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WO2018151150A1 - Dispositif et procédé de mesure de concentration de corps diffusé - Google Patents

Dispositif et procédé de mesure de concentration de corps diffusé Download PDF

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Publication number
WO2018151150A1
WO2018151150A1 PCT/JP2018/005072 JP2018005072W WO2018151150A1 WO 2018151150 A1 WO2018151150 A1 WO 2018151150A1 JP 2018005072 W JP2018005072 W JP 2018005072W WO 2018151150 A1 WO2018151150 A1 WO 2018151150A1
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WO
WIPO (PCT)
Prior art keywords
light
living body
irradiation
light intensity
wavelength
Prior art date
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Ceased
Application number
PCT/JP2018/005072
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English (en)
Japanese (ja)
Inventor
一也 飯永
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Photonics Co Ltd
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Medical Photonics Co Ltd
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Filing date
Publication date
Application filed by Medical Photonics Co Ltd filed Critical Medical Photonics Co Ltd
Priority to JP2018568564A priority Critical patent/JP6894088B2/ja
Publication of WO2018151150A1 publication Critical patent/WO2018151150A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated

Definitions

  • a step of detecting the received light intensity of 2 a step of calculating an absorption coefficient from the second received light intensity, a step of calculating a light scattering coefficient in the living body based on the first received light intensity and the absorption coefficient, and And calculating a scatterer concentration in the living body based on the light scattering coefficient.
  • the scatterer concentration measurement apparatus 1 includes a first irradiation unit 21 and a second irradiation unit that irradiate light from a predetermined irradiation position A of the living body E toward the inside of the living body E. 22, a first light intensity detection unit 31 and a second light intensity detection unit that detect the light intensity at a predetermined detection position B of the living body E, and a third light that detects the light intensity at the predetermined detection position C.
  • the light intensity detected by the intensity detector 33 and the first light intensity detector 31 is corrected using the light intensity detected by the second light intensity detector 32 and the third light intensity detector 33.
  • a control unit 4 for calculating the corrected to calculate the scattering coefficient mu s of the light in the light intensity based vivo, scatterers in vivo based on the scattering coefficient of the calculated optical mu s (lipid) concentration.
  • the second light intensity detection unit 32, and the third light intensity detection unit 33 are formed by increasing the distance between the first irradiation unit 21 and the second irradiation unit 22 and the first light intensity detection unit 31, the second light intensity detection unit 32, and the third light intensity detection unit 33. Since the optical path length becomes long, the number of collisions with lipids increases, and the detected light is greatly affected by scattering, so that it is easy to capture the influence of scattering that has been weak and difficult to detect.
  • the control unit 4 has an absorption coefficient calculated from the received light intensity detected by the first light intensity detector 31 and the received light intensity detected by the second light intensity detector 32 and the third light intensity detector 33. Based on the above, the light scattering coefficient ⁇ s in the living body is calculated. Note that the scattering coefficient ⁇ s in the embodiment is not limited to a numerical value obtained by quantifying the efficiency of a general scattering process, and is a value obtained by quantifying the influence of scattering under a certain condition in consideration of a scattering phenomenon. Is also included.
  • D is represents the diffusion coefficient
  • mu a is the absorption coefficient
  • the above equation (1) is expected to be applied to biological scatter measurement as a calculation formula that linearly approximates the measured light attenuation and derives the absorption coefficient from the intercept and the scattering coefficient from the slope.
  • Figure 6 shows the results of correction of absorption coefficient in phantom measurement. As a result of multiplying the correction coefficient due to water absorption at 950 nm, it was confirmed that the absorption coefficient could be calculated accurately.
  • the controller 4 causes the controller 4 to detect the light intensity of the first irradiation light detected by the first light intensity detector 31, the second light intensity detector 32, and Based on the absorption coefficient calculated from the received light intensity detected by the third light intensity detector 33, the light scattering coefficient ⁇ s in the living body is calculated.
  • the method for calculating the scattering coefficient ⁇ s has been described above.
  • the scatterer concentration can be calculated by acquiring the light intensity distribution emitted from the living body.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

[Problème] Mesurer un coefficient de diffusion dans un composite à diffusion absorbante avec une précision élevée. [Solution] La présente invention est pourvue de : une première unité d'irradiation qui irradie une lumière d'une première longueur d'onde à une première intensité d'irradiation vers l'intérieur d'un corps vivant depuis l'extérieur du corps vivant ; une deuxième unité d'irradiation qui irradie de la lumière d'une deuxième longueur d'onde à une deuxième intensité d'irradiation vers l'intérieur du corps vivant depuis l'extérieur du corps vivant ; une première unité de détection d'intensité de lumière qui détecte une première intensité de lumière reçue de la lumière de la première longueur d'onde émise par le corps vivant à une première position de détection à une première distance à partir d'une position d'irradiation de lumière par la première unité d'irradiation ; une deuxième unité de détection d'intensité de lumière qui détecte une deuxième intensité de lumière reçue de la lumière de la deuxième longueur d'onde émise par le corps vivant à une deuxième position de détection à une deuxième distance de la position d'irradiation de la lumière par la deuxième unité d'irradiation ; et une unité de commande qui calcule un coefficient d'absorption sur la base de la deuxième intensité de lumière reçue, calcule un coefficient de diffusion de la lumière à l'intérieur du corps vivant sur la base de la première intensité de lumière reçue et du coefficient d'absorption, et calcule une concentration de corps diffusé à l'intérieur du corps vivant sur la base du coefficient de diffusion de la lumière calculé.
PCT/JP2018/005072 2017-02-14 2018-02-14 Dispositif et procédé de mesure de concentration de corps diffusé Ceased WO2018151150A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018568564A JP6894088B2 (ja) 2017-02-14 2018-02-14 散乱体濃度計測装置及びその方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017-025311 2017-02-14
JP2017025311 2017-02-14

Publications (1)

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WO2018151150A1 true WO2018151150A1 (fr) 2018-08-23

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PCT/JP2018/005072 Ceased WO2018151150A1 (fr) 2017-02-14 2018-02-14 Dispositif et procédé de mesure de concentration de corps diffusé

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JP (1) JP6894088B2 (fr)
WO (1) WO2018151150A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138225A1 (fr) * 2018-12-26 2020-07-02 メディカルフォトニクス株式会社 Dispositif de mesure de calories absorbées, procédé de mesure de calories absorbées et programme de mesure de calories absorbées
WO2020246455A1 (fr) * 2019-06-04 2020-12-10 メディカルフォトニクス株式会社 Dispositif, procédé et programme de mesure non invasive
WO2022262221A1 (fr) * 2021-06-18 2022-12-22 中国科学院深圳先进技术研究院 Procédé de mesure d'hématocrite, appareil, terminal et support de stockage lisible
JP2024508717A (ja) * 2021-02-11 2024-02-28 先陽科技有限公司 生体組織成分の検出方法、装置及びウェアラブル機器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517300A (ja) * 2000-07-28 2004-06-10 アボット・ラボラトリーズ 組織の水分補給効果の補償による分析物濃度の非観血的決定方法
JP2013070822A (ja) * 2011-09-27 2013-04-22 Seiko Epson Corp 濃度定量装置、光吸収係数算出方法、等価散乱係数算出方法、濃度定量方法、光吸収係数の算出を行うプログラム及び濃度の算出を行うプログラム
WO2014087825A1 (fr) * 2012-12-06 2014-06-12 国立大学法人北海道大学 Mesureur non invasif de concentration en biolipides, dispositif non invasif de mesure de métabolisme de biolipides, procédé non invasif pour mesure la concentration en biolipides, et procédé non invasif pour examiner le métabolisme de biolipides
WO2016041073A1 (fr) * 2014-09-17 2016-03-24 2352409 Ontario Inc. Dispositif et procédé de surveillance d'équilibre de graisse

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5595534B2 (ja) * 2007-05-15 2014-09-24 キヤノン株式会社 生体情報イメージング装置、生体情報の解析方法、及び生体情報のイメージング方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517300A (ja) * 2000-07-28 2004-06-10 アボット・ラボラトリーズ 組織の水分補給効果の補償による分析物濃度の非観血的決定方法
JP2013070822A (ja) * 2011-09-27 2013-04-22 Seiko Epson Corp 濃度定量装置、光吸収係数算出方法、等価散乱係数算出方法、濃度定量方法、光吸収係数の算出を行うプログラム及び濃度の算出を行うプログラム
WO2014087825A1 (fr) * 2012-12-06 2014-06-12 国立大学法人北海道大学 Mesureur non invasif de concentration en biolipides, dispositif non invasif de mesure de métabolisme de biolipides, procédé non invasif pour mesure la concentration en biolipides, et procédé non invasif pour examiner le métabolisme de biolipides
WO2016041073A1 (fr) * 2014-09-17 2016-03-24 2352409 Ontario Inc. Dispositif et procédé de surveillance d'équilibre de graisse

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138225A1 (fr) * 2018-12-26 2020-07-02 メディカルフォトニクス株式会社 Dispositif de mesure de calories absorbées, procédé de mesure de calories absorbées et programme de mesure de calories absorbées
JP2020106318A (ja) * 2018-12-26 2020-07-09 メディカルフォトニクス株式会社 吸収カロリー計測装置、吸収カロリー計測方法、及び、吸収カロリー計測プログラム
WO2020246455A1 (fr) * 2019-06-04 2020-12-10 メディカルフォトニクス株式会社 Dispositif, procédé et programme de mesure non invasive
JP2024508717A (ja) * 2021-02-11 2024-02-28 先陽科技有限公司 生体組織成分の検出方法、装置及びウェアラブル機器
WO2022262221A1 (fr) * 2021-06-18 2022-12-22 中国科学院深圳先进技术研究院 Procédé de mesure d'hématocrite, appareil, terminal et support de stockage lisible

Also Published As

Publication number Publication date
JP6894088B2 (ja) 2021-06-30
JPWO2018151150A1 (ja) 2020-01-09

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