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WO2018037229A8 - Clinical diagnosis of non-alcoholic fatty liver disease using a panel of human blood protein biomarkers - Google Patents

Clinical diagnosis of non-alcoholic fatty liver disease using a panel of human blood protein biomarkers Download PDF

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Publication number
WO2018037229A8
WO2018037229A8 PCT/GB2017/052486 GB2017052486W WO2018037229A8 WO 2018037229 A8 WO2018037229 A8 WO 2018037229A8 GB 2017052486 W GB2017052486 W GB 2017052486W WO 2018037229 A8 WO2018037229 A8 WO 2018037229A8
Authority
WO
WIPO (PCT)
Prior art keywords
liver disease
fatty liver
panel
alcoholic fatty
human blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2017/052486
Other languages
French (fr)
Other versions
WO2018037229A1 (en
Inventor
Bevin Gangadharan
Abhinav Kumar
Raymond A. Dwek
Nicole Zitzmann
Mark Thursz
Jeremy Francis Lars COBBOLD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to EP17758917.3A priority Critical patent/EP3504555B1/en
Priority to CN202211149976.6A priority patent/CN116068195A/en
Priority to ES17758917T priority patent/ES2940313T3/en
Priority to CN201780065604.6A priority patent/CN110088627B/en
Priority to US16/326,737 priority patent/US11366124B2/en
Priority to EP22165044.3A priority patent/EP4047372A3/en
Publication of WO2018037229A1 publication Critical patent/WO2018037229A1/en
Publication of WO2018037229A8 publication Critical patent/WO2018037229A8/en
Anticipated expiration legal-status Critical
Priority to US17/746,341 priority patent/US12130293B2/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4741—Keratin; Cytokeratin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to methods of diagnosing, prognosing, or monitoring or staging the progression of non-alcoholic fatty liver disease (NAFLD) using biomarkers. The invention also relates to a method of scoring to determine the severity of NAFLD, and a method of treating NAFLD.
PCT/GB2017/052486 2016-08-24 2017-08-23 Apolipoprotein f as biomarker for non-alcoholic fatty liver disease Ceased WO2018037229A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP17758917.3A EP3504555B1 (en) 2016-08-24 2017-08-23 Apolipoprotein f as a biomarker for non-alcoholic fatty liver disease
CN202211149976.6A CN116068195A (en) 2016-08-24 2017-08-23 Application of biomarkers, antibodies and reagents in the preparation of kits
ES17758917T ES2940313T3 (en) 2016-08-24 2017-08-23 Apolipoprotein f as a biomarker for nonalcoholic fatty liver disease
CN201780065604.6A CN110088627B (en) 2016-08-24 2017-08-23 Biomarkers
US16/326,737 US11366124B2 (en) 2016-08-24 2017-08-23 Clinical diagnosis of non-alcoholic fatty liver disease using a panel of human blood protein biomarkers
EP22165044.3A EP4047372A3 (en) 2016-08-24 2017-08-23 Lipopolysaccharide-binding protein as biomarker for non-alcoholic fatty liver disease
US17/746,341 US12130293B2 (en) 2016-08-24 2022-05-17 Clinical diagnosis of non-alcoholic fatty liver disease using a panel of human blood protein biomarkers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1614455.2 2016-08-24
GBGB1614455.2A GB201614455D0 (en) 2016-08-24 2016-08-24 Biomarkers

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/326,737 A-371-Of-International US11366124B2 (en) 2016-08-24 2017-08-23 Clinical diagnosis of non-alcoholic fatty liver disease using a panel of human blood protein biomarkers
US17/746,341 Continuation US12130293B2 (en) 2016-08-24 2022-05-17 Clinical diagnosis of non-alcoholic fatty liver disease using a panel of human blood protein biomarkers

Publications (2)

Publication Number Publication Date
WO2018037229A1 WO2018037229A1 (en) 2018-03-01
WO2018037229A8 true WO2018037229A8 (en) 2018-03-29

Family

ID=57045459

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2017/052486 Ceased WO2018037229A1 (en) 2016-08-24 2017-08-23 Apolipoprotein f as biomarker for non-alcoholic fatty liver disease

Country Status (6)

Country Link
US (2) US11366124B2 (en)
EP (2) EP4047372A3 (en)
CN (2) CN110088627B (en)
ES (1) ES2940313T3 (en)
GB (1) GB201614455D0 (en)
WO (1) WO2018037229A1 (en)

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CN114113439A (en) * 2021-06-17 2022-03-01 福建医科大学孟超肝胆医院(福州市传染病医院) Application of serum LRG1 protein in preparation of intrahepatic bile duct cancer lymph node diagnosis kit
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Also Published As

Publication number Publication date
CN110088627B (en) 2022-10-11
CN116068195A (en) 2023-05-05
US11366124B2 (en) 2022-06-21
US12130293B2 (en) 2024-10-29
ES2940313T3 (en) 2023-05-05
EP4047372A2 (en) 2022-08-24
US20190339288A1 (en) 2019-11-07
EP3504555B1 (en) 2023-01-18
WO2018037229A1 (en) 2018-03-01
EP4047372A3 (en) 2023-01-18
GB201614455D0 (en) 2016-10-05
EP3504555A1 (en) 2019-07-03
US20230117596A1 (en) 2023-04-20
CN110088627A (en) 2019-08-02

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