maladie d'alzheimer par stimulation lumineuse du nerf optique

Country Status (2)

Country Link
CN (2) CN107019849A (fr)
WO (1) WO2018177182A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12053670B2 (en) 2012-08-31 2024-08-06 Blue Goji Llc System and method for targeted neurological therapy using brainwave entrainment

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107019849A (zh) * 2017-03-27 2017-08-08 关夫 利用光刺激视觉神经治疗阿尔茨海默病的便携式治疗仪
CN108310665B (zh) * 2017-12-20 2020-08-11 贵州民族大学 一种基于led灯珠阵列的光治疗仪
CN113457022A (zh) * 2019-06-17 2021-10-01 浙江莱恩海思医疗科技有限公司 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法
CN110251798A (zh) * 2019-07-18 2019-09-20 中国计量大学 一种用于阿尔茨海默病的头戴式声光治疗仪
CN115779277B (zh) * 2022-11-03 2024-04-12 东北大学 一种面向脑重大疾病的红外光神经调控方法、存储介质

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201543118U (zh) * 2009-11-25 2010-08-11 胡明云 保健眼镜
CN101869740A (zh) * 2010-06-23 2010-10-27 上海理工大学 治疗脑中枢神经系统疾病的头罩装置
CN102300604A (zh) * 2008-12-30 2011-12-28 皇家飞利浦电子股份有限公司 用于向受试者提供光疗的系统和方法
CN203634651U (zh) * 2013-11-27 2014-06-11 杨小浩 Led光疗面膜
KR20140090332A (ko) * 2013-01-07 2014-07-17 대한민국(전북기계공업고등학교장) 테라피 글라스
US20160016004A1 (en) * 2014-07-17 2016-01-21 Troy HUDSON Light therapy glasses and mobile application
CN106039578A (zh) * 2016-05-11 2016-10-26 付金龙 一种穿戴式治疗设备以及设备控制方法
US20170056650A1 (en) * 2015-08-31 2017-03-02 Zoll Medical Corporation Electrode Use Indication
CN107019849A (zh) * 2017-03-27 2017-08-08 关夫 利用光刺激视觉神经治疗阿尔茨海默病的便携式治疗仪

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201308726Y (zh) * 2008-12-02 2009-09-16 南通同润生物科技有限公司 近红外光激活大脑活性的健脑仪
RU2545904C2 (ru) * 2008-12-30 2015-04-10 Конинклейке Филипс Электроникс Н.В. Система и способ для проведения фототерапии
CN203710557U (zh) * 2014-03-09 2014-07-16 山东中医药大学 脑血管病人康复用头部按摩器
CN104162233A (zh) * 2014-09-04 2014-11-26 电子科技大学 用于治疗脑疾病的近红外光治疗仪
US20160235980A1 (en) * 2015-02-06 2016-08-18 NooThera Technologies LLC Systems and methods for directed energy therapeutics
EP3271011B1 (fr) * 2015-03-20 2020-01-15 Lim, Teng Lew Système pour une thérapie de neurostimulation non invasive du cerveau

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300604A (zh) * 2008-12-30 2011-12-28 皇家飞利浦电子股份有限公司 用于向受试者提供光疗的系统和方法
CN201543118U (zh) * 2009-11-25 2010-08-11 胡明云 保健眼镜
CN101869740A (zh) * 2010-06-23 2010-10-27 上海理工大学 治疗脑中枢神经系统疾病的头罩装置
KR20140090332A (ko) * 2013-01-07 2014-07-17 대한민국(전북기계공업고등학교장) 테라피 글라스
CN203634651U (zh) * 2013-11-27 2014-06-11 杨小浩 Led光疗面膜
US20160016004A1 (en) * 2014-07-17 2016-01-21 Troy HUDSON Light therapy glasses and mobile application
US20170056650A1 (en) * 2015-08-31 2017-03-02 Zoll Medical Corporation Electrode Use Indication
CN106039578A (zh) * 2016-05-11 2016-10-26 付金龙 一种穿戴式治疗设备以及设备控制方法
CN107019849A (zh) * 2017-03-27 2017-08-08 关夫 利用光刺激视觉神经治疗阿尔茨海默病的便携式治疗仪

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12053670B2 (en) 2012-08-31 2024-08-06 Blue Goji Llc System and method for targeted neurological therapy using brainwave entrainment

Also Published As

Publication number Publication date
CN107019849A (zh) 2017-08-08
CN111867676A (zh) 2020-10-30

Similar Documents

Publication Publication Date Title
WO2018177182A1 (fr) Dispositif thérapeutique portable destiné à être utilisé dans le traitement de la maladie d'alzheimer par stimulation lumineuse du nerf optique
CN114206435B (zh) 中枢神经系统障碍的治疗
US11633621B2 (en) System and method for automated personalized brain modulation with photobiomodulation
US20090005837A1 (en) Method and apparatus for stimulating the neurochemistry of the brain resulting in increased overall brain function, cognitive performance, and intelligence quota
US8868177B2 (en) Non-invasive treatment of neurodegenerative diseases
JP6260953B2 (ja) 認知症状やうつ様症状改善のための光照射装置、この光照射装置を備えた部屋、及び認知症状やうつ様症状改善のための照明器具
US6135117A (en) Non-ocular circadian clock resetting in humans
US6669627B1 (en) REM sleep augmentation with extra-ocular light
Merabet et al. Suppression of complex visual hallucinatory experiences by occipital transcranial magnetic stimulation: a case report
KR20140037803A (ko) 의료 질환 치료용 장치, 시스템 및 방법
JP2017192812A5 (fr)
KR20210060117A (ko) 알츠하이머병 환자를 위한 광치료 헤드셋
Wang et al. Neural mechanism underlying task-specific enhancement of motor learning by concurrent transcranial direct current stimulation
CN101869740B (zh) 治疗脑中枢神经系统疾病的头罩装置
KR101885678B1 (ko) 베타아밀로이드 플라크의 축적 억제용 광선조사 제어장치
CN118807100B (zh) 用于治疗阿尔兹海默症的神经调控装置
Vandewalle et al. Neuroimaging the effects of light on non-visual brain functions
JP2018166568A (ja) ガンマ波誘発装置およびガンマ波誘発方法
CN113425976A (zh) 20～40Hz频闪光对应激相关障碍的改善或治疗作用
CN118949276B (zh) 一种经颅物理刺激装置
US20250262446A1 (en) Body tissue radiofrequency applicators, head device and uses thereof
Casey Electricity in the brain
Altamimi et al. Comparative Effectiveness of Sound Therapy, Transcranial Direct Current Stimulation, and Low-Level Laser Therapy for Chronic Tinnitus Management: A Randomized Clinical Trial
Klaver Effect of stimulation of mRGCs on Alzheimer's and Parkinson's disease
Moossavi Few tips for management of tinnitus

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18776210

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18776210

Country of ref document: EP

Kind code of ref document: A1