WO2014198563A1 - Laboratory system and method for acting on a living being, observing a living being and/or caring for a living being - Google Patents

Abstract

The present invention relates to a laboratory system and method for acting on a living being or observing a living being. The laboratory system (10) according to the invention comprises a working chamber (100) for acting upon living beings (500), observing living beings (500) and/or caring for living beings (500), particularly an animal, under controlled environmental parameters such as temperature, air humidity and composition of fresh air. The working chamber (100) has a working opening (120) and at least one flow device for realizing one or more substantially laminar gas flows (130) in the working chamber (100). Said laboratory system (10) also comprises a container system (300) having a plurality of containers (400) for receiving a respective living being (500). According to the invention, an access (800) is arranged between the working chamber (100) and the container system (300), and the working chamber (100) and the container system (300) are arranged relative to one another in such a manner that at least one container (400) can be transported from the container system (300) into the working chamber (100) through the access (800).

Description

 Laboratory system and method for acting on a living being, observation of a living being and / or care of a living being

The present invention relates to a laboratory system and to a method for acting on a living being, observing a living being and / or supplying a living being, in particular an animal, under controlled environmental parameters, such as e.g. Temperature, humidity and fresh air composition.

 Special laboratory facilities are usually used to carry out experiments on living beings or for the treatment of living organisms. These laboratory devices and the devices used therein are usually adapted to the size and nature of the animals to be treated or to be examined, as well as any dangers that may occur, such as, for example, the release of viruses. Likewise, certain environmental conditions such as temperature and relative humidity must be maintained. Since the escaping air is loaded with certain harmful substances (C02, ammonia, odors and / or infectious agents) it must be replaced to 100%.

For the purpose of manipulation of living beings, a delimited work area is usually used, which is flowed through by at least one gas flow in order to prevent the entry or exit of hazardous substances. Usually, air is used as the gas stream. Such a device is also referred to as "laminar box" or "laminar flow box". Such devices often include a high efficiency particulate air filter (HEPA filter) for filtering the gas withdrawn from the work area and feeding the filtered gas back into the work area. The advantage of this embodiment is, in particular, that examination objects stored in the working area, such as cell cultures or microbial media, are substantially fluidically separated from the environment by the gas flow, since the gas flow from the particle air filter flows onto the examination objects and on the ground of the local flow pressure, a flow of the examination objects from the environment is prevented. Laboratory facilities that do not realize gas flows in the work area have a correspondingly higher risk of contaminating the test objects by ambient air flowing into the work area.

 A disadvantage of these devices is that withdrawn from the work area gas or gas mixture, which does not pass through the particulate filter, is discharged to the environment, so that can not be ruled out in the air transferable germs or chemicals are discharged into the environment. In addition, such a gas outlet also gives rise to the risk that pollutants from the environment may penetrate into the working area and / or damage the operating personnel. Furthermore, it is problematic that gases are often discharged into the environment via the particulate filter, but small molecules, solvents and the like are not filtered by the particulate filter.

In the field of laboratory equipment storage or storage systems are also known with which arranged in extra containers living beings can be arranged and stored relatively space-saving and clear. Such a storage system usually comprises a housing in which a plurality of containers are arranged with living beings placed therein. The housing is closed substantially gas-tight, so that coupled to an air conditioner Luftbzw. Gas supply can flow through the entire housing and thereby can flow into the container provided with corresponding openings and can flow out of these again. Such a container system typically includes at least one access opening laterally for facilitating the transport of a container from the container system and into the container system. In order to prevent hazardous substances from escaping from the containers during transport of the containers from the container system or into the container system, this transport is usually to be carried out in a separate protective space, the ventilation of which is realized by means of a particle filter. This prevents the organisms in the containers of pathogens can be attacked outside of the room or can be achieved by pollutants from the environment. Air conditioning of the shelter as well as of the tank system ensures the maintenance of a certain temperature and a certain humidity in an entire outdoor space in which the plants are located. Due to the flushing of the container system by the gas supply reliably exhaust gases such as ammonia and C0 _{2 are} removed. A disadvantage of these container systems However, the relatively high energy costs to maintain the desired temperature and humidity in the entire outdoor area. Due to the flushing of the container with substantially the same gas flow can not prevent transmission of diseases between living things. In addition, there is an increased need for personnel to clean the container, the container system and the shelter and to maintain or control the necessary functions of the technical units. Likewise, there is an increased personal or mechanical effort to transport the container from the container system and the shelter in a workspace. The latter disadvantages can also occur in container systems in which the individual containers are each provided with a gas supply and with a gas discharge.

 The containers commonly used in the container system are often relatively stable boxes with an insert, which is efficient and inexpensive to use or can be cleaned and sterilized. The containers are designed such that the use of particulate filters with low aids can be realized.

 A disadvantage of the usual containers is their relative inflexibility in terms of receiving different sized living beings and their material and manufacturing costs. In addition, they are relatively heavy, have a short life and can be converted to gas flow only with relatively high effort.

 It will be appreciated that conventional laboratory equipment requires relatively many safety measures such as filters, exhaust and air conditioning and gas flow systems to store, transport, and inspect or observe the animals under optimal circumstances. These systems are also dimensioned for the rooms in which they are used, which requires the use of very high-performance and costly systems and is expensive to install and maintain.

From the German utility model DE 840 8469 U1 a test cabinet with integrated suction and branching of the extracted air flow and appropriate filtering is known. Document DE 100 262 08 C1 discloses an IVC cage shelf system with a plurality of cages for test animals supplied with sterile air. Here in each cage is associated with an extra air supply and air discharge.

 U.S. Patent 3,122,127 discloses a vessel for smaller animals such as mice. This vessel comprises a separable insert, which is so inexpensive to produce that it can be disposed of after a single use.

 U.S. Patent 5,220,882A discloses a therapy chamber that is mobile-handleable and has ventilation in the door closing that chamber.

The disclosure of the intellectual property rights mentioned here is hereby included in the description of the invention.

 The present invention is based on the object to provide a laboratory system and a method impact on living things, observation and / or care of living beings with which in more efficient, space-saving and cost-effective and safe for living beings and the environment studies or Observations, supplies or even treatments of living things under laboratory conditions is made possible.

 This object is achieved by the laboratory system according to the invention according to claim 1 and by the method according to the invention for acting on a living being and / or observation of a living being according to claim 16. Advantageous embodiments of the laboratory system according to the invention are specified in the subclaims 2 to 15.

The laboratory system according to the invention comprises a working space for acting on living beings, for observing living beings, and / or care of living beings, in particular an animal under controlled environmental parameters such as temperature, humidity and fresh air composition, wherein the working space a work opening and at least one flow device for realization having one or more substantially laminar gas flows in the working space. Furthermore, the laboratory system comprises a container system with a plurality of containers for holding a living being. According to the invention, an access is arranged between the working space and the container system, and the working space and the container system are arranged relative to one another in such a way that at least one container is opened by access from the container system to the working space. Spaces can be transported. The access is thus formed in the working space housing or realized by an opening in the working space bounding the inner wall. This means that the working opening and the access each represent extra openings, wherein the working opening is preferably arranged at the front of the working space and the access is arranged laterally on the working space. According to the invention thus the working space is combined with a container system, so that in a simple way from the working space a container from the container system in the working space is preferably manually transportable, the living being in the container in the working room is treatable or observable or the living being in the working space of the Container can be taken and treated or observed in the working area of the working space and then back with the container through the access in the container system is transported back. The working opening is accordingly arranged on the working space in such a way that an operator is enabled in a simple manner to manually treat the container or living beings positioned in the working area of the working space. It should not be ruled out that the transport of the container from the container system into the working space and vice versa is automated.

 The supply can also include an air conditioning supply, that is, the living beings are supplied with fresh air of certain temperature and humidity.

 The work opening can be realized by a glove box, a so-called "glove box".

 The flow device preferably serves to realize one or more substantially laminar gas flows and is preferably a centrifugal blower.

The advantage of the invention resides in the fact that the containers stored in the container system with the living beings can be reached from the working space and can be transported from the container system into the working area without bridging an intermediate space, so that there is no risk of contamination or pathogens of the living beings and of the living organisms Environment of the working space and the container system consists. Since the containers from the container system can be transported in a simple manner manually or with little effort automated into the workspace, they can be just as easy to open manually or automatically in the workspace of the workspace and the living being can out of the container. be taken. For the purpose of fluidic isolation of the working area of the working space is preferably provided that gas flows are realized in the working space, which prevent exposure of living beings with gases contained in the environment.

It is preferably provided that the containers in the container system each have their own gas supply device and their own gas discharge device. It is advisable that the container system comprises a shelf in which the containers are arranged in tiers or can be arranged, wherein each floor or each container space is associated with a gas supply and a Gasabfuhrein- direction.

 For essentially gas-tight separation of the containers from the environment, the container system should also comprise a container system housing, which is essentially and preferably completely gastight. The present invention realized between the container system and the work space access is thus formed in this embodiment in the container system housing. Preferably, the housing of the container system is at least partially transparent, for better recognition of the occupancy of the individual container positions with containers and / or for the observation of the recorded in the containers living beings. Consequently, the container system housing is made gas-tight substantially up to any supply and discharge devices arranged to generate a gas volume flow in the housing along the container.

In a particularly volume- and material-saving embodiment, it is provided that the working space has a working space housing, wherein a part of the working space housing is formed by a region of the container system housing. That is, in this embodiment, an outer wall of the container system housing at least partially forms the inner wall of the working space. The working space preferably has a volume of 0.5 m ³ to 3.0 m ³ .

The working room protects living beings recorded on the work table, such as cell cultures and media of microbiology, or even forensic examination objects from environmental influences. However, the working space also works in the opposite direction, so that the environment is also protected from pathogens released from the examination objects. In addition, the objects to be examined are protected from chemicals which they may secrete themselves or which are used elsewhere in the work space, such as for example volatile substances, test substances, formaldehydes and alcohols, which are preferably extracted under the laminar flow.

 In particular, in one embodiment of the laboratory system, in which a certain volume of gas flow per unit time leaves the working space, it is provided that the working space comprises a working area and an inflow area, via which from the environment of the working space gas or gas mixture can be flowed into the working space. Preferably, the gas flows from the environment through the inflow first under the working area and from there deflected by the working space.

The work area is arranged in the working space such that manual activities of a person located in front of the working space in the work area can be carried out in a simple and ergonomic manner.

 Advantageously, the laboratory system according to the invention further comprises a deflection device for generating a steered gas flow through the working area, below the working area, from there laterally past the working area to a height above the working area, through a suspended matter filter and from there back down to the working area , This deflection device can be realized in particular by simple geometric configurations of the inside of the working space. The used Schwebstofffil- ter may be in particular a so-called HEPA filter (High Efficiency Particulate Air Filter), that is, a filter for filtering out viruses, respirable dusts, mite eggs and excretions, pollen, smoke particles, asbestos, bacteria, various toxic dusts and Aerosols from the air.

 Furthermore, in the laboratory system according to the invention in its working space, a branching device is preferred for branching the flow path of the gas volume flow below the working area for the purpose of discharging a partial gas volume through a second filter into the surrounding space surrounding the laboratory system and / or into the atmosphere. Furthermore, the laboratory system comprises a guide for guiding the gas volume flow coming from the second filter into the ambient space and / or into the atmosphere.

With the first branching device, part of the volume of the gas under the working area is directed out of the working space. With the guide is a part of the volume of gas from the work area, which is the second filter has flowed through into the environment of the working space, so that this gas can also get back into the work space, or even passed into the atmosphere, so that this gas can not get into the work space, since the working space of the atmosphere usually by a Laboratory building is separated. Preferably, the working space is set up in such a way that about 1/3 of the gas volume in the working space from this is let out via the branching device, and about 1/3 of the gas volume of the working space is admitted into the working space in the same time unit by the inflow area.

 The access between the container system and the working space should preferably be closable or closed by means of a sliding element. In the embodiment in which an area of the container system housing forms part of the inner wall of the working space, the sliding element is arranged on the housing of the container system. The advantage of the sliding element is that it is very flat executable and can still ensure a substantially gas-tight closure of the container system housing. Consequently, the sliding element does not protrude far into the working space or into the container system housing, so that laminar gas flow generated in the working space and / or in the container system housing is not disturbed by the sliding element, so that the formation of gas turbulence in the working space or in the container system housing is avoided - can become. Preferably, the thickness of the sliding element is less than 3 cm.

 The sliding element may be made of glass and / or be fixable by means of a magnetic fixing device in its closed and / or open position on or in the working space.

For ease of achieving and easy transport of each container is advantageously provided that each container or container position in the container system is associated with a sliding element which can close a respective access. This means that in an embodiment of the laboratory system in which the working space has its own housing, each sliding element in the container system housing is assigned an access opening in the housing of the working space. It should be possible to operate each of these sliding elements separately. This ensures that only between a respective container or its compartment on the shelf of the container system and the working space a connection is made, so that a corresponding risk of contamination of all containers in the container system and / or the working space is reduced or excluded.

 In a particular embodiment, it is provided that the container system comprises a plurality of subdivisions for receiving the container and the container system has a device for generating a gas volume flow along a container in each case a subdivision.

 In this embodiment too, the flat sliding element acts in such a way that the laminar gas flow along a respective container in the container system is not disturbed, so that unfavorable turbulence does not lead to unfavorable turbulences on the container even with movement of the sliding element and concomitant release of the access and / or comes in the workroom near the entrance. The subdivisions essentially correspond to shelves, wherein these can be closed by the container system housing substantially gas-tight, with the exception of the flow path for the gas flow along the respective container. The gas flow along a container constitutes an additional safety device which, when the access is open, prevents substances from entering the working space from the container system and vice versa.

In this embodiment, at least one container in the container system may have a flow inlet for realizing a gas volume flow from a subdivision into the container. A gas discharge from the container preferably takes place via the provided gas discharge device. That is, in this embodiment, part of the gas stream introduced into the subdivision flows past the vessel and another part of the gas stream flows into and out of the vessel.

Each individual space in the container or its gas outlet can be exposed to a negative pressure. This makes it possible to keep in each individual space living beings, each with different health status, among other things, as from the subdivision and / or the gas supply constantly fresh air flows into the respective container.

The container may be provided with a lateral opening in order to be able to more easily check the condition of the living beings. Regardless of the type and position of the gas supply and the gas removal, the container should preferably have connector elements to the container in a simple and time-saving manner be able to connect with a gas-supplying line and with a gas-discharging line.

 In material and weight-saving design, the container system on support means, on each of which a container can be received, with the support means only the edge regions of a container are partially supported. Such, for example, for receiving trays known support means can be arranged in an increased number in the container system housing and thus increase the flexibility with respect to the position of a container in the container system.

However, it should not be ruled out the use of a support device which supports the bottom of the container.

 For improved optical observation of the living beings and / or for supplying the living beings with light, it is provided that the container system comprises at least one light source for illuminating the containers. Depending on requirements, it is also possible to assign each container or each container position in the container system its own light source.

 In addition, the container system according to the invention should have an air conditioner with which the temperature and / or the humidity of the gas or gas mixture to be supplied into the container can be adjusted. Thus, the climate and the humidities in the containers can be adjusted independently of the environmental conditions of the surrounding area. Due to the inventive design of the container system with each of the individual containers associated gas supply and gas discharge devices, the energy costs generated by the air conditioner are blatantly reduced, since according to the invention, only the relatively small volume of the individual containers is to be supplied with air-conditioned gas. In the embodiment in which a gas volume flow is generated in the container system housing along the container, this gas volume flow can also be conditioned.

 This means that the air flowing into the individual containers is conditioned.

This embodiment of the container system can also be realized without the working space. The air conditioner can be kept small in their performance due to the small volume of container to be supplied and be arranged directly on or in the container system housing. As a result, a gas flow, in particular an air flow, is guaranteed by each container, which is pathogen-free and which in each case has suitable temperature and relative humidity.

 It is preferably provided that the air-conditioning system has at least one Peltier element for generating air-conditioning refrigeration. This means that the air conditioning system can be equipped with a Peltier element for cooling and dehumidification, wherein the Peltier element generates electricity when flow of electric current and this cold cooling of one or more containers is provided via the gas supply ,

 The container system housing may be partially transparent or completely opaque configured so that it is completely darkened inside, with arranged lighting systems for specific lighting of each container are preferably provided.

The container system designed according to the invention protects the living beings placed in the container system from diseases as well as from environmental influences and / or from pathogens secreted by operators. Due to the constant influx of a gas or gas mixture, in particular clean, fresh air and its removal from the containers, gases which collect in the container, such as, for example, ammonia and CO _2, can also be efficiently removed from the containers. Preferably, a flushing of the container with the gas mixture takes place 15 times per hour. This means that no continuous flow through the container is provided, so that the air conditioner can be operated accordingly energy saving.

Preferably, each container system includes its own lighting control system so that the illumination duration and intensity of the illumination in each container system, and preferably for each subdivision or for each container, is individually controllable.

The combination of the advantages mentioned makes it possible to influence and / or store objects of observation and, in particular, living organisms under laboratory conditions, without having to monitor and control the temperature and / or the relative humidity as well as the lighting throughout the laboratory. The containers used should each comprise an upper part and a lower part, which are formed substantially the same in terms of their shape and size, wherein the upper part and the lower part are hinged together or connectable. Due to the same shape and size of the upper part and the lower part, these parts are inexpensive to produce. They are no longer limited to a particular orientation in their use, so they are more flexible than conventional, equipped with a flat lid container. The containers should be designed to be transparent, at least regionally, in order to be able to observe from outside the living being picked up therein. In a particularly preferred embodiment, the containers should be equipped as standard with food, padding material and a water supply, in particular with a water gel, and be delivered to the customer with this equipment. This blatantly reduces the effort in the laboratory to assemble the container and ensures that the living being in the container receives the necessary care.

 In particular, when the upper part is separated from the lower part, both parts can be used as shell-like containers independently of each other. In this case, each of these parts is assigned a cover, which the shell-like Oberbzw. Bottom part completes. The ventilation openings or water inlets can be arranged in the upper or lower part or in the cover.

 Due to the simple and inexpensive construction of the containers, they can be disposed of after a single use, without incurring cleaning and sterilization costs. The design of the container, in which the same shape and size has the same upper part and lower part, has the advantage that in such a container due to its relatively large height correspondingly large animals, such as rats and guinea pigs, can be recorded.

 The containers are preferably preferably completely gastight except for the gas removal and the gas supply.

The container system can therefore be tower-like, so that the containers are arranged one above the other and supported on documents which separate the respective subdivisions and are part of a shelf of a container system, or on the support means. At the top of such a container Systems, the air conditioning system should be arranged. Each subdivision of the container system should be assigned a light source. In container system housing each container or each subdivision is preferably associated with an opening which is closed or closable with a sliding element. This opening forms the access between the working space and the container system. Through the opening of the sliding element, the access between the container system and the working space is exposed, so that from the working space a container can be transported through the access from the container system in the working space and from there again through the access in the container system can be transported back.

The inventive design of the laboratory system, it is now possible all to be performed on the objects to be examined or living beings or on the containers operations, such as changing the container, feeding, impregnation, monitoring, performing tests and / or operations and autopsies in one To perform work under constant conditions, without risk during transport and in the storage of living things to risk that they are undesirably changed by penetrating into the container influences.

 To achieve the object, there is also provided a method for acting on a living being, observing and / or caring for a living being, in particular an animal, under controlled environmental parameters, e.g. Temperature, humidity and fresh air composition, is provided, wherein the living being is received in a container, the container is received in a container system of a laboratory system according to the invention, the living being in the container of a supply of gas, in particular air, exposed and the gas from the Is discharged again container, the container is separated from the gas supply and gas discharge and transported through the access into the work space, the container is received in the working area of the working space and the living being is acted upon in the work area and / or the living being is observed.

 This means that a preferred embodiment of the method according to the invention is one in which the living being is cared for and kept alive.

In particular, the method according to the invention may be one in which neither therapeutic nor surgical steps are performed on the subject or diagnoses of the condition or health or disease of the subject Living creature are created, especially if it involves procedures on the human or animal body. This means that the method according to the invention can be carried out in particular in the non-medical field. In particular, the method can also be applied to plants. Another application of the method is in in vitro gene therapy. In addition, the method can be used for administering performance-changing, such as performance-enhancing means, as well as for carrying out cosmetic experiments on the living beings. Further applications of the method consist in the embodiment as a measuring method, for example after administration of a drug as well as in the excorporeal treatment of the body's own substances. In addition, the method can be carried out on the animal body if the animal does not survive. Another field of application of the method lies in the non-invasive determination of chemical or physical states within the intact, animal body as well as for the genetic modification and for the treatment of microorganisms. Furthermore, the method according to the invention may be one which is used for therapeutic purposes when a device is used on the body of the animal and there is no functional connection between the measures taken on the device and the therapeutic effect exerted by the device on the body, for example only the living being in the working space body fluid is removed and / or This is examined. In the method according to the invention, the container is not necessarily open, but the treatment or the observation can also be made through the container wall, wherein the treatment may in particular comprise irradiation.

The invention will be explained below with reference to the embodiments illustrated in the accompanying drawings.

 It shows

 1 a separately shown work space,

 2 a container to be used preferably in the closed and in the opened state,

 3 shows a laboratory system according to the invention in a front view,

Fig. 4 shows a detail of a container system of the laboratory system according to the invention in front view. The laboratory system according to the invention is composed of the two modules working space and container system.

 For an explanation of the working space, reference is first made to FIG. The working space 100 is surrounded by a working space housing delimiting the working space from the environment. In the working space housing 1 10 a work opening 120 is provided, which is accessible, for example, by a lock 121. Through this lock 121 or through the working opening 120, an operator 20 can carry out manual operations in a working area 140 in the working space 100. In order to prevent contamination of the living beings in the work area, the working space 100 flows through gas flows 130, which are preferably laminar. These prevent any foreign substances entering the working space, such as dusts or germs, from entering the working area 140, if necessary, from the outside. The underside of the working area 140 is essentially delimited by a work table 150, on which containers 400 can be received. For the purpose of removing the gas flow 130 flowing onto the work table 150, the work table 150 has through openings 151. In the working space housing 1 10 one or more deflection devices 170 are present, which are created in a simple embodiment by a corresponding shape of the inner wall and / or through channels of the working space housing 1 10. The deflecting devices 170 are used to implement controlled gas flows 180, namely below the work table 150, into an edge region of the working chamber 100, flowing up there to the upper region of the working chamber 100, and from there through a suspended matter filter 190 again downwards in the direction of the working region 140 and the work table 150th

Contaminated gas or air used in the working space 100 can discharge from the working area 140, preferably only from the area forming the work table 150, via a branching device 200 through a second filter 210 into the surrounding space surrounding the working space 100 and / or into the atmosphere become. In the flow path to the second filter 210 may also be arranged a guide device 220, is passed via the gas flow rate in the atmosphere and / or in the environment of the working space, depending on how the directional control valve is adjusted.

This amount of gas is about 1/3 of the gas volume of the working space. The remaining 2/3 of the gas volume are as shown in Figure 1 on the Umlenkeinrich- tion 170 in the working space 100 only in the upper region of the working space and sent there again via the particulate filter 190 down in the direction of the work area. The volume flow is realized in a simple embodiment of the invention via one or more suction devices not shown here for reasons of clarity.

 The laboratory system according to the invention is not limited to the fact that the branching device and the guide are present, but the laboratory system may also have only the branching device 200, so that the withdrawn under the work table 150 volume flow enters the atmosphere or in the surrounding space; or the laboratory system does not include a branching device 200, so that the gas volume is circulated only in the working space 100, which embodiment is not suitable for laboratory conditions in which the organisms to be treated in the working space are exposed to the risk of contamination.

To avoid the formation of a negative pressure in the working space 100, the gas volume discharged from the second filter 210 has to be replaced by a gas flow 130 which is realized through an inflow region 160 in the vicinity of the working opening 120 or through the latter into the working space 100 However, this gas flow 130 should preferably be filtered before entering the working space 100.

A preferably to be used in the laboratory system according to the invention container 400 is shown in Figure 2 in the left view in the closed state and in the right view in the open state. Such a container comprises an upper part 450 and a lower part 460 which, in a preferred embodiment, are identical in terms of their shape and size. The upper part 450 is connected to the lower part 460 via a connecting region 470, this connecting region being articulated, so that the support 400 of the upper part 450 on the lower part 460 can close the container 400, as shown in the right-hand illustration. This embodiment has the advantage that the container can be placed on the upper side or on the lower side in the container system and in the working area, regardless of the position of its upper part and its lower part. The container 400 preferably comprises a ventilation opening 480 and a water inlet 490. The container 400 may already be fitted with a food 510 as standard Upholstery 520 and / or be equipped with a water gel 530. It is advisable to carry out the upper part 450 and / or the lower part 460 transparent.

 FIG. 3 shows a laboratory system 10 according to the invention assimilated from a working space and a container system. The laboratory system 10 comprises the modules working space 100 and two container systems 300, which are arranged on both sides of the working space 100. A container system in this case comprises a container system housing 320, which at least in sections, the inner wall of the working space housing 1 10 can form. The container system preferably has the structure of a shelf 310 inside, so that subdivisions 330 are formed, in which containers 400 can be received or received. It is apparent that each of the containers 400 in the container system 300 has its own gas supply device 410 as well as its own gas discharge device 420. The respective gas supply devices 410 are coupled via a central line to an air conditioning system 700, so that conditioned air or gas can be conducted into the containers 400. The gas discharge devices 420 are also connected to central lines in order to be able to discharge the discharged gas via a single strand of treatment or filtration or directly into the environment.

 Each container 400 is a light source 600 assigned to the optimal illumination of the container or the living therein 500. In the area between the container system housing 320 and the working space 100 and its working space housing 1 10, an access 800 is arranged, in the embodiment shown here with a sliding element 810 is closed.

For a detailed explanation of this sliding element 810 and its advantages, reference is made to FIG. It can be seen here that due to the flat design of the sliding element 810, a laminar flow 820 on the sliding element within the working space 100 is not disturbed, regardless of whether the sliding element 810 is in the open or closed position. This ensures that the laminar flow in the working space 100 is not disturbed even by a movement of the sliding element 810 into the open position for the purpose of opening the access 800, so that turbulences do not arise which would endanger the contamination of the living beings 500 and / or. or the environment. In the embodiment shown in Figure 4 it can be seen that in the container system 300 outside ßerdem still a gas flow 900 can be generated along a respective container which passes through a flow 331 in the respective subdivisions 330, flows through them and from a flow discharge 332 again from the Subdivision is let out. A portion of this gas flow 900, however, can be diverted after entry into the respective subdivision 330 and thus passes through flow inlets 430 in the respective container 400. This gas flow 440 can be derived by the provided gas discharge 420 again from the container, preferably also by a filter element - the. The flow feed 331 of a subdivision is preferably realized by a hollow profile fluidically coupled with this subdivision, this hollow profile simultaneously serving as a flow divider for an adjacent subdivision and being subdivided longitudinally into chambers which form channels for the flow feed 331 and the flow discharge 332.

It can be seen that, even though it should be arranged on the side of the container system housing 320 facing the respective container 400, the gas volume flow 900 along the container 400 is not disturbed by a flatly configured sliding element 810.

LIST OF REFERENCE NUMBERS

Laboratory system 10 Operator 20

Workroom 100

Working space housing 1 10

Work opening 120

Lock 121

Gas flow 130

Workspace 140

Work table 150

Passage opening 151

Inflow region 160

Bypass 170 directed gas flow 180

HEPA filter 190

Branching device 200 second filter 210

Guide 220

Container system 300

Shelf 310

Container system housing 320

Subdivision 330

Flow supply 331

Flow discharge 332 Container 400

Gas supply device 410

Gas discharge device 420 Flow inlet 430

Gas volume flow 440

Top part 450

Lower part 460

Connection area 470 Ventilation opening 480

Water inlet 490

Critters 500 Foods 510

Upholstery 520

Water gel 530

Light source 600 air conditioning 700

Access 800

Sliding element 810

Laminar flow on the sliding element 820

Gas flow along a container 900

Claims

claims 1 . Laboratory system (10), comprising:  a working space (100) for acting on living beings (500), observation of living beings (500) and / or supply of living beings (500), in particular of an animal under controlled environmental parameters, such as e.g. Temperature, humidity and fresh air composition, wherein the working space (100) has a working opening (120) and at least one flow device for realizing one or more substantially laminar gas flows (130) in the working space (100), and  a container system (300) having a plurality of containers (400) for respectively receiving a living being (500), characterized, in that an access (800) is arranged between the working space (100) and the container system (300) and the working space (100) and the container system (300) are arranged relative to one another in such a way that at least one container (400) passes through the access (800 ) from the container system (300) in the working space (100) is transportable. 2. Laboratory system according to claim 1, characterized in that the container (400) in the container system (300) each have their own gas supply means (410) and a separate gas discharge means (420). 3. Laboratory system according to one of the preceding claims, characterized in that the container system (300) comprises a container system housing (320) for substantially gas-tight separation of the container (400) from the environment. 4. Laboratory system according to one of the preceding claims, characterized in that the working space (100) has a working space housing (1 10), wherein a part of the working space housing (1 10) through a portion of the Behälterystemsge- housing (320) is formed. 5. Laboratory system according to one of the preceding claims, characterized in that the working space (100) comprises a working area (140) and an inflow area (160) via which from the environment of the working space (100) gas or gas mixture in the working space (100 ) is einströmbar. 6. Laboratory system according to claim 5, characterized in that in the working space (100) a deflection device (170) is arranged for generating a steered gas flow (180) in the order given in the following flow path: below the working area (140), laterally past this and past the work area (140), through a particulate filter (190) and down onto the work area (140). 7. Laboratory system according to claim 6, characterized in that in the working space (100) a branching device (200) for branching the flow path of the gas volume flow below the working area (140) is arranged, for the purpose of discharging a partial gas volume through a second filter (210) surrounding the laboratory system surrounding space and / or in the atmosphere, and that the laboratory system a guide (220) for directing the coming of the second filter gas flow in the surrounding space and / or in the atmosphere sphere. 8. Laboratory system according to one of the preceding claims, characterized in that the access (800) by means of a sliding element (810) is closed or closed. 9. Laboratory system according to one of the preceding claims, characterized in that each container (400) or each container position, a sliding element (810) is assigned, with which a respective access (800) of the working space (100) is closable. 10. Laboratory system according to one of the preceding claims, characterized in that the container system (300) comprises a plurality of subdivisions (330) for receiving the container (400) and the container system (300) comprises means for generating a gas volume flow (900) along a container (400) in each case a subdivision (330). 1 1. Laboratory system according to claim 10, characterized in that at least one container (400) has a flow inlet (430) for realizing a gas volume flow (440) from a subdivision (330) into the container (400). 12. Laboratory system according to one of the preceding claims, characterized in that the container system (300) comprises at least one light source (600) for illuminating the container (400). 13. Laboratory system according to one of the preceding claims, characterized in that the container system (300) comprises an air conditioner (700) with which the temperature and / or the humidity of the gas to be supplied to the container (400) or gas mixture is adjustable , 14. Laboratory system according to claim 13, characterized in that the air conditioning system has at least one Peltier element for generating air-conditioning refrigeration. 15. Laboratory system according to one of the preceding claims, characterized in that a respective container (400) each comprise an upper part (450) and a lower part (460) which are formed substantially equal in shape and size, wherein the upper part (450 ) and the lower part (460) are hinged together. 16. A method for acting on a living being, observation and / or care of a living being (500), in particular an animal under controlled environmental parameters such as temperature, humidity and fresh air composition, in which the living being (500) is received in a container (400), the container (400) is received in a container system (300) of the laboratory system (10) according to any one of claims 1 to 15 exposed to organisms (500) in the container (400) of a gas supply and gas is discharged from the container (400) , the container (400) is separated from the gas supply and gas discharge and by the Zu- passage (800) into the working space (100), the container (400) is received in the working area (140) of the working space (100) and the living being (500) is acted upon in the working area (140) and / or the living being ( 500) is observed.