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WO2018146679A3 - Photoreceptor cells for the treatment of retinal diseases - Google Patents

Photoreceptor cells for the treatment of retinal diseases Download PDF

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Publication number
WO2018146679A3
WO2018146679A3 PCT/IL2018/050145 IL2018050145W WO2018146679A3 WO 2018146679 A3 WO2018146679 A3 WO 2018146679A3 IL 2018050145 W IL2018050145 W IL 2018050145W WO 2018146679 A3 WO2018146679 A3 WO 2018146679A3
Authority
WO
WIPO (PCT)
Prior art keywords
photoreceptor cells
treatment
retinal diseases
disclosed
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2018/050145
Other languages
French (fr)
Other versions
WO2018146679A2 (en
Inventor
Benjamin E. Reubinoff
Masha GORSHTEIN
Hanita KHANER
Alex Obolensky
Eyal Banin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hadasit Medical Research Services and Development Co
Original Assignee
Hadasit Medical Research Services and Development Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hadasit Medical Research Services and Development Co filed Critical Hadasit Medical Research Services and Development Co
Priority to CN201880021741.4A priority Critical patent/CN110520139A/en
Priority to IL268357A priority patent/IL268357B2/en
Priority to AU2018217992A priority patent/AU2018217992B2/en
Priority to CA3052872A priority patent/CA3052872A1/en
Priority to EP18750704.1A priority patent/EP3579851A4/en
Priority to US16/484,420 priority patent/US12281328B2/en
Publication of WO2018146679A2 publication Critical patent/WO2018146679A2/en
Publication of WO2018146679A3 publication Critical patent/WO2018146679A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Acoustics & Sound (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A method of generating photoreceptor cells is disclosed. Cell populations comprising photoreceptor cells and uses thereof are also disclosed.
PCT/IL2018/050145 2017-02-08 2018-02-08 Photoreceptor cells for the treatment of retinal diseases Ceased WO2018146679A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201880021741.4A CN110520139A (en) 2017-02-08 2018-02-08 For treating the photosensory cell of retinal disease
IL268357A IL268357B2 (en) 2017-02-08 2018-02-08 Photoreceptor cells for the treatment of retinal diseases
AU2018217992A AU2018217992B2 (en) 2017-02-08 2018-02-08 Photoreceptor cells for the treatment of retinal diseases
CA3052872A CA3052872A1 (en) 2017-02-08 2018-02-08 Photoreceptor cells for the treatment of retinal diseases
EP18750704.1A EP3579851A4 (en) 2017-02-08 2018-02-08 PHOTO RECEPTOR CELLS FOR TREATMENT OF NETWORK DISEASES
US16/484,420 US12281328B2 (en) 2017-02-08 2018-02-08 Photoreceptor cells for the treatment of retinal diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762456155P 2017-02-08 2017-02-08
US62/456,155 2017-02-08

Publications (2)

Publication Number Publication Date
WO2018146679A2 WO2018146679A2 (en) 2018-08-16
WO2018146679A3 true WO2018146679A3 (en) 2018-09-20

Family

ID=63107965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2018/050145 Ceased WO2018146679A2 (en) 2017-02-08 2018-02-08 Photoreceptor cells for the treatment of retinal diseases

Country Status (7)

Country Link
US (1) US12281328B2 (en)
EP (1) EP3579851A4 (en)
CN (1) CN110520139A (en)
AU (1) AU2018217992B2 (en)
CA (1) CA3052872A1 (en)
IL (1) IL268357B2 (en)
WO (1) WO2018146679A2 (en)

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FI3551216T3 (en) 2016-12-07 2024-10-14 Mayo Found Medical Education & Res Methods and materials for using fibrin supports for retinal pigment epithelium transplantation
US12281328B2 (en) 2017-02-08 2025-04-22 Hadasit Medical Research Services And Development Ltd. Photoreceptor cells for the treatment of retinal diseases
CA3065145A1 (en) * 2017-06-05 2018-12-13 Mayo Foundation For Medical Education And Research Methods and materials for culturing, proliferating, and differentiating stem cells
WO2019078781A1 (en) 2017-10-17 2019-04-25 National University Of Singapore Systems and methods for producing photoreceptor progenitors
CN112481199B (en) * 2020-11-12 2023-04-07 广东普罗凯融生物医药科技有限公司 Method for preparing photosensitive cells
KR102525093B1 (en) * 2021-04-16 2023-04-27 가톨릭대학교 산학협력단 Pharmaceutical composition for preventing or treating retinal degenerative disease, comprising human neural crest derived nasal turbinate stem cells as an active ingredient
US20250262248A1 (en) * 2022-04-25 2025-08-21 Cell Cure Neurosciences, Ltd. Methods and compositions for treating vision loss
WO2024036094A2 (en) * 2022-08-06 2024-02-15 Purdue Research Foundation Compounds and methods of use thereof for the treatment of photoreceptor rod degenerations and generation of photoreceptors

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WO2017021972A1 (en) * 2015-08-05 2017-02-09 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
WO2017091844A1 (en) * 2015-12-04 2017-06-08 Bond University Ltd Methods of differentiating retinal cells

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Also Published As

Publication number Publication date
CA3052872A1 (en) 2018-08-16
AU2018217992A1 (en) 2019-08-15
IL268357B2 (en) 2025-07-01
IL268357A (en) 2019-09-26
US12281328B2 (en) 2025-04-22
US20200032204A1 (en) 2020-01-30
CN110520139A (en) 2019-11-29
AU2018217992B2 (en) 2023-12-14
WO2018146679A2 (en) 2018-08-16
EP3579851A2 (en) 2019-12-18
IL268357B1 (en) 2025-03-01
EP3579851A4 (en) 2020-10-07

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