WO2015135631A1 - Closing cap for containers, production method and injection mould - Google Patents

Abstract

The present invention relates to a closing cap (1) for containers and has a cap body (2) which has a carrier plate (25) on an upper side, in which there is at least one insertion opening (24). The insertion opening (24) is covered by a closing membrane (4) and forms a self-closing fluid port. Furthermore, the closing cap (1) has a closing element which tightly covers the closing membrane (4) at least in a region below which the insertion opening (24) is located. The closing membrane (4) is injection-moulded from above onto the carrier plate (25) at least in a region which surrounds the insertion opening (24). Furthermore, a production method for the closing cap (1) and an injection mould for carrying out the method are disclosed.

Description

 0474

CAP FOR CONTAINERS, MANUFACTURING METHOD AND

 MOLDING TOOL

The following invention relates to a closure cap for containers, a manufacturing method thereof and an injection molding tool. For the removal of liquid or the injection of additives from or into medical-technical container (s) such as infusion bottles, ampoules, bags for blood conserves, etc., closure caps are known which have one or more fluid ports, which after puncturing with a cannula or reseal a spike of an infusion set itself, so that no germs, air or other contaminants can penetrate into the container interior and also no potentially infectious substances get out of the container.

Often, such caps have a thread with which they are screwed onto the respective container. For example, they consist of a hollow-cylindrical cap body made of a material with a comparatively high modulus of elasticity, while the self-closing function is usually provided by a

Elastomeric membrane, which is placed over openings in the cap body is realized.

DE 10 2004 051 300 B3 describes such a closure cap. The cap has a withdrawal port and an injection port, both of which are formed by a pierceable membrane which self-seals after piercing. To ensure fluid tightness at the extraction and injection ports, the membranes in the port area have an adapted cross-sectional shape. The membranes of the extraction and injection ports are separate from each other injected separate components which are inserted into the cover part.

Another cap is known from WO 02 098748 A1, wherein the self-closing effect is realized there via a common membrane, which consists of an elastic material. This is injected after spraying the cap body from the inside into the cap body, wherein the membrane or sealing layer is welded during this with the cap part. The cap has, in addition to the cap member, a cover member which closes the opening (s) of the cap member. The cover is sprayed after spraying the cap part in a further injection process to the area surrounding the cap opening. The material of the cover is chosen so that this enters into a cohesive connection neither with the cap part nor with the sealing layer, so that the cover can be easily removed before use. The inserted membrane is not dimensionally stable connected to the surrounding lid. This can lead to slipping or tilting of the sealing washer during piercing.

From DE 10 2010 004 536 A1, a two-component sealing disc for pharmaceutical containers is known, which has a comparatively rigid carrier plate, which has at least one insertion opening for cannulas. This sealing disc is intended to be inserted in a cap. A multi-pierced raised wall is arranged circumferentially around the feed-through opening, above which there is a pot-shaped accumulation of elastic material, on the upper side of which there is a cup-shaped depression which forms the puncture point. The wall, which surrounds the through opening, serves to ensure a sufficient rigidity for the elastic material so that the piercing opening can be sealed during / after piercing. As a result, the membrane can be made thinner in the piercing region, which reduces the necessary piercing force.

Based on this prior art, the present invention, the object of the invention to provide an improved closure cap for containers that is less expensive to produce than known caps with fewer process steps and thereby has an improved sealing performance and leads to lower piercing forces.

This object is achieved by a closure cap having the features of independent claim 1. In addition, the task results to provide a manufacturing method for the cap, which allows the cap with the least possible expenditure on equipment and produce virtually no rework.

This object is achieved by the manufacturing method having the features of claim 12. Finally, there is the task of creating a tool with which the closure cap can be produced with fewer steps and with optimized cycle times. This object is achieved by a two-component injection molding tool with the features of claim 14.

Preferred embodiments are each described by the subclaims. The closure cap for containers according to the invention has a cap body which has on its top a carrier plate in which one or more insertion opening (s) is present / present. Each push-through opening is covered with a sealing membrane and forms a self-closing fluid port. Furthermore, the closure cap has a closure element which tightly covers the closure membrane at least in a region under which the insertion opening lies. The closure membrane is molded onto the carrier plate from above, at least in a region surrounding the insertion opening.

The cap body is a cup-shaped, d. H. cylindrical structure, which is constructed similar to a screw cap: It has a side wall (lateral surface), wherein the support plate as a kind of "bottom" forms an end face.

As used herein, "top" means a side of the cap facing away from the container, i.e., the "piercing side". For connection to the container (eg infusion bottles, ampoules, etc., but also dispensing containers for cannulas), the closure cap according to the invention may have common connection elements in medical technology, such as a connection flange, a thread, preferably an internal thread, or a bayonet connection.

The closure cap according to the invention is also suitable for non-medical applications, for example in chemical and / or biological laboratories. The sealing membrane is dimensioned in terms of its material properties and dimensions so that it contracts after a puncture with a needle, cannula or a spike around the puncture site around and punctures the puncture automatically.

In this case, the closure element is arranged above the closure membrane and precisely covers the region of the closure membrane below which the insertion opening of the carrier plate lies. "Density" means that there is no exchange of gas, liquid and particles between the interior of the container and the environment takes place. In this way it can be ensured that no dirt, germs or the like can penetrate into the puncture area of the sealing membrane, this area being kept sterile in the case of sterile production. For this purpose, the closure part is closed during production under sterile conditions and only removed shortly before the use of the closure cap before puncturing the closure membrane.

Unlike in the case of known closure caps with a molded closure membrane, the closure membrane in the closure cap according to the invention is injection-molded onto the cap body from above, which makes it possible to produce the closure cap in a tool without running the risk of causing thin spots, for example the predetermined breaking points of the closure cap Tear tabs, melted again and thereby destroyed.

Incidentally, a hitherto conventional assembly step, in which the separately molded sealing washer and cap body are joined together, omitted. The closure element may be a cover part, which is non-detachably connected to an upper edge of the cap body, the cover part covering the insertion opening. Alternatively or additionally, the closure element may comprise or consist of a sealing film which covers at least the region of the closure membrane around the insertion opening, preferably the support plate, in full area. The sealing film may be a metal foil, in particular aluminum foil. The sealing film can be connected in a heat sealing process with the cap body, whereby advantageously the cost of materials for the cover part can be saved, disadvantageous but a further manufacturing step is necessary. Such sealing is a common procedure in the manufacture of infusion bottles. The cap will be described below in closed form. The cap itself can be made according to common standards in medical technology, ie bottle-pack cap, Twinport cap or tear-off cap.

In a further embodiment, the cover part can be pivotally connected to the cap body via at least one hinge, preferably a film hinge. The film hinge can be advantageously injected in the same spray pass as well as the cap body and the cover part.

In a further embodiment, the cap body, the film hinge 15 000474

and the lid part may be integrally formed. The respective cavities of the injection molding tool, which form the cap body and the cover part, are connected by a film hinge cavity. As a result, a montage-free production of the cap body and the hinged lid part attached thereto is made possible; the assembly can be taken together with molded closure membrane the injection mold.

Furthermore, the insertion opening may be surrounded by a wall, which rises from the support plate. The wall can also have one or more interruptions, which are particularly preferably present at uniform angular intervals, wherein the pressing force can be adjusted over the distance of the interruptions. This wall ensures that the membrane material does not diverge radically when piercing with a cannula or spike, or only to a much lesser extent; it ensures the necessary rigidity of the membrane in the puncture area. Thus, the membrane can generate a sufficiently large restoring force, which is sufficient to re-close the puncture after removal of a cannula or to achieve a seal between the membrane material and cannula. The membrane material acts in the area within the wall like a press ring, in which a sealing effect against the piercing body is achieved by preventing the radial deflection of membrane material. In addition to an improvement of the sealing effect but also the holding force is increased, which is exerted on an inserted cannula via frictional engagement, which is advantageous because in medical containers often a hanging mounting is made so that the cannulas not already by the influence of gravity from the membrane slip out. By preventing the elastic material from escaping the infusion pin during insertion, the elastic material can be made thinner at the puncture site, which also reduces the Zustechkraft and thus significantly improves the operability for the doctor; In particular, the accidental damage to an infusion set in a Zustechversuch can be prevented.

In addition, the membrane may be injection-molded onto the wall and, in the region surrounding the insertion opening, form an upward-pointing bulge following the wall geometry. The lid part may have a cup-shaped depression whose shape corresponds to the bulge of the membrane. The bulge of the membrane can be accommodated in the cup-shaped depression of the cover part. The interaction of the bulge of the membrane with the cup-shaped recess ensures that a deflection of the membrane can be prevented even more effectively when puncturing, since the membrane material is pressed against the wall of the cup-shaped recess of the lid part. The cross section of the cup-shaped depression of the cover part can be smaller than the cross-section of the bulge of the membrane, in particular, so that the bulge is received under prestress in the cup-shaped depression. In this way, an increased bias of the membrane can be achieved in the radial direction, whereby the self-sealing effect is further improved. Alternatively or additionally, the cup-shaped depression can taper, which, in combination with the abovementioned relationships of the cross-sections, contributes to the fact that the lid part can be closed more easily.

In a further embodiment, biocompatible and chemically inert marker particles can be present at least in a partial volume of the cap body or the lid part. The marker particles are preferably present in a range of from 70 to 850 ppm, preferably in a range of from 80 to 800 ppm. The marker particles may in this case have certain properties which are known as

Authenticity feature, the properties can either be visible to the naked eye or only by irradiation, such as UV light visible. This makes it possible to plagiarize by the absence of the

 Automatically recognize and sort out authenticity feature or identify it during use. It may even be provided to code the contents of a container via different marker particles.

When used in medical technology, the marker particles are preferably non-toxic, chemically inert and biocompatible. In order to be processed easily during production, it is also advantageous if the marker particles have the highest possible melting temperature, for example, higher than 1,600 ° C.

The marker particles may in particular have a diameter in a range from 0.15 to 110 μm, preferably in a range from 0.2 to 100 μm. In this case, they can be fluorescent marker particles, which fluoresce in particular because of the anti-Stokes effect, or they can be diatom shells or a ceramic powder. According to yet another embodiment, the closure membrane may be integrally molded onto the carrier plate and / or the carrier plate may have one or more infiltrations, which are bulged upwards. The infiltration of the carrier plate increases the rigidity of the carrier plate itself, whereby a stiffer structure is obtained, which deforms less under the influence of the puncturing force. In combination with a full-surface membrane coating, the membrane is not only held cohesively by the injection molding on the support plate, but also form-fitting between the ribbed areas.

The cover part may have a detachable tab, which may be tear-off or twist-off, which is arranged above the insertion opening and covers it and, in a detached state, releases a passage to the insertion opening. The tab serves to keep sterile the gap between the closure membrane and the lid part from manufacture to use; the tab is only removed shortly before use. The tab may in particular be formed integrally with the cover part and preferably connected via a thin web with the cover part. Alternatively or additionally, the passage may additionally be sealed with a seal, for example a sealing foil, in particular a metallic sealing foil. The one-piece design of the tabs as part of the cover part is made possible to produce the lid part and the tabs in a single step in the same injection mold, which among other sterility requirements can be more easily achieved than in a subsequent assembly or a downstream Anspritzschritt as from the prior Technique known. The seal can be used as a backup in addition to the tear-off tab. According to a further embodiment, the closure membrane in a region which lies above the insertion opening, have a puncture mark, which may preferably be an embossing or stamping, which is already generated in the injection molding tool. The puncture mark can be arranged in particular centrally to the insertion opening and about a rotationally symmetrical symmetrical pattern, such as a three or four-pointed star be. The markings mark the respective puncture sites of the membrane and cause a targeted weakening of the material in order to allow easy puncturing. In the case of several through-openings, which form an injection and a removal port together with the respective sealing membranes, it is also possible to use 4

be provided different Einstechpunkt markings, so that the injection and withdrawal port can be distinguished beyond doubt.

The cap body may be non-destructively releasably latched with its upper side with a pointing to the cap body lower edge of the lid part via a latching mating. The latching pair can in this case be formed in particular by a circumferential collar on the upper side of the cap body and a corresponding circumferential groove on the lower edge of the cover part. Suitably, however, the collar and channel can also be reversed, so that the channel is present at the top of the cap body and the circumferential collar on the underside of the cover part. By bottom and top are meant herein the upper and lower portions of the respective lateral surfaces of the cap body and the lid part. The cover part can in particular have a slightly larger inner diameter than the outer diameter of the cap body on its upper side, so that the cap body can be placed on it for latching.

According to yet another embodiment, the cap may have two fluid ports, a withdrawal port and an injection port. As already described, the puncture markings at the removal port can be different than at the injection port. It can also be provided that the closure membrane at the injection and removal port have different geometries to meet specific requirements; for example, the membrane at the removal port has to seal securely against a spike of an injection set inserted therein, while the injection port tends to focus on sealing after pulling the cannula. But there are also caps with even more fluid ports possible, even four or more.

Finally, at least the support plate, preferably the entire cap body, the cover part and the film hinge may consist of a thermoplastic material, with polyethene or polypropenes being possible materials, for example. The sealing membrane can for example consist of an elastomer, preferably of a silicone, or of a thermoplastic elastomer, without these materials being restrictive.

The manufacturing method according to the invention for the closure cap according to the invention for containers is using an apparent two-component 4

Comprising: one) providing and melting a first fusible material at least for the cap body and a second fusible material for the closure membrane, b) injecting the first molten material into a cap body cavity of the mold half c) replacement of the first counter-mold half of the injection-molding tool facing the carrier plate of the cap body by a second counter-mold half, which has a closure membrane cavity for forming the closure membrane,

d) injecting the second molten material into the closure diaphragm cavity of the second counter-mold half, thereby from above the sealing membrane onto the carrier plate, at least in a region surrounding the insertion opening and e) removing the article obtained from d) and sealingly with the closure element Cover the area of the sealing membrane under which the insertion opening lies.

Unlike known manufacturing methods, the sealing membrane is produced in the same injection molding tool by being injection-molded onto the cap body from above. It is after the removal of the cap body no assembly step more necessary to attach the closure membrane. The method according to the invention can advantageously be carried out in a sterile environment, whereby a sterile puncture site is obtained after closing or covering the closure membrane with the lid part or the sealing foil.

In a further embodiment, in step b), the first molten material can also be injected into a cover part cavity of the mold half of the injection mold, after which the material is allowed to cool and the cover part is obtained. Thereafter, in step e) the cover part can be permanently connected to the upper edge of the cap body. Alternatively, in step e), the region of the closure membrane under which the insertion opening lies, preferably the closure membrane over the entire surface, can be covered with a sealing film.

In yet another embodiment of the method is provided that the film hinge is injected in step b) with. The cover part and the cap body can be removed as a contiguous component from the injection mold; An assembly step for the hinge can be omitted. The two-component injection molding tool according to the invention is suitable for carrying out the manufacturing method according to the invention and has in a first embodiment disclosed moldings, of which a mold half has at least one Kappenkörperkavität which is limited on the other side of a mold separation of a first Gegenformhälfte. The cap body of the closure cap is pointing with its carrier plate to the first Gegenformhälfte, sprayable in the Kappenkörperkavität. The injection molding tool further has a second counter-mold half which is interchangeable with the first counter-mold half and which has a closure membrane cavity which is designed for subsequent injection of the closure membrane against the carrier plate of a cap body injected in the cap body cavity.

It is provided with the two-component injection molding tool - as described above - to produce the cap according to the invention in a tool with very little installation effort. In an embodiment in which the closure element is a sealing film, it must be applied in a downstream process step. Furthermore, the mold half can have a lid part cavity, which is bounded on the other side of the mold parting by the first counter-mold half. The cap body cavity and the lid part cavity may be arranged in the mold half approximately at an angle which is in a range of 90 ° to 180 °, preferably in a range of 120 ° to 180 °.

In addition, the Deckelteilkavität and the Kappenkörperkavität can be connected by a film hinge cavity, wherein the film hinge can be injected in the same spray pass. In an advantageous embodiment, the injection molding tool may be a turning tool.

These and other advantages are set forth by the following description with reference to the accompanying figures. The reference to the figures in the description serves to assist in describing and facilitating the understanding of the subject matter. The figures are merely schematic representations of embodiments of the invention. It shows: a perspective view of an unfinished cap with unfolded lid part,

 a longitudinal sectional view of the unfinished cap with closed lid part

 a perspective view of the cap with unfolded lid part,

 a longitudinal sectional view of the cap with closed lid part,

 a perspective view of the cap with closed lid part,

 a perspective view of the cap with closed lid part and torn tabs,

 a top view of the cap with closed lid part and torn tabs,

 a perspective view of another unfinished cap with unfolded lid part,

 a longitudinal sectional view of the other unfinished cap with closed lid part,

 a perspective view of the other cap with opened lid part,

a longitudinal sectional view of the other cap with closed lid part. An example of a closure cap 1 'according to the invention as a so-called "twin-peat" cap, ie with two separate fluid ports, is shown in FIGS. 1 a to 5. 1 a and 1 b are in an "unfinished" state, ie without the sealing closure membrane, which is why it is denoted by 1 'In this state, the closure cap 1' generally becomes itself can not be seen in the production process, since the closure membrane is injection-molded onto the carrier plate 25 directly after spraying the cap body 2 and the lid part 3. The closure cap V is in one piece, the cap body 2 being hingedly connected to the lid part 3 via a film hinge 33 These can be manufactured in a common injection molding tool in an injection molding, which are positioned in the injection molding tool approximately at an angle of 90 to 180 "to each other. The Ver- End cap V is intended to be fluid-tightly connected to the lower edge 21 of the cap body 2 with a container, wherein known connection means can be used. At the top of the cap body 2 has a circumferential collar 26 which is locked with a corresponding groove 313 of the cover part 3 when closing, so that the end customer can not open the cover part 3 destructive. In order to obtain an improved rigidity of the carrier plate 25, the carrier plate 25 has upwardly projecting ribs. Around the push-through openings 24, a wall 22 is arranged in each case, which is actually composed of three partial walls between which the interruptions 23 are located. The wall is over-injected with the elastic pierceable membrane material in a subsequent injection molding step. It serves to prevent lateral deflection of the membrane material when piercing with a cannula or an infusion set; As a result, the closure membrane in the region of the insertion opening 24 can be dimensioned thinner than before, which reduces the Zustechkraft and thereby reduces the risk of breaking the infusion set.

In the longitudinal section of Fig. 1 b can be seen that at the bottom of a circumferential cavity 211 is provided, which forms a circumferential ribbing and thus increases the rigidity of the wall of the cap body 2. If the lid part 3 is locked with the cap body 2, it can no longer be opened without destruction. In order to be able to give an infusion or to be able to inject medication into an infusion bottle, one or both tear-off tabs 32, which are connected to the lid part 3 via a thin circumferential rib 321, must be torn off, whereupon the opening 314 and the passage 312 be released to the insertion opening 24. The tabs 32 are in this case sprayed in the same spray pass together with the cover part 3. When manufactured under sterile conditions, the passageway 312 can be kept sterile from manufacture to use.

In Fig. 2a, the state of the closure cap 1 after the injection of the closure membrane 4 is now shown. The closure membrane 4 is molded onto the carrier plate 25 completely from above, resulting in a cohesive connection; a mounting of a sealing washer or a separately sprayed membrane can be omitted when using a 2K injection molding tool. Concentric with the insertion opening 24 (see FIGS. 1a, b), the closure membrane 4 has a depression 411, at the bottom of which a membrane piece with a precisely defined shape is formed. P T7EP2015 / 000474

material strength, which forms the puncture point. The spills 27 (see FIGS. 1 a, b) are overmolded here and, as a form-fitting connection component, ensure that the closure membrane 4 does not unintentionally slip / tilt under the action of the puncturing force. Also, the wall 22 is over-injected with the membrane material, so that the closure membrane 4 in this area has a bulge 41, which is received in the cup-shaped recess 31 when closing the lid part 3. In order to achieve a radially inwardly facing bias of the membrane material, the recess 31 is slightly conical, which also facilitates the closing of the lid part 3. Furthermore, the webs 3 serve to generate a radial bias; these are arranged in accordance with the angular positions of the interruptions 23 of the wall 22 (see Fig. 1a, b).

The shape of the closure membrane 4 in the region above the insertion opening 24 can be seen in the longitudinal section of FIG. 2b; the sealing membrane 4 is comparatively thin at the bottom of the depression 411, as a result of which it can easily be punctured. Nevertheless, a sufficiently large sealing force can be exerted on an infusion set, since the closure membrane 4 is prevented from elastically escaping the puncture both by the wall 22 and by its cohesive injection onto the carrier plate 25. At the top of the closure membrane 4, puncture markings 43, 43 'are arranged above the push-through openings 24, which are different and characterize the injection / removal port.

FIG. 3 shows a perspective view of the closed closure cap 1 with tear-off tabs 32, while in FIG. 4 the tabs 32 are torn off in order to gain access to the puncturing points, the different puncturing markings 43, 43 'in FIG The top view of FIG. 5 can be seen.

In Figures 6a to 7b there is shown a cap variant which is a so-called "bottle-pack cap." This is just another standard, the function of the cap 1 being the same as that of the cap "Twin-port" variant.

Claims

PATENT CLAIMS 1. Closure cap (1) for containers, - which has a cap body (2) which has a support plate (25) on one top side in which there is at least one push-through opening (24), - wherein the push-through opening (24) is covered with a closure membrane (4) and forms a self-closing fluid port, - and has a closure element which tightly covers the closure membrane (4) at least in an area under which the push-through opening (24) lies, characterized in that the closure membrane (4) is molded from above onto the carrier plate (25), at least in an area that surrounds the push-through opening (24). 2. Closure cap (1) according to claim 1, characterized in that the closure element - has a cover part (3) which is permanently connected to an upper edge of the cap body (2), and/or - has a sealing film which completely covers at least a region of the closure membrane (4) which surrounds the push-through opening, preferably the carrier plate, the sealing film preferably being a metal foil, particularly preferably an aluminum foil. 3. Closure cap (1) according to claim 2, characterized in that the cover part (3) is pivotally connected to the cap body (2) via at least one hinge, preferably a film hinge (33), the cap body (2), the film hinge (33) and the cover part (3) preferably being formed in one piece. 4. Closure cap (1) according to at least one of claims 1 to 3, characterized in that the push-through opening (24) is surrounded by a wall (22) which rises from the support plate (25), the wall (2) preferably having one or more un- has refractions (23), which are particularly preferably present at uniform angular distances. Closure cap (1) according to claim 4, characterized in that - the closure membrane (4) is molded onto the wall (22) and, in the area surrounding the push-through opening (24), has an upward-pointing bulge (41) following the wall geometry, and - the cover part (3) has a cup-shaped depression (31), the shape of which corresponds to the shape of the bulge (41) of the closure membrane (4), - the bulge (41) of the closure membrane (4) being accommodated in the cup-shaped recess (31) of the cover part (3), where preferred - the cross section of the cup-shaped recess (31) of the cover part (3) is smaller than the cross section of the bulge (41) of the closure membrane (4) and the bulge (41) is accommodated under prestress in the cup-shaped recess (31) and/or - The cup-shaped depression (31) tapers conically. 6. Closure cap (1) according to at least one of claims 2 to 5, characterized in that biocompatible and/or chemically inert marker particles are present at least in a partial volume of the cap body and/or the lid part, preferably with a content in a range of 70 to 850 ppm, preferably in a range of 80 to 800 ppm, wherein the marker particles have a diameter in a range from 0.5 to 10 μm, preferably in a range from 0.2 to 100 μm and/or - Fluorescent marker particles are, preferably fluorescent marker particles, whose fluorescence is based on the anti-Stokes effect and/or - Diatom shells and/or - a ceramic powder with a predetermined chemical composition, are. Closure cap (1) according to at least one of claims 1 to 6, characterized in that - the closure membrane (4) is molded over the entire surface onto the carrier plate (25) and/or - The carrier plate (25) has at least one beading (27) that is curved upwards. Closure cap (1) according to at least one of claims 2 to 7, characterized in that the cover part (3) has a removable, preferably tear-off or twist-off tab (32) which is arranged above the push-through opening (24) and covers it and, in a detached state, opens a passage (312) to the push-through opening (24), where preferred - the tab (32) is formed in one piece with the cover part (3) and is particularly preferably connected to the cover part (3) via a thin web (321) and/or - The passage (312) is additionally closed with a seal, preferably a sealing film, preferably a metallic sealing film. Closure cap (1) according to at least one of claims 1 to 8, characterized in that the closure membrane (4) has a puncture point marking (43, 43') in an area that lies above the push-through opening (24), preferably an embossing, which is particularly preferably aligned centrally to the opening (24), the puncture point marking Marking (43,43') is most preferably a rotationally symmetrical pattern, preferably a three- or four-pointed star. Closure cap (1) according to at least one of claims 2 to 9, characterized in that the top side (O) of the cap body (2) is non-detachably locked with a lower edge (21) of the cover part (3) facing the cap body (2) via a locking pairing, the locking pairing preferably having a circumferential collar (26) on the top of the cap body (2) and a corresponding circumferential groove (313) on the lower edge (21) of the cover part (3). 11. Closure cap (1) according to at least one of claims 1 to 10, characterized in that the closure cap (1) has two fluid ports, a removal port and an injection port, preferably at least the puncture point marking (43, 43 ') on the removal port being different from that on the injection port. 12. Manufacturing process for a closure cap (1) for containers according to at least one of claims 1 to 11, using a two-component injection molding tool with a mold half and two interchangeable counter-mold halves comprising the steps: a) providing a first material melt for at least the cap body (2) and a second material melt for the closure membrane (4), b) injecting the first material melt into a cap body cavity of the mold half of the injection molding tool, allowing it to cool and preserving the cap body (2), c) replacing a first counter-mold half of the injection molding tool facing the carrier plate (25) of the cap body (2) with a second counter-mold half which has a closure membrane cavity to form the closure membrane (4), d) injecting the second material melt into the closure membrane cavity of the second counter-mold half, thereby injecting the closure membrane (4) onto the carrier plate (25) from above at least in an area that surrounds the push-through opening (24), e) demoulding the object obtained from d) and sealing with the closure element covering the area of the closure membrane (4) under which the push-through opening (24) lies. 13. Manufacturing method according to claim 12, where - in step b) injecting the first material melt into a cover part cavity of the mold half of the injection molding tool, allowing the cover part (3) to cool and maintaining it, preferably in step b) co-injecting the film hinge (33) and in step e) permanently connecting the cover part (3) with the upper edge of the cap body (2) or - in step e) covering the area of the closure membrane (4), under which the push-through opening (24) lies, with a sealing film, preferably covering the entire surface of the closure membrane (4) with the sealing film, is performed. 14. Two-component injection molding tool for carrying out the manufacturing process for a closure cap (1) according to at least one of claims 12 or 13 with open molded parts, of which one mold half has at least one cap body cavity, which is delimited on the other side of a mold separation by a first counter-mold half, wherein the cap body (2) of the closure cap (1) with its carrier plate (25) facing the first counter-mold half can be sprayed in the cap body cavity, characterized in that the injection molding tool has a second counter-mold half, - which can be exchanged for the first counter-mold half, and - which has a closure membrane cavity which is designed for subsequent injection molding of the closure membrane onto the carrier plate of a cap body (2) injection-molded in the cap body cavity. 15. Two-component injection molding tool according to claim 14, characterized in that the mold half has a cover part cavity which is delimited on the other side of the mold separation by the first counter-mold half, wherein preferably the cap body cavity and the cover part cavity are arranged in the mold half at an angle which is in a range of 90 ° to 180 °, preferably in one Range from 120 ° to 180 °, lies, wherein preferably the lid part cavity and the cap body cavity are connected by a film hinge cavity.