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WO2015155629A1 - Procédé de saturation d'un médicament à usage dentaire - Google Patents

Procédé de saturation d'un médicament à usage dentaire Download PDF

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Publication number
WO2015155629A1
WO2015155629A1 PCT/IB2015/052352 IB2015052352W WO2015155629A1 WO 2015155629 A1 WO2015155629 A1 WO 2015155629A1 IB 2015052352 W IB2015052352 W IB 2015052352W WO 2015155629 A1 WO2015155629 A1 WO 2015155629A1
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WO
WIPO (PCT)
Prior art keywords
tooth
cone
poly
infected
medicated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2015/052352
Other languages
English (en)
Inventor
Ajay Reddy MAREDDY
Harivinder Reddy KONYALA
Swetha Reddy MOOTHUKPALLY
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Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2015155629A1 publication Critical patent/WO2015155629A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Definitions

  • the present disclosure is generally related to the field of endodontics, newer obturation method of primary teeth. More particularly the present disclosure relates to an infected tooth medicated using a cone molded with Poly-Lactic Acid and Poly-Glycolic Acid.
  • Pulpitis is one of the most common infections that can be notified in any person irrespective of the age.
  • the method used to treat infected pulp is specified as Pulp therapy.
  • Pulp therapy aims in cleaning and shaping of root canal followed by obturation.
  • Pulp therapy for deciduous teeth aims to retain treated deciduous tooth in a symptom free state until it is lost naturally during the transition from primary to permanent dentition.
  • Significance of obturation relies on prevention of under filling and overzealous filling, which may cause biologic irritation to the surrounding tissue.
  • Zinc oxide Eugenol and metapex paste are the common root canal filling materials recommended for primary teeth. However they have certain disadvantages like slow resorption, irritation to the periapical tissues, necrosis of bone and cementum and alter the path of eruption of succedaneous tooth.
  • An exemplary objective of the present disclosure is to medicate the periapical infected tooth with a medicated cone molded with PLGA copolymer blend, while non infected tooth obtruated with non medicated PLGA cone.
  • Another exemplary embodiment of the present disclosure is directed towards a method of saturation of a control drug release in endodontics.
  • the method comprises obturation of tooth attained with a blend of copolymer composition comprising a Poly- Lactic Acid; and a Poly- Glycolic Acid and inserting a cone molded with copolymer composition into prepared canals up to a reliable length.
  • the method comprises a step of metabolizing the copolymer composition with its biocompatible; and bioresorbable property, a step of excluding a toxic effect of the cone to the apical tissue of the one or more tooth with the biocompatibility property of the copolymer composition and a step of attaining metabolism in vivo through hydrolysis into alpha hydraulic acids present within the body.
  • the method comprises a step of inserting the cone of reliable length into the one or more tooth attained using radiography and a step of exhibiting proper operative assessment by visualization of Radio-opacity using radiographs.
  • FIG. 1A is a diagram illustrating an exemplary arrangement of cone molded with copolymer composition.
  • FIG. IB is a diagram illustrating an exemplary arrangement of cone inserted into the root canal of the tooth
  • FIG. 2 A is a diagram illustrating an exemplary arrangement of decay formed over the tooth with periapical infection.
  • FIG. 2B is a diagram illustrating an exemplary arrangement of medicated copolymer molded cone predicted as a constant controlled drug release system by its slow bioresorbablity for medicating the infected tooth.
  • FIG. 2C is a diagram illustrating an exemplary arrangement of copolymer molded cone predicted as a constant controlled drug release system by its slow bioresorbablity resulting in effective control of the infection.
  • FIG. la is a diagram 100a illustrating a perspective view of cones molded with biocompatible and bioresorbable composition.
  • the diagram 100a including the ISO size cones 102a are molded with a copolymer blend of Poly-Lactic Acid and Poly-Glycolic Acid referred as PLGA to form a molded cone.
  • PLGA Poly-Lactic Acid and Poly-Glycolic Acid
  • 104a determines a medicated copolymer blend in form of cone.
  • the present disclosure depicts only about two cones 102a molded with copolymer blend to form cone and medicated PLGA cone 104a.
  • the International Organization for Standardization size cones 102a also referred as ISO size cones 102a used in the primary teeth and the medicated PLGA cone 104a is used in both primary and permanent teeth.
  • ISO size cones 102a used in the primary teeth
  • medicated PLGA cone 104a is used in both primary and permanent teeth.
  • the present disclosed cones molded with chemical composition are used for obturating and eradicating peri apical infection in tooth that may be included and/or supported by a system 100a consistent with the disclosed embodiments.
  • the copolymer molded cone 104a is used for filling the root canal of infected tooth with medicated PLGA.
  • the cone 104a molded with a copolymer composition can alter the degradation rate and mechanical properties of the obturating cone by changing the PLA-PGA ratio.
  • FIG. lb is a diagram 100b illustrating a perspective view of a cone inserted into the pulp canal of the primary tooth.
  • the diagram 100b including the cone 102b is molded with a copolymer blend of Poly-Lactic Acid and Poly-Glycolic Acid referred as PLGA.
  • the molded cone 102b is then inserted into the pulp canal of the primary tooth 104b up to a reliable length of the tooth 106b.
  • the present disclosure depicts only about a cone 102b molded with copolymer blend inserted into the pulp canal of the infected tooth 104b.
  • the copolymer molded cone 102b is used for obturating the pulp canal of the infected tooth 104b.
  • the cone 102b molded with PLGA composition is inserted into the root canal 106b up to reliable length of the infected tooth 104b.
  • the cone 102b molded with PLGA composition gives a constant resorption rate with less inflammatory reactions.
  • FIG.2a is a diagram 200a illustrating a perspective view of a tooth infected with decay.
  • the diagram 200a including decay 204a is formed on the enamel of the tooth 202a. If the decay 204a is neglected at the earlier stage, then the decay 204a may spread to the bottom of the root canal 206a resulting damage to the tooth 202a.
  • the present disclosure depicts only about a tooth 202a infected with decay 204a. However it should be understood that in general there may be any number of teeth that can be infected with decay as similar as the tooth 202a infected with the decay 204a that may be included in the system. Therefore the present disclosed tooth infected with decay that may be included and/or supported by a system 200a consistent with the disclosed embodiments.
  • tooth 202a is infected with decay 204a which is further affecting the root canal 206a. If the development of the decay 204a is neglected at its earlier stage, then the decay 204a may spread to the bottom of the root canal 206a which may lead to periapical abscess 208a at the bottom of the effected root canal 206a.
  • FIG.2b is a diagram 200b illustrating a perspective view of an infected tooth medicated using a cone molded with blend of medicated copolymer material.
  • the diagram 200b including abscess 208b at the bottom of the effected root canal 206b is medicated using a cone 204b molded with the medicated copolymer blend.
  • the copolymer is a composition of Poly-Lactic Acid and Poly-Glycolic Acid together with medicament.
  • the present disclosure depicts only about an infected tooth 202b having abscess 208b is medicated using a cone 204b molded with the medicated copolymer blend.
  • the infected tooth 202b formed with abscess 208b at the bottom of the effected root canal 206b is medicated using a cone 204b molded with a medicated copolymer blend.
  • the cone 204b is inserted into the root canal 206b up to a reliable length.
  • the medicated copolymer blend molded to the cone 204b is then placed into the root canal 206b combats the bacterial contamination and reinfection in the infected tooth 202b.
  • the insertion of cone 204b up to a reliable length is achieved using radiography.
  • the proper operative assessment is achieved using visualization of Radio-opacity, radiographs and the like.
  • FIG.2c is a diagram 200c illustrating a perspective view of a medicated tooth 202c that is effected with decay and abscess.
  • the diagram 200c including the abscess at the bottom of the root canal 206 is cured after medicating with the cone 204c molded with the medicated copolymer composition.
  • the present disclosure depicts about a medicated tooth 202c infected with decay and abscess using a cone 204c molded with medicated copolymer blend.
  • teeth can be medicated using a medicated ISO size cones moulded with copolymer blend as similar as the tooth 202c medicated using a cone 204c molded with copolymer blend that may be included in the system. Therefore the present disclosed teeth medicated with the cone that may be included are supported by a system 200c consistent with the disclosed embodiments.
  • tooth 202c is medicated using the cone 204c molded with medicated PLGA composition.
  • the dental abscess is controlled using the medicated PLGA composition molded cone 204c.
  • Cone 204c molded with medicated PLGA has the biocompatible and bioresorbable property which controls the drug released at constant rate resulting in effective control of the infection.
  • the cone 204c because of bioresorbability degrades in vivo by hydrolysis into alpha hydroxyl acids that are metabolized by the body which further cannot result in unresorbtion.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dental Preparations (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Chemical & Material Sciences (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)

Abstract

Un procédé de saturation d'un médicament à usage dentaire comprend l'obturation d'un ou plusieurs canaux pulpaires atteints à l'aide d'une composition copolymère mélangée comprenant un acide polylactique et un acide polyglycolique, et l'insertion d'une pluralité de cônes de PLGA non-médicamentés dans un canal infecté d'une ou de plusieurs dents sur une longueur fiable, et du cône incorporant divers médicaments utilisés pour le système de libération de médicaments contrôlée constante dans une ou plusieurs dents à infection périapicale.
PCT/IB2015/052352 2014-04-11 2015-03-31 Procédé de saturation d'un médicament à usage dentaire Ceased WO2015155629A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1912/CHE/2014 2014-04-11
IN1912CH2014 2014-04-11

Publications (1)

Publication Number Publication Date
WO2015155629A1 true WO2015155629A1 (fr) 2015-10-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/052352 Ceased WO2015155629A1 (fr) 2014-04-11 2015-03-31 Procédé de saturation d'un médicament à usage dentaire

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WO (1) WO2015155629A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535668A (zh) * 2003-04-07 2004-10-13 成都航利生物材料研究所 一种牙科用根管充填新材料
WO2011030552A1 (fr) * 2009-09-11 2011-03-17 独立行政法人国立長寿医療研究センター Obturateur de canal radiculaire pour dent non extraite et procédé d'extraction destiné à la régénération du tissu dentaire

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535668A (zh) * 2003-04-07 2004-10-13 成都航利生物材料研究所 一种牙科用根管充填新材料
WO2011030552A1 (fr) * 2009-09-11 2011-03-17 独立行政法人国立長寿医療研究センター Obturateur de canal radiculaire pour dent non extraite et procédé d'extraction destiné à la régénération du tissu dentaire

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