WO2018082140A1 - Preoperative beam dose measurement device - Google Patents

Abstract

A preoperative beam dose measurement device, comprising a device casing (1), an optical conversion module (2), a reflection transmission module (3) and a signal detection module (4), wherein the optical conversion module (2), the reflection transmission module (3) and the signal detection module (4) are all mounted on the device casing (1); the optical conversion module (2) is used for receiving an externally transmitted beam signal, converting the beam signal into an optical signal and transmitting the optical signal to the reflection transmission module (3); the reflection transmission module (3) is used for transmitting the received optical signal to the signal detection module (4); and the signal detection module (4) is used for obtaining an optical signal distribution map according to the received optical signal and transmitting the optical signal distribution map to an image analysis system so as to obtain beam dose distribution by means of the image analysis system. The preoperative beam dose measurement device has a fast reaction speed, a high measurement precision and a small size. A computer can directly convert image data into dose data in real time due to advanced calibration of the preoperative beam dose measurement device.

Description

Preoperative beam dose measuring device Technical field

The invention belongs to the technical field of dose verification devices, and in particular relates to a preoperative beam current dose measuring device.

Background technique

Traditional radiotherapy uses X-ray (gamma photon) as the illuminating particle, which has been widely promoted due to its low cost and small footprint. Due to the interaction of photons and matter, when X-rays (gamma photons) are used to irradiate tumors, X-rays (gamma photons) deposit most of the radiation dose at the front end of the tumor, and at the same time deposit a considerable portion of the tumor after the tumor. At the end, only a small amount of the dose is deposited in the tumor area. This can cause radiation damage to healthy organs or tissues in the area before and after the tumor, which is an unavoidable side effect of X-ray (gamma photon) radiotherapy. When a tumor is irradiated with a proton beam or a heavy ion beam, almost all of the dose can be deposited at the end of the path due to the Brag effect of the proton and the heavy ion itself. Adjusting the energy of the incident proton/heavy ion allows it to be located just in the tumor region at the end of the path inside the body. This achieves the goal of depositing most of the dose in the tumor area. At this time, radiation therapy has less influence on the anterior region of the tumor, and has less influence on the region of the tumor candidate. This is why the use of proton/heavy ion radiotherapy is superior to X-ray (gamma photon) radiotherapy.

In summary, proton/heavy ion radiotherapy is a more precise radiotherapy than traditional X-ray (gamma photon) radiotherapy – because it deposits most of the dose in the tumor area with little damage. Healthy tissue around.

The current dose measurement instruments used for pre-surgery are mainly imaging plates or other offline agents. The measuring instrument is mainly used.

The pixelated ionization chamber is a real-time on-line measurement dose verification system that uses a spatially distributed plurality of tiny ionization chambers with an electronic readout unit and a data processing system to measure the spatial dose distribution of the proton/heavy ion beam in real time.

The imaging plate cannot read the dose data in real time during the irradiation. The experiment process is cumbersome and time consuming, and the verification takes about 60 minutes, and the valuable time of the treatment terminal cannot be fully utilized. Pixelated ionization chamber This kind of instrument is bulky, complex in structure, low in spatial resolution, and inconvenient to use. It is mostly used for periodic inspection or special case study.

Summary of the invention

In order to overcome the deficiencies of the prior art, it is an object of the present invention to provide a pre-operative beam dose measuring device that solves the technical problem of reading a dose distribution in real time.

The object of the invention is achieved by the following technical solutions:

A pre-operative beam dose measuring device comprises a device housing, a light conversion module, a reflection transmission module and a signal detection module, wherein the optical conversion module, the reflection transmission module and the signal detection module are all mounted on the device housing;

The optical conversion module is configured to receive an externally transmitted beam signal and convert the beam signal into an optical signal, and then transmit the optical signal to the reflective transmission module;

The reflection transmission module is configured to transmit the received optical signal to the signal detection module;

The signal detection module obtains an optical signal distribution map according to the received optical signal, and transmits the optical signal distribution map to an image analysis system, and the beam dose distribution is obtained by the image analysis system.

Preferably, the light conversion module is a fluorescent scintillation screen. It can further disclose the light The specific structure of the conversion module.

Preferably, the reflection transmission module is a mirror. It further discloses the specific structure of the reflection transmission module.

Preferably, the signal detecting module is a camera, and the camera comprises a lens and a photosensitive device, and the optical signal received by the reflective transmission module is received by the photosensitive device after passing through the lens. It further discloses the specific structure of the signal detection module.

Preferably, the signal detecting module comprises a lens and a photosensitive device, and the optical signal received by the reflective transmission module is sensed by the photosensitive device after passing through the lens. It further discloses the specific structure of the signal detection module.

Preferably, the angle between the mirror and the fluorescent scintillation screen is 45 degrees, and the incident surface of the fluorescent scintillation screen is perpendicular to the incident surface of the lens. It further discloses a technical problem that solves beam radiation.

Compared with the prior art, the beneficial effects of the present invention are:

The beam current measuring device of the invention has high reaction speed, high measuring precision and small equipment. Since the beam current measuring device is subjected to prior standard and calibration, the computer can directly convert the image data into dose data in real time; by setting the reflected light path The system mounts the camera in the vertical direction of the proton/heavy ion beam to reduce the influence of radiation on the camera, further extending the life of the camera, reducing the noise in the image through image processing, and shielding the instrument from radiation. Reasonable optimization of the radiation protection of the instrument.

The significance is: 1. The advantage of proton/heavy ion cancer treatment is to accurately kill tumor cells and maximize the protection of healthy tissues. However, the potential risk is due to the treatment plan or the impact of the accelerator's working state, resulting in deviations in the dose of radiation. Imaging dose verification The application of the instrument, from the preoperative stage, the measurement of the dose of proton/heavy ion cancer treatment to ensure the quality of radiotherapy and prevent the risk of treatment. Combined with the corresponding intraoperative verification method, proton/heavy ion cancer treatment can achieve more accurate illumination target area than traditional verification methods, greatly reducing the dose of healthy tissue adjacent to the tumor area, and protecting patients. Life is healthy. 2. Due to the use of pre-operative real-time dose verification instrument, the daily pre-dose verification time can be shortened from the current 60 minutes to 15 minutes, and the time saved can be used for patient irradiation, thereby improving the utilization of proton/heavy ion accelerator terminals. , to treat more patients in a limited time; save medical resources and improve the utilization of medical resources. 3. The pre-operative verification instrument, combined with the intraoperative dose verification method, can more accurately determine the patient's dose, so that the same patient can increase the single dose by appropriately increasing the total dose, thereby reducing The number of exposures.

DRAWINGS

1 is a schematic view showing the structure of a pre-operative beam dose measuring device of the present invention.

Reference numerals: 1, device housing; 2, optical conversion module; 3, reflective transmission module; 4, signal detection module; 41, lens; 42, photosensitive device.

detailed description

The present invention will be further described below in conjunction with the drawings and specific embodiments.

As shown in FIG. 1 , the present invention provides a pre-operative beam dose measuring device, including a device housing 1, a light conversion module 2, a reflection transmission module 3, and a signal detection module 4, the optical conversion module 2, and a reflection transmission module. The signal detecting module 4 is mounted on the device casing 1; the light converting module 2 is a fluorescent scintillation screen; the reflective transmission module 3 is a mirror; the signal detecting module 4 is a camera, and the camera includes Lens 41 and photographic The optical signal received by the reflective transmission module 3 through the lens 41 is sensed by the photosensitive device 42;

The optical conversion module 2 is configured to receive an externally transmitted beam signal and convert the beam signal into an optical signal, and then transmit the optical signal to the reflective transmission module 3; under the irradiation of proton/heavy ions, a Strong X-ray (gamma photons) and background radiation such as neutrons, which have a great damage to the camera's photosensitive device, seriously affecting its service life, and the test results that have been done show that if the camera is used in the beam direction For the fluorescent scintillation screen, only one measurement is required to scrape the photosensitive element of the camera; therefore, a reflected light path system is designed;

The reflective transmission module 3 of the reflected optical path system is configured to transmit the received optical signal to the signal detecting module 4; the signal detecting module 4 obtains an optical signal distribution map according to the received optical signal, and transmits the optical signal distribution map to An image analysis system obtains a beam dose distribution by the image analysis system; wherein the angle between the mirror and the fluorescent scintillation screen is 45 degrees, and the fluorescence scintillation screen is incident perpendicular to the incident surface of the lens 41; Mounting the camera in the vertical direction of the proton/heavy ion beam reduces the effects of radiation on the camera and increases its useful life.

And the image analysis system can effectively remove the noise in the acquired picture. The whole process of image analysis is as follows: after transmitting the image to the analysis system, the salt and pepper noise of the image is removed by Gaussian filtering; then the Gaussian noise is removed by two-dimensional adaptive Wiener filtering; the obtained dose distribution information and resolution information are obtained. To obtain a calibrated dose distribution, which is the final beam dose distribution.

The working principle of the invention:

When the proton/heavy ion beam is applied to the fluorescent scintillation screen, the fluorescent scintillation screen emits scintillation light. The purpose of the scintillation screen is to convert the energy and intensity information of the particle into optical information and then optically detect it, and then the mirror will flash the light. Transmission to the camera, the camera measures the distribution of the scintillation light, through which the dose distribution of the beam particles can be obtained, and finally the image processing and analysis means can be used to obtain the dose distribution information of the particle beam, through different shades of different colors Or different gray scales represent the level of the dose.

Various other changes and modifications may be made by those skilled in the art in light of the above-described technical solutions and concepts, and all such changes and modifications are intended to fall within the scope of the appended claims.

Claims (6)

A pre-operative beam dose measuring device, comprising: a device housing, a light conversion module, a reflection transmission module and a signal detection module, wherein the optical conversion module, the reflection transmission module and the signal detection module are all mounted on the device housing; The optical conversion module is configured to receive an externally transmitted beam signal and convert the beam signal into an optical signal, and then transmit the optical signal to the reflective transmission module; The reflection transmission module is configured to transmit the received optical signal to the signal detection module; The signal detection module obtains an optical signal distribution map according to the received optical signal, and transmits the optical signal distribution map to an image analysis system, and the beam dose distribution is obtained by the image analysis system. The preoperative beam dose measuring device according to claim 1, wherein the light conversion module is a fluorescent scintillation screen. The preoperative beam dose measuring device of claim 1 wherein said reflective transmission module is a mirror. The preoperative beam dose measuring device according to claim 1, wherein the signal detecting module is a camera, and the camera comprises a lens and a photosensitive device, and the optical signal received by the reflective transmitting module passes through the lens and is Photosensitive device sensing. The preoperative beam dose measuring device according to claim 1, wherein the signal detecting module comprises a lens and a photosensitive device, and the optical signal received by the reflective transmission module is sensed by the photosensitive device after passing through the lens. A preoperative beam dose measuring device according to claim 4 or 5, wherein The angle between the mirror and the fluorescent scintillation screen is 45 degrees, and the incident surface of the fluorescent scintillation screen is perpendicular to the incident surface of the lens.

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