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WO2015075486A3 - Heparosan saccharides for the treatment of inflammatory skin diseases - Google Patents

Heparosan saccharides for the treatment of inflammatory skin diseases Download PDF

Info

Publication number
WO2015075486A3
WO2015075486A3 PCT/GB2014/053495 GB2014053495W WO2015075486A3 WO 2015075486 A3 WO2015075486 A3 WO 2015075486A3 GB 2014053495 W GB2014053495 W GB 2014053495W WO 2015075486 A3 WO2015075486 A3 WO 2015075486A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
heparosan
saccharides
skin diseases
inflammatory skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2014/053495
Other languages
French (fr)
Other versions
WO2015075486A2 (en
Inventor
Charles Daniel Bavington
Claire Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycomar Ltd
Original Assignee
Glycomar Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomar Ltd filed Critical Glycomar Ltd
Publication of WO2015075486A2 publication Critical patent/WO2015075486A2/en
Publication of WO2015075486A3 publication Critical patent/WO2015075486A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to glycosaminoglycan (GAGs) polysaccharides, and oligosaccharides derived from GAGs, suitably sulphated heparosan saccharide wherein the SO3- / COO- ratio of the sulphated heparosan is in the range 1 to 3.8, which have been determined to inhibit keratinocyte inflammatory activation, for use in the treatment of inflammatory disorders of the skin, in particular psoriasis, eczema and atopic dermatitis.
PCT/GB2014/053495 2013-11-25 2014-11-25 Medicament Ceased WO2015075486A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1320786.5A GB201320786D0 (en) 2013-11-25 2013-11-25 Medicament
GB1320786.5 2013-11-25

Publications (2)

Publication Number Publication Date
WO2015075486A2 WO2015075486A2 (en) 2015-05-28
WO2015075486A3 true WO2015075486A3 (en) 2015-09-03

Family

ID=49918171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2014/053495 Ceased WO2015075486A2 (en) 2013-11-25 2014-11-25 Medicament

Country Status (2)

Country Link
GB (1) GB201320786D0 (en)
WO (1) WO2015075486A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002083155A1 (en) * 2001-04-12 2002-10-24 Universita' Degli Studi Di Brescia Use of sulfated bacterial polysaccharides suitable for the inhibition of angiogenesis
WO2003106503A1 (en) * 2002-06-12 2003-12-24 Inalco S.P.A. O-sulphated bacterial polysaccharides and their use
US20090005341A1 (en) * 2002-06-18 2009-01-01 Glycores 2000 S.R.L. Process for the preparation of n-acyl-(epi)k5-amine-o-sulfate-derivatives and products thus obtained

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002083155A1 (en) * 2001-04-12 2002-10-24 Universita' Degli Studi Di Brescia Use of sulfated bacterial polysaccharides suitable for the inhibition of angiogenesis
WO2003106503A1 (en) * 2002-06-12 2003-12-24 Inalco S.P.A. O-sulphated bacterial polysaccharides and their use
US20090005341A1 (en) * 2002-06-18 2009-01-01 Glycores 2000 S.R.L. Process for the preparation of n-acyl-(epi)k5-amine-o-sulfate-derivatives and products thus obtained

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARCO RUSNATI ET AL: "Biotechnological Engineering of Heparin/Heparan Sulphate: A Novel Area of Multi-Target Drug Discovery", CURRENT PHARMACEUTICAL DESIGN, vol. 11, no. 19, July 2005 (2005-07-01), NL, pages 2489 - 2499, XP055147505, ISSN: 1381-6128, DOI: 10.2174/1381612054367553 *

Also Published As

Publication number Publication date
WO2015075486A2 (en) 2015-05-28
GB201320786D0 (en) 2014-01-08

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