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WO2016110872A1 - Compositions de soin des pieds - Google Patents

Compositions de soin des pieds Download PDF

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Publication number
WO2016110872A1
WO2016110872A1 PCT/IN2016/000012 IN2016000012W WO2016110872A1 WO 2016110872 A1 WO2016110872 A1 WO 2016110872A1 IN 2016000012 W IN2016000012 W IN 2016000012W WO 2016110872 A1 WO2016110872 A1 WO 2016110872A1
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WIPO (PCT)
Prior art keywords
agents
extract
oil
composition
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2016/000012
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English (en)
Inventor
Hema Sharma DATTA
Mehta Arti CHANDRAKANTBHAI
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Zydus Wellness Ltd
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Zydus Wellness Ltd
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Publication of WO2016110872A1 publication Critical patent/WO2016110872A1/fr
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • the present invention relates to new foot care compositions, the oily phase of which comprises extracts of at least five different plants wherein at least one plant extract is selected from the group comprising buchanania lanzan extract, cassia tora extract, pongamia glabra extract, shorea robusta extract.
  • the invention also relates to compositions comprising such plant extracts and process for preparing these compositions.
  • Human skin consists of two major layers, a relatively thicker layer called dermis and a superficial layer called epidermis.
  • dermis a relatively thicker layer
  • epidermis a superficial layer
  • the skin serves both to keep out noxious material, disease producing organisms and to keep in valuable commodities such as water.
  • Prolonged standing in ill-fitting shoes can become a problem due to added pressure.
  • US publication number 2010/0303742 relates to skin compositions comprising hydrocortisone; allantoin; and a water-based vehicle that is essentially free of petroleum jelly, mineral oil and wax; and related method for protecting, healing and/or soothing the skin.
  • US publication number 2007/0014749 relates to a novel base material for manufacturing cream, comprising of cooling and soothing agent on the skin.
  • the invention relates to herbal compositions suspended in a cream based on novel vehicle "Ghee” (clarified butter).
  • the present invention provides a combination of extracts of natural botanicals/herbs formulated in a base. When applied, it reduces the rate of water loss from the surface of the cracked heels and hands to the extent that water is conserved and the horny layer hydrates.
  • the cream is rapidly absorbed through the skin and at the same time natural herbal extracts heal the wound and prevent it from infections making the skin soft and supple.
  • the composition helps reduce severe dryness and pain in a short period of time.
  • the present invention relates to a topical composition
  • a topical composition comprising about 10% to about 30% oil extract wherein the oil extract comprises extracts of at least five different plants wherein at least one plant extract is selected from the group comprising buchanania lanzan extract, cassia tora extract, pongamia glabra extract, shorea robusta extract.
  • a topical composition wherein at least five different plants are selected from the group comprising buchanania lanzan, cassia tora, pongamia glabra, shorea robusta. papavar somniferam, curcuma longa and helianthus annus.
  • a topical composition wherein the oil extract comprises not more than 1% by weight of preservatives.
  • a topical composition wherein the composition is in the form of creams, emulsions, dispersions, oils, ointments, balsams, lotions, gels, cream gels or liniments.
  • composition in the form of cream.
  • compositions may further comprise one or more cosmetically or pharmaceutically acceptable ingredients comprising preservatives/antioxidants/chelating agents, vitamins, dyes/coloring agents, proteins/amino acids, plant extracts, humectants/conditioners/moisturizers, fragrances/perfumes, oils/emollients/lubricants, penetrants, thickeners/viscosity modifiers, surfactants/ detergents/ emulsifiers/opacifying agents, liquid vehicles/solvents and pH adjusting agents/buffers/neutralizing agents.
  • cosmetically or pharmaceutically acceptable ingredients comprising preservatives/antioxidants/chelating agents, vitamins, dyes/coloring agents, proteins/amino acids, plant extracts, humectants/conditioners/moisturizers, fragrances/perfumes, oils/emollients/lubricants, penetrants, thickeners/viscosity modifiers, surfactants/ detergents/ emulsifiers/
  • a topical composition wherein the composition further comprises one or more cosmetically or pharmaceutically active ingredients comprising antiseptic agents, antiperspirant agents, anti-inflammatory agents and/or analgesics, anti-itching agents, calming agents, anesthetic agents, skin relaxant agents, free radical scavengers and/or agents against atmospheric pollution, reactive carbonyl species scavengers, antimicrobial agents, antifungal agents, fungistatic agents, bactericidal agents, bacteriostatic agents, agents stimulating the synthesis of dermal or epidermal macromolecules and/or capable of inhibiting or preventing their degradation, collagen synthesis-stimulating agents, elastin synthesis-stimulation agents, agents stimulating the synthesis of lipids and components of the stratum corneum, ceramides, fatty acids, agents that inhibit collagen degradation, matrix metalloproteinase inhibitory agents, agents that inhibit elastin degradation, comedolytic agents, , stabilizers, agents for the treatment and
  • a topical composition wherein the oil extract is prepared by a process comprising the steps:
  • composition prepared by a process comprising the steps:
  • the present invention provides a combination of extracts of natural botanicals/herbs formulated in a base. When applied, it reduces the rate of water loss from the surface of the cracked heels and hands to the extent that water is conserved and the horny layer hydrates. The cream is rapidly absorbed through the skin and at the same time natural herbal extracts heal the wound and prevent it from infections making the skin soft and supple.
  • the present invention relates to a foot care formulation of herbal cream. Since the components in the formulation are from herbal sources it is very safe and ecofriendly and does not produce any adverse effect on the skin. It comprises wound healing herbal extract comprising buchanania lanzan, cassia tora, pongamia glabra, shorea robusta. papavar somniferam, curcuma longa and helianthus annus, and fragrant oil.
  • the wound healing herbal extract acts as a humectant, prevents infection and heals the cracks quickly and effectively.
  • the cream spreads evenly and smoothly when applied on the affected parts.
  • the composition occludes and prevents water loss from effected parts, which quickens healing and restores the natural softness and suppleness and also serves as an antiseptic.
  • the present invention also provides for masking of malodors.
  • the compositions of the invention provides for masking of the malodor by incorporation of fragrant oils, it advantageously helps preventing the growth of small microorganisms responsible for the odor by incorporation of plant extracts having antibacterial properties and may further comprise other antibacterial agents.
  • plant extract refers to the extracts obtained by separation of medicinally active portions of plant from the inert components by using selective solvents in standard extraction procedures. These include classes of preparations known as decoctions, infusions, fluid extracts, tinctures, pilular (semisolid) extracts and powdered extracts.
  • Curcuma longa is commonly used in cooking it adds a distinctive flavor and color to foods. It is also prized for its medicinal properties. Turmeric is used to treat and help prevent a wide range of diseases including rheumatoid arthritis, Alzheimer's disease and fibromyalgia. For centuries it has been applied as a paste on skin eruptions and to heal damaged and dry skin. It is also well known for its anti- bacterial properties. It has the tendency to stain because of its deep yellow colour.
  • Buchanania lanzan has been used in ointments to cure itches, blemishes, rashes and spots. It belongs to the anacardiaceae family.
  • the incorporation of the fat/extract of Shorea robusta provides, principally, softness and unctuousness during application of the compositions to the skin and provides a non- shiny, soft and protective film.
  • the extract comes from the stones of the fruits of the tree of the same name which grows essentially in India.
  • the Pongamia pinnata commonly known as 'Karanj', has been recognized in different system of traditional medicines for the treatment of different diseases and ailments of human beings. It contains several phytoconstituents belonging to category flavonoids and fixed oils.
  • the fruits and sprouts of P. pinnata were used in folk remedies for abdominal tumours in India, the seeds for keloid tumours in Sri Lanka and a powder derived from the plant for tumours in Vietnam. In Sanskritic India, seeds were used for skin aliments.
  • the oil is used as a liniment for rheumatism.
  • Leaves are active against Micrococcus; their juice is used for cold, cough, diarrhoea, dyspepsia, flatulence, gonorrhoea and leprosy. Roots are used for cleaning gums, teeth and ulcers. Bark is used internally for bleeding piles.
  • the present invention incorporates the oils from the plant which serves as an antiseptic.
  • Cassia tora is a dicot legume known as sickle senna or sickle pod.
  • the plant and seeds are edible. Since Cassia tora has an external germicide and antiparasitic character, it has been used for treating skin diseases such as leprosy, ringworm, itching and psoriasis and also for snakebites.
  • Other medicinal provisions from plant parts include balm for arthritis using leaves of Cassia tora, Papaver somniferum.
  • the oil and seed of the white poppy contains at most negligible amounts of opium and are therefore toxicologically irrelevant.
  • the oils have advantageously been found to restore skin's natural barrier function and incorporation of the oil in the present composition has been found to enhance the organoleptic properties of the composition while providing rapid absorption.
  • composition of the present invention is a novel mixture of plant extracts and one or more cosmetically or pharmaceutically acceptable ingredients characterized in that the combination is effective in reducing severity of foot cracks and other symptoms such as dryness and pain from week 1 of application.
  • compositions may include one or more preservatives, antioxidants, chelating agents to extend the shelf-life and/or prevent the degradation of the components of the inventive composition.
  • Antioxidants used in topical compositions include reducing agents and/or free radical scavengers.
  • Exemplary preservative, antioxidants, and chelating agents useful in the inventive compositions include methylisothiazolinone, vitamin C (ascorbic acid), glutathione, lipoic acid, uric acid, carotenes (e.g., beta-carotene), alpha-tocopherol (vitamin E), ubiquinol (coenzyme Q), melatonin, ethylenediamine tetraacetic acid (EDTA) and salts thereof, citric acid and salts thereof, EGTA, aminotrimethylene phosphonic acid, resveratrol, flavonoids, lycophene, propyl gallate, tertiary butylhydroquinone, butylated hydroxyanisole, butylated hydroxytoluene, benzoates, nitrites, nitrates, sulfites, calcium propionate, sodium bisulfite, potassium hydrogen sulfite, benzyl alcohol, methylparaben, prop
  • antioxidants include acer palmatum leaf extract, acetamidocaproic acid, acetyl benzoyloxy prasterone, acetyl cysteine, agrimonia eupatoria root extract, aminoethanesulfinic acid, aminopropyl ascorbyl phosphate, aminopropyl tocopheryl phosphate, anserine, arbutin, alphaarbutin, ascorbyl dipalmitate, ascorbyl glucoside, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate, ascorbyl tetraisopalmitate, ascorbyl tocopheryl maleate, asiaticoside, avena sativa (oat) kernel extract, bacillus/ rice bran extract/soybean extract ferment filtrate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), bis-
  • Exemplary chelating agents useful in accordance with the present invention include acrylic acid/acrylamidomethyl propane . sul ⁇ onic acid copolymer, beta-alanine diacetic acid, ammotnmethylene phosphonic acid, calcium disodium EDTA, citric acid, cyclodextrin, cyclohexanediamine tetraacetic acid, diammonium citrate, diammonium EDTA, diethylenetriamine pentamethylene phosphonic acid, dipotassium EDTA, disodium azacycloheptane diphosphonate, disodium EDTA, disodium pyrophosphate, EDTA, etidronic acid, galactaric acid, galacturonic acid, alpha-glucan, gluconic acid, glucuronic acid, HEDTA, humic acids, hydroxypropyl cyclodextrin, lauroyl ethylenediamine triacetic acid, methyl cyclodextrin, methyl dihydroxybenz
  • the preservative is ascorbic acid. In certain embodiments, the preservative is butylated hydroxytoluene (BHT). In certain embodiments, the preservative is tocopherol acetate. In certain embodiments, the preservative is a combination of butylated hydroxytoluene (BHT), ascorbic acid or a derivative thereof (e.g., vitamin C palmitate), and tocopherol or a derivative thereof. In certain embodiments, the preservative is Germazide PMP.
  • the composition of the present invention may include 0% to about 4% by weight of the preservative, antioxidant, or chelating agent.
  • the composition includes about 0.01% to about 5% by weight of the preservative, antioxidant, or chelating agent. In certain embodiments, the composition includes about 0.05% to about 3% by weight of the preservative, antioxidant, or chelating agent. In certain embodiments, the composition includes about 0.01% to about 2% by weight of the preservative, antioxidant, or chelating agent. In certain embodiments, the composition includes about 0.1% to about 1% by weight of the preservative, antioxidant, or chelating agent.
  • compositions of the present invention may include one or more of a vitamin to nourish or replenish the treated skin.
  • exemplary vitamins include vitamin A, vitamin B ! (thiamine), vitamin B 2 (riboflavin), vitamin B 3 (niacin), vitamin B 4 (adenine), vitamin B 5 (pantothenic acid), vitamin B 6 (pyridoxine), vitamin B 7 (biotin), vitamin B 9 (folic acid), vitamin B J2 (cyanocobalamin), vitamin C (ascorbic acid), vitamin D (ergocalciferol), vitamin E (tocopherol), vitamin K, and combinations thereof. Salts, esters, and other forms of a vitamin are also acceptable for use in the invention.
  • the inventive composition may include 0% to about 10% by weight of the vitamin.
  • the composition includes about 0.0001% to about 5% by weight of the vitamin. In certain embodiments, the composition includes about 0.001% to about 5% by weight of the vitamin. In certain embodiments, the composition includes about 0.0005% to about 3% by weight of the vitamin. In certain embodiments, the composition includes about 0.001% to about 2% by weight of the vitamin.
  • compositions of the present invention may include one or more dye or other coloring agent. Any dye or coloring agent approved for use on humans by the U.S. Food and Drug Administration may be used in the inventive compositions.
  • the dye or coloring agent is a FD&C or D&C dye, lake, or pigment. Such materials are well known in the art.
  • Exemplary dyes and coloring agents include but are not limited to 1,7- dihydroxyaphthalene; 1,3-diaminobenzene; 1 -methyl -2,5-diaminobenzene; 1,4- diaminobenzene; 1,3-Dihydroxybenzene; 1,3-Benzenediol, 4-chloro-; l-Hydroxy-2- aminobenzene; 3-amino-phenol; l-Hydroxy-4-aminobenzene; 1-Hydroxynaphthalene; 1,5- Dihydroxynaphthalene; 2,7-Dihydroxynaphthalene; 1,4-Dihydroxybenzene; l-Hydroxy-4- methylaminobenzene; 6-Hydroxybenzomorpholine; l-Methyl-2-hydroxy-4-aminobenzene; 1- Methyl-2-hydroxy-4-(2'-hydroxyethyl)aminobenzene; 1 -Phen
  • compositions of the present invention may include one or more of a protein, peptide, or amino acid.
  • Such ingredients may be added to the inventive composition to nourish the skin, impart a desired characteristic to skin, or impart a desired characteristic to the composition (e.g., thickening the composition).
  • Exemplary proteins that may be added to inventive compositions include elastin, fibrillin, fibronectin, laminin, keratin, proteoglycans, wheat protein, gelatin, collagen, silk, soy protein, wheat protein, rice protein, corn protein, jojoba protein, milk protein, whey protein, casein, albumin, egg protein, and fragments thereof.
  • any of the twenty natural amino acids may be included in the inventive cosmetic composition.
  • the proteins, peptides, or amino acids are included in the composition in a range from about 0.0001% to about 10% by weight. In certain embodiments, the proteins, peptides, or amino acids are included in the composition in a range from about 0.01% to about 5% by weight.
  • Other plant extracts useful in implementing the teachings of the present invention include but are not limited to acacia arabica gum, acacia concuine pods, acacia decurrens willd. var.
  • oleoresin allium sativum 1. oil china, allium sativum 1. oleoresin, allspice oil (pimenta officinalis lindl.), allspice oleoresin (pimenta officinalis lindl.), almond oil bitter (amygdalus communis linn. var. amara), almonds bitter, almonds sweet, alnus rubra bark (alnus serrulata willd.), aloe barbadensis leaves, aloe leaves, aloe vera linn, leaves, aloe wood gum, alpinia officinarum 1. oleoresin, alpinia officinarum 1. root oil, alstonia constricta f.
  • compositions of the present invention may include one or more of a humectant/conditioner/moisturizer.
  • a humectant is a hydrogroscopic substance. It is typically a chemical compound containing hydrophilic groups such as hydroxyl groups, amines, carboxylates, amides, esters, etc. Humectants are typically found in compositions to reduce static and/or to provide a moisturizing quality to the composition. The humectants attract and hold moisture on the skin.
  • humectants useful in the inventive compositions include but are not limited to acetyl glucosamine, ascorbic acid, diglycerin, erythritol, fructose, glucose, inositol, lactitol, lactose mannose, methylglucamine, methylpropanediol, phytantriol, raffinose, riboflavin, maltose, glycerin, glycerol, hyaluronic acid, atelocollagen, propylene glycol, glyceryl triacetate, polyols, sorbitol, sorbityl acetate, sorbityl furfural, sorbityl silanediol, xylose, tromethamine, zinc glucoheptonate, xylitol, maltitol, polydextrose, quillaia, lactic acid, sodium lactate, triacetin, urea,
  • the humectant is used in the composition in an amount ranging from about 0.01% to about 30% by weight. In certain embodiments, the humectant is used in the cosmetic composition in an amount ranging from about 0.1% to about 20% by weight. In certain embodiments, the humectant is used in the cosmetic composition in an amount ranging from about 1% to about 25% by weight. In certain embodiments, the humectant is used in the cosmetic composition in an amount ranging from about 1% to about 10% by weight.
  • compositions of the present invention may include one or more of a fragrance or perfume.
  • Fragrance ingredient as defined by the International Fragrance Association, is "any basic substance used in the manufacture of fragrance materials for its odorous, odor- enhancing, or blending properties. Fragrance ingredients may be obtained by chemical synthesis from synthetic, fossil, or natural raw materials, or by physical operations from natural sources. The function comprises aroma chemicals, essential oils, natural extracts, distillates and isolates, oleoresins, etc.”
  • a fragrance is any natural or synthetic substance or substances used solely to impart an odor to a cosmetic product.
  • the perfume or fragrance is commercially available.
  • the perfume or fragrance may be blended from raw ingredients used in the cosmetics industry.
  • fragrance ingredients include abies alba leaf oil, abies balsamea (balsam alle) resin, abies pectinata oil, abies sibirica oil, acacia catechu gum, acacia Senegal gum, acetaldehyde, acetanilid, acetyl hexamethyl indan, acetyl hexamethyl tetralin, acetyl tributyl citrate, acetyl triethyl citrate, achillea millefolium extract, achillea millefolium flower water, achillea millefolium oil, achyrocline satureiodes flower oil, actinidia chinensis (kiwi) fruit water, adipic acid, agar, agropyron repens root extract, alanine, albizia julibrissin bark extract, alcohol, alcohol dena , algae extract, algin, allyl caproate
  • compositions of the present invention may include one or more of oil, emollient or lubricant. These terms are used interchangeably herein. Oils are used in compositions for moisturization and nourishment. In certain embodiments, oil is any fatty substance which is liquid at room temperature (25°C).
  • oils, emollients, lubricants include butters example kokum butter; silicone oils; phenylsilicones; silicone resins; silicone gums; mineral oils such as paraffin oil or vaseline oil; oils of animal origin such as perhydrosqualene, squalene, lanolin; oils of plant origin such as liquid triglycerides, e.g., sunflower oil, corn oil, soybean oil, rice oil, jojoba oil, babusscu oil, pumpkin oil, grapeseed oil, sesame oil, walnut oil, apricot oil, macadamia oil, avocado oil, sweet almond oil, castor oil, triglycerides of caprylic/capric acids, olive oil, peanut oil, rapeseed oil, and coconut oil; synthetic oils such as purcellin oil, isoparaffins, linear and/or branched fatty alcohols and fatty acid esters, esters such as dioctyl adipate, diisopropyl dimer d
  • Exemplary plant derived oils include almond oil, apricot kernel oil, arnica oil, avocado oil, babusscu oil, black cumin seed oil, borage seed oil, castor oil, coconut oil, colza oil, corn oil, cotton seed oil, cowslip oil, evening primrose seed oil, grapeseed oil, hazelnut oil, hemp seed oil, jojoba oil, kukui nut oil, lady's-smock oil, linseed oil, macadamia nut oil, menhaden oil, neem seed oil, olive oil, palm oil, palm seed oil, peanut oil, pine oil, pomegranate seed oil, pumpkin seed oil, rape oil, rapeseed oil, rice oil, rice palm oil, rosehip seed oil, safflower oil, seabuckthorn oil, sesame oil, sesame seed oil, shea nut oil, soya oil, soybean oil, sunflower oil, tamanu oil, vitamin E oil, wheat germ oil, and walnut oil.
  • Exemplary animal-derived oils include squalene, perhydrosqualene, and lanolin.
  • the oil is a glyceryl ester which is primarily a fatty acid mono-, di-, or triglyceride modified by reaction with other alcohols, for example, acetylated castor oil, glyceryl stearate, glyceryl dioleate, glyceryl distearate, glyceryl trioctanoate, glyceryl distearate, glyceryl linoleate, glyceryl myristate, glyceryl isostearate, PEG castor oils, PEG glyceryl oleates, PEG glyceryl stearates, PEG glyceryl tallowates, etc.
  • the oil is a sorbitan derivative.
  • the emollient is isopropyl myristate or cetosteryl alcohol.
  • the oil is used in the composition in an amount ranging from about 1% to about 20% by weight. In certain embodiments, the oil is used in the cosmetic composition in an amount ranging from about 1% to about 10% by weight.
  • compositions of the present invention may include one or more of a thickening agent or a viscosity modifier.
  • the thickening agent may be a natural or synthetic thickening agent.
  • the thickening agent is polymeric.
  • the thickening agent is a polysaccharide.
  • the thickening agent is a protein.
  • the thickening agent is a low melting point wax. Examples of low melting point waxes include emulsifying wax, and fatty alcohols having the formula R--OH, wherein R is a straight or branched chain, unsaturated or unsaturated alkyl moiety having from about 4 to 35, more preferably about 6 to 22, carbon atoms.
  • the thickening agent is a synthetic polymeric thickener.
  • synthetic polymeric thickeners include polymers of acrylic acid, methacrylic acid and their simple esters, which may be co-polymerized with one or more organic groups such as ethoxylated or , propoxylated polymeric moieties.
  • compositions of the present invention may include one or more of surfactants, detergents or emulsifiers.
  • surfactants suitable for the purpose of the present invention include anionic, cationic, non-ionic, zwitterionic or amphoteric surfactants.
  • the surfactant used in the inventive composition may be chosen based on its HLB (Hydrophilic-Lipophilic Balance) value.
  • HLB Hydrophilic-Lipophilic Balance
  • the surfactant has an average HLB of less than or equal to about 10.
  • the surfactant has an average HLB of greater than or equal to about 10.
  • the surfactant has an average HLB of ranging from about 10 to about 15.
  • the surfactant has an average HLB of ranging from about 10 to about 12.
  • the surfactant has an average HLB of ranging from about 12 to about 18.
  • Exemplary surfactants useful in the present invention include but are not limited to polysorbate 80, sodium dioctyl sulfo succinate, sodium dodecyl sulfate, cocoamidopropyl betaine, and sodium laureth sulfate, alkyl and alkyl ether sulfates, succinamates, sulfosuccinamates, olefin sulfonates, hydroxy-alkanesulfonates, beta-alkyloxy alkane sulfonates, dioctyl esters of sodium sulfosuccinic acid, alkyl ethoxylated sulfates, alkyl sulfates, aliphatic secondary and tertiary amines, alkyl amphoglycinates; alkyl amphopropionates; alkyl ethoxylated sulfates; alkyl sulfates; aliphatic quaternary ammonium compounds
  • compositions of the present invention may include one or more of vehicles/solvents.
  • exemplary solvents useful in the inventive compositions include but are not limited to water, acetone, alcohol, alcohol denatured, amyl acetate, benzyl alcohol, benzyl benzoate, benzyl glycol, benzyl laurate, benzyl laurate/myristate/palmitate, 1,4-butanediol, 2,3-butanediol, buteth-3, butoxydiglycol, butoxyethanol, butoxyethyl acetate, butyl acetate, n-butyl alcohol, t-butyl alcohol, butylene glycol, butylene glycol propionate, butyl ethylpropanediyl ethylhexanoate, butyl lactate, butyloctanol, butyloctyl benzoate, butyloctyl salicylate, butyl phthalimide
  • compositions of the present invention may include one or more of pH adjusting agents/buffers/neutralizing agents.
  • Exemplary pH buffering agents useful in the present invention include but are not limited to aluminum glycinate, aluminum lactate, ammonium acetate, ammonium carbonate, ammonium hexafluorophosphate, ammonium lactate, ammonium phosphate, boric acid, calcium carbonate, calcium phosphate, cyclohexylamine, diammonium citrate, diammonium phosphate, diethanolamine bisulfate, diethylamine, diethyl ethanolamine, disodium fumarate, disodium phosphate, disodium pyrophosphate, ectoin, ethanolamine HCI, glycine, hydroxyethylpiperazine ethane sulfonic acid, lauryl p- cresol ketoxime, lithium fluoride, magnesium acetate, MEA-Boate, MIPArate, PEG- 114yl
  • the concentration of the pH adjusting agent, buffer, or neutralizing agent in the final composition is in the range from about 0.01% to about 5% by weight. In certain embodiments, the concentration of the agent is about 0.1% to about 3% by weight. In certain embodiments, the concentration of the agent is about 0.1% to about 1% by weight.
  • compositions of the present invention may include one or more of absorbents.
  • Absorbents are typically ingredients with a large surface area which can attract other materials such as lipids.
  • Exemplary absorbents useful in accordance with the present invention include but are not limited to acrylates/bis-hydroxypropyl dimethicone, crosspolymer, acrylates crosspolymer, activated clay, alumina magnesium metasilicate, aluminum silicate, aluminum starch octenylsuccinate, ammonium silver zinc aluminum silicate, amylodextrin, attapulgite, avena sativa (oat) bran, avena sativa (oat) kernel flour, avena sativa (oat) kernel meal, avena sativa (oat) starch, bentonite, butyl acrylate crosspolymer, calamine and calcium silicate.
  • compositions of the present invention may further comprise one or more cosmetically or pharmaceutically active ingredients comprising antiseptic agents(e.g., Zinc oxide), antiperspirant agents, anti-inflammatory agents and/or analgesics, anti-itching agents, calming agents, anesthetic agents, skin relaxant agents, free radical scavengers and/or agents against atmospheric pollution, reactive carbonyl species scavengers, antimicrobial agents, antifungal agents, fungistatic agents, bactericidal agents, bacteriostatic agents, agents stimulating the synthesis of dermal or epidermal macromolecules and/or capable of inhibiting or preventing their degradation, collagen synthesis-stimulating agents, elastin synthesis- stimulation agents, agents stimulating the synthesis of lipids and components of the stratum corneum, ceramides, fatty acids, agents that inhibit collagen degradation, matrix metalloproteinase inhibitory agents, agents that inhibit elastin degradation, comedolytic agents , stabilizers, agents for the treatment and/or care of
  • compositions of the invention may comprise a blended aqueous phase and an oil phase.
  • compositions of the invention may comprise a blended aqueous phase and an oil phase; wherein the oil phase further comprises not more than 1% by weight of preservatives, more preferably not more than 0.5% by weight.
  • compositions of the invention may comprise a blended aqueous phase and an oil phase; wherein the oil phase comprises extracts of at least five different plants wherein at least one, preferably at least two, more preferably at least three plant extracts are selected from the group comprising buchanania lanzan extract, cassia tora extract, pongamia glabra extract, shorea robusta extract.
  • compositions of the invention may comprise a blended aqueous phase and an oil phase; wherein the aqueous phase further comprises additional ingredients.
  • compositions as described herein may be prepared by processes known to the person having ordinary skill in the art of emulsion technology.
  • the process of preparing emulsion is as follows:
  • the aqueous phase is prepared by blending water, and other water soluble ingredients.
  • the composition of the invention is made from an oil phase that has been prepared by mixing the oil/oils and heating the same at a temperature of about 80-90°C, more preferably 85°C.
  • composition of the invention comprises oil extract from about 10% to about 30% by weight, more preferably from about 15% to about 25% by weight.
  • the aqueous and the oil phase are mixed together at an elevated temperature, preferably at 75-85°C, more preferably at 80°C.
  • Dosage forms for topical administration of the compositions of present invention may include creams, emulsions, dispersions, oils, ointments, balsams, lotions, gels, cream gels or liniments.
  • compositions of the present invention may be evaluated for different physical, chemical and organoleptic properties including appearance, texture, color, oil globule size, pH, loss on drying, saponification value, chloroform extractives, saponification value, total fatty matter, microbial count and viscosity.
  • Oil globule size The increase or decrease in the globule sizes indicates the process of instability (Florence and Whitehill, 1982).
  • the multiple droplets may coalesce with the other oil drops, or the internal aqueous droplets may be expelled out individually; or more than one drop may be expelled; or the internal globules may coalesce before being expelled out resulting in the shrinkage of internal droplets; or water may pass from the external phase to the internal aqueous phase resulting in the swelling of internal droplets and then complete rupture of droplets.
  • the globule sizes can be determined by light microscope (Groves, 1 84), (Omotosho et al., 1986) or by electron microscope (Davis et al., 1978), (Adeyeye and Price, 1991). Light scattering and diffraction methods are also used for the determination of globule sizes.
  • the compositions of the invention have oil globule size from about 35 to about lOOmicrons, more preferably from 40 to about 80microns.
  • Viscosity Viscosity of compositions of the invention was determined using Brookfield Viscometer model. The corresponding reading on the viscometer was noted. The compositions of the invention have a viscosity greater than from about 150000 to about 200000 cps as measured by Brookfield viscometer DVII with helipath.
  • pH value of freshly prepared emulsions and emulsions kept at different conditions were determined by a digital pH-Meter. pH values of compositions of the invention kept at different storage conditions up to 4 weeks have been determined.
  • compositions of the present invention fall within the pH range 7.4 to 8.1, more preferably 7.4 to 7.8.
  • mice Multiple emulsions were analyzed under microscope to confirm the multiple characters. A drop of emulsion was placed on the glass slide and diluted with water and covered by glass cover. A drop of immersion oil was placed on the cover slide and observed under the microscope.
  • Stability tests were performed at different storage conditions for the present compositions to see the effect of these conditions on the storage of the compositions. These tests were performed on samples kept at 37°C ⁇ 0.1 °C, 45°C ⁇ 0.1 °C, 40°C ⁇ 0.1 °C with 75% relative humidity (RH), room temperature (RT; about 25°C).
  • compositions of present invention exhibit excellent physical stability characteristics i.e., the compositions show no separation when stored at room temperature (RT) for at least 24 months, more preferably for at least 36 months.
  • RT room temperature
  • compositions of the present invention have been evaluated clinically using a clinical grading and self-assessment study during a 4-week treatment period with twice daily application. Changes in the skin as a result of the use of the compositions may be measured using any number of techniques known in the art. In certain embodiments, improvements are based on visual appearance by a dermatologist or by self-assessment by the user. In certain embodiments, one or more skin characteristics may be assessed. Such characteristics as tactile roughness, dryness, cracks on the foot heels and pain in the heels may be measured. In certain embodiments, the Physician Preference based on digital images of skin treated with the inventive composition is used to assess the effect of the inventive compositions. In certain embodiments, silicon replicas of the skin may be used to assess the inventive compositions.
  • compositions of the invention may be used to treat ailments including dry, chapped, cracked or irritated skin, skin lesions and itch, pain and other such symptoms associated with such ailments.
  • Part A Oil extract composition:
  • curcuma longa rhizome powder was added and mixed
  • Part B Cream composition:
  • composition was also found to be stable at six month stability testing at 40°C at 75% relative humidity conditions.
  • the remedy will be effective in healing other dry skin conditions such as chapped hands, chilblains etc.

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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
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Abstract

La présente invention concerne des nouvelles compositions de soin des pieds, dont la phase huileuse comprend des extraits d'au moins cinq plantes différentes, au moins un extrait de plante étant sélectionné dans le groupe comprenant les extraits suivants : extrait de buchanania lanzan, extrait de cassia tora, extrait de pongamia glabra, extrait de shorea robusta. L'invention concerne également des compositions comprenant lesdits extraits de plantes ainsi qu'un procédé pour préparer lesdites compositions.
PCT/IN2016/000012 2015-01-08 2016-01-08 Compositions de soin des pieds Ceased WO2016110872A1 (fr)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019123483A1 (fr) * 2017-12-22 2019-06-27 Jap Herbals Préparation antiseptique à base de plantes et de cicatrisation de plaie
WO2022026383A1 (fr) * 2020-07-31 2022-02-03 Ecolution.Ag Llc Fongicide et bactéricide organiques à large spectre
WO2025083459A1 (fr) * 2023-10-21 2025-04-24 Carlos Alvarado Composition vulnérable multifonctionnelle

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019123483A1 (fr) * 2017-12-22 2019-06-27 Jap Herbals Préparation antiseptique à base de plantes et de cicatrisation de plaie
WO2022026383A1 (fr) * 2020-07-31 2022-02-03 Ecolution.Ag Llc Fongicide et bactéricide organiques à large spectre
GB2612553A (en) * 2020-07-31 2023-05-03 Ecolution Ag Llc Broad-spectrum organic fungicide & bactericide
WO2025083459A1 (fr) * 2023-10-21 2025-04-24 Carlos Alvarado Composition vulnérable multifonctionnelle

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