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WO2017133038A1 - Gel antivieillissement et de maintien de l'hydrataton et son procédé de préparation - Google Patents

Gel antivieillissement et de maintien de l'hydrataton et son procédé de préparation Download PDF

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Publication number
WO2017133038A1
WO2017133038A1 PCT/CN2016/074604 CN2016074604W WO2017133038A1 WO 2017133038 A1 WO2017133038 A1 WO 2017133038A1 CN 2016074604 W CN2016074604 W CN 2016074604W WO 2017133038 A1 WO2017133038 A1 WO 2017133038A1
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WO
WIPO (PCT)
Prior art keywords
pig skin
skin
gel
aging
sheep placenta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2016/074604
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English (en)
Chinese (zh)
Inventor
程雪娇
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Individual
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Individual
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Publication of WO2017133038A1 publication Critical patent/WO2017133038A1/fr
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/982—Reproductive organs; Embryos, Eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985—Skin or skin outgrowth, e.g. hair, nails
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to the field of household chemicals and preparation methods, and more particularly to an anti-aging moisturizing gel and a preparation method thereof.
  • the purpose of the present invention is to address the above-mentioned existing moisturizing anti-aging products and the deficiencies in the preparation process thereof, and provide a human skin absorption, a good moisturizing effect, a reduction in skin wrinkles, an increase in elasticity, and an effective anti-aging effect.
  • Anti-aging moisturizing gel and preparation method thereof is to address the above-mentioned existing moisturizing anti-aging products and the deficiencies in the preparation process thereof, and provide a human skin absorption, a good moisturizing effect, a reduction in skin wrinkles, an increase in elasticity, and an effective anti-aging effect.
  • Anti-aging moisturizing gel and preparation method thereof thereof.
  • the present invention provides an anti-aging moisturizing gel, which comprises 8%-10 ⁇ 3 ⁇ 4 of sheep placenta extract, 45 ⁇ 3 ⁇ 4-60 ⁇ 3 ⁇ 4 of pig skin collagen, 10%-12 according to the mass percentage. % alginate, 5%-8 ⁇ 3 ⁇ 4 auxiliary moisturizer and 6%-12% deionized water.
  • the auxiliary moisturizer is olive oil or honey having a mass ratio of 3:5.
  • the present invention also provides a method for preparing an anti-aging moisturizing gel for preparing the above anti-aging moisturizing gel, which comprises the following steps:
  • S10 respectively selecting pre-treatment of pig skin and sheep placenta that meet the conditions, and obtaining pig skin collagen and sheep placenta extract
  • S20 taking the auxiliary moisturizing agent, alginate and the sheep placenta extract obtained in step S10 within a set ratio range, mixing uniformly and stirring for 15-30 minutes to obtain a mixed liquid
  • the pig skin collagen described in step S10 is prepared by the following steps: [0011] Sl l, taking fresh pig skin, washing, scraping off the surface fat layer with a cutter;
  • the pig skin scraped off the surface fat layer is chopped into small particles, uniformly sprayed with vinegar water and allowed to stand for 50 minutes, and the vinegar aqueous solution has a vinegar volume percentage of 20-30% ;
  • step S15 the pig skin granules treated in step S13 are placed in boiling water for 30_60 seconds, and then drained;
  • the pig skin gel mixture is filtered through a 200-300 mesh filter for 2-3 times to obtain pig skin collagen.
  • the sheep fetus extract is prepared by washing the sheep placenta that meets the requirements, breaking into a meat slurry, placing it in a container, adding a protease, digesting at a temperature of 20-25 ° C for 4 days and then filtering.
  • the anti-aging moisturizing gel provided by the invention can effectively resist aging, reduce skin wrinkles, maintain skin moisture, and has good beauty and health care effects.
  • the present invention provides an anti-aging moisturizing gel, which comprises 8%-10 ⁇ 3 ⁇ 4 of sheep placenta extract, 45 ⁇ 3 ⁇ 4-60 ⁇ 3 ⁇ 4 of pig skin collagen, 10%-12 according to the mass percentage. % alginate, 5%-8 ⁇ 3 ⁇ 4 auxiliary moisturizer and 6%-12% deionized water.
  • the auxiliary moisturizer is olive oil or honey having a mass ratio of 3:5.
  • Pig skin collagen is a transparent substance composed of three spiral fibers. This "three-helix” structure is more magical than the "double helix” structure of DNA molecules, which can strongly lock water molecules.
  • pig skin collagen also contains a large number of amino acids, such as proline, hydroxyproline, glycine, glutamic acid, etc., which are natural moisturizing factor components, and because they are very close to the collagen and amino acids of human skin.
  • Sheep Placenta It is a kind of polypeptide protein substance from the fresh three-month pregnant embryonic placenta or sheep embryo (in this embodiment, the sheep placenta), which is extracted by a certain process. It can resist the invasion of free radicals in the body, stimulate the differentiation and proliferation of epidermal tissue cells, regulate the body's immunity, accelerate metabolism, strengthen cell synthesis and secrete glial substances, such as hyaluronic acid and glycoprotein, improve skin microcirculation, maintain skin moisture and Elastic, effectively supplements metabolic anti-aging factors, soothes wrinkles and delays aging.
  • Alginate It is a polysaccharide gum extracted from seaweed. It is a polymer of ⁇ -anhydro-dextrose sodium uronic acid sodium. It is soluble in water and insoluble in organic solvents such as ethanol, ether and chloroform. It has significant advantages in terms of thickening, stability, gelation, shape retention, film formability, etc. It can increase the skin's water retention and tightening properties, improve the secretion of dry and oily skin, and make it gradually It tends to be neutral and promotes fine shrinkage of the pores.
  • Olive oil has a history of thousands of years in the countries along the Mediterranean Sea. It is known in the West as “liquid gold”, “Queen of vegetable oil” and “Mediterranean dew” because of its excellent natural health benefits and beauty benefits. Olive oil, commonly known as “beauty oil”, is a pale yellow transparent liquid. It is rich in squalene and essential fatty acids with excellent skin affinity. It absorbs quickly and effectively maintains skin elasticity and moisture. It is rich in monounsaturated fatty acids and fat-soluble vitamins and phenolic antioxidants that are easily absorbed by the skin, such as vitamins A, D, E, K, and F. It can eliminate facial wrinkles, prevent skin aging, shrink pores, and increase skin. Gloss and elasticity, firming and moisturizing.
  • Honey is an ideal natural cosmetic agent, has strong moisturizing properties, can absorb moisture in the air, and can better prevent moisture evaporation on the surface of the epidermis. Improve the nutritional status, promote skin metabolism, increase Strong skin vitality and antibacterial power, reduce pigmentation, prevent dry skin, make skin soft, white and delicate, keep natural white and rosy, and reduce wrinkles.
  • the present invention also provides a method for preparing an anti-aging moisturizing gel, comprising the following steps:
  • step S20 taking an auxiliary moisturizer, alginate and the sheep placenta extract obtained in step S10 in a set ratio range, mixing uniformly and stirring for 15-30 minutes to obtain a mixed liquid;
  • the pig skin collagen described in the step S10 is prepared by the following steps:
  • This step is a preliminary physical degreasing.
  • the pig skin treated by the step S11 is chopped into small particles, uniformly sprayed with vinegar water and allowed to stand for 50 minutes.
  • the vinegar aqueous solution has a vinegar volume percentage of 20-30%;
  • the pig skin is broken into small particles and sprayed with vinegar water, so that the vinegar component is uniformly infiltrated into the pig skin, the unique smell of the pig skin is removed, and the same vinegar is sterilized.
  • the protein is condensed to ensure that the useful protein components in the pig skin are not lost in later processes.
  • step S15 the pig skin granules treated in step S13 are placed in boiling water for 30_60 seconds, and then drained;
  • the protein in pig skin is a low molecular hard protein present in a fibrous solid, insoluble in water and an alkaline solution, but heating under appropriate acidic conditions causes gel dissolution. This step is based on this principle, will step S
  • the pig's skin granules infiltrated with vinegar water in 13 are placed in boiling water to effectively remove excess fat from the pig skin and accelerate the formation of gel dissolution on the other hand.
  • the heating time is 30_60 seconds, too short, the fat can not be fully removed
  • step S17 the pig skin granules treated in step S15 are heated to boiling together with water under a pressure of 0.7-lkgf/cm 2 , stirred while heating, and maintained for 10-15 minutes to obtain a pig skin gel mixture.
  • the powdered pig skin particles can be formed into a uniform state of the skin jelly, and finally form a condensation Glue mixture.
  • the sheep placenta extract described in step S10 is prepared by the following method: [0041] Washing the sheep placenta that meets the requirements, crushing it into a meat slurry, placing it in a container, adding The appropriate amount of protease was digested at 20-25 ° C for 4 days, and the sheep placenta extract was obtained by filtration.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1 :
  • step S20 taking 18.75 g of olive oil, 31.25 g of honey, 100 g of alginate, and 80 g of sheep placenta extract obtained in step S10, mixing uniformly and stirring for 28 minutes to obtain a mixed solution;
  • S10 respectively selecting pre-treatment of pig skin and sheep placenta that meet the conditions, and obtaining pig skin gel and sheep placenta extract
  • S20 taking 22.5g of olive oil, 37.5g of honey, 120g of alginate, and 85g of sheep placenta extract obtained in step S10, mixing uniformly and stirring for 30 minutes to obtain a mixed liquid
  • test results are as follows:
  • the inventors extracted one experiment from each of the first to third groups of experimenters to explain
  • Case 1 Hex, female, 45 years old, using the present invention, the average skin moisture of the face was 18.8%, and the forehead had fine wrinkles. After 28 days of using the product of the experimental example 1, the skin moisture average of the face was used. It was 23.2%, which was 4.4% higher than before. The fine wrinkles at the forehead were significantly relieved, and the facial skin was more elastic than before. There were no adverse symptoms during the whole use.
  • Case 2 Li xx, female, 43 years old, for dry skin, the skin often peels off, especially in dry weather, the peeling phenomenon is more obvious, the average skin moisture of the front face using the present invention is only 13.6%, using After 28 days in this experimental example 3 product, the average skin moisture of the face was 22.3%, which was 8.7% higher than before, and the dry skin was considerably improved. Even in dry weather, skin peeling rarely occurred. There are no adverse symptoms throughout the use.
  • the invention has simple process and convenient operation, and the core component pig skin collagen is conveniently extracted from natural animal pig skin, has no toxicity and side effects; and has the same amino acid composition and human skin, so has good skin compatibility and affinity. Strong, good absorption.
  • the invention adopts sheep placenta extract, alginate, olive oil, honey as auxiliary moisturizer and antioxidant, and combines the inherent beauty and health effects of pig skin collagen to achieve double moisturizing and anti-aging effects.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne un gel antivieillissement et de maintien de l'hydratation comprenant, en pourcentage en poids, 8 à 10 % d'extrait liquide de placenta d'agneau, 45 à 60 % de collagène de peau de porc, 10 à 12 % d'algine, 5 à 8 % d'humectants d'appoint et 6 à 12 % d'eau désionisée.
PCT/CN2016/074604 2016-02-03 2016-02-25 Gel antivieillissement et de maintien de l'hydrataton et son procédé de préparation Ceased WO2017133038A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610077913.2A CN105687081A (zh) 2016-02-03 2016-02-03 一种抗衰老保湿凝胶及制备方法
CN201610077913.2 2016-02-03

Publications (1)

Publication Number Publication Date
WO2017133038A1 true WO2017133038A1 (fr) 2017-08-10

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PCT/CN2016/074604 Ceased WO2017133038A1 (fr) 2016-02-03 2016-02-25 Gel antivieillissement et de maintien de l'hydrataton et son procédé de préparation

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CN (1) CN105687081A (fr)
WO (1) WO2017133038A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022265603A1 (fr) 2021-06-15 2022-12-22 Oezkan Oemer Formulation dermique mésoporeuse comprenant de l'huile d'olive

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106137932A (zh) * 2016-08-26 2016-11-23 马玉玲 一种去角质嫩肤保湿美容凝胶
CN106994110B (zh) * 2017-04-20 2020-04-14 成都希望食品有限公司 猪胎盘冻干粉的抗氧化用途
CN108379184A (zh) * 2018-03-26 2018-08-10 天马（安徽）国药科技股份有限公司 一种石斛肽嫩白修复液
CN108309919A (zh) * 2018-05-08 2018-07-24 王清秀 羊胎盘肽-骨胶原蛋白多肽组合物、含有该组合物的面膜液
CN111728927A (zh) * 2019-03-25 2020-10-02 童柯 一种美容液的制备工艺及其使用方法

Citations (2)

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CN101023916A (zh) * 2007-04-13 2007-08-29 桂林莱茵生物科技股份有限公司 一种使用岩茶提取物和羊胎素配制的化妆品
CN104434732A (zh) * 2014-11-19 2015-03-25 青岛高哲思服饰有限公司 一种保湿免洗面膜及其制备方法

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CN1273096A (zh) * 2000-04-07 2000-11-15 吴文惠 羊胎素提取工艺

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101023916A (zh) * 2007-04-13 2007-08-29 桂林莱茵生物科技股份有限公司 一种使用岩茶提取物和羊胎素配制的化妆品
CN104434732A (zh) * 2014-11-19 2015-03-25 青岛高哲思服饰有限公司 一种保湿免洗面膜及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022265603A1 (fr) 2021-06-15 2022-12-22 Oezkan Oemer Formulation dermique mésoporeuse comprenant de l'huile d'olive

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Publication number Publication date
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