WO2015062505A1 - Sampling head for quick sampling - Google Patents

Abstract

Disclosed is a sampling head, comprising a capillary (1), wherein the capillary (1) composed of an inner-diameter-adjustable tube body (1-4), wherein a liquid inlet (1-2) is provided at one end of the inner-diameter-adjustable tube body (1-4), and a liquid outlet (1-1) is provided at the other end of the inner-diameter-adjustable tube body (1-4), and the ratio of the inner diameter of the liquid outlet (1-1) of the capillary (1) and the inner diameter of the liquid inlet (1-2) is 0.3-0.8:1; or the capillary (1) is composed of an inner-diameter-equal tube body (1-3) and an inner-diameter -adjustable tube body (1-4) communicating with each other, wherein a liquid inlet (1-2) is provided at one end of the inner-diameter-equal tube body (1-3), and a liquid outlet (1-2) is provided at one end of the inner-diameter-adjustable tube body (1-4), and the ratio of the inner diameter of the liquid outlet (1-1) of the capillary (1) and the inner diameter of the liquid inlet (1-2) is 0.3-0.8:1. The sampling head is suitable for quantitative sampling in biological, chemical, and medical field, and has the advantage of being easy to use and significantly increasing sampling rate.

Description

Quick sampling sampling head Technical field

The present invention relates to a sampling head, and more particularly to a rapid sampling sampling head suitable for quantitative sampling in the biological, chemical, and medical fields.

Background technique

Capillary tubes are widely used in the sampling process of the turbidity test, and are generally used for sampling small or small samples. Existing capillaries are generally glass capillaries, which are costly and waste large after being discarded. An injection-molded capillary has been developed which greatly reduces the cost compared to a glass capillary, but like the glass capillary, it is a tubular structure having a small inner diameter and uniformity. The existing capillary has an inner diameter of usually 0.2 to 2 mm, which ensures that the liquid can be automatically sucked in by the siphon action of the capillary.

Known by Bernoulli's law, formula (1).

  公式(1)

Formula 1)

Where p is the pressure of the fluid;

ρ is the density of the fluid;

v is the fluid velocity;

h is the plumb height;

g is the acceleration of gravity;

c is a constant.

The above formulas represent the pressure energy p, gravity potential energy ρgh and kinetic energy (1/2)*ρv2 of the fluid per unit volume. During the movement along the streamline, the sum remains unchanged, that is, the total energy is conserved. As the velocity increases in the flow, the pressure decreases; as the velocity decreases, the pressure increases. Therefore, as the rising height of the liquid in the capillary increases, the gravitational potential energy increases, the velocity decreases, and the pressure further increases. When the liquid rises to about 80% of the total height of the capillary, the speed becomes slow, and the height rise time of about 20% remains about 10 times that of the previous period.

Therefore, the existing capillary sampling time is long and even the liquid cannot be sucked to the tip end, so that the purpose of quantification is not achieved. However, in some tests, especially the sample to be collected is a blood sample. If the sampling time is long, the wound needs to be punctured again after the blood is coagulated, which will cause a certain physical burden on the subject. Therefore, it is necessary to develop a capillary tube capable of increasing the sampling speed.

The sampling head has a wide range of applications during the sampling process. It is generally installed on a dosing device to complete various Precise sampling. After sampling, the sampling head is inserted into the reaction cup containing the diluent, and the reaction cup is shaken, and the liquid sample in the sampling head can be mixed with the diluent through the outlet. The sampling head and the quantitative filling device may be a one-piece structure or a split structure, and the split structure may be convenient for storage and use, but if the insertion is not secure, the loss may even affect the final detection result.

The prior art gives different technical solutions based on changes in capillary shape that are easy to grip and mount to the dosing device:

Chinese patent CN101581729A discloses a liquid sample processing device, wherein a capillary tube is used for collecting a sample and inserting it into a cavity pre-filled with a reagent to realize integration of sample collection and reagent loading.

Chinese Patent No. CN101835423A discloses a sampling and dispensing device in which a front end of a sampler is provided with a capillary for sampling, and the integration of sample collection and reagent loading is realized by inserting a container filled with a reagent and cooperating with a piston.

Chinese patent CN102072949B discloses an integrated quantitative sampling and reagent device, wherein a quantitative capillary at the front end is inserted into a quantitative injector composed of a stent, a reagent cartridge body and a piston to realize integration of sample collection and reagent installation.

Chinese patent CN202903768U discloses an improved structure of a quantitative sampling and reagent device, the sampling head is composed of a capillary tube, a strut and a connecting head, wherein the capillary is used for sampling, the strut is used for fixing the capillary, and the connecting head is used for the connector. The quantitative filling device consisting of a sealing ring and a reagent tube realizes the integration of sample collection and reagent loading.

Summary of the invention

The technical problem to be solved by the present invention is to provide a sampling head which can improve the sampling rate of the existing capillary tube and is convenient to hold and can realize rapid sampling in cooperation with other devices.

In order to solve the above technical problem, the technical solution adopted by the present invention is as follows:

The sampling head of the present invention comprises a capillary tube composed of an inner diameter reducing pipe body, one end of the inner diameter reducing pipe body is provided with a liquid inlet, and the other end of the inner diameter reducing pipe body is provided with a liquid outlet, The ratio of the inner diameter of the liquid outlet of the capillary to the inner diameter of the liquid inlet is 0.3 to 0.8:1.

The sampling head of the present invention comprises a capillary tube composed of a communicating inner diameter equal diameter pipe body and an inner diameter reducing pipe body, and one end of the inner diameter equal pipe body is provided with a liquid inlet, and the inner diameter reducing pipe body One end is provided with a liquid outlet, and the ratio of the inner diameter of the liquid outlet of the capillary to the inner diameter of the liquid inlet is 0.3 to 0.8:1.

Further, when the capillary of the present invention is composed of a connecting inner diameter equal diameter tube body and an inner diameter reducing diameter tube body, the length ratio of the inner diameter equal diameter tube body to the inner diameter reducing diameter tube body is 0 to 90:1.

Further, when the capillary of the present invention is composed of a connecting inner diameter equal diameter tube body and an inner diameter reducing diameter tube body, The length ratio of the inner diameter equal diameter pipe body to the inner diameter reduction pipe body is 5 to 20:1.

Further, when the capillary of the present invention is composed of a connecting inner diameter equal diameter tube and an inner diameter reducing tube body, the ratio of the inner diameter of the liquid inlet to the length of the inner diameter reducing tube body is 0.5 to 2.0:1. .

Further, when the capillary of the present invention is composed of a connecting inner diameter equal diameter tube body and an inner diameter reducing diameter tube body, the ratio of the liquid inlet inner diameter to the inner diameter reducing diameter tube length is 0.7 to 1.0:1. .

Further, the capillary of the present invention has a length of 5 to 15 mm.

Further, the sampling head of the present invention further includes a bracket for fixing the capillary, the bracket including a cavity between the strut and the strut, and the liquid outlet of the capillary is exposed to the cavity.

Further, the width of the cavity of the sampling head of the present invention is 2 to 6 times the width of the capillary, and the height is 0.5 to 2 times the height of the capillary.

Further, a baffle is disposed on the strut of the portion corresponding to the liquid outlet in the cavity of the sampling head of the present invention.

Further, the height of the flow guiding table of the sampling head of the present invention is 20% to 70% of the height of the cavity.

Further, the flow head of the sampling head of the present invention has a wedge shape, and is further preferably an isosceles wedge shape.

Further, the sampling head of the present invention further includes a bracket for fixing the capillary, the bracket including a strut and a groove provided on the strut to expose the liquid outlet.

Further, the side of the groove corresponding to the liquid outlet of the sampling head of the present invention is provided with a flow guiding table, and further preferably, the flow guiding table is curved.

Further, the sampling head of the present invention further includes a fixing post disposed at the rear end of the bracket.

Further, the sampling end of the sampling head of the present invention is provided with a buckle at the tail end.

Further, the buckle of the sampling head of the present invention comprises a center body and an elastic card disposed outside the center body, and the top of the buckle is composed of the center body and the elastic card to form a tapered guiding structure.

Further, the sampling head of the present invention includes a center body and a boss disposed on an outer side of the center body.

Further, the sampling head of the present invention has one or two capillary tubes fixed to the stent.

The capillary of the present invention refers to a thin tube having a small inner diameter which allows the liquid to rise or fall against the gravity of the inside of the liquid, and is usually a thin tube having an inner diameter of 0.2 to 2 mm. The capillary of the present invention may be a quantitative capillary or a conventional capillary.

The ratio of the inner diameter equal diameter pipe body to the inner diameter variable diameter pipe body of the present invention is 0 to 90:1, and when the ratio of the inner diameter equal diameter pipe body to the inner diameter reduction pipe body is 0:1, there is no inner diameter equal diameter pipe body. , a capillary with uniform diameter reduction. However, setting the inner diameter equal diameter tube can shorten the length of the sampling head when the same sampling rate is reached.

The bracket of the present invention has one or two capillary tubes fixed thereto, and the fixing manner can be a conventional fixing manner adopted by those skilled in the art, such as plugging, snapping, etc., or an integral injection molding method.

The fixing post fixed to the rear end of the bracket of the present invention, the fixing post and the bracket can be fixed in a conventional manner, such as plugging, snapping, etc., or an integral injection molding method.

The positive effects obtained by the present invention using the above technical solutions are:

The inner diameter of the quantitative capillary of the present invention adopts a variable size design, and the inner diameter of the outlet is smaller than the inner diameter of the inlet, which accelerates the rate of entry of the liquid sample into the capillary. According to Bernoulli's equation, formula (2); there is a steady flow of fluid in the pipeline, and different sections in the pipeline The height of the liquid column in the vertical open capillary tube is different, indicating that in a stable flowing liquid, the pressure is small in a place where the flow rate is large, and the pressure is strong in a place where the flow rate is small.

p+(pv ² /2)=constant formula (2)

Where p is the pressure of the fluid;

ρ is the density of the fluid;

v is the fluid velocity;

According to the adsorption motive force formula (3), the flow rate of the liquid in the capillary is related to the inner diameter (d) of the capillary and the height (H) of the suction liquid. When the height of the capillary is constant, reducing the inner diameter of the capillary can increase the flow velocity of the fluid and further reduce The pressure of the fluid.

  公式(3)

Formula (3)

In the formula, √ is the root number;

V is the average flow velocity of the siphon section;

g is the acceleration of gravity;

H is the action head of the capillary, that is, the height difference between the water surface at the inlet end of the capillary and the water surface at the outlet end;

为毛细管的局部阻力系数；

Is the local resistance coefficient of the capillary;

λ is the resistance coefficient of the capillary along the path;

d is the inner diameter of the capillary.

The ratio of the inner diameter of the liquid outlet of the capillary of the invention to the inner diameter of the liquid inlet is 0.3-0.8:1, and the inner diameter of the liquid outlet is reduced, which can increase the internal air flow speed and reduce the internal pressure, thereby effectively increasing the rising rate of the liquid in the sampling head at the last 20%. At the same time, because the inner diameter of the sampling head is reduced, the siphon flow rate is effectively increased.

The inner diameter of the capillary tube of the present invention is composed of an inner diameter equal diameter pipe body and an inner diameter variable diameter pipe body; the length ratio of the inner diameter equal diameter pipe body to the inner diameter variable diameter pipe body is 0 to 90:1; when the sampling speed is constant Setting the inner diameter equal diameter tube body can reduce the length of the capillary tube.

The structure of the capillary of the present invention is particularly suitable for use in capillaries having a length of 5 to 15 mm.

The sampling head of the invention further comprises a bracket, the front end of the bracket is used for fixing the capillary tube, the bracket is composed of a strut, the sampling head can be conveniently held by the bracket, and the direct contact between the hand and the capillary is eliminated, and the capillary is avoided Pollution or infection to the operator. Optionally, the cavity can be formed by the struts or the grooves can be arranged on the struts, the purpose of which is to expose the liquid outlet of the capillary tube, so that the capillary tube communicates with the atmosphere, so that the air can be freely discharged with the entry of the liquid during sampling. So that the sampling is convenient.

The sampling head of the present invention is provided with a flow guiding table at a position corresponding to the liquid outlet of the capillary on the cavity. After the capillary is sampled, the sampling head is inserted into the reaction cup, and the sample is swayed, and the sample therein is discharged through the liquid outlet and Mix with the diluent in the cuvette, and the sample can be shunted through the baffle to prevent liquid splashing. Further, when the flow guiding table is a wedge body, the apex angle of the wedge shape corresponds to the liquid outlet of the capillary tube, preventing the frontal impact of the liquid from generating foam, and the reduction of the foam is favorable for increasing the accuracy of sample detection.

The sampling head of the present invention is provided with a flow guiding table at a position corresponding to the liquid outlet of the capillary on the groove. After the capillary is sampled, the sampling head is inserted into the reaction cup, and the sample is pulverized, and the sample therein is discharged through the liquid outlet and Mixing with the diluent in the cuvette, the sample can be diverted through the baffle when it flows out. When the baffle is curved, the liquid is not easily attached to the baffle and affects the amount of sample added.

The invention may further comprise a fixing post fixed to the rear end of the bracket, wherein the fixing post is used for connecting with the dosing device, and when the buckle is provided at the tail end of the fixing post, the connection between the two can be made stronger even in an external force. It is also not easy to slip under the influence of it.

The buckle of the invention comprises a central body and an elastic card disposed outside the central body, the elastic card shrinks when pressed, and can be conveniently inserted into the quantitative filling device; when subjected to an external force, the elastic card further Stretch out and stop pulling out. The elastic card of the invention is 1-2 pieces, which can save materials while ensuring the connection effect.

Alternatively, the buckle of the present invention comprises a central body and a boss disposed on the outer side of the central body, which is pressed into the connecting groove in a direction perpendicular to the dosing device during use, and the boss is arranged to prevent the filling in the cis limit When the force is applied, the sampling head is separated from the quantitative injector. The bosses of the present invention have 1 to 2 bosses, and the materials can be saved while ensuring the connection effect.

The quantitative capillary of the invention is 1-2, which can meet the requirements of different sampling quantities, or can meet the requirement of simultaneously detecting two samples in one test.

The invention is an integral injection molding, which ensures the tight connection between components, and is not easy to cause sample discharge and the like which affect sampling accuracy.

DRAWINGS

1 is a schematic structural view of Embodiment 1 of the present invention;

2 is a schematic structural view of Embodiment 2 of the present invention;

Figure 3 is a cross-sectional view showing a second embodiment of the present invention;

4 is a schematic perspective view of a second embodiment of the present invention;

Figure 5 is an assembled view of a second embodiment of the present invention and a dosing device;

Figure 6 is a schematic structural view of Embodiment 3 of the present invention;

Figure 7 is a schematic structural view of a capillary tube according to Embodiment 3 of the present invention;

Figure 8 is a schematic structural view of Embodiment 4 of the present invention;

In the drawing, 1 capillary, 1-1 liquid outlet, 1-2 liquid inlet, 1-3 inner diameter equal diameter pipe body, 1-4 inner diameter reducer pipe body, 2 brackets, 2-1 strut, 2-2 Cavity, 2-3 guide, 2-4 groove, 3 fixed column, 4 snap, 4-1 center body, 4-2 elastic card, 4-3 boss, 5 mount, 6 piston, 6 -1 reagent compartment, 6-2 sealing membrane, 7 sleeve, 8 snap ring.

detailed description

The cross-section of the quantitative capillary 1 of the present invention is generally circular, and may be other shapes such as square, elliptical, etc., as is well known to those skilled in the art, the shape of the cross-section of the capillary does not affect the effect of its use.

Alternatively, the invention may be used alone or in combination with a dosing device including, but not limited to, a commercially available dosing device or a portion of the applicator disclosed in the patent CN202204706U (excluding Part of the capillary).

The sampling head of the present invention may consist of only a capillary tube, which may be used alone by holding the outer wall of the capillary tube, or may be inserted or snapped onto the holder of the metering dispenser. Since the capillary of the present invention employs a variable diameter design, the sampling speed can be increased.

The sampling head of the invention may comprise a capillary tube and a bracket, the front end of the bracket is used for fixing the capillary tube, the sampling head can be conveniently held by the bracket, and the direct contact between the hand and the capillary tube is eliminated, and the contamination of the capillary tube or the operator is avoided. infection. The bracket is composed of a strut, and the strut may be one or more, and the function is to support the capillary. When it is a strut, the preferred capillary is disposed on one side of the strut; In the case of the root strut, the preferred strut is symmetrically arranged, and the end of the strut that is in contact with the capillary forms a certain angle, and the capillary is disposed at the intersection of the strut; from the viewpoint of saving the process, the number of the general strut does not exceed 4 roots, more generally 1 or 2 roots.

It is possible to select a cavity between the struts or to provide a groove on the struts, the purpose of which is to expose the liquid outlet of the capillary, and to connect the capillary to the atmosphere, and the air can be freely discharged as the liquid enters during sampling. Convenient sampling is achieved. The cavity or the groove is only required to expose the liquid outlet of the capillary tube and can make the sample flow out, and the specific shape thereof is not limited, and may be selected from a square shape, a fan shape, a triangle shape or a prism shape; the same is for the cavity or the concave shape. The size of the groove is not specifically limited, and the width of the cavity that can be selected is 2 to 6 times the width of the capillary, and the height is the capillary height. 0.5 to 2 times, when further increased, the liquid is more likely to flow out, but the volume of the sampling head is increased.

The sampling head of the present invention may include a capillary tube, a bracket and a fixing column, and is inserted into the quantitative filling device through the fixing column 3, and the selection of the number of the fixed column is one or more functions that do not affect the plugging. It is itself, and depending on the needs of the particular plug-in process, the shape and number of fixed posts can be determined and selected by those skilled in the art based on common general knowledge.

The stent of the present invention can hold a capillary tube when it is convenient to use. The fixed column of the present invention is used to insert the present invention into a dosing device when needed. Since the selection of the bracket and the fixing post has no effect on the functional realization of the capillary, if the reducing capillary of the present invention is used, the structure of other fixed connecting capillary, such as a sleeve, etc., should also belong to the present invention. protected range.

The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments are obvious to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but the scope of the invention is to be accorded

Example 1

As shown in FIG. 1, the capillary tube 1 of the present embodiment is composed of a connecting inner diameter equal-diameter tube body 1-3 and an inner diameter reducing tube body 1-4; one end of the inner diameter equal-diameter tube body 1-3 A liquid inlet 1-2 is provided, one end of the inner diameter reducing pipe body 1-4 is provided with a liquid outlet 1-1; the inner diameter (D1) of the liquid outlet 1-1 and the inner diameter (D2) of the liquid inlet 1-2 The ratio is 0.5:1; the ratio of the length (L2) of the inner diameter equalizing pipe body 1-3 to the length (L1) of the inner diameter reducing pipe body 1-4 is 20:1; the liquid inlet (1-2) The ratio of the inner diameter (D2) to the length (L1) of the inner diameter reducing pipe body is 1:1; the capillary length is 10 mm, and the liquid inlet 1-2 inner diameter (D2) is 1 mm.

The technical effect of the capillary is that the sampling speed can be greatly increased, which is related to the fluidity of the collected sample, and the sampling rate can be increased by 5 to 20 times.

Example 2

As shown in FIG. 2 to FIG. 4, the embodiment includes a capillary tube 1, a bracket 2, and a fixing post 3. The front end of the bracket 2 is fixed to the capillary tube 1, and the rear end is connected to the fixing post 3. The bracket 2 includes two symmetrically arranged poles. 2-1 and a cavity 2-2 composed of two struts 2-1; the liquid outlet 1-1 of the capillary is exposed to the upper portion of the cavity 2-2, and the liquid sample collected by the capillary 1 passes through the liquid outlet 1-1 flows out through the cavity 2-2; a portion of the cavity 2-1 corresponding to the liquid outlet 1-1 is provided with a flow guiding table 2-3, and the sample can be shunted through the flow guiding table 2-3 when flowing out To prevent liquid splashing. Further, when the flow guiding table 2-3 is a wedge body, the apex angle of the wedge shape corresponds to the liquid outlet of the capillary tube, preventing the frontal impact of the liquid from generating foam, and the foam The reduction is beneficial to increase the accuracy of sample detection.

The tail end of the fixing post 3 of the embodiment is provided with a buckle 4 for connecting with the fixing frame 5 of the dosing device. The buckle 4 of the present invention comprises a center body 4-1 and is disposed outside the center body 4-1. The elastic card 4-2, the elastic card 4-2 is contracted when pressed, and can be conveniently inserted into the quantitative filling device; when subjected to an external force, the elastic card is further stretched to prevent the pulling out due to the reverse force. The capillary 1, the holder 2 and the fixing post 3 of the present embodiment are integrally injection molded.

As shown in Fig. 5, in the present embodiment, the fixing post 3 is connected to the fixing frame 5 of the dosing device by the fixing post 3, and is attached to the dosing device. The capillary 1 is used for accurate sampling, and the sample is immersed in the sample at the front end of the capillary. The sample is automatically sampled by capillary action and the sample is automatically stopped when the sample reaches the tip of the capillary 1. Since the sampling volume of the capillary is constant, accurate quantification can be achieved. The sampled device (the sampling head connected to the micro-acquisition injector) is inserted into the reaction cup containing the diluent, and the reaction cup is shaken, so that the sample in the capillary 1 flows out through the outlet 1-1 and the diluent in the reaction cup Mix well. At this time, the reagent is filled with a quantitative injector, and the piston 6 is pressed hardly, so that the piston 6 breaks through the locking of the snap ring 8 and relative movement with respect to the sleeve 7. At this time, the piercing thimble provided at the tail of the fixing frame 5 is pierced. The sealing film 6-2 disposed at the reagent cartridge 6-1 at the front end of the piston 6 continues to press the piston 6 to cause the reagent stored in the reagent cartridge 6-1 to flow into the cuvette through a center hole provided in the holder 5.

As shown in FIG. 3, the capillary tube 1 of the present embodiment is composed of a connecting inner diameter equal-diameter tube body 1-3 and an inner diameter reducing tube body 1-4; one end of the inner diameter equal-diameter tube body 1-3 is provided with a liquid inlet 1-2, the other end of the inner diameter reducing pipe body 1-4 is provided with a liquid outlet 1-1; a ratio of an inner diameter of the liquid outlet 1-1 to an inner diameter of the liquid inlet 1-2 is 0.3:1; The ratio of the length of the inner diameter equal diameter pipe body 1-3 to the length of the inner diameter reducing pipe body 1-4 is 30:1; the ratio of the inner diameter of the liquid inlet 1-2 to the length of the inner diameter reducing pipe body is 1.2:1; capillary length is 15 mm.

The technical effect of the capillary is that the sampling speed can be greatly increased, which is related to the fluidity of the collected sample, and the sampling rate can be increased by 5 to 20 times.

Example 3

As shown in FIG. 6 , the embodiment includes a capillary tube 1 , a bracket 2 , and a fixing post 3 . The front end of the bracket 2 is fixed with two capillary tubes 1 , and the rear end is connected to the fixing post 3 . The bracket 2 includes a strut 2-1 and A groove 2-4 is provided on the strut 2-1 to expose the liquid outlet 1-1. The liquid sample collected by the capillary 1 flows out through the liquid outlet 1-1 through the grooves 2-4.

As shown in FIG. 6, the tail end of the fixing post 3 of the present embodiment is provided with a buckle 4 for connecting with the fixing frame 5 of the dosing device. The buckle 4 of the present invention includes a center body 4-1 and is disposed on The elastic card 4-2 on the outer side of the center body 4-1, the elastic card 4-2 is contracted when pressed, and can be conveniently inserted into the quantitative filling device; when subjected to an external force, the elastic card is further stretched due to the reverse force. Prevent pulling out.

In this embodiment, when it is used, it is connected to the fixing frame 5 of the quantitative filling device through the fixing column 3, and is installed to the quantitative filling. On the device. The capillary 1 is used for accurate sampling, and the sample is immersed in the sample at the front end of the capillary. The sample is automatically sampled by capillary action and the sample is automatically stopped when the sample reaches the tip of the capillary 1. Since the sampling volume of the capillary is constant, accurate quantification can be achieved. Since the two capillaries 1 are mounted, it is possible to increase the amount of the sample taken once, and the sample amounts of the two capillaries may be the same or different. The sampled device (the sampling head connected to the micro-acquisition injector) is inserted into the reaction cup containing the diluent, and the reaction cup is shaken, so that the sample in the capillary 1 flows out through the outlet 1-1 and the diluent in the reaction cup Mix and refill with a dosing device.

As shown in FIG. 7, the capillary tube 1 of the present embodiment is composed of an inner diameter reducing pipe body 1-4, and one end of the inner diameter reducing pipe body 1-4 is provided with a liquid inlet 1-2, and the inner diameter is reduced. The other end of the tube body 1-4 is provided with a liquid outlet 1-1, the ratio of the inner diameter of the liquid outlet 1-1 of the capillary tube 1 to the inner diameter of the liquid inlet 1-2 is 0.7:1; the inner diameter of the liquid inlet 1-2 is The ratio of the length of the inner diameter reducing pipe body was 0.5:1; the length of the capillary tube was 5 mm.

The technical effect of the capillary is that the sampling speed can be greatly increased, which is related to the fluidity of the collected sample, and the sampling rate can be increased by 5 to 20 times.

Example 4

As shown in FIG. 8, Embodiment 4 shows another method of fixing the sampling head to the dosing device, which employs a buckle 4 including a center body 4-1 and a convex portion disposed outside the center body 4-1. Taiwan 4-3. When in use, the center body 4-1 is pressed into the connecting groove at the front end of the micro-sampler, and the connecting groove corresponds to the position of the center body 4-1 to fix the sampling head. The boss 4-3 is arranged to prevent the sampling head from being detached from the micro-sampler when the squeezing injector is forced.

The capillary tube 1 of the present embodiment is composed of a connecting inner diameter equal diameter pipe body and an inner diameter reducing pipe body 1-4; one end of the inner diameter equal pipe body is provided with a liquid inlet 1-2, and the inner diameter reducing pipe The other end of the body 1-4 is provided with a liquid outlet 1-1; the ratio of the inner diameter of the liquid outlet 1-1 to the inner diameter of the liquid inlet 1-2 is 0.8:1; the length of the inner diameter equal-diameter body 1-3 is The ratio of the length of the inner diameter reducing pipe body 1-4 is 5:1; the ratio of the inner diameter of the liquid inlet 1-2 to the length of the inner diameter reducing pipe body is 0.8:1; and the capillary length is 7 mm.

The technical effect of the capillary is that the sampling speed can be greatly increased, which is related to the fluidity of the collected sample, and the sampling rate can be increased by 5 to 20 times.

Examples 5-9

Examples 5 to 9 differed from Examples 1 and 2 only in the inner diameter and shape of the capillary tube, and the parameters thereof are shown in Table 1.

Comparative examples 1 to 4

Comparative Examples 1 to 4 differed from Examples 1 and 2 only in the inner diameter and shape of the capillary. For example, Comparative Example 1 is a capillary having a uniform inner diameter, and the outer diameter of the outlet of the capillary of Comparative Example 2 is only 0.2 of the inner diameter of the inlet, each pair The parameters of the scale are shown in Table 1.

A comparison of the examples with the comparative examples is shown in Table 1. And the sampling time of the water collected by the sampling heads of the respective examples and the comparative examples is compared.

Table 1 Experimental data of Examples 1 to 10 and Comparative Examples

From the test data of Table 1, it can be seen that the sampling time can be changed by changing the internal diameter structure of the capillary under the same sampling medium (water). As shown in Example 2, when the ratio of the liquid outlet inner diameter (D1) to the liquid inlet inner diameter (D2) was 0.3:1, although the capillary length was 1.5 times the length of the capillary of Comparative Example 1, the sampling time was significantly shortened. , indicating that the sampling speed is significantly increased. As shown in Example 4, when the ratio of the liquid outlet inner diameter (D1) to the liquid inlet inner diameter (D2) was 0.8:1, although the capillary length was slightly shorter than that of Comparative Example 1, the sampling time was only Comparative Example 1 At 1/4, the sampling rate is significantly increased. As shown in other embodiments, when the ratio of the liquid outlet inner diameter (D1) to the liquid inlet inner diameter (D2) is 0.3 to 0.8: 1, both have a significant effect of increasing the sampling rate. In particular, in Example 6 and Example 7, when the ratio of the liquid outlet inner diameter (D1) to the liquid inlet inner diameter (D2) was 0.5 to 0.6: 1, although the capillary length was about 1.5 times the length of the capillary of Comparative Example 1, sampling was performed. The time is very significant.

Further, the ratio of the length (L2) of the inner diameter equal diameter pipe body to the length (L1) of the inner diameter reducing pipe body, and the ratio of the inner diameter (D2) of the liquid inlet 1-2 to the length (L1) of the inner diameter reducing pipe body, Synergistically with the ratio of the liquid outlet inner diameter (D1) to the liquid inlet inner diameter (D2), which is shown in the effects of the embodiment 6 and the embodiment 9, the liquid outlet inner diameter (D1) and the liquid inlet inner diameter (D2) The ratio of each is 0.6:1, and the synergy of Example 6 is more obvious than that of Example 9; as shown in Table 1, the length (L2) of the inner diameter equal diameter pipe body and the length of the inner diameter reduction pipe body (L1) When the ratio is 5 to 20:1, the synergistic effect is more pronounced when the ratio of the inner diameter (D2) of the liquid inlet 1-2 to the length (L1) of the inner diameter reducing pipe body is 0.7 to 1.0:1. This conclusion can be further confirmed by Comparative Example 2 and Comparative Example 4.

Furthermore, the ratio of the inner diameter of the liquid outlet (D1) to the inner diameter of the liquid inlet (D2) is the main factor affecting the sampling speed of the capillary. The factor, as shown in Comparative Example 3, although the other variables, that is, the values of L2/L1 and D2/L1 meet the requirements, the value of D1/D2 is 0.9, which has little effect on the capillary sampling speed. The remarkable effect expected by the invention.

Claims (20)

A fast sampling sampling head, characterized in that it comprises a capillary tube (1) composed of an inner diameter reducing diameter tube body (1-4), the inner diameter reducing diameter tube body (1-4) One end is provided with a liquid inlet (1-2), and the other end of the inner diameter reducing pipe body (1-4) is provided with a liquid outlet (1-1), and a liquid outlet (1-1) of the capillary (1) The ratio of the inner diameter to the inner diameter of the liquid inlet (1-2) is 0.3 to 0.8:1; Or the capillary (1) is composed of a communicating inner diameter equalizing pipe body (1-3) and an inner diameter reducing pipe body (1-4), and one end of the inner diameter equal pipe body (1-3) is provided a liquid inlet (1-2), one end of the inner diameter reducing pipe body (1-4) is provided with a liquid outlet (1-1), and an inner diameter of the liquid outlet (1-1) of the capillary (1) and a liquid inlet (1-2) The ratio of the inner diameter is from 0.3 to 0.8:1. The fast sampling sampling head according to claim 1, wherein when said capillary (1) is composed of a communicating inner diameter equalizing pipe body (1-3) and an inner diameter reducing pipe body (1-4) The length ratio of the inner diameter equal diameter pipe body (1-3) to the inner diameter diameter reducing pipe body (1-4) is 0 to 90:1. A fast sampling sampling head according to claim 2, wherein when said capillary (1) is composed of a communicating inner diameter equalizing pipe body (1-3) and an inner diameter reducing pipe body (1-4) The length ratio of the inner diameter equal diameter pipe body (1-3) to the inner diameter diameter reducing pipe body (1-4) is 5 to 20:1. The fast sampling sampling head according to claim 1, wherein when said capillary (1) is composed of a communicating inner diameter equalizing pipe body (1-3) and an inner diameter reducing pipe body (1-4) The ratio of the inner diameter of the liquid inlet (1-2) to the length of the inner diameter reducing pipe body (1-4) is 0.5 to 2.0:1. A fast sampling sampling head according to claim 4, wherein when said capillary (1) is composed of a communicating inner diameter equalizing pipe body (1-3) and an inner diameter reducing pipe body (1-4) The ratio of the inner diameter of the liquid inlet (1-2) to the length of the inner diameter reducing pipe body (1-4) is 0.7 to 1.0:1. A fast sampling sampling head according to claim 1, characterized in that the capillary (1) has a length of 5 to 15 mm. The fast sampling sampling head according to any one of claims 1 to 6, characterized in that it further comprises a bracket (2) for fixing the capillary (1), the bracket (2) comprising a strut (2- 1) and a cavity (2-2) between the struts (2-1), the liquid outlet (1-1) of the capillary (1) being exposed to the cavity (2-2). The fast sampling sampling head according to claim 7, wherein the width of the cavity is 2 to 6 times the width of the capillary and the height is 0.5 to 2 times the height of the capillary. The sampling head of the fast sampling according to claim 8, characterized in that the stem (2-1) in the cavity (2-1) corresponding to the liquid outlet (1-1) is provided with a diversion Taiwan (2-3). A fast sampling sampling head according to claim 9, wherein said height of said flow guiding table (2-3) is said The cavity (2-2) has a height of 20% to 70%. A fast sampling sampling head according to claim 10, wherein said flow guiding table (2-3) is wedge shaped. A fast sampling sampling head according to claim 11, wherein said flow guiding table (2-3) is an isosceles wedge shape. The fast sampling sampling head according to any one of claims 1 to 6, characterized in that it further comprises a bracket (2) for fixing the capillary (1), the bracket (2) comprising a strut (2- 1) and a groove (2-4) provided on the strut (2-1) to expose the liquid outlet (1-1). A fast sampling sampling head according to claim 13, characterized in that the side of the groove (2-4) corresponding to the liquid outlet (1-1) is provided with a flow guiding table (2-3). A fast sampling sampling head according to claim 14, wherein said flow guiding table (2-3) is curved. The fast sampling sampling head according to any one of claims 7 to 15, characterized in that it further comprises a fixing post (3) provided at the rear end of the bracket (2). A fast sampling sampling head according to claim 16, characterized in that the end of the fixing post (3) is provided with a snap (4). A fast sampling sampling head according to claim 17, wherein said buckle (4) comprises a center body (4-1) and an elastic card (4-2) disposed outside the center body (4-1). The top of the buckle (4) is composed of the central body (4-1) and the elastic card (4-2) to form a tapered guiding structure. A sampling probe according to claim 18, wherein said buckle (4) comprises a center body (4-1) and a boss (4-3) disposed outside the center body (4-1). . A fast sampling sampling head according to any one of claims 7 to 19, characterized in that one or two capillaries (1) are fixed to the holder (2).

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