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WO2016005564A3 - Antibodies against activated factor v - Google Patents

Antibodies against activated factor v Download PDF

Info

Publication number
WO2016005564A3
WO2016005564A3 PCT/EP2015/065848 EP2015065848W WO2016005564A3 WO 2016005564 A3 WO2016005564 A3 WO 2016005564A3 EP 2015065848 W EP2015065848 W EP 2015065848W WO 2016005564 A3 WO2016005564 A3 WO 2016005564A3
Authority
WO
WIPO (PCT)
Prior art keywords
activated factor
antibodies against
against activated
factor
fva
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2015/065848
Other languages
French (fr)
Other versions
WO2016005564A2 (en
Inventor
Heidi Lindgreen Holmberg
Gustav RØDER
Kristoffer Winther BALLING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of WO2016005564A2 publication Critical patent/WO2016005564A2/en
Publication of WO2016005564A3 publication Critical patent/WO2016005564A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to monoclonal antibodies or fragments thereof, that bind to activated Factor V (FVa), that display pro-coagulant effect and therapeutic uses in thereof.
PCT/EP2015/065848 2014-07-11 2015-07-10 Antibodies against activated factor v Ceased WO2016005564A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14176717 2014-07-11
EP14176717.8 2014-07-11

Publications (2)

Publication Number Publication Date
WO2016005564A2 WO2016005564A2 (en) 2016-01-14
WO2016005564A3 true WO2016005564A3 (en) 2016-04-07

Family

ID=51162604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/065848 Ceased WO2016005564A2 (en) 2014-07-11 2015-07-10 Antibodies against activated factor v

Country Status (3)

Country Link
AR (1) AR101185A1 (en)
TW (1) TW201617371A (en)
WO (1) WO2016005564A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3077084A1 (en) 2017-10-05 2019-04-11 Epivax, Inc. Regulatory t cell epitopes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910576A (en) * 1994-02-14 1999-06-08 Rijks Universiteit Leiden Method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein
WO2005111075A2 (en) * 2004-05-18 2005-11-24 University Of Vermont And State Agricultural College CRYSTAL STRUCTURE OF FACTOR VAi AND METHOD FOR IDENTIFYING BLOOD FACTOR Va MODULATORS
WO2007101106A2 (en) * 2006-02-23 2007-09-07 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis using variant forms of activated factor v
WO2008067056A2 (en) * 2006-10-16 2008-06-05 Novelmed Therapeutics, Inc. Method of inhibiting coagulation with human anti-factor va antibodies and use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910576A (en) * 1994-02-14 1999-06-08 Rijks Universiteit Leiden Method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein
WO2005111075A2 (en) * 2004-05-18 2005-11-24 University Of Vermont And State Agricultural College CRYSTAL STRUCTURE OF FACTOR VAi AND METHOD FOR IDENTIFYING BLOOD FACTOR Va MODULATORS
WO2007101106A2 (en) * 2006-02-23 2007-09-07 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis using variant forms of activated factor v
WO2008067056A2 (en) * 2006-10-16 2008-06-05 Novelmed Therapeutics, Inc. Method of inhibiting coagulation with human anti-factor va antibodies and use thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANNETTE VON DRYGALSKI ET AL: "Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice", vol. 120, no. 21, 1 November 2012 (2012-11-01), XP002722413, ISSN: 0006-4971, Retrieved from the Internet <URL:https://ash.confex.com/ash/2012/webprogram/Paper50002.html> [retrieved on 20150917] *
KALAFATIS M ET AL: "Contribution of the heavy and light chains of factor Va to the interaction with factor Xa", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 21, 31 May 1994 (1994-05-31), pages 6538 - 6545, XP002590638, ISSN: 0006-2960 *
KENNETH SEGERS ET AL: "Coagulation factor V and thrombophilia: Background and mechanisms", THROMBOSIS AND HAEMOSTASIS, vol. 98, no. 3, 17 October 2007 (2007-10-17), pages 530 - 42, XP055175994, ISSN: 0340-6245, DOI: 10.1160/TH07-02-0150 *
SCHLACHTERMAN A ET AL: "Factor V Leiden improves in vivo hemostasis in murine hemophilia models", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, vol. 3, no. 12, 1 December 2005 (2005-12-01), pages 2730 - 2737, XP008130621, ISSN: 1538-7933, DOI: 10.1111/J.1538-7836.2005.01639.X *
SUHNG WOOK KIM ET AL: "Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis +", BIOCHEMISTRY, vol. 39, no. 8, 1 February 2000 (2000-02-01), pages 1951 - 1958, XP055171137, ISSN: 0006-2960, DOI: 10.1021/bi992256r *
W B FOSTER ET AL: "Monoclonal Antibodies Selective for Activated Factor V", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 9, 10 March 1983 (1983-03-10), pages 5606 - 5613, XP055177012, Retrieved from the Internet <URL:http://www.jbc.org/content/258/9/5608.full.pdf> [retrieved on 20150316] *

Also Published As

Publication number Publication date
AR101185A1 (en) 2016-11-30
TW201617371A (en) 2016-05-16
WO2016005564A2 (en) 2016-01-14

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