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WO2016056023A3 - Intermediates and processes to prepare micafungin - Google Patents

Intermediates and processes to prepare micafungin Download PDF

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Publication number
WO2016056023A3
WO2016056023A3 PCT/IN2015/000379 IN2015000379W WO2016056023A3 WO 2016056023 A3 WO2016056023 A3 WO 2016056023A3 IN 2015000379 W IN2015000379 W IN 2015000379W WO 2016056023 A3 WO2016056023 A3 WO 2016056023A3
Authority
WO
WIPO (PCT)
Prior art keywords
micafungin
intermediates
prepare
processes
active esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2015/000379
Other languages
French (fr)
Other versions
WO2016056023A2 (en
Inventor
Lakshmi Prasad ALAPARTHI
Anand Vijaykumar MANTRI
Kumar HUCHANNA Yogish
Talluri Bhushaiah CHOWDARY
Gaurav Kulkarni
Ganga Ramu VASANTHAKUMAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP15849490.6A priority Critical patent/EP3226885A4/en
Publication of WO2016056023A2 publication Critical patent/WO2016056023A2/en
Publication of WO2016056023A3 publication Critical patent/WO2016056023A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The present invention relates to active esters of compound of Formula I-A and Formula I-B which are used as key intermediates in the synthesis of Micafungin, an antifungal agent and process of preparation of said active esters. The invention also relates to process of preparing Micafungin from said active esters.
PCT/IN2015/000379 2014-10-07 2015-10-07 Intermediates and processes to prepare micafungin Ceased WO2016056023A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15849490.6A EP3226885A4 (en) 2014-10-07 2015-10-07 Intermediates and processes to prepare micafungin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3174MU2014 2014-10-07
IN3174/MUM/2014 2014-10-07

Publications (2)

Publication Number Publication Date
WO2016056023A2 WO2016056023A2 (en) 2016-04-14
WO2016056023A3 true WO2016056023A3 (en) 2016-07-07

Family

ID=55653918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000379 Ceased WO2016056023A2 (en) 2014-10-07 2015-10-07 Intermediates and processes to prepare micafungin

Country Status (2)

Country Link
EP (1) EP3226885A4 (en)
WO (1) WO2016056023A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106866650A (en) * 2017-01-09 2017-06-20 博瑞生物医药泰兴市有限公司 A kind of synthesis of MFG and method of purification
WO2019138299A1 (en) * 2018-01-09 2019-07-18 Aurozymes An improved process for the preparation of micafungin sodium
CN113087775B (en) * 2018-05-31 2022-07-08 杭州中美华东制药有限公司 Novel micafungin sodium crystal form II and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011210A1 (en) * 1994-10-07 1996-04-18 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides having antibiotic activity
WO2000075178A1 (en) * 1999-06-09 2000-12-14 Aventis Pharma S.A. Novel echinocandin derivatives, method for preparing same and use as antifungal agents
WO2004014879A1 (en) * 2002-08-08 2004-02-19 Fujisawa Pharmaceutical Co., Ltd. New process
WO2013034670A1 (en) * 2011-09-09 2013-03-14 Sandoz Ag Preparation of micafungin intermediates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011210A1 (en) * 1994-10-07 1996-04-18 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides having antibiotic activity
WO2000075178A1 (en) * 1999-06-09 2000-12-14 Aventis Pharma S.A. Novel echinocandin derivatives, method for preparing same and use as antifungal agents
WO2004014879A1 (en) * 2002-08-08 2004-02-19 Fujisawa Pharmaceutical Co., Ltd. New process
WO2013034670A1 (en) * 2011-09-09 2013-03-14 Sandoz Ag Preparation of micafungin intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3226885A4 *

Also Published As

Publication number Publication date
WO2016056023A2 (en) 2016-04-14
EP3226885A4 (en) 2018-07-18
EP3226885A2 (en) 2017-10-11

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