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WO2018093163A1 - Dispositif de mesure d'apnée néonatale, procédé de fonctionnement associé et système de mesure d'apnée néonatale - Google Patents

Dispositif de mesure d'apnée néonatale, procédé de fonctionnement associé et système de mesure d'apnée néonatale Download PDF

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Publication number
WO2018093163A1
WO2018093163A1 PCT/KR2017/012993 KR2017012993W WO2018093163A1 WO 2018093163 A1 WO2018093163 A1 WO 2018093163A1 KR 2017012993 W KR2017012993 W KR 2017012993W WO 2018093163 A1 WO2018093163 A1 WO 2018093163A1
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WIPO (PCT)
Prior art keywords
newborn
apnea
chest
electrodes
voltage
Prior art date
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Ceased
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PCT/KR2017/012993
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English (en)
Korean (ko)
Inventor
우응제
오동인
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Kyung Hee University
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Kyung Hee University
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Publication date
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4818—Sleep apnoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0536—Impedance imaging, e.g. by tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M1/00—Substation equipment, e.g. for use by subscribers
    • H04M1/72—Mobile telephones; Cordless telephones, i.e. devices for establishing wireless links to base stations without route selection
    • H04M1/724—User interfaces specially adapted for cordless or mobile telephones
    • H04M1/72403—User interfaces specially adapted for cordless or mobile telephones with means for local support of applications that increase the functionality
    • H04M1/72409—User interfaces specially adapted for cordless or mobile telephones with means for local support of applications that increase the functionality by interfacing with external accessories
    • H04M1/72415—User interfaces specially adapted for cordless or mobile telephones with means for local support of applications that increase the functionality by interfacing with external accessories for remote control of appliances
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M1/00—Substation equipment, e.g. for use by subscribers
    • H04M1/72—Mobile telephones; Cordless telephones, i.e. devices for establishing wireless links to base stations without route selection
    • H04M1/725—Cordless telephones

Definitions

  • the present invention relates to a neonatal apnea measurement apparatus and its operation method, and a neonatal apnea measurement and alarm system, and more specifically to the newborn apnea symptoms based on the image and the bio-signal according to the impedance data in the chest of the newborn or premature infants
  • the present invention relates to a newborn apnea measurement apparatus and method for operating the same, and a newborn apnea measurement and alarm system for diagnosing and transmitting an alarm signal according to a diagnosis result.
  • Sleep apnea is a serious health care problem that causes adults with heart disease, obesity, fatigue and drowsiness, and there is an increasing number of people worldwide. These sleep apneas can be fatal to newborns and infants.
  • the present invention provides a newborn apnea measurement apparatus for attaching a plurality of electrodes to the chest of the newborn or wearing an electrode belt or electrode vest and imaging changes in the air distribution in the lung according to the impedance data measured from the electrodes attached to the chest surface and It is intended to provide a method of operation and a neonatal apnea measurement system.
  • the present invention lowers the probability of false alarms using changes in the air distribution inside the lung based on anatomical location on the chest image of the newborn, and diagnoses more accurate newborn apnea symptoms through integrated analysis with sensed bio signals.
  • the present invention provides a newborn apnea measurement apparatus and its operation method, and a newborn apnea measurement system.
  • the present invention is to provide a newborn baby apnea measurement apparatus and its operation method, and a newborn apnea measurement and alarm system that can provide care to newborns more safely and conveniently by providing an immediate warning to the designated caregiver of the newborn apnea symptoms.
  • the newborn apnea measurement apparatus is formed with a plurality of electrodes for current injection and voltage sensing, the chest electrode portion attached along the chest circumference of the newborn to be measured, the contact area of the newborn
  • a sensing unit for sensing a bio-signal, selectively supplying current to at least one or more selected pairs of electrodes in the plurality of electrodes, measuring a voltage through the unselected electrodes, and obtaining impedance data at the measured voltage
  • Apnea diagnosis for diagnosing apnea symptoms of the newborn by using a controller for imaging the inside of the chest of the newborn and an imaged chest image and the sensed biosignal, and transmitting an alarm according to the diagnosis result Contains wealth.
  • the neonatal apnea measurement system selectively supplies current to at least one or more selected electrode pairs of a plurality of electrodes attached along the chest circumference of the newborn, and measures the voltage through the unselected electrodes.
  • Neonatal apnea for diagnosing apnea symptoms in newborns by imaging the inside of the chest according to the distribution of air in the lungs of the newborn from the acquired impedance data and using the imaged chest image and the bio signals sensed in contact with the newborn's target And an external terminal for receiving any one of a measuring device and an alarm signal according to the diagnosis result, and the chest image to monitor the apnea state of the newborn baby.
  • a method of measuring neonatal apnea using a newborn apnea measurement apparatus comprises the steps of selectively supplying current to at least one or more selected electrode pairs of a plurality of electrodes attached along the chest circumference of the newborn Measuring a voltage through the unselected electrodes of the plurality of electrodes, imaging the inside of the chest based on the acquired impedance data at the measured voltage, and contacting a measurement target part of the newborn And sensing a signal, diagnosing the apnea symptoms of the newborn by using the quantified result of the imaged chest image and the sensed biosignal, and transmitting an alarm according to the diagnosis result.
  • FIG. 1 is a block diagram illustrating the configuration of a newborn apnea measurement apparatus according to an embodiment of the present invention.
  • Figure 2a shows an embodiment of a newborn apnea measurement apparatus according to an embodiment of the present invention
  • Figure 2b shows a schematic view of the chest electrode portion.
  • 3A and 3B schematically illustrate a composite electrode employed in the newborn apnea measurement apparatus shown in FIG. 2B.
  • FIG. 4A to 4D schematically illustrate the electrode belt
  • FIG. 4E illustrates an example in which the electrode belt is attached to a human body of a newborn baby.
  • 5A and 5B show changes in measurement data and chest images in the apnea section.
  • Figure 6 illustrates the configuration of the newborn apnea measurement and alarm system according to an embodiment of the present invention.
  • Figure 7 shows an example of monitoring the symptoms of apnea in newborns.
  • FIG. 8 is a flowchart illustrating a method of measuring apnea symptoms in a newborn baby using a newborn apnea measuring apparatus according to an embodiment of the present invention.
  • an embodiment As used herein, “an embodiment”, “an example”, “side”, “an example”, etc., should be construed that any aspect or design described is better or advantageous than other aspects or designs. It is not.
  • the term 'or' means inclusive or 'inclusive or' rather than 'exclusive or'.
  • the expression 'x uses a or b' means any one of natural inclusive permutations.
  • FIG. 1 is a block diagram illustrating the configuration of a newborn apnea measurement apparatus according to an embodiment of the present invention.
  • a newborn apnea measuring apparatus 100 images impedance data measured from a plurality of electrodes attached to a chest circumference of a newborn, and uses a chest image and a sensed biosignal. Diagnose apnea symptoms in the newborn and send an alarm signal.
  • the newborn apnea measurement apparatus 100 includes a chest electrode 110, a detector 120, a control unit 130 and the apnea diagnosis unit 140.
  • the chest electrode 110 is formed with a plurality of electrodes for current injection and voltage sensing, and is attached along the chest circumference of the newborn to be measured.
  • the plurality of electrodes may be electrical impedance tomography (EIT) electrodes attached along the chest circumference of the newborn to measure impedance data for the chest.
  • EIT electrical impedance tomography
  • the EIT electrode may be arranged on one surface of a base plate made of a flexible material and attached to a circumference of a newborn baby's chest.
  • the EIT electrode may have a belt shape or a vest shape.
  • the EIT electrode may be disposed on one surface of the base plate made of a fiber material corresponding to the sensitive skin of the newborn.
  • EIT electrodes are used to inject relatively low currents, for example, high frequency currents of 1 mA or less, and to measure induced voltages, which are not detectable by newborns. It can be used to detect the form of closure and the structural changes that cause it.
  • the plurality of electrodes may be at least one of a simple electrode and a composite electrode.
  • the detector 120 is in contact with a measurement target part of the newborn and senses a bio signal.
  • the sensing unit 120 may include a plurality of sensors, and may perform a function of sensing a biological signal of a newborn baby sleeping with a fiber-based sensor.
  • the plurality of sensors may be fiber sensors corresponding to sensitive skin of a newborn baby.
  • the detection unit 120 detects a blood oxygen saturation level sensor for measuring blood oxygen saturation degree (SpO 2 ) signal of arterial blood according to a measurement target site when the baby is sleeping, and detects a sound according to the biological activity of the newborn. At least one of a sound sensor, a posture measurement sensor for detecting the movement of the newborn, and an ECG sensor for measuring the ECG of the measurement target site.
  • a blood oxygen saturation level sensor for measuring blood oxygen saturation degree (SpO 2 ) signal of arterial blood according to a measurement target site when the baby is sleeping, and detects a sound according to the biological activity of the newborn.
  • a sound sensor for detecting the movement of the newborn
  • an ECG sensor for measuring the ECG of the measurement target site.
  • the blood oxygen saturation measurement sensor is to measure the blood saturation degree (SpO 2 , Saturation of peripheral Oxygen) that is attached to the measurement target of the newborn and indicates the oxygen content present in hemoglobin among various components constituting the blood. Can be.
  • SpO 2 Saturation of peripheral Oxygen
  • the blood oxygen saturation measurement sensor uses light to measure a signal relating to the photoplethysmography (PPG) of the human body of a newborn baby reflected or transmitted, and based on the measured signal related to the optical volumetric pulse wave Blood oxygen saturation can be measured.
  • PPG photoplethysmography
  • the sound sensor may detect the sound of at least one of breathing, snoring, crying and drooling according to the sleep, according to the embodiment, the sound sensor is attached to the measurement target of the newborn, or the newborn during sleep It may be in the form of a non-contact present at a distance away from it.
  • the posture measuring sensor may be formed from at least one of a gyro sensor and an acceleration sensor, and may be attached to a measurement target portion of the newborn to measure a posture according to the movement of the newborn.
  • the posture measuring sensor may detect a change in the sleeping posture of the newborn using an acceleration sensor.
  • cardiograph (BCG) and the cardiopulmonary wave (SCG) near the heart may be detected from the output of the minute attitude sensor.
  • the ECG sensor may contact an area to be measured of the newborn and measure an electrocardiogram (ECG).
  • ECG electrocardiogram
  • the electrocardiogram is a waveform composed of a vector sum of action potentials generated by a special excitatory & conductive system of the heart.
  • SA node sinoatrial node
  • AV node atrioventricular node
  • His bundle His bundle
  • Hiss branch aundle branch
  • furkinje fibers furkinje fibers
  • the vector sum signal of the generated action potential may be referred to as a signal measured from an electrode attached to the body.
  • the detector 120 may detect at least one of electroencephalogram (EEG), electromyography (EMG), eye conduction (EOG), thoracic oscillation wave (SCG), and cardioballography (BCG). You can also measure.
  • EEG electroencephalogram
  • EMG electromyography
  • EOG eye conduction
  • SCG thoracic oscillation wave
  • BCG cardioballography
  • the sensing unit 140 of the sleep apnea measurement apparatus 100 may further include a sleep environment sensor for measuring a sleep environment, and the sleep environment sensor has a predetermined distance from a newborn baby. Located at a distance, at least one of noise, light, vibration, temperature, and humidity of the sleeping space may be measured.
  • the controller 130 selectively supplies current to at least one or more selected electrode pairs in the plurality of electrodes, measures the voltage through the unselected electrodes, and based on the acquired impedance data at the measured voltage, Imaging the inside of the chest
  • the controller 130 may include a current injection module 131, a voltage measuring module 132, an image generating module 133, and a control module 134.
  • the current injection module 131 may inject a current having a plurality of frequency ranges through at least one selected electrode pair among a plurality of electrodes attached to the chest of the newborn baby.
  • the current injection module 131 may select the selected electrode pair and frequency, generate a voltage signal according to the selected frequency, convert the current into a current, and inject the converted current into the chest of the newborn through the selected electrode pair. have.
  • the current injection module 131 converts a voltage signal into two currents of different phases, corrects the two currents so that their amplitude and frequency are the same, and corrects the two currents corrected to the chest of the newborn through the selected electrode pair. It can also be injected.
  • the voltage measuring module 132 may measure the induced voltage according to the current injected from the non-selected electrodes among the plurality of electrodes.
  • the voltage measuring module 132 removes noise included in the detected voltage based on the measured slope of the voltage, and exceeds the threshold value when the slope of the detected voltage exceeds a preset threshold.
  • the voltage of the section to be replaced by a predetermined voltage value.
  • the image generation module 133 may image the inside of the chest by measuring impedance data at the chest based on the measured voltage.
  • the image generation module 133 acquires a voltage difference signal induced by the injected current through electrodes that are not selected among the plurality of electrodes, and acquires impedance data according to a chest circumference and electrode position of the newborn baby. Can be.
  • the image generating module 133 may image the chest image by restoring the conductivity and dielectric constant image of the chest of the newborn with the measured impedance data value.
  • the image generation module 133 may control the sensitivity and the resolution according to the position of the chest electrode 110 because the imaging protocol has a measurement protocol of the plurality of electrodes for imaging the chest of the newborn baby.
  • Conductivity and dielectric constant images, i.e., impedance images, in the chest of a newborn baby, using an improved sensitivity matrix from three-dimensional modeling images generated through the chest electrode unit 110 and a combination of the measured values or a combination thereof using a plurality of measurement protocols Generate a chest image.
  • the control module 134 controls the selection of at least one or more electrode pairs in the plurality of electrodes, controls the selection of non-selected electrodes, and controls the sensing of the sensing unit 120 in contact with the measurement target part of the newborn baby. can do.
  • the control module 134 may control the current injecting module 131 to measure impedance data of the newborn's chest and control the sensing unit 120 to measure the biosignal for the measurement target part of the newborn. .
  • the control module 134 monitors the contact state of the electrodes in the chest electrode unit 110 to lower the possibility of false alarms due to electrode contact.
  • control module 134 may control at least one of the voltage measuring module 132 and the image generating module 133 to measure the vertical and horizontal impedance of the newborn's chest.
  • controller 130 may further include a communication module 135.
  • the communication module 135 may transmit the health state information according to the apnea symptoms of the newborn to the outside.
  • the communication module 135 may transmit the generated protocol packet to the outside through a communication module which is a WIFI method, and, when present within a predetermined distance from a server that receives the protocol packet, generates a radio frequency identification (RFID). It can also be used for transmission.
  • the communication module 135 may transmit and receive information using BLE (Bluetooth Low Energy) or a data communication network in addition to WIFI and RFID.
  • BLE Bluetooth Low Energy
  • control module 134 may provide the guardian with the alarm signal of any one of image, voice, and vibration according to the apnea symptom information of the newborn through the communication module 135.
  • control module 134 transmits a control command based alarm signal when the diagnosis result diagnosed from the apnea diagnosis unit 140 is out of a predetermined normal range. 135 may be controlled to transmit to the outside.
  • control module 134 may control to transmit a false alarm (false alarm) according to the contact state of the electrodes in the chest electrode unit 110 to the outside.
  • An electric impedance tomography (EIT) method for acquiring chest images of a newborn baby of the newborn apnea measuring apparatus 100 according to an embodiment of the present invention is as follows.
  • the controller 130 selects a channel and a sinusoidal frequency according to the command, and selects a pair of electrodes in the chest electrode unit 110 corresponding to the selected channel.
  • the selected pair of electrodes is used to inject current into the chest of the newborn, and the unselected electrodes are used to measure the voltage on the surface of the newborn.
  • the controller 130 When the frequency of the channel and the sine wave is selected, the controller 130 outputs a control signal for controlling the FPGA (not shown).
  • the control signal may include information about the selected frequency.
  • the FPGA receives and stores control signals and generates sinusoidal voltage signals based on the received control signals.
  • the FPGA generates a voltage signal based on the frequency information included in the control signal, and transmits the generated voltage signal to two 16-bit D / A converters (not shown).
  • the FPGA controls an 8-bit D / A converter (not shown) to adjust the full width of the voltage signal transmitted to the 16-bit D / A converter.
  • the voltage signals output to the two 16-bit D / A converters are converted into currents by voltage-current converters (not shown), and the two currents are transmitted to the calibrator (not shown).
  • a calibrator (not shown) regulates both currents so that their amplitude and frequency are the same.
  • the two currents have a phase difference of 180 °.
  • control module 134 of the controller 130 injects current into the chest of the newborn through the current injection module 131 so that the two currents passed through the braces are transmitted to the selected electrode pair in the chest electrode unit 110, respectively. do.
  • the current injected around the chest of a newborn will induce different magnitudes of voltage on its surface depending on the difference in resistivity or conductivity of the internal tissues. If electrodes not selected at the chest electrode 110 detect a surface voltage around the chest of the newborn, the voltage measurement module 132 receives the sensed surface voltages corresponding to the unselected electrodes.
  • the voltage measuring module 132 determines whether noise is included in the surface voltage data based on the detected slope of the surface voltage data, and if the noise is included, replaces the voltage data with another voltage value.
  • the control module 134 adjusts the gain of the voltage amplifier (not shown) according to the maximum value of the voltage data. For example, the control module 134 does not adjust the gain of the voltage amplifier when the maximum value of the voltage data reaches 90% of the maximum output of the A / D converter (not shown). If it does not reach 90% of the maximum output of the D converter, increase the gain of the voltage amplifier.
  • the voltage measuring module 132 When noise is removed from the voltage data and the gain of the voltage amplifier is adjusted, the voltage measuring module 132 amplifies the voltage data according to the adjusted gain value, and the A / D converter converts the voltage data into a digital value.
  • the image generating module 133 processes the voltage data in consideration of channel-specific gain information based on the channel information and the gain information. Because the gain values are different, if the detected voltage data is used as it is, it is difficult to accurately represent the electrical characteristics inside the chest of the newborn baby. Therefore, the corresponding voltage value should be subtracted or increased according to the gain value. For example, if the gain value is greater than the reference gain value, the corresponding voltage value may be reduced, and the ratio of the gain value and the reference gain value may be multiplied with the corresponding voltage value.
  • the image generation module 133 may process the voltage data in consideration of gain information for each channel, and then obtain impedance data using the voltage data.
  • the image generating module 133 images the inside of the chest of the newborn from the impedance data.
  • various methods for imaging the inside of the measurement target (the chest) using voltage data of the chest surface of the newborn may be applied.
  • the image generating module 133 may acquire the appearance information by using the optical imaging device and the length measuring device using a marker located on the electrode to form a three-dimensional reconstruction model according to the shape of the newborn's rib cage.
  • a reconstruction algorithm can be generated.
  • a reconstruction algorithm may be generally used as an algorithm for reconstructing a 3D image.
  • the apnea diagnosis unit 140 of the newborn apnea measurement apparatus 100 diagnoses apnea symptoms of a newborn baby using an imaged chest image and a sensed biosignal, and diagnoses the diagnosis.
  • the alarm signal is transmitted according to the result.
  • the apnea diagnostic unit 140 may quantify at least one of a change, a degree, and a shape of the air distribution inside the lung over time based on the anatomical position of the imaged chest image and the average heart rate and respiratory rate of the newborn baby.
  • the apnea diagnosis unit 140 classifies the ages of newborns at birth, 6 months, 1 year, 3-4 years, 5-10 years, 10-15 years, and 15 years or more, and the classified ages. As described above, the apnea symptom can be diagnosed based on the preset normal range of breathing rate / minute and heart rate / minute.
  • the apnea diagnosis unit 140 acquires a fast and stable signal for a predetermined time, thereby accurately diagnosing the apnea symptoms of the newborn.
  • the apnea diagnosis unit 140 may diagnose the apnea symptom using the quantification result in the chest image and the biosignal sensed by the detection unit 120.
  • the newborn apnea measurement apparatus 100 may include a user interface (not shown) to display and provide an alarm signal according to the apnea symptoms of the newborn, diagnosed from the apnea diagnosis unit 140 If the result is out of the predetermined normal range, it may further include a warning signal providing unit (not shown) for providing a warning signal of at least one of the sound, vibration and color change.
  • Figure 2a shows an embodiment of a newborn apnea measurement apparatus according to an embodiment of the present invention
  • Figure 2b shows a schematic view of the chest electrode portion.
  • the newborn apnea measurement apparatus includes a chest electrode portion 110 that can be attached to the chest of the newborn, and includes a detector 120 attached to the measurement target site of the newborn. Can be.
  • the chest electrode 110 attached to the chest circumference of the newborn is formed by maintaining a distance of a certain distance on the base plate, attached to the chest of the newborn to measure the impedance from the lung shape due to breathing during the newborn's sleeping state Can be.
  • the plurality of electrodes on the chest electrode unit 110 may include a conductive fiber electrode manufactured based on silver (Ag) plated elastic fibers or polymer nanofibers (PVDF nanofiber web). Therefore, the electrode may be formed of various materials having less skin response to long-term measurement, but is not limited thereto.
  • the base plate on which the chest electrode unit 110 according to the embodiment of the present invention is formed is not necessarily limited to the shape of the belt-shaped array electrode.
  • the chest electrode unit 110 of the array having at least one of the shape or structure of the vest form, belt form and patch form
  • the base plate can also be sufficiently applied.
  • the plurality of electrodes of the chest electrode unit 110 are formed at regular intervals on the base plate or arranged in various arrangements and structures according to the characteristics and utilization of the measurement target site (thorax). Can be.
  • the base plate may have a predetermined length and width so as to measure impedance in a state in which the measurement target including the chest or abdomen of the newborn is measured, but the length and width may be modified according to the embodiment. It is not.
  • the chest electrode 110 is attached to the chest of the newborn to the plurality of electrodes arranged in a two-dimensional or three-dimensional manner by changing the electrode arrangement structure and measurement structure on the surface near the chest The electric field distribution of can be measured effectively.
  • the chest electrode portions 110 formed on the base plate are arranged in a three-dimensional array to enable impedance measurement corresponding to each layer, thereby providing only a two-dimensional cross-sectional image at a specific position. More accurate and effective diagnosis can be achieved.
  • the detection unit 120 of the newborn apnea measurement apparatus may be in contact with the measurement target site of the newborn to sense a bio-signal.
  • the sensing unit 120 may be in contact with any place of the measurement target of the newborn, the position and number of the measurement target region to be contacted are not limited to those shown in FIG. 2A.
  • the sensing unit 120 may be at least one of a sound sensor, a posture measuring sensor, and an ECG sensor, and may be a fiber-based sensor for attaching to a human body of a newborn baby.
  • the detection unit of the newborn apnea measurement apparatus in order to measure the blood oxygen saturation of the newborn, the light to measure the amount of light transmitted through the blood flow through the peripheral blood vessels at the fingertips or toes using a red light source Sensors can be used to measure SpO 2 signals.
  • the sensing unit is configured in the form of a measuring terminal fitted to the fingertips
  • the light emitting unit is composed of a 660nm red LED and 940nm infrared LED
  • the light receiving unit is attached with a photo diode and a photo transistor It may be composed of one optical module.
  • the chest electrode unit 110 may be provided with a plurality of electrodes 20 and may be mounted along a chest circumference of a newborn to be measured.
  • the chest electrode unit 110 includes a base plate 30 (hereinafter referred to as an electrode belt) in which a plurality of electrodes 20 are provided.
  • an electrode belt including a plurality of electrodes 20 will be described in detail with reference to FIGS. 3A and 3B.
  • 3A and 3B schematically illustrate a composite electrode employed in the newborn apnea measurement apparatus shown in FIG. 2B.
  • the cable belt 61 is connected to a connector 22 that exposes a plurality of electrodes 20 (hereinafter referred to as composite electrodes) through fixed electrode mounting holes 31.
  • the cable belt 61 may include a plurality of connection cable terminals 61a for injecting a current, corresponding to the composite electrode 20.
  • the voltage measuring module 132 of the newborn apnea measuring apparatus 100 measures the voltage induced by the current injected into the composite electrode 20 through the cable belt 61. Specifically, while generating a multi-frequency current through the cable belt 61 to control the size and phase, a current is applied to the plurality of electrodes 20 of the electrode belt 30 mounted on the newborn chest. In this case, the multi-frequency current is injected through the first electrode 21 of the composite electrode 20, and the voltage difference signal induced by the injected current is applied to the second electrode 24 of the composite electrode 20. Obtain by using.
  • the composite electrode 20 is a button connected to a first electrode 21 of a conductive material for injecting current, a second electrode 24 of a conductive material for measuring a voltage, and a cable belt 61. It consists of a connector 22 of the form.
  • the first electrode 21 injects a current having a relatively large area compared to the second electrode 24, and the second electrode 24 has a relatively small area compared to the first electrode 21 to apply voltage. It is measured and provided in pairs on the second electrode 24 and the cable belt 61 of the repeated composite electrode 20.
  • the first electrode 21 has a flat plate shape
  • the button-shaped connector 22 has a pair of protrusion shapes so as to protrude and connect with the first electrode 21 and the second electrode 24.
  • the first and second electrodes 21 and 24 of each of the plurality of composite electrodes 20 are installed on the electrode belt 30 with the non-conductor 23 formed of a non-conductive material therebetween.
  • the plurality of electrodes 20 is shown and illustrated as including a composite electrode, but is not limited to this, a modification including a simple electrode 20 'as shown in Figure 3b is possible.
  • the simple electrode 20 ' the injection of current or the measurement of the voltage is made of one conductive electrode 21' and supported by the non-conductor 22 '.
  • the electrodes 20 and 20 ' may be made of a conductive fiber of a flexible material or a conductive polymer material or have a dry electrode form.
  • FIG. 4A to 4D schematically illustrate the electrode belt
  • FIG. 4E illustrates an example in which the electrode belt is attached to a human body of a newborn baby.
  • the electrode belt 30 is formed of an elastic material such as a polymer compound such as fiber or silicon, and the number of the plurality of electrode installation holes 31 and the number of the plurality of composite electrodes 20 installed. Is changeable.
  • both ends of the electrode belt 30 is provided with a pair of fixing portions 32 are coupled to each other, to maintain the state wound around the human body of the newborn baby.
  • the electrode belt 30 is shown and illustrated as being fixed to each other by a Velcro-type fixing part 32 is provided on both ends wrapped around the chest circumference of the newborn subject.
  • the fixing part 32 may be adopted as one of various fixing means such as a hook type.
  • the electrode belt 30 is provided with a plurality of composite electrodes 20 to face the contact surface 33 contacting the newborn and the contact surface 33 as shown in FIG. 4C.
  • the first electrode 21 and the second electrode 24 of the composite electrode 20 are exposed on the contact surface 33 of the electrode belt 30, and the connector 22 connected to the cable belt is exposed on the exposed surface 34.
  • a display unit 40 formed of a plurality of colors and patterns corresponding to information of each of the plurality of composite electrodes 20, that is, a marker is formed on the exposed surface 34 of the electrode belt 30.
  • a plurality is provided to correspond to each of the 20).
  • the display unit 40 that is, the marker, may be formed in a different shape for each composite electrode 20, and may include different channel numbers or data information accordingly, thereby recognizing (detecting) the display unit 40. ), You can check the position of the electrode.
  • the electrode belt 30 may further include a detector 120 attached to a measurement target site of the newborn baby, and the detector 120 may be attached to the surface of the newborn baby.
  • the composite electrode 20 included in the electrode belt is disposed in a three-dimensional array along the circumference of the human body of the newborn baby 1 to be measured, injects current through the selected electrode pair, and injects the injected current.
  • the applied voltage can be measured by measuring the impedance corresponding to each layer, it is possible to obtain a three-dimensional image at a specific position (chest).
  • 5A and 5B show changes in measurement data and chest images in the apnea section.
  • FIG. 5A shows measurement data of lung EIT according to voltage detected in the chest of a newborn and measurement data of optical volume pulse wave (PPG) and blood oxygen saturation (SpO 2 ) signals sensed from the detection unit. .
  • PPG optical volume pulse wave
  • SpO 2 blood oxygen saturation
  • the newborn apnea measurement apparatus apnea based on the measurement data of the lung EIT according to the air distribution in the lungs, the measured optical volume pulse wave signal and blood oxygen saturation signal (apnea)
  • the section can be detected, and it is more direct and immediate than the conventional method of using indirect bio signals such as PPG and SpO 2 .
  • 5B shows chest images of newborns imaged in the detected apnea section.
  • the neonatal apnea measurement apparatus may check expiration and inspiration according to air distribution in the lung through a chest image.
  • the newborn apnea measuring apparatus detects an apnea section based on the image of the chest image, the sensed biosignal, and the voltage measured from the chest electrode unit. Neonate apnea can be diagnosed more accurately based on the air distribution inside the lung in the detected apnea section.
  • Figure 6 illustrates the configuration of the newborn apnea measurement and alarm system according to an embodiment of the present invention.
  • the newborn apnea measurement system monitors an apnea symptom diagnosed by a newborn apnea measurement device 610 through an external terminal 620.
  • the newborn apnea measurement system includes a newborn apnea measurement device 610 and an external terminal 620.
  • the newborn apnea measurement apparatus 610 of the newborn apnea measurement system may transmit and receive data or control commands with the guardian terminal 620a and the external server 620b through a network.
  • the neonatal apnea measurement apparatus 610 may transmit the apnea symptom result of the newborn to the guardian terminal 620a or the external server 620b in real time, and the guardian terminal 620a or the external server 620b may monitor the newborn. At least one of the apnea symptoms, the chest image, and the acquired impedance data may be monitored in real time.
  • At least one of apnea symptoms, chest images, and acquired impedance data of the newborn may be stored in an external database.
  • the guardian terminal 620a may measure impedance data measured from a plurality of electrodes and a sensing unit attached to the chest circumference of the newborn in real time from the newborn apnea measuring apparatus 610 according to an embodiment of the present invention.
  • a biosignal can be received, and thus chest images and neonatal apnea symptoms can be monitored in real time.
  • the guardian terminal 620a compares at least one of the apnea symptom, the chest image, and the acquired impedance data of the newborn baby received from the newborn apnea measuring apparatus 610 based on a preset normal range, and the numerical value, value, At least one of a percentage, an image, a picture, a graph, a message, and a voice may be output, and in some embodiments, a notification signal including at least one of a warning message, an alarm, a voice, a light, and a vibration may be provided.
  • the guardian terminal 620a may control the newborn apnea measurement apparatus 610 based on a control command input from the guardian.
  • the guardian terminal 620a monitors at least one of apnea symptoms, a chest image, and acquired impedance data of a newborn baby received from the newborn apnea measuring apparatus 610, and accordingly, monitors the newborn apnea measuring apparatus 610.
  • a control command including at least one of an operation (On / Off), a biosignal detection cycle change, an impedance data calculation cycle change, and a communication cycle change may be generated and transmitted.
  • the guardian terminal 620a may be at least one of a terminal, a smartphone, a tablet PC, and a PC carried by a guardian of a newborn baby, and the type of the terminal is not limited thereto.
  • the external terminal 620 including the guardian terminal 620a and the external server 620b may include an application processor for data transmission, reception, control command generation, and display.
  • the external server 620b comprehensively manages the apnea symptom results of the newborn baby received from the newborn apnea measuring apparatus 610 or the guardian terminal 620a, and analyzes the apnea symptoms of the newborn guardian terminal 620a. ) Can provide analysis results.
  • the external server 620b may provide apnea symptoms of the newborn to doctors, nurses, pharmacists, and managers who manage the health of the newborn, and may provide real-time services for neonatal health care and prevention to the guardian terminal 620a. It may be.
  • the external server 620b may further provide a service for managing various neonatal apnea symptoms in addition to the above-described services, and thus may be configured to establish a database or to communicate with another external server. It is not.
  • the external server 620b may be at least one of a sleep management server, a newborn health care server, a data integration server, a disease diagnosis server, and a monitoring server.
  • Figure 7 shows an example of monitoring the symptoms of apnea in newborns.
  • the guardian can monitor the apnea symptoms of the newborn from the information (push) pushed through the application installed in the possession of the terminal.
  • the newborn apnea measurement apparatus may transmit an emergency message to the guardian terminal when the apnea symptoms of the diagnosed newborn are out of a predetermined normal range.
  • the emergency message may be transmitted as a message as shown in FIG. 7, but may be provided to the guardian through an output signal of at least one of an alarm, a vibration, and a light.
  • the guardian terminal illustrated in FIG. 7 may have an application that is responsible for various application functions, and may communicate with an external server or a newborn apnea measurement apparatus using an application installed in the terminal. Therefore, the guardian terminal may refer to an application installed in the terminal.
  • the example of monitoring the apnea symptoms of the newborn illustrated in FIG. 7 may be made based on the caregiver's or user's preset settings, but various examples may be applied to provide a caregiver with apnea symptoms of the newborn in real time, and the present invention is limited thereto. It doesn't happen.
  • FIG. 8 is a flowchart illustrating a method of measuring apnea symptoms in a newborn baby using a newborn apnea measuring apparatus according to an embodiment of the present invention.
  • a current is selectively supplied to at least one or more selected electrode pairs in the plurality of electrodes attached along the chest circumference of the newborn.
  • Step 810 may be a step of selecting a selected electrode pair and a frequency among the plurality of electrodes, generating a voltage signal according to the selected different frequency, converting the current into current, and injecting current into the chest of the newborn through the selected electrode pairs. have.
  • a voltage is measured through electrodes that are not selected among the plurality of electrodes.
  • the inside of the chest is imaged based on the acquired impedance data at the voltage measured at step 830.
  • Step 830 may be a step of obtaining a voltage difference signal induced by the injected current through the unselected electrodes among the plurality of electrodes, and imaging the inside of the chest by acquiring impedance data according to the chest circumference and electrode position of the newborn baby. have.
  • the target area of the newborn baby is touched to sense a biological signal.
  • step 850 the apnea symptoms of the newborn are diagnosed using the quantified result of the imaged chest image and the sensed biosignal.
  • the operation 850 may be a step of outputting at least one warning signal among sound, vibration, and color change.
  • step 850 may be a step of transmitting a warning signal to an external terminal when the diagnosis result is out of a predetermined normal range.
  • the method according to the embodiment may be embodied in the form of program instructions that can be executed by various computer means and recorded in a computer readable medium.
  • the computer readable medium may include program instructions, data files, data structures, etc. alone or in combination.
  • the program instructions recorded on the media may be those specially designed and constructed for the purposes of the embodiments, or they may be of the kind well-known and available to those having skill in the computer software arts.
  • Examples of computer-readable recording media include magnetic media such as hard disks, floppy disks, and magnetic tape, optical media such as CD-ROMs, DVDs, and magnetic disks, such as floppy disks.
  • Examples of program instructions include not only machine code generated by a compiler, but also high-level language code that can be executed by a computer using an interpreter or the like.
  • the hardware device described above may be configured to operate as one or more software modules to perform the operations of the embodiments, and vice versa.

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Abstract

La présente invention concerne un dispositif de mesure d'apnée néonatale, un procédé de fonctionnement associé et un système de mesure d'apnée néonatale qui diagnostique le symptôme d'apnée d'un nouveau-né sur la base d'une image obtenue à partir de données d'impédance de la poitrine du nouveau-né et sur un signal biologique du nouveau-né, et transmet un signal d'alarme en fonction du résultat de diagnostic. En utilisant un changement de la distribution d'air à l'intérieur du poumon basée sur un site anatomique dans une image de poitrine obtenue à partir de données d'impédance mesurées par des électrodes fixées à la surface de la poitrine du nouveau-né, la probabilité d'une fausse alarme peut être réduite et, en interprétant le changement conjointement à un signal biologique détecté, le symptôme d'apnée du nouveau-né peut être diagnostiqué et signalé plus précisément.
PCT/KR2017/012993 2016-11-18 2017-11-16 Dispositif de mesure d'apnée néonatale, procédé de fonctionnement associé et système de mesure d'apnée néonatale Ceased WO2018093163A1 (fr)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2592366A (en) * 2020-02-24 2021-09-01 Bilab Co Ltd Apparatus and method of extracting component associated with specific physiological phenomenon by measuring electric property and of reconstructing eit data
CN114024522A (zh) * 2021-12-20 2022-02-08 广州国家实验室 模拟肺部呼吸的电阻网络、装置和方法
CN114588443A (zh) * 2022-03-09 2022-06-07 北京航空航天大学江西研究院景德镇分院 一种基于肺部成像的经鼻高流量氧疗智能调节系统

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12226224B2 (en) 2020-12-08 2025-02-18 Samsung Electronics Co., Ltd. Method for detecting sleep apnea and electronic device for supporting the same
KR102668657B1 (ko) * 2021-02-25 2024-05-29 (주)비스토스 미숙아의 자세변경 기능이 포함된 인큐베이터
KR102688458B1 (ko) * 2021-02-25 2024-07-26 (주)비스토스 무호흡 상태의 미숙아를 깨우는 기능이 포함된 인큐베이터

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015389A (en) * 1995-12-06 2000-01-18 Btg International Limited Impedance pneumography
KR100700112B1 (ko) * 2006-02-03 2007-03-28 경희대학교 산학협력단 전기 임피던스 단층촬영 방법 및 시스템
US20100228143A1 (en) * 2009-03-09 2010-09-09 Drager Medical Ag & Co. Kg Apparatus and method to determine functional lung characteristics
KR20120122148A (ko) * 2011-04-28 2012-11-07 주식회사 헤르메티스 무선 측정 생체 신호를 이용한 신생아 건강 관리 시스템
KR20150111061A (ko) * 2014-03-25 2015-10-05 주식회사 엠에스피 인체 내 임피던스 측정장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010107827A (ko) 2001-10-25 2001-12-07 주식회사 베베콤 신생아 종합 관리 장치
KR20060087753A (ko) 2005-01-31 2006-08-03 고등기술연구원연구조합 Ｒｆｉｄ를 이용한 신생아 종합관리시스템 및 그 방법
KR101003837B1 (ko) * 2008-07-11 2010-12-23 황정숙 무호흡/저호흡 경보장치 및 경보시스템
KR101623167B1 (ko) 2014-05-16 2016-05-24 수상에스티(주) 신생아 모니터링 시스템

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015389A (en) * 1995-12-06 2000-01-18 Btg International Limited Impedance pneumography
KR100700112B1 (ko) * 2006-02-03 2007-03-28 경희대학교 산학협력단 전기 임피던스 단층촬영 방법 및 시스템
US20100228143A1 (en) * 2009-03-09 2010-09-09 Drager Medical Ag & Co. Kg Apparatus and method to determine functional lung characteristics
KR20120122148A (ko) * 2011-04-28 2012-11-07 주식회사 헤르메티스 무선 측정 생체 신호를 이용한 신생아 건강 관리 시스템
KR20150111061A (ko) * 2014-03-25 2015-10-05 주식회사 엠에스피 인체 내 임피던스 측정장치

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2592366A (en) * 2020-02-24 2021-09-01 Bilab Co Ltd Apparatus and method of extracting component associated with specific physiological phenomenon by measuring electric property and of reconstructing eit data
CN114024522A (zh) * 2021-12-20 2022-02-08 广州国家实验室 模拟肺部呼吸的电阻网络、装置和方法
CN114588443A (zh) * 2022-03-09 2022-06-07 北京航空航天大学江西研究院景德镇分院 一种基于肺部成像的经鼻高流量氧疗智能调节系统

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