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WO2017035315A8 - Procédés et dispositif pour la classification phénotypique de cellules basée sur le comportement migratoire - Google Patents

Procédés et dispositif pour la classification phénotypique de cellules basée sur le comportement migratoire Download PDF

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Publication number
WO2017035315A8
WO2017035315A8 PCT/US2016/048575 US2016048575W WO2017035315A8 WO 2017035315 A8 WO2017035315 A8 WO 2017035315A8 US 2016048575 W US2016048575 W US 2016048575W WO 2017035315 A8 WO2017035315 A8 WO 2017035315A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cells based
cells
phenotypic
migratory behavior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/048575
Other languages
English (en)
Other versions
WO2017035315A1 (fr
Inventor
Onur Kilic
Paula V. SCHIAPPARELLI
Alfredo QUINONES-HINOJOSA
Andre Levchenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of WO2017035315A1 publication Critical patent/WO2017035315A1/fr
Publication of WO2017035315A8 publication Critical patent/WO2017035315A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • G01N33/575—

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un dispositif et des procédés qui permettent des études à résolution temporelle de migration avec une résolution monocellulaire sur une surface fibrillaire qui imite la migration in vivo de cellules. Cette plate-forme est utilisée pour le tri, avec un contenu élevé, d'échantillons de glioblastome spécifiques à un patient pour analyser les hétérogénéités dans le phénotype de cellules migratoires. Les informations que la plate-forme fournit ont une valeur de pronostic puisqu'elles présentent des différences significatives dans le temps en termes de récurrence et d'emplacement de tumeur sur la base des classificateurs phénotypiques.
PCT/US2016/048575 2015-08-27 2016-08-25 Procédés et dispositif pour la classification phénotypique de cellules basée sur le comportement migratoire Ceased WO2017035315A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562210860P 2015-08-27 2015-08-27
US62/210,860 2015-08-27

Publications (2)

Publication Number Publication Date
WO2017035315A1 WO2017035315A1 (fr) 2017-03-02
WO2017035315A8 true WO2017035315A8 (fr) 2017-07-20

Family

ID=58100972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/048575 Ceased WO2017035315A1 (fr) 2015-08-27 2016-08-25 Procédés et dispositif pour la classification phénotypique de cellules basée sur le comportement migratoire

Country Status (1)

Country Link
WO (1) WO2017035315A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7357366B2 (ja) * 2018-02-28 2023-10-06 国立大学法人東海国立大学機構 薬剤評価方法
EP3968025A1 (fr) 2020-09-15 2022-03-16 Institut Gustave Roussy Procédés pour la détermination de la capacité d'invasion de cellules de tumeurs cérébrales et pour le diagnostic et le pronostic de tumeurs cérébrales

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468468A (en) * 1989-02-09 1995-11-21 The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Method for making a monoclonal antibody, monoclonal antibodies to α PD
US5935850A (en) * 1996-09-30 1999-08-10 The Research Foundation Of State University Of New York Model for cell migration and use thereof
WO2005047863A2 (fr) * 2003-11-10 2005-05-26 Platypus Technologies, Llc Substrats, dispositifs et procedes de dosages cellulaires
US8962581B2 (en) * 2008-10-30 2015-02-24 The Translational Genomics Research Institute Methods and kits to identify invasive glioblastoma
JP2014516582A (ja) * 2011-06-15 2014-07-17 ザ チャールズ スターク ドレイパー ラボラトリー インク 生体模倣環境において細胞を培養するためのデバイスおよび方法

Also Published As

Publication number Publication date
WO2017035315A1 (fr) 2017-03-02

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