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WO2016018425A1 - Embout buccal chauffé par système fermé et activant une composition - Google Patents

Embout buccal chauffé par système fermé et activant une composition Download PDF

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Publication number
WO2016018425A1
WO2016018425A1 PCT/US2014/049355 US2014049355W WO2016018425A1 WO 2016018425 A1 WO2016018425 A1 WO 2016018425A1 US 2014049355 W US2014049355 W US 2014049355W WO 2016018425 A1 WO2016018425 A1 WO 2016018425A1
Authority
WO
WIPO (PCT)
Prior art keywords
mouthpiece
oral cavity
main body
user
saliva
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/049355
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JBL Radical Innovations LLC
Original Assignee
JBL Radical Innovations LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JBL Radical Innovations LLC filed Critical JBL Radical Innovations LLC
Publication of WO2016018425A1 publication Critical patent/WO2016018425A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A61C19/066—Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0071—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a resistor, e.g. near the spot to be heated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body

Definitions

  • the present invention relates to a closed system mouthpiece with light and heat generation to activate a formulation to increase its volume.
  • the mouth is no different, with a warm, nutrient rich environment, continuously bathed with saliva, and with a pH normally between 6.75-7.25, essentially neutral between acidic and basic.
  • the oral cavity is a home for around 600 species and 8 billion bacteria all living together and vying for nutrients and resources to feed themselves, most of which are beneficial organisms and live in harmony with each other and the host.
  • microbiological community figures out how to live together, and not only survive, but to thrive in this natural ecosystem.
  • the ability to work together and share the resources in their community is referred to as homeostasis, a balancing act that lives in our mouth in spite of numerous external changes.
  • Plaque is a very sticky substance that forms on the teeth in a matter of minutes and causes gum inflammation in a matter of days if the plaque is not timely removed.
  • the areas in the mouth that are difficult to clean are the surfaces of the tongue and areas between the teeth that create an anaerobic environment. Without oxygen, the bacteria that cause bad breath and periodontal disease now colonize if they are not timely removed. If we look at ways to mitigate the dominance of the bad bacteria over the healthy ones, if we can impact the pH of our mouths and effectively decrease the bad bacteria in the mouth, we will have an effective way to promote good health in the mouth.
  • the objective is to change the environment from oxygen poor-low pH sites where the pathogenic bacteria thrive to a safer, more effective way to rebalance homeostasis in the mouth toward enhanced health with an oxygen-rich - higher ph.
  • gingivalis bacterium had twice as great a risk of developing pancreatic cancer over individuals with lower levels of these bacterium.
  • Oral care products traditionally have focused on taking either a specific kill of a bacterium or to indiscriminately kill all bacteria. This thinking needs to be replaced with an approach that improves the environment to change the bacterial balance in the mouth in a safe way that will have a healthier and more balanced affect long term.
  • the use of light and heat in oral care is known to kill bacteria in the 470 - 490 nm wavelength range. The use of light alone will have an impact specifically on p.gingivalis and to eliminate this bacteria.
  • Applicant's original invention involves incorporation of light and heat to optimize the effectiveness of a whitening formulation by keeping the actives around longer and pushing them into the hard to reach areas to whiten.
  • This mouthpiece has a warming element with a TPR or other thermoplastic material that warms, softens, and conforms to the mouth upon use to create a peripheral seal around the outside of the mouthpiece to seal actives inside.
  • the universal mouthpiece because of the flexible circuits, fits to any mouth, any arch form and the thermoplastic material forms the peripheral seal closed system.
  • the mouth is a dark, moist environment, where the hard to reach areas are void of oxygen, creating the perfect living headquarters for the anaerobic bacteria that thrive and cause the most damage.
  • the present invention relates to a closed system mouthpiece with light and heat generation to activate a formulation to increase its volume.
  • the present invention includes the following interrelated objects, aspects and features: [0027] (1)
  • the present invention employs a gel formulation that may be coated into a mouthpiece, the mouthpiece subsequently being inserted into the mouth of the user.
  • the mouthpiece is specifically designed to create a hermetic seal such that the mouth behind the teeth is transformed into a sealed chamber.
  • the gel when the application of heat causes the gel to expand into foam, the foam expands out throughout the oral cavity into nooks and crannies that are normally difficult to access.
  • a mouthpiece with integral light and heat sources to facilitate illuminating and heating the inside of the mouth of a user.
  • the structure of the gasket effect of the mouthpiece includes a peripheral flange that creates a "gasket flange" that has a wiper blade and a rolled peripheral seal to ensure a tight seal to create a sealed environment.
  • the pH sensor will tell the wearer when their mouth is healthy, and using specific formulations will improve the overall health through pH detection.
  • Figure 1 shows a perspective view of the inventive mouthpiece with portions broken away to show details of the embedded flexible circuit.
  • Figure 2 shows a cross-sectional view which depicts how the flexible circuit is located embedded within the mouthpiece and the mouthpiece effects a hermetic seal of the oral cavity.
  • Figure 3 shows a further perspective view of the inventive
  • Figure 4 shows a side view of the inventive mouthpiece showing the electrodes of the pH sensor.
  • Figure 5 a shows a schematic representation of some of the circuitry of the inventive mouthpiece.
  • Figure 5b shows a circuit diagram of one embodiment of circuitry.
  • Figure 5c shows a circuit diagram of a second embodiment of circuitry.
  • Figures 6- 17 show the sequence of intended operation of the inventive mouthpiece.
  • the inventive mouthpiece is generally designated by the reference numeral 10 and includes a bite surface 12, central and perpendicular to the main body 14, and which extends outwardly from a central portion of the inner surface of the main body on one side thereof as best seen in Figure 2.
  • the bite surface 12 is configured to ensure stability of the mouthpiece 10 when it is positioned in the user's mouth between the upper and lower arches.
  • the bite surface 12 may be formed from two or more segmented or separated portions, or, alternatively can be made of a single continuous bite surface 13.
  • the segmented bite surface is preferred because it better allows for adjustments in the curvature of the mouthpiece 10 to more easily adapt to mouths of differing shapes and configurations.
  • the mouthpiece includes a double seal bead 18 ( Figures 1 and 2) extending about its periphery that is designed to seal at just above the gum margins to provide a hermetic sealed environment within the oral cavity when the mouthpiece is in place.
  • the double seal bead includes a seal bead 3 and a wiper blade 5. These seals extend about the periphery of the mouthpiece 10 and seal at the margin of the gums 2, thereby creating a closed chamber in the oral cavity, isolating the teeth 4 from the
  • a plurality of textured bands 16 are also provided, specifically designed to channel LED light more diversely over the entirety of the teeth and oral cavity.
  • the bite surface 12 is specifically designed to be transparent so that light from the LEDs embedded within the mouthpiece (as will be described in greater detail hereinafter) and co-planar with the bite surface 12 can find its way behind the teeth and into the oral cavity for purposes to be described in greater detail hereinafter. As explained above, reflective surfaces within the mouthpiece enhance light transmission and its spread within the oral cavity.
  • Reflective surfaces are also provided in the mouthpiece to guide light from the LEDs 24 into the oral cavity. (Jonathan, please provide the structure of the reflective surfaces.)
  • Embedded within the mouthpiece 10 is a flexible circuit board 22 that has integrally mounted therein two rows of heat generating resistors 26 between which is a single row of illuminating LEDs 24.
  • the flexibility of the circuit board 22 permits the mouthpiece 10 to be bent to adapt to differing curvatures and
  • the inner surface 30 of the mouthpiece above and below the bite surface 12 is tilted inward at an angle in the range of 5 to about 15 degrees to enhance the seal of the peripheral bead 18.
  • Figure 2 which shows, schematically, a tooth 34 as well as the gum 35 with the seal bead 18 sealing at the margin between the tooth 34 and the gum 35 so that beams of light 32 impinge upon all of the tooth surfaces, in use.
  • Reference numeral 20 depicts an electrical conductor which supplies power to the flexible circuit board 22 from a source of power not shown in Figures 1 and 2. Many of the details described above are also found in Applicant's prior U.S. Patent No. 8,371,853, the details of which are incorporated by reference herein.
  • the inventive mouthpiece disclosed in U.S. Patent No. 8,371 ,853 was disclosed as principally usable for teeth whitening. It was also disclosed as usable in methods of desensitizing teeth, accelerating healing of mouth sores or ulcerations, for treating gum disease or freshening a patient's breath.
  • the present invention expands upon the uses contemplated in Applicant's prior mouthpiece invention by operating in conjunction with a formulation usable for other purposes.
  • the present invention is intended to be used in connection with a gel formulation which when heated above a threshold temperature transforms into foam dramatically expanding its volume and spreading throughout the oral cavity for the purposes disclosed herein.
  • a gel may include as constituent ingredients including PEG-8, propylene glycol, canola oil, hydrogen peroxide, glycerin, dimethylisosorbide, a formulation of poloxamer ascorbic acid, xylitol, and other substances including flavoring and coloration.
  • the substance employed may be spread over the surfaces of the mouthpiece and maintains its gel consistency at room temperature. However, when placed in the mouth, the mouth temperature begins to raise the temperature of the gel. When the heating resistors 26 are activated, they elevate the temperature of the mouth over 100 .
  • the gel begins to expand, transforming into foam that begins to spread throughout the oral cavity coating all of the tooth surfaces as well as the surfaces of the oral cavity including the tongue, the roof of the mouth, interstices between teeth and gums, and other hard to reach areas.
  • the gel begins to slowly transform into foam at the normal temperature of the oral cavity, 37°C.
  • the heating resistors 26 activated, at 40°C, the transformation speeds up.
  • the heating resistors 26 can heat the oral cavity to up to about 50°C, a high enough temperature to quickly transform the gel into foam without making the user uncomfortable from the heat.
  • the mouthpiece 10 has a gripping tab 15 that may be gripped by the user in placing the mouthpiece 10 within the oral cavity.
  • the gripping tab 15 also includes a display 27 that includes a series of lights 29, 31 , 33 and 35. Those lights comprise a display used in conjunction with a pH sensor incorporated into the inventive device.
  • the electrodes 37 and 39 are located on the mouthpiece 10 in a location in which they are consistently immersed in saliva. The saliva between the electrodes 37 and 39 closes an electrical circuit that may be measured as a voltage that corresponds to the pH of the oral cavity.
  • Figure 5a shows the electrode 37 embedded within the mouthpiece 10 and including a conductor 41 preferably made of a material such as copper.
  • the pH sensor electrodes 37 and 39 are made of a pH sensitive material and are electrically connected to the flexible circuit board 22.
  • the preferred location for the electrodes is at either end of the arch of the mouthpiece 10.
  • the electrodes may be made of any solid material that develops hydrogen ion dependent electrical potentials. Such materials include Iridium Oxide, Silver Chloride, Graphene, Carbon Nanotubes, and other Nano materials.
  • the electrodes As the electrodes are exposed to saliva, they develop a measurable electrical potential.
  • the electrical potential on the electrodes is measured as a voltage and correspondingly increases or decreases responsive to the pH value of the saliva.
  • the voltage measured at the sensor is computed by a microprocessor in the mouthpiece and converted into an indication of the pH.
  • the measured pH is displayed by the color coded lights 29, 31, 33 and 35 of the display 27, in one embodiment thereof.
  • a green indicator light can be used to signify a pH of saliva within a healthy range, for example, 6.75 to 7.25.
  • a red indicator light can be used to signify a pH of saliva in an unhealthy range, for example, below 6.75.
  • the red and green lights can be programmed to illuminate responsive to other pH ranges.
  • the green light can be illuminated to signify a healthy pH for saliva where the pH is 7.0 or higher
  • the red light can be illuminated to signify a saliva pH of below 7.0.
  • the display can be separate from the mouthpiece and the microprocessor can be connected to the display via a remote wired or wireless link.
  • a preferred manner of practicing the present invention is to measure the pH of saliva in the user's oral cavity before the mouthpiece is coated with gel and before the LEDs and heating resistors are activated. In this way, the baseline measurement of pH before treatment can be established so that restoration of the pH to a healthy range can be demonstrated.
  • pH below 7.0 signifies acidic saliva which demonstrates the existence of active disease.
  • the pH of saliva in the oral cavity is elevated to a neutral pH signifying a healthy oral cavity.
  • FIG. 5b and 5c two examples of electrical circuitry usable in connection with the present invention are schematically shown.
  • a source of power is schematically shown referred to by reference numeral 45. This may comprise a battery contained within the mouthpiece 10 or, alternatively, the source of power remotely located and connected via the conductor 20 ( Figures 1 and 2). In either event, an on-off switch 47 controls activation and deactivation of the system.
  • the heating resistors 26 and LED 24 are schematically shown.
  • Reference numeral 36 refers to a combination sensor microprocessor while the associated display is referred to with reference numeral 49.
  • the microprocessor is connected to the display via a hard wired electrical conductor 51.
  • the microprocessor is connected to a transmitter 53 which has an antenna 55 that transmits signals corresponding to the pH via the antenna 55 to a receiver 57 antenna 59 which then provides the information via a conductor 61 to the display 49.
  • gel from a canister thereof is applied to the upper and lower areas of the mouthpiece 10 above and below the bite surface 12.
  • the mouthpiece is inserted into the mouth and the LEDs 24 and heat resistors 26 are activated.
  • peripheral bead 18 of the mouthpiece 10 creates a seal at the margin between the teeth and gums so that the oral cavity of the user is completely sealed off from the outside environment.
  • the foam kills off undesirable bacteria from the tooth enamel, tongue, and other oral cavity surfaces.
  • the tongue, teeth, and oral cavity are cleansed of harmful bacteria and the pH of the oral cavity rises to the healthy range of 6.75 to 7.25.
  • the pH of the oral cavity is continually monitored during the process via the display 27 ( Figure 3) or 49 ( Figures 5b and 5c).
  • each light corresponds to a unique pH or pH range.
  • the mouthpiece 10 may be deactivated and removed from the mouth and the oral cavity may be rinsed to remove the foam therefrom.
  • Treatments such as that which is described above may be repeated on a daily basis or multiple times during a day to maintain the pH of the oral cavity within a healthy range to not only enhance the health of the user's oral cavity, but to enhance health generally.
  • the present invention takes a unique formulation that works in conjunction with the closed system mouthpiece that has heat and light activating the gel to increase volume and change into a foam.
  • This foam can expand against the walls of the oral cavity and push its contents into these dark, oxygen poor areas where the "bad" bacteria thrive.
  • the objective is to change the environment from oxygen poor- low pH loving sites where the pathogenic bacteria thrive to a safer, more effective way to rebalance homeostasis in the mouth towards health.
  • a first formulation includes a mixture of PEG-8, Propylene Glycol, Canola Oil, P VP- Hydrogen Peroxide K-90 (1.7% peroxide), Glycerin, Dimethyl Isosorbide, Poloxamer 407, Ascorbic Acid, Green Tea Extract, Vitis Vinifera (Grape Seed) Extract, Sodium Bicarbonate, Flavor, Xylitol, and Aqua.
  • a second formulation includes a mixture of PEG-8, Propylene Glycol, Canola Oil, PVP-Hydrogen Peroxide K-30 (1.7% peroxide), Glycerin, Dimethyl Isosorbide, Poloxamer 188, Xylitol, Ascorbic Acid, Green Tea Extract, Vitis Vinifera (Grape Seed) Extract, Flavor, and Aqua.
  • a third formulation includes a mixture of PEG-8, Propylene Glycol, Canola Oil, Glycerin, PVP-Hydrogen Peroxide K-90, Dimethyl Isosorbide, PVP-Hydrogen Peroxide K-30, Xylitol, Poloxamer 188, Flavor, Potassium Olivoyl Hydrolyzed Oat Protein, Sorbitol, Tocopherol Acetate, Tetrahexyldecyl Ascorbate, Green Tea Extract, Vitis Vinifera (Grape Seed) Extract, Aqua, Mica, Titanium Dioxide, Sodium Bicarbonate,
  • a fourth formulation includes a mixture of PEG-8, Propylene Glycol, Canola Oil, Glycerin, PVP- Hydrogen Peroxide K-90, PVP-Hydrogen Peroxide K-30, Fumed Silica (Vendor #2), Dimethyl Isosorbide, Potassium Olivoyl Hydrolyzed Oat Protein, Stevia Glucosides, Tocopherol Acetate, Hydrogenated Cotton Seed Oil, Tetrahexyldecyl Ascorbate, Xylitol, Flavor (Flavorchem), Sorbitol, Aqua, Sodium Bicarbonate, Potassium
  • Chloride, Mica, and Titanium Dioxide Chloride, Mica, and Titanium Dioxide.
  • the invention defines a mouthpiece that uses light and heat in a closed system and a peripheral seal that works in conjunction with a formulation that transforms from a gel to a foam upon application of heat. Once the foam expands into a closed system, the gasket effect of the closed container seals all contents and optimizes the formulation's effect.
  • the gasket seal 3, 5 gives an additional layer of protection to prevent oxygen escape at the periphery of the mouthpiece where it meets the soft tissue of the gums and the lips.
  • an invention has been disclosed in terms of a preferred embodiment thereof as well as a preferred manner of use, that fulfill each and every one of the objects of the invention as set forth hereinabove, and provide a new, useful and unobvious closed system mouthpiece with light and heat generation to activate a formulation to increase its volume, of great novelty and utility.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Biophysics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

Cet embout buccal à système fermé utilise une production de lumière et de chaleur pour activer une composition à base de gel, afin d'augmenter le volume de celle-ci. La composition à base de gel est enduite à l'intérieur de l'embout buccal, lequel est inséré dans la bouche de l'utilisateur. L'application de chaleur au-dessus d'une température seuil provoque la transformation du gel en mousse et le foisonnement de cette mousse à l'extérieur de l'embout buccal et dans la cavité buccale. L'embout buccal crée un joint hermétique, de sorte que la mousse foisonne à travers la cavité buccale et se loge dans des recoins et interstices qui sont normalement difficiles d'accès. L'activation d'une source de lumière encastrée dans l'embout buccal améliore les propriétés de destruction des bactéries de la matière en mousse. Le procédé et l'appareil de l'invention restaurent l'équilibre du pH buccal à un niveau neutre se situant dans la plage de 6,75 à 7,25.
PCT/US2014/049355 2014-08-01 2014-08-01 Embout buccal chauffé par système fermé et activant une composition Ceased WO2016018425A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201413956787A 2014-08-01 2014-08-01
US13/956,787 2014-08-01

Publications (1)

Publication Number Publication Date
WO2016018425A1 true WO2016018425A1 (fr) 2016-02-04

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PCT/US2014/049355 Ceased WO2016018425A1 (fr) 2014-08-01 2014-08-01 Embout buccal chauffé par système fermé et activant une composition

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Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629424A (en) * 1984-08-30 1986-12-16 Integrated Ionics, Inc. Intraoral ambient sensing device
US20020172919A1 (en) * 2000-03-27 2002-11-21 Zavitsanos Peter D. Teeth treatment system
US6626844B1 (en) * 1998-01-30 2003-09-30 Aerocrine Ab Method and composition for inhibition of nitric oxide production in the oral cavity
US20050279367A1 (en) * 2002-03-26 2005-12-22 Klemperer Walter G Mouthpiece, nasal seal, head appliance, apparatus, and methods of treating sleep apnea
US20070009856A1 (en) * 2005-05-25 2007-01-11 Biolase Technology, Inc. Device having activated textured surfaces for treating oral tissue
US7347825B2 (en) * 2001-04-17 2008-03-25 University Of Virginia Patent Foundation Device and method for assessing asthma and other diseases
US20080255498A1 (en) * 2005-08-25 2008-10-16 Houle Philip R Sensitizer Solutions, Systems, and Methods of Use
WO2008141459A1 (fr) * 2007-05-24 2008-11-27 Photon Wind Research Ltd. Dispositif de saisie à commande buccale
US20080306352A1 (en) * 2004-03-26 2008-12-11 Healthcarelink Apparatus and System for Predictive Health Monitoring
US20090320845A1 (en) * 2008-06-30 2009-12-31 Linde Ag Method of demand valve oxygen therapy for rapid abort of cluster headache
US20110104633A1 (en) * 2008-10-06 2011-05-05 Levine Jonathan B Mouthpiece that adjusts to user arch sizes and seals from oxygen exposure and methods for effecting an oral treatment
US20120021375A1 (en) * 2010-07-26 2012-01-26 Curt Binner Devices and methods for collecting and analyzing fluid samples from the oral cavity
US20120172679A1 (en) * 2010-12-30 2012-07-05 Logan Robert J Systems and methods for monitoring and processing biometric data

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629424A (en) * 1984-08-30 1986-12-16 Integrated Ionics, Inc. Intraoral ambient sensing device
US6626844B1 (en) * 1998-01-30 2003-09-30 Aerocrine Ab Method and composition for inhibition of nitric oxide production in the oral cavity
US20020172919A1 (en) * 2000-03-27 2002-11-21 Zavitsanos Peter D. Teeth treatment system
US7347825B2 (en) * 2001-04-17 2008-03-25 University Of Virginia Patent Foundation Device and method for assessing asthma and other diseases
US20050279367A1 (en) * 2002-03-26 2005-12-22 Klemperer Walter G Mouthpiece, nasal seal, head appliance, apparatus, and methods of treating sleep apnea
US20080306352A1 (en) * 2004-03-26 2008-12-11 Healthcarelink Apparatus and System for Predictive Health Monitoring
US20070009856A1 (en) * 2005-05-25 2007-01-11 Biolase Technology, Inc. Device having activated textured surfaces for treating oral tissue
US20080255498A1 (en) * 2005-08-25 2008-10-16 Houle Philip R Sensitizer Solutions, Systems, and Methods of Use
WO2008141459A1 (fr) * 2007-05-24 2008-11-27 Photon Wind Research Ltd. Dispositif de saisie à commande buccale
US20090320845A1 (en) * 2008-06-30 2009-12-31 Linde Ag Method of demand valve oxygen therapy for rapid abort of cluster headache
US20110104633A1 (en) * 2008-10-06 2011-05-05 Levine Jonathan B Mouthpiece that adjusts to user arch sizes and seals from oxygen exposure and methods for effecting an oral treatment
US20120021375A1 (en) * 2010-07-26 2012-01-26 Curt Binner Devices and methods for collecting and analyzing fluid samples from the oral cavity
US20120172679A1 (en) * 2010-12-30 2012-07-05 Logan Robert J Systems and methods for monitoring and processing biometric data

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