[go: up one dir, main page]

WO2014210233A1 - Système pour produire des produits en feuilles portant des dessins qui varient parmi les feuilles successives - Google Patents

Système pour produire des produits en feuilles portant des dessins qui varient parmi les feuilles successives Download PDF

Info

Publication number
WO2014210233A1
WO2014210233A1 PCT/US2014/044208 US2014044208W WO2014210233A1 WO 2014210233 A1 WO2014210233 A1 WO 2014210233A1 US 2014044208 W US2014044208 W US 2014044208W WO 2014210233 A1 WO2014210233 A1 WO 2014210233A1
Authority
WO
WIPO (PCT)
Prior art keywords
design
pattern
design pattern
along
equal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/044208
Other languages
English (en)
Inventor
Mildred Frances GANN-FETTER
Pamela Marie Snyder
Mario Castillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Priority to EP14742063.2A priority Critical patent/EP3013574A1/fr
Publication of WO2014210233A1 publication Critical patent/WO2014210233A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B31—MAKING ARTICLES OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER; WORKING PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31F—MECHANICAL WORKING OR DEFORMATION OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31F1/00—Mechanical deformation without removing material, e.g. in combination with laminating
    • B31F1/07—Embossing, i.e. producing impressions formed by locally deep-drawing, e.g. using rolls provided with complementary profiles
    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21F—PAPER-MAKING MACHINES; METHODS OF PRODUCING PAPER THEREON
    • D21F3/00—Press section of machines for making continuous webs of paper
    • D21F3/02—Wet presses
    • D21F3/08—Pressure rolls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B31—MAKING ARTICLES OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER; WORKING PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31F—MECHANICAL WORKING OR DEFORMATION OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31F2201/00—Mechanical deformation of paper or cardboard without removing material
    • B31F2201/07—Embossing
    • B31F2201/0707—Embossing by tools working continuously
    • B31F2201/0715—The tools being rollers
    • B31F2201/0723—Characteristics of the rollers
    • B31F2201/0733—Pattern

Definitions

  • the sheets may be provided on a continuous roll of a length of web material from which, for example, consecutive individual sheets may be separated by tearing along perforations across the width, and pulled away.
  • the sheets may be provided in a continuous length that is folded in accordion-fashion, and thereby gathered into a consolidated structure resembling a stack, with individual sheets made separable via perforations across the width.
  • the sheets may be provided in stacks of individually pre-cut, stacked sheets from which individual sheets may be drawn consecutively from the top or bottom of the stack.
  • Individual sheets in a stack may be folded and stacked simply, or folded and interleaved to form a stack.
  • interleaving and friction between consecutive sheets may be employed to cause leading sheets, as they are drawn from the stack, to partially draw with them consecutive following sheets, such that, for example, the following sheets are partially drawn through a dispensing opening in the dispenser or container in which the stack is provided and/or stored, for easy access when next needed.
  • Such sheet products may be formed of web materials, typically nonwoven web materials, such as webs formed of natural or synthetic fibers, such as cellulose pulp, polymeric fibers or combinations thereof.
  • Embossing or molding may be performed in a manner or by a technique that not only imparts the visual aspects of the chosen design, but also enhances characteristics such as sheet loft, absorbency, and/or texture that enhances wiping/cleaning efficacy. Embossing or molding may be done by a variety of techniques including rolling and hydroembossing.
  • Fig. 1 is a schematic side view of a roller embossing system and a web material.
  • Fig. 2 is a schematic side view of a hydroembossing system and a web material.
  • Figs. 3A and 3B are schematic plan views of web material bearing features of a design pattern that repeats within a repeat length RL, with the variation of the design with respect to portions of the web of varying lengths SL between separation lines schematically represented by a sine curve.
  • Figs. 4A-4D are schematic plan views of web material bearing features of a design pattern that repeats within a repeat length RL, with the variation of the design with respect to portions of the web of varying lengths SL between separation lines schematically represented by a sine curve.
  • Fig. 5 is a schematic top/plan view of an arrangement such as depicted in Fig. 2, including a view of web material bearing features of a design pattern that repeats along the machine and cross directions within repeat length RL and repeat width RW, with the variation of the design with respect to portions of the web of lengths SL and widths SW between separation lines schematically represented by a sine curve.
  • Figs. 6A and 6B depict plan views of examples of design patterns wherein the pattern repeat lengths are greater than the sheet lengths, and reflecting examples of attributes that minimize the appearance of natural locations for separation lines.
  • Fig. 7 depicts a plan view of an example of a design pattern reflecting examples of attributes that minimize the appearance of natural locations for separation lines.
  • Associated sheets means a plurality of sheets that are consecutively: stacked one on top of another, folded, interleaved and stacked one on top of the other, gathered on a roll, or gathered by accordion folding.
  • At least partially separated applies to and describes two portions of a web material at a location where they are divided by a complete cut; or by a partial cut, perforation or scoring along a separation line, at which the first portion may be separated from the second portion by application of tensile force to the first portion, either without tearing of the web material, or by tearing that propagates along the separation line.
  • continuous means that consecutive, congruous portions of the repeating pattern appear on consecutive sheets.
  • the term "imparting” includes printing the features on the material, impressing the features into the material, embossing the features onto/into the material, or any other technique or process for causing the material to bear visible and/or tactilely-perceptible features of the design.
  • Machine direction with respect to a web material undergoing processing in a manufacturing or processing line that includes imparting the material with a design pattern, means generally parallel to the direction in which the material is conveyed through the line in the process(es) that cause the material to be imparted with a design pattern.
  • cross direction means generally perpendicular to the machine direction.
  • Nonwoven web material means web material formed of fibers that are neither woven nor knitted, including fibers formed of natural or synthetic materials, including but not limited to cellulose fibers, polymer fibers, and combinations thereof.
  • Sheet is a portion of a nonwoven material web of one or both of length or width dimensions smaller than the greater length or width dimensions, respectively, of the nonwoven material web.
  • An "x-y dimension” is a dimension of a sheet or material web measured along a plane approximately defined by the sheet or web when laid and/or extended out flat and lying on a horizontal, planar surface.
  • z-direction with respect to a material web or sheet, is the direction that is orthogonal to the plane approximately defined by the material web or sheet when laid out flat on horizontal, planar surface.
  • manufacturing or processing line relates to the direction of travel of the item being conveyed and/or processed in the line, with the movement of the item through the line being analogous to the movement of water in a stream.
  • a "wipe” is a sheet suitable for use in wiping and/or cleaning any surface.
  • Non-limiting examples include skin cleansing wipes, baby wipes, paper towels, bath tissues, facial tissues, and household cleaning and/or dusting wipes.
  • a first stamp may be used to impart features of a first design to a first sheet; a second stamp may be used to impart features of a second design to a second sheet succeeding the first, a third stamp may be used to impart features of a third design to a third sheet succeeding the second, and so on, and the sheets may then be gathered on a roll, in a stack, etc.
  • a first stamp may be used to impart features of a first design to a first sheet
  • a second stamp may be used to impart features of a second design to a second sheet succeeding the first
  • a third stamp may be used to impart features of a third design to a third sheet succeeding the second, and so on, and the sheets may then be gathered on a roll, in a stack, etc.
  • the design features are imparted by use of a roller or cylinder, e.g. , a printing roller, an embossing roller, a hydroembossing or hydromolding cylinder, etc.
  • a roller or cylinder e.g. , a printing roller, an embossing roller, a hydroembossing or hydromolding cylinder, etc.
  • embossing the roller or cylinder will have an acting surface bearing 3-dimensional features corresponding to the desired design features to be imparted.
  • the roller or cylinder will be paired with an opposing roller or cylinder, the two meeting at a nip.
  • roller embossing roller As the web is passed through the nip, the features of the embossing roller are impressed into the web.
  • a bank or beam of water jets will be positioned adjacent the roller or cylinder, and arranged to direct jets of water toward the cylindrical surface of roller or cylinder.
  • jets of water therefrom impact the web and urge and displace portions thereof to conform to the 3-dimensional features of the roller, thereby imparting the design features to the web material.
  • Roller embossing is described in, for example, PCT Application Pub. No. WO 2008/107845, and references cited therein.
  • Hydroembossing also known as hydromolding
  • hydromolding Hydroembossing
  • a web material 10 may be conveyed into and through the nip between a pair of rollers including an embossing, printing or calender roller 100 and opposing roller 101.
  • the roller 100 may have features of a decorative design reflected in lands 100a and depressions 100b, formed on its outer cylindrical surface by etching, machining or other forming technique. As it passes through the nip between rollers 100 and 101, the web material is imparted with printed, molded or embossed features 11 of the decorative design.
  • Opposing roller 101 may be featureless, or may also have features reflecting a design formed on its rolling surface, which may be complementary or cooperative with the features on roller 100.
  • a web material 10 may be rolled over the surface of a rotating hydroembossing drum or cylinder 102.
  • Cylinder 102 may have formed on its outer surface features reflecting a decorative design, in lands 102a and depressions 102b, in the surface.
  • web material 10 may be passed under one or more banks of hydroembossing jets 103 that expel high-energy streams of water 104 at the web material.
  • the streams 104 impinge the fibers of the material, thereby displacing portions of the fibers into the depressions 102b in the surface of the cylinder 102.
  • the web material is imparted with hydroembossed features 11 of the decorative design.
  • the outer surface of roller 100 or cylinder 102 will have radius r. Accordingly, the circumference of the outer surface of roller 100 or cylinder 102 will be 2 ⁇ . It will be appreciated, then, that features of any decorative design reflected on the roller or cylinder surface will be imparted to the web material such that the design is repeated on the web material along the machine direction, at least, with each complete rotation of the roller or cylinder. On the web material, the repeat length will be, at most, approximately 2 ⁇ , and the repeat frequency will be, at least, approximately 1/2 ⁇ along the machine direction. Of course, the design may be created and features arranged on the roller or cylinder such that it repeats more than once about the circumference as well, and thus, has a repeat length RL shorter than 2 ⁇ and a frequency greater than 1/2 ⁇ along the machine direction.
  • a continuous belt adapted to impart features of a decorative design, and adapted to ride on pulleys, may be used for embossing, molding, printing, hydroembossing, etc.
  • the design pattern repeat length will be less than or equal to the running length of the belt (i.e., the length of the belt if it were cut along a line perpendicular to the machine direction, and laid out flat).
  • the changing appearance of a design pattern imparted to a web along an x-axis parallel with the machine direction may be schematically represented by the changing position of a sine curve 200, where the y-axis would be perpendicular with the machine direction.
  • each y value along the curve 200 corresponds with a particular arrangement of the pattern at a corresponding distance along the x-axis from a starting point.
  • pattern repeat length RL is necessarily less than or equal to approximately 2 ⁇ .
  • the cycle of the sine curve 200 represents a cycle of the repeating design pattern, i.e., the wavelength of the sine curve represents pattern repeat length RL.
  • the web material may be cut or perforated along separation lines 201 spaced apart by a distance representing the intended length SL of individual sheets 300, and the features of the design pattern through its cycle are continuous across a plurality of the sheets 300.
  • SL is selected to be equal to or greater than pattern repeat length RL
  • features of the design will be substantially replicated on two consecutive sheets 300. This is illustrated by way of example in Fig. 3 A, where it can be seen that SL is greater than RL, and each of the depicted consecutive sheets 300 includes more than an entire cycle of the sine curve 200.
  • SL is selected to be less than pattern repeat length RL
  • the design features will not be substantially replicated on two consecutive sheets 300. This is illustrated by way of example in Fig. 3B, where it can be seen that SL is less than RL, and each of any pair of two consecutive sheets 300 bears a differing, less-than-entire-cycle portion of sine curve 200.
  • RL and SL In order to determine the number of sheets of length SL that will be present in a series of consecutive sheets before the pattern on a sheet is replicated by some succeeding sheet, relative the sheet separation lines 201, we first determine RL and SL. Next, we identify the lowest common factor (LCF) which, when multiplied by each of RL and SL, will yield the smallest possible integer in both multiplications.
  • the LCF is the number by which RL and SL may both be multiplied such that the ratio RL/SL may be expressed as a ratio of the smallest possible integers.
  • the integer resulting from the multiplication RL x LCF is the number of sheets N of length SL in a series that will be present in consecutive succession before the begins anew on the next successive sheet, relative the sheet separation lines 201.
  • the number of sheets N of length SL that will be present in succession in a series before the pattern is replicated on the next sheet following the series, relative sheet separation lines 201, is the product of RL and LCF, i.e.,
  • N RL x LCF.
  • series number N is the numerator in the ratio of smallest possible integers, 200/43, equal to 100/21.5.
  • the ratio of RL/SL is 2/1.
  • series number N 2.
  • the ratio of RL/SL is 3/2.
  • series number N 3.
  • the pattern as positioned on the sheets, relative the sheet separation lines 201 is replicated after a series of 3 sheets.
  • series number N be no less than a minimum, e.g., no less than 2, more preferably no less than 3, still more preferably no less than 4, and even more preferably no less than 5.
  • the ratio RL/SL as a ratio of two integers in which the numerator is 5 or a greater integer.
  • SL be equal to or less than RL/2, or more preferably equal to or less than RL/3, even more preferably equal or less than RL/4, or still more preferably equal to or less than RL/5.
  • This feature may be desired by itself, or may be desired in combination with a minimum number for N, as described in the preceding paragraph.
  • a design pattern as reflected by features of a roller or cylinder 101 or 102, and as those features 11 are imparted to a web material 10, can repeat in both the machine direction MD and the cross direction, and can have a repeat length RL and repeat width RW along those directions, respectively.
  • the arrangement of the design pattern as it changes along each direction again, can be schematically represented by sine curves 200. It can be appreciated that, depending upon the method of manufacture of the product, consecutive sheets 300 in a series may be cut and gathered into a supply according to their order along the machine direction or the cross direction.
  • sheets 300a, 300b, 300c, 300d, etc., appearing in succession along the machine direction may be cut or perforated along cross direction separation lines 201a, and gathered and collected into a supply with consecutive sheets presented according to the same order of succession (or the reverse thereof).
  • the pattern repeat length RL is less than or equal to 2 ⁇ .
  • sheets 300i, 300H, 300iii, 300iv, etc. appearing in succession along the cross direction may be cut or perforated along machine direction separation lines 201b, and may be gathered and collected into a supply with
  • pattern repeat length RL sheet length SL and series number N
  • RW pattern repeat width
  • sheet width SW sheet width SW
  • series number N along the cross direction
  • a roller 101 or cylinder 102 will have a fixed axial acting length along which it bears features adapted to impart features of the selected design pattern to the web material. Therefore, the pattern repeat width RW is, at most, less than or equal to that axial acting length.
  • Fig. 5 reflects a design pattern that has design elements that are discontinuous in both the machine direction and cross direction. It is formed by series of discrete, individually identifiable design elements separated by linear pathways of substantially unadorned space between them. These pathways are arranged in the machine and cross directions. Separation lines 201a, 201b may be arranged along these pathways. It may be appreciated that a web bearing such a pattern may, most preferably, be cut into sheets along separation lines located in these unadorned pathways as suggested in Fig. 5, to cause discrete design elements to be approximately centered and appear balanced and/or symmetrical on the sheets, and/or to avoid dividing the discrete design elements, compromising their aesthetic appeal and/or creating a haphazard appearance in the separated sheet products. In order to maintain the centered, symmetrical and/or balanced locations of the discrete design elements relative the separation lines, it may be necessary to implement a system and method for maintaining alignment of the pattern relative the separation lines.
  • a registration system may add complexity and cost to the manufacturing line.
  • a design pattern in combination with a repeat length in the machine or cross direction greater than sheet length or width which may further include any of the mathematical relationships described above, is that the pattern may be composed and arranged such that there are no apparently natural pathways for the locations of separation lines. Examples of such patterns on portions of web are depicted in Figs. 6A and 6B, shown with possible (but not necessarily preferred) locations of separation lines 201
  • a pattern may be configured to change in content and arrangement of particular design elements thereof, along one or both of machine direction MD and cross direction CD, and along its repeat length, such that consecutive individual sheets defined by separation lines 201 will have varying appearances, regardless of the particular locations of the separation lines.
  • the pattern may be configured such that there is no apparent natural line of demarcation between design elements (or groups or combinations of them) for a location of a separation line. Granting that individual perceptions may be subjective, the general result is that individual sheets are less likely to be perceived as having a haphazard appearance because of a perceived off-center, asymmetrical or unbalanced location of a design element relative the separation lines, regardless of where separation lines fall relative the pattern.
  • design element means any discrete visible feature comprising a deposit of ink, or any impression of a feature or image or portion thereof, that is imprinted on or embossed into the web.
  • embossing or bonding roller Where a design pattern is imparted to a web by use of an embossing or bonding roller, it may be desirable particularly that no such unadorned pathway exists along the cross direction.
  • the absence of such a corresponding pathway of depression between lands on the surface of an embossing roller may help reduce or eliminate periodic, abrupt changes in the forces imposed on the roller surface and transferred through the roller to its axle and/or bearing mechanism, thereby reducing equipment wear and/or the need for shock-absorbing equipment.
  • embossment is done via embossing or bonding roller, where it is desired for aesthetic design or other purposes that the pattern include such machine- or cross-direction unadorned pathways
  • another attribute that may be imparted to the pattern is to limit the width of such unadorned pathways so that they are not immediately noticeable and/or do not form apparent natural pathways for the location of separation lines.
  • the depicted design has an unadorned cross-direction pathway between the depicted
  • the pathway has a width APW, in which no portion of a design element is present. It is believed that limiting the width of such a pathway to 7 percent or less, more preferably 5 percent or less, of the dimension of the sheet measured between the separation lines that are parallel to the pathway (in the example depicted in Fig. 7, the ratio APW/SL, expressed as a percentage) is effective for avoiding the appearance of a natural pathway for the location of a separation line, i.e., a division between sequential sheets. Where the design is imparted to the web by use of an embossing roller, limiting the width of a cross-direction unadorned pathway may also serve to minimize equipment wear from periodic abrupt changes in embossing pressure, as described above.
  • lines AL form angles with the machine direction between 10 degrees and 80 degrees, more preferably between 20 degrees and 70 degrees, even more preferably between 30 degrees and 60 degrees, and most preferably between 40 degrees and 50 degrees, for example, 45 degrees.
  • a design pattern includes any realistic or fanciful image of all or a portion of a person, animal, anthropomorphic character or cartoon character, which image includes at least the head and/or face
  • another attribute that may be imparted to the pattern to avoid giving individual sheets a haphazard appearance is to limit the size of the image. It is believed that such an image is effectively limited in size when a rectangle drawn with its sides parallel to the machine and cross directions, and circumscribing the image in its congruous entirety, occupies no more than 10 percent of the area of the sheet as established by the separation lines.
  • the pattern depicted in Fig. 6 A includes fanciful images of a bird, a giraffe and an elephant, each of which includes a head and/or face.
  • the design pattern may be configured such that separation lines may be spaced and located partially or completely independently of the dimensions of the pattern, reducing or eliminate the need for use of a registration system or other system for maintaining alignment of the pattern relative the separation lines.
  • a system for manufacturing pluralities of consecutive sheets bearing successively varying arrangements of design features comprising: a pattern imparting roller having a radius r, a rotation axis, an outer circumference 2nr, and a substantially cylindrical acting surface reflecting features of a design pattern thereon, a machine direction tangent to the acting surface and perpendicular to the rotation axis, and a cross direction parallel to the rotation axis, the acting surface having an axial acting surface length AL measured along the cross direction, the design pattern having a machine direction repeat length RLM; and a separating mechanism disposed downstream of the pattern imparting roller, configured to effect repeated and spaced complete cutting, or repeated and spaced partial cutting, perforating or scoring along separation lines, between portions of a material web, the separation lines being spaced apart on the web by sheet length SL measured along the machine direction, wherein SL is less than RLM; and wherein the design pattern has one or more of the following attributes: the design pattern has no linear, continuous unadorned pathway along the cross direction that has a pathway width greater than 7
  • a system for manufacturing pluralities of consecutive sheets bearing successively varying arrangements of design features comprising: a pattern imparting roller having a radius r, a rotation axis, an outer circumference 2nr, a substantially cylindrical acting surface reflecting features of a design pattern thereon, a machine direction tangent to the acting surface and perpendicular to the rotation axis, and a cross direction parallel to the rotation axis, the acting surface having an axial acting surface length AL measured along the cross direction, the design pattern having a cross direction repeat length RLC; and a separating mechanism disposed downstream of the pattern imparting roller, configured to effect spaced complete cutting, or spaced partial cutting, perforating or scoring, along separation lines, between portions of a material web, the separation lines being spaced apart on the web by sheet length SL measured along the cross direction, wherein SL is less than RLC; and wherein the design pattern has one or more of the following attributes: the design pattern has no linear, continuous unadorned pathway along the machine direction that has a pathway width greater than 7 percent of SL

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)

Abstract

L'invention concerne un système pour la fabrication de pluralités de feuilles consécutives portant successivement des agencements variables de caractéristiques de dessin. Le système comprend un rouleau communiquant un motif (100, 102) possédant une surface d'action sensiblement cylindrique reflétant les caractéristiques d'un motif de dessin sur celui-ci, le motif de dessin possédant une longueur de répétition dans la direction de la machine ; et un mécanisme de séparation disposé en aval du rouleau communiquant un motif, conçu pour effectuer une découpe, une perforation ou une entaille répétée et espacée le long des lignes de séparation, entre des parties d'une bande de matériau, les lignes de séparation étant espacées sur la bande par la longueur de feuille mesurée le long de la direction de la machine. La longueur de feuille est inférieure à la longueur de répétition du motif de dessin.
PCT/US2014/044208 2013-06-27 2014-06-26 Système pour produire des produits en feuilles portant des dessins qui varient parmi les feuilles successives Ceased WO2014210233A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14742063.2A EP3013574A1 (fr) 2013-06-27 2014-06-26 Système pour produire des produits en feuilles portant des dessins qui varient parmi les feuilles successives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/928,533 US20150000854A1 (en) 2013-06-27 2013-06-27 Sheet products bearing designs that vary among successive sheets, and apparatus and methods for producing the same
US13/928,533 2013-06-27

Publications (1)

Publication Number Publication Date
WO2014210233A1 true WO2014210233A1 (fr) 2014-12-31

Family

ID=51213000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/044208 Ceased WO2014210233A1 (fr) 2013-06-27 2014-06-26 Système pour produire des produits en feuilles portant des dessins qui varient parmi les feuilles successives

Country Status (3)

Country Link
US (1) US20150000854A1 (fr)
EP (1) EP3013574A1 (fr)
WO (1) WO2014210233A1 (fr)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020047002A1 (fr) 2018-08-28 2020-03-05 10X Genomics, Inc. Procédé de marquage spatial induit par transposase et d'analyse d'adn génomique dans un échantillon biologique
WO2020047005A1 (fr) 2018-08-28 2020-03-05 10X Genomics, Inc. Résolution de réseaux spatiaux
WO2020123320A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Matériel de système d'imagerie
WO2020176788A1 (fr) 2019-02-28 2020-09-03 10X Genomics, Inc. Profilage d'analytes biologiques avec des réseaux d'oligonucléotides à codes-barres spatiaux
WO2020190509A1 (fr) 2019-03-15 2020-09-24 10X Genomics, Inc. Méthodes d'utilisation de matrices spatiales pour le séquençage d'organismes unicellulaires
WO2020198071A1 (fr) 2019-03-22 2020-10-01 10X Genomics, Inc. Analyse spatiale tridimensionnelle
WO2020243579A1 (fr) 2019-05-30 2020-12-03 10X Genomics, Inc. Procédés de détection de l'hétérogénéité spatiale d'un échantillon biologique
WO2021092433A2 (fr) 2019-11-08 2021-05-14 10X Genomics, Inc. Amélioration de la spécificité de la liaison d'un analyte
WO2021091611A1 (fr) 2019-11-08 2021-05-14 10X Genomics, Inc. Agents de capture d'analytes marqués spatialement pour le multiplexage d'analytes
WO2021097255A1 (fr) 2019-11-13 2021-05-20 10X Genomics, Inc. Génération de sondes de capture pour analyse spatiale
WO2021102005A1 (fr) 2019-11-22 2021-05-27 10X Genomics, Inc. Systèmes et procédés d'analyse spatiale d'analytes à l'aide d'un alignement de repères
WO2021102039A1 (fr) 2019-11-21 2021-05-27 10X Genomics, Inc, Analyse spatiale d'analytes
WO2021102003A1 (fr) 2019-11-18 2021-05-27 10X Genomics, Inc. Systèmes et procédés de classification de tissu
DE202020004663U1 (de) 2019-11-06 2021-06-23 10X Genomics, Inc. Hardware für bildgebende Systeme
US11162132B2 (en) 2015-04-10 2021-11-02 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
WO2022061152A2 (fr) 2020-09-18 2022-03-24 10X Genomics, Inc. Appareil de manipulation d'échantillon et procédés système de distribution de fluide
WO2022061150A2 (fr) 2020-09-18 2022-03-24 10X Geonomics, Inc. Appareil de manipulation d'échantillons et procédés d'enregistrement d'images
US11514575B2 (en) 2019-10-01 2022-11-29 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2023044071A1 (fr) 2021-09-17 2023-03-23 10X Genomics, Inc. Systèmes et procédés de recalage ou d'alignement d'images
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2023122033A1 (fr) 2021-12-20 2023-06-29 10X Genomics, Inc. Auto-test pour dispositif d'imagerie
WO2023172670A2 (fr) 2022-03-11 2023-09-14 10X Genomics, Inc. Appareil de manipulation d'échantillon et procédés système de distribution de fluide
WO2023229982A2 (fr) 2022-05-24 2023-11-30 10X Genomics, Inc. Confinement de structure poreuse pour suppression de convection
WO2024031068A1 (fr) 2022-08-05 2024-02-08 10X Genomics, Inc. Systèmes et procédés de quantification d'immunofluorescence
WO2024036191A1 (fr) 2022-08-10 2024-02-15 10X Genomics, Inc. Systèmes et procédés de colocalisation
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2024145224A1 (fr) 2022-12-29 2024-07-04 10X Genomics, Inc. Compositions, procédés et systèmes d'analyse spatiale à haute résolution
US12112833B2 (en) 2020-02-04 2024-10-08 10X Genomics, Inc. Systems and methods for index hopping filtering
US12128403B2 (en) 2020-06-10 2024-10-29 10X Genomics, Inc. Fluid delivery methods
US12168801B1 (en) 2020-07-02 2024-12-17 10X Genomics, Inc. Hybrid/capture probe designs for full-length cDNA
US12421558B2 (en) 2020-02-13 2025-09-23 10X Genomics, Inc. Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3019910T3 (en) 2012-10-17 2025-05-21 10X Genomics Sweden Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
CN118345148A (zh) 2013-06-25 2024-07-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
EP4081656A1 (fr) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions et méthodes d'utilisation d'échantillons biologiques fixés dans des dosages basés sur des compartiments
SG11202106899SA (en) 2019-12-23 2021-09-29 10X Genomics Inc Methods for spatial analysis using rna-templated ligation
WO2021142233A1 (fr) 2020-01-10 2021-07-15 10X Genomics, Inc. Procédés de détermination d'un emplacement d'un acide nucléique cible dans un échantillon biologique
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (fr) 2020-02-07 2021-08-12 10X Genomics, Inc. Évaluation quantitative et automatisée de la performance de perméabilisation pour la transcriptomique spatiale
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US12399123B1 (en) 2020-02-14 2025-08-26 10X Genomics, Inc. Spatial targeting of analytes
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
WO2021168278A1 (fr) 2020-02-20 2021-08-26 10X Genomics, Inc. Procédés pour combiner les synthèses d'adnc des premier et de deuxième brins pour l'analyse spatiale
EP4107282A1 (fr) 2020-02-21 2022-12-28 10X Genomics, Inc. Capture de cibles génétiques à l'aide d'une approche d'hybridation
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
ES3014967T3 (en) 2020-04-22 2025-04-28 10X Genomics Inc Methods for spatial analysis using targeted rna depletion
CN115803454A (zh) 2020-05-04 2023-03-14 10X基因组学有限公司 空间转录组学转移模式
CN116134308B (zh) 2020-05-19 2025-05-27 10X基因组学有限公司 电泳盒和仪器
EP4414459B1 (fr) 2020-05-22 2025-09-03 10X Genomics, Inc. Mesure spatio-temporelle simultanée de l'expression génique et de l'activité cellulaire
WO2021237056A1 (fr) 2020-05-22 2021-11-25 10X Genomics, Inc. Analyse d'intégrité d'arn dans un échantillon biologique
WO2021237087A1 (fr) 2020-05-22 2021-11-25 10X Genomics, Inc. Analyse spatiale pour détecter des variants de séquence
WO2021242834A1 (fr) 2020-05-26 2021-12-02 10X Genomics, Inc. Procédé de réinitialisation d'un réseau
WO2021247543A2 (fr) 2020-06-02 2021-12-09 10X Genomics, Inc. Procédés de banques d'acides nucléiques
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (fr) 2020-06-08 2021-12-16 10X Genomics, Inc. Méthodes de détermination de marge chirurgicale et méthodes d'utilisation associées
US20230279474A1 (en) 2020-06-10 2023-09-07 10X Genomics, Inc. Methods for spatial analysis using blocker oligonucleotides
US12435363B1 (en) 2020-06-10 2025-10-07 10X Genomics, Inc. Materials and methods for spatial transcriptomics
ES2999535T3 (en) 2020-06-10 2025-02-26 10X Genomics Inc Methods for determining a location of an analyte in a biological sample
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US20230287475A1 (en) 2020-07-31 2023-09-14 10X Genomics, Inc. De-crosslinking compounds and methods of use for spatial analysis
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
EP4530358A3 (fr) 2020-09-15 2025-06-18 10x Genomics, Inc. Procédés de libération d'une sonde de capture étendue à partir d'un substrat et leurs utilisations
AU2021345133A1 (en) 2020-09-16 2023-03-30 10X Genomics, Inc. Methods of determining the location of an analyte in a biological sample using a plurality of wells
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022081643A2 (fr) 2020-10-13 2022-04-21 10X Genomics, Inc. Compositions et procédés pour générer des molécules de liaison à un antigène recombinant à partir de cellules uniques
EP4214330A1 (fr) 2020-10-22 2023-07-26 10X Genomics, Inc. Procédés d'analyse spatiale utilisant l'amplification par cercle roulant
CN116829733A (zh) 2020-11-06 2023-09-29 10X基因组学有限公司 用于将分析物结合至捕获探针的组合物和方法
WO2022109181A1 (fr) 2020-11-18 2022-05-27 10X Genomics, Inc. Méthodes et compositions pour analyser une infiltration immunitaire dans un stroma cancéreux pour prédire un résultat clinique
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20240068017A1 (en) 2020-12-30 2024-02-29 10X Genomics, Inc. Methods for analyte capture determination
US20240076723A1 (en) 2020-12-30 2024-03-07 10X Genomics, Inc. Cleavage of capture probes for spatial analysis
US12398262B1 (en) 2021-01-22 2025-08-26 10X Genomics, Inc. Triblock copolymer-based cell stabilization and fixation system and methods of use thereof
EP4284942B1 (fr) 2021-01-29 2024-08-14 10X Genomics, Inc. Procédé de marquage spatial induit par transposase et d'analyse d'adn génomique dans un échantillon biologique
WO2022198068A1 (fr) 2021-03-18 2022-09-22 10X Genomics, Inc. Capture multiplex de gène et expression de protéines à partir d'un échantillon biologique
AU2022256031A1 (en) 2021-04-05 2023-10-12 10X Genomics, Inc. Recombinant ligase composition and uses thereof
EP4428246B1 (fr) 2021-04-14 2025-12-24 10X Genomics, Inc. Procédés de mesure de la localisation erronée d'un analyte
US20240218432A1 (en) 2021-04-20 2024-07-04 10X Genomics, Inc. Methods for assessing sample quality prior to spatial analysis using templated ligation
EP4320271B1 (fr) 2021-05-06 2025-03-19 10X Genomics, Inc. Procédés pour augmenter la résolution d'une analyse spatiale
WO2022256503A1 (fr) 2021-06-03 2022-12-08 10X Genomics, Inc. Procédés, compositions, kits et systèmes pour améliorer la capture d'analytes pour une analyse spatiale
US20240368711A1 (en) 2021-06-22 2024-11-07 10X Genomics, Inc. Spatial detection of sars-cov-2 using templated ligation
EP4352252B1 (fr) 2021-07-13 2026-01-28 10X Genomics, Inc. Procédés d'analyse spatiale utilisant un silençage de sonde ciblée
WO2023018799A1 (fr) 2021-08-12 2023-02-16 10X Genomics, Inc. Procédés, compositions et systèmes pour identifier des molécules de liaison à l'antigène
ES3011462T3 (en) 2021-09-01 2025-04-07 10X Genomics Inc Methods for blocking a capture probe on a spatial array
WO2023076345A1 (fr) 2021-10-26 2023-05-04 10X Genomics, Inc. Procédés d'analyse spatiale utilisant la capture ciblée d'arn
WO2023086824A1 (fr) 2021-11-10 2023-05-19 10X Genomics, Inc. Procédés d'identification de molécules de liaison à l'antigène
US20230167495A1 (en) 2021-11-30 2023-06-01 10X Genomics, Inc. Systems and methods for identifying regions of aneuploidy in a tissue
EP4305195A2 (fr) 2021-12-01 2024-01-17 10X Genomics, Inc. Procédés, compositions et systèmes pour la détection améliorée d'analytes in situ et analyse spatiale
EP4479933A1 (fr) 2022-02-15 2024-12-25 10x Genomics, Inc. Systèmes et procédés d'analyse spatiale d'analytes à l'aide d'un alignement de repères
WO2024015578A1 (fr) 2022-07-15 2024-01-18 10X Genomics, Inc. Procédés pour déterminer l'emplacement d'un acide nucléique cible dans un échantillon biologique
EP4577670A1 (fr) 2022-08-24 2025-07-02 10X Genomics, Inc. Compositions et procédés de cartographie d'épitopes antigéniques dans des échantillons biologiques
WO2024081212A1 (fr) 2022-10-10 2024-04-18 10X Genomics, Inc. Transcription in vitro d'acides nucléiques capturés spatialement
WO2024086167A2 (fr) 2022-10-17 2024-04-25 10X Genomics, Inc. Procédés, compositions et kits pour déterminer l'emplacement d'un analyte dans un échantillon biologique
EP4500178A1 (fr) 2023-05-15 2025-02-05 10x Genomics, Inc. Normalisation de données d'anticorps spatial

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070238383A1 (en) 2006-04-06 2007-10-11 The Procter & Gamble Company One-dimensional continuous molded element
US20080199660A1 (en) * 2005-03-01 2008-08-21 Fabio Perini S.P.A. Embossing Roller, Embossing Device Including Said Roller and Paper Article Produced With Said Embossing Device
WO2008107845A2 (fr) 2007-03-05 2008-09-12 The Procter & Gamble Company Produits papetiers en rouleau profondément gaufrés à espacement réduit sur les bords sens machine
EP1970193A2 (fr) * 2007-03-09 2008-09-17 Fabio Perini S.p.A. Matériau en feuille gaufré, unité de gaufrage et procédé de fabrication

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348131B1 (en) * 1999-11-12 2002-02-19 Fort James Corporation Multi-ply embossed absorbent paper products
US7842163B2 (en) * 2005-12-15 2010-11-30 Kimberly-Clark Worldwide, Inc. Embossed tissue products

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080199660A1 (en) * 2005-03-01 2008-08-21 Fabio Perini S.P.A. Embossing Roller, Embossing Device Including Said Roller and Paper Article Produced With Said Embossing Device
US20070238383A1 (en) 2006-04-06 2007-10-11 The Procter & Gamble Company One-dimensional continuous molded element
WO2008107845A2 (fr) 2007-03-05 2008-09-12 The Procter & Gamble Company Produits papetiers en rouleau profondément gaufrés à espacement réduit sur les bords sens machine
EP1970193A2 (fr) * 2007-03-09 2008-09-17 Fabio Perini S.p.A. Matériau en feuille gaufré, unité de gaufrage et procédé de fabrication

Cited By (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11739372B2 (en) 2015-04-10 2023-08-29 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11162132B2 (en) 2015-04-10 2021-11-02 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11299774B2 (en) 2015-04-10 2022-04-12 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11390912B2 (en) 2015-04-10 2022-07-19 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11613773B2 (en) 2015-04-10 2023-03-28 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
WO2020047004A2 (fr) 2018-08-28 2020-03-05 10X Genomics, Inc. Procédés permettant de générer un réseau
WO2020047010A2 (fr) 2018-08-28 2020-03-05 10X Genomics, Inc. Augmentation de la résolution d'un réseau spatial
US12270077B2 (en) 2018-08-28 2025-04-08 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US12344892B2 (en) 2018-08-28 2025-07-01 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020047002A1 (fr) 2018-08-28 2020-03-05 10X Genomics, Inc. Procédé de marquage spatial induit par transposase et d'analyse d'adn génomique dans un échantillon biologique
WO2020047005A1 (fr) 2018-08-28 2020-03-05 10X Genomics, Inc. Résolution de réseaux spatiaux
US12378607B2 (en) 2018-08-28 2025-08-05 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020047007A2 (fr) 2018-08-28 2020-03-05 10X Genomics, Inc. Procédés de génération de matrices à codes-barres spatiaux
EP4603594A2 (fr) 2018-08-28 2025-08-20 10x Genomics, Inc. Augmentation de la résolution d'un réseau spatial
US12404544B2 (en) 2018-12-10 2025-09-02 10X Genomics, Inc. Methods of capturing multiple analytes on a spatial array
US12180543B2 (en) 2018-12-10 2024-12-31 10X Genomics, Inc. Imaging system hardware
US11933957B1 (en) 2018-12-10 2024-03-19 10X Genomics, Inc. Imaging system hardware
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
US12024741B2 (en) 2018-12-10 2024-07-02 10X Genomics, Inc. Imaging system hardware
US12497654B2 (en) 2018-12-10 2025-12-16 10X Genomics, Inc. Resolving spatial arrays by proximity-based deconvolution
WO2020123320A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Matériel de système d'imagerie
WO2020123309A1 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Résolution de réseaux spatiaux par déconvolution basée sur la proximité
WO2020123311A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Résolution de réseaux spatiaux à l'aide d'une déconvolution
EP4567127A2 (fr) 2018-12-10 2025-06-11 10x Genomics, Inc. Procédés de détermination d'un emplacement d'un analyte biologique dans un échantillon biologique
WO2020123318A1 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Résolution de réseaux spatiaux à l'aide d'une déconvolution
US12385083B2 (en) 2018-12-10 2025-08-12 10X Genomics, Inc. Methods of using master / copy arrays for spatial detection
WO2020123317A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc Analyse spatiale tridimensionnelle
WO2020123301A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Génération de réseaux spatiaux avec des gradients
WO2020123319A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Procédés d'utilisation de réseaux maître/copie pour la détection spatiale
WO2020123316A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Procédés de détermination d'un emplacement d'un analyte biologique dans un échantillon biologique
WO2020123305A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Génération de sondes de capture pour analyse spatiale
US11753675B2 (en) 2019-01-06 2023-09-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020176788A1 (fr) 2019-02-28 2020-09-03 10X Genomics, Inc. Profilage d'analytes biologiques avec des réseaux d'oligonucléotides à codes-barres spatiaux
WO2020190509A1 (fr) 2019-03-15 2020-09-24 10X Genomics, Inc. Méthodes d'utilisation de matrices spatiales pour le séquençage d'organismes unicellulaires
WO2020198071A1 (fr) 2019-03-22 2020-10-01 10X Genomics, Inc. Analyse spatiale tridimensionnelle
US12442045B2 (en) 2019-05-30 2025-10-14 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
US11965213B2 (en) 2019-05-30 2024-04-23 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020243579A1 (fr) 2019-05-30 2020-12-03 10X Genomics, Inc. Procédés de détection de l'hétérogénéité spatiale d'un échantillon biologique
US11514575B2 (en) 2019-10-01 2022-11-29 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
US12125260B2 (en) 2019-10-01 2024-10-22 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
US12157124B2 (en) 2019-11-06 2024-12-03 10X Genomics, Inc. Imaging system hardware
DE202020004663U1 (de) 2019-11-06 2021-06-23 10X Genomics, Inc. Hardware für bildgebende Systeme
WO2021091611A1 (fr) 2019-11-08 2021-05-14 10X Genomics, Inc. Agents de capture d'analytes marqués spatialement pour le multiplexage d'analytes
WO2021092433A2 (fr) 2019-11-08 2021-05-14 10X Genomics, Inc. Amélioration de la spécificité de la liaison d'un analyte
US11592447B2 (en) 2019-11-08 2023-02-28 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
US11808769B2 (en) 2019-11-08 2023-11-07 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
WO2021097255A1 (fr) 2019-11-13 2021-05-20 10X Genomics, Inc. Génération de sondes de capture pour analyse spatiale
EP4589016A2 (fr) 2019-11-13 2025-07-23 10x Genomics, Inc. Génération de sondes de capture pour analyse spatiale
US12154266B2 (en) 2019-11-18 2024-11-26 10X Genomics, Inc. Systems and methods for binary tissue classification
WO2021102003A1 (fr) 2019-11-18 2021-05-27 10X Genomics, Inc. Systèmes et procédés de classification de tissu
WO2021102039A1 (fr) 2019-11-21 2021-05-27 10X Genomics, Inc, Analyse spatiale d'analytes
EP4538971A2 (fr) 2019-11-21 2025-04-16 10x Genomics, Inc. Analyse spatiale d'analytes
EP4435718A2 (fr) 2019-11-22 2024-09-25 10X Genomics, Inc. Systèmes et procédés d'analyse spatiale d'analytes à l'aide d'un alignement de repères
US11501440B2 (en) 2019-11-22 2022-11-15 10X Genomics, Inc. Systems and methods for spatial analysis of analytes using fiducial alignment
WO2021102005A1 (fr) 2019-11-22 2021-05-27 10X Genomics, Inc. Systèmes et procédés d'analyse spatiale d'analytes à l'aide d'un alignement de repères
US12229974B2 (en) 2019-11-22 2025-02-18 10X Genomics, Inc. Systems and methods for spatial analysis of analytes using fiducial alignment
US12112833B2 (en) 2020-02-04 2024-10-08 10X Genomics, Inc. Systems and methods for index hopping filtering
US12421558B2 (en) 2020-02-13 2025-09-23 10X Genomics, Inc. Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
US12128403B2 (en) 2020-06-10 2024-10-29 10X Genomics, Inc. Fluid delivery methods
US12508590B2 (en) 2020-06-10 2025-12-30 10X Genomics, Inc. Fluid delivery methods
US12168801B1 (en) 2020-07-02 2024-12-17 10X Genomics, Inc. Hybrid/capture probe designs for full-length cDNA
WO2022061152A2 (fr) 2020-09-18 2022-03-24 10X Genomics, Inc. Appareil de manipulation d'échantillon et procédés système de distribution de fluide
EP4491742A2 (fr) 2020-09-18 2025-01-15 10x Genomics, Inc. Appareil de manipulation d'échantillons et procédés d'enregistrement d'images
WO2022061150A2 (fr) 2020-09-18 2022-03-24 10X Geonomics, Inc. Appareil de manipulation d'échantillons et procédés d'enregistrement d'images
US12249085B2 (en) 2020-09-18 2025-03-11 10X Genomics, Inc. Sample handling apparatus and image registration methods
WO2023044071A1 (fr) 2021-09-17 2023-03-23 10X Genomics, Inc. Systèmes et procédés de recalage ou d'alignement d'images
WO2023122033A1 (fr) 2021-12-20 2023-06-29 10X Genomics, Inc. Auto-test pour dispositif d'imagerie
US12223751B2 (en) 2021-12-20 2025-02-11 10X Genomics, Inc. Self-test for imaging device
WO2023172670A2 (fr) 2022-03-11 2023-09-14 10X Genomics, Inc. Appareil de manipulation d'échantillon et procédés système de distribution de fluide
WO2023229982A2 (fr) 2022-05-24 2023-11-30 10X Genomics, Inc. Confinement de structure poreuse pour suppression de convection
WO2024031068A1 (fr) 2022-08-05 2024-02-08 10X Genomics, Inc. Systèmes et procédés de quantification d'immunofluorescence
WO2024036191A1 (fr) 2022-08-10 2024-02-15 10X Genomics, Inc. Systèmes et procédés de colocalisation
WO2024145224A1 (fr) 2022-12-29 2024-07-04 10X Genomics, Inc. Compositions, procédés et systèmes d'analyse spatiale à haute résolution

Also Published As

Publication number Publication date
EP3013574A1 (fr) 2016-05-04
US20150000854A1 (en) 2015-01-01

Similar Documents

Publication Publication Date Title
US20150000854A1 (en) Sheet products bearing designs that vary among successive sheets, and apparatus and methods for producing the same
RU2514502C2 (ru) Волокнистый продукт, тиснильный вал для изготовления такого волокнистого продукта, устройство и способ изготовления такого волокнистого продукта
KR102540278B1 (ko) 패턴이 있는 티슈 제품
US8389092B2 (en) Stack of folded material
EP1855876B2 (fr) Rouleau de gaufrage, dispositif de gaufrage comprenant ledit rouleau
RU2520911C2 (ru) Волокнистый продукт, способ его изготовления и устройство для изготовления такого волокнистого продукта
US3326365A (en) Napkins or similar articles and method of manufacturing same
MX2011005774A (es) Producto fibroso con un relieve entramado y metodo para producir el mismo.
JP2010535111A (ja) エンボス加工装置
US20150001783A1 (en) Sheet products bearing designs that vary among successive sheets, and apparatus and methods for producing the same
EP2999820A1 (fr) Procédé de production d'un produit de papier absorbant comportant des éléments visuels
AU2015270114A1 (en) Process and apparatus for embossing tissue plies
RU2484968C2 (ru) Тиснильный валик для изготовления волокнистых изделий с растровым тиснением, устройство, использующее подобный тиснильный валик, и выполнение тиснильных выступов на подобном тиснильном валике
WO2014190105A1 (fr) Produit de papier absorbant comportant des éléments visuels
EP3154775B1 (fr) Produit en papier mousseline gaufré multicouche
CN215882785U (zh) 一种新型卫生卷纸压花复合机构

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14742063

Country of ref document: EP

Kind code of ref document: A1

REEP Request for entry into the european phase

Ref document number: 2014742063

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2014742063

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE