Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
  • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23K—FODDER
  • A23K50/00—Feeding-stuffs specially adapted for particular animals
  • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
  • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
  • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/04—Anorexiants; Antiobesity agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/06—Antihyperlipidemics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
  • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/12—Antihypertensives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
  • A61K36/488—Pueraria (kudzu)

Definitions

• the present invention generally relates to the field of health and wellness.
• the present invention addresses metabolic disorders and disorders associated therewith.
• the present invention describes a composition comprising phytosterols and Kudzu for use in the treatment, alleviation or prevention of metabolic disorders.
• Obesity develops when energy intake is greater than energy expenditure, the excess energy being stored mainly as fat in adipose tissue. Body weight loss and prevention of weight gain can be achieved by reducing energy intake or bioavailability, increasing energy expenditure and /or reducing storage as fat. Obesity represents a serious threat to health because it is associated with an array of chronic diseases, including diabetes, atherosclerosis, degenerative disorders, airway diseases and some cancers.
• Kudzu and phytosterols are well known to have beneficial health effects; however, both individual ingredients have their limitations.
• Kudzu (Radix Pueraria) is a rich source of isoflavone glucosides, has traditional been used to treat alcoholism, diabetes, gastroenteritis, and deafness.
• the most abundant isoflavone of kudzu is puerarin (daidzein 8-C-glucoside) . Its compound also contains daidzein, daidzin (daidzei 7-0- glucoside) and other isoflavones.
• Phytosterols are known to be able to reduce blood concentrations of total and LDL cholesterol by reducing cholesterol absorption in the gut. A daily intake of around 2.4 g of plant sterols (or its saturated form, stands) is associated with ci.n 8 "6 reduction of blood total cholesterol concentrations. There are also some indications that phytosterols might have an effect on diabetes (Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds; Tanaka et al . , Biological and Pharmaceutical Bulletin Vol. 29 (2006), No. 7 1418). However, if administered in significant amounts, phytosterols may have unwanted side effects. For example, they are known to inhibit alpha and beta carotene absorption. Beta carotene is an important source of Vitamin A which is essential, e.g., for growth and development.
• the inventors have found in a hamster model that - when administered together - kudzu and phytosterols act synergistically and allow reducing blood lipids, body weight gain and fat buildup statistically significant, while keeping the individual dosages of phytosterols and kudzu sufficiently low to avoid unwanted side effects and discomfort.
• the present invention relates in part to a composition comprising phytosterols and kudzu for use in the treatment, alleviation or prevention of metabolic disorders.
• the present invention also relates to the use of phytosterols and kudzu in the preparation of a composition for treating, alleviating or preventing metabolic disorders.
• the combination of kudzu and phytosterols was shown to be very effective in prevention the build-up of high blood lipid concentrations in particular when consuming a high-fat diet.
• a diet to be considered "high-fat” if its fat content is at least 10%, at least 25%, at least 50%, at least 75% or at least 100% above the daily recommended intake (RDI) . Consequently, the metabolic disorder that can be prevented, ameliorated or treated with the composition of the present invention may be associated with hypertriglyceridemia.
• the metabolic disorder may be selected from the group consisting of overweightness , obesity, diabetes, hypertension, liver cirrhosis, metabolic syndrome and combinations thereof.
• Body mass index or “BMI” means the ratio of weight in kg divided by the height in metres, squared.
• “Obesity” is a condition in which the natural energy reserve, stored in the fatty tissue of animals, in particular humans and other mammals, is increased to a point where it is associated with certain health conditions or increased mortality. "Obese” is defined for an adult human as having a BMI greater than 30. Of particular importance are for the potential development of further metabolic disorders are high body weights, in particular an elevated fat mass.
• composition of the present invention could be used to prevent or reduce the accumulation of excessive amounts of perirenal fat.
• the composition of the present invention may be for use in reducing or preventing an increase of the perirenal fat to body weight ratio.
• Perirenal fat thickness is also an independent predictor of chronic kidney disease, increased renal resistance index and hyperuricaemia in type-2 diabetic patients (lamacchia et al . , Nephrol. Dial. Transplant. (2011) 26 (3) : 892-898) . Consequently, the composition of the present invention may be used in the treatment of prevention of these disorders as well. The inventors have also found that the composition of the present invention can very well be used to prevent or reduce the build-up of abdominal fat. Hence, the composition may be for use in reducing or preventing an increase of the abdominal fat to body weight ratio .
• Abdominal fat may be visceral fat surrounding the abdominal organs or subcutaneous located in between the skin and the abdominal wall.
• composition of the present invention has an effect on visceral fat and on subcutaneous fat.
• visceral fat is the main fat deposit that is correlated with risk factors such as insulin resistance
• subcutaneous fat may also be involved in such risk factors, in particular in men (Goodpaster et al . , Diabetes, October 1997, vol. 46 no. 10 1579-1585) .
• NIDDM non- insulin-dependent diabetes mellitus
• compositions of the present invention may be useful. They may for example be used to support weight management .
• Weight management may be beneficial to maintain or improve an individual's satisfaction with its appearance and wellness. Weight management may also be seen as preventive measure to reduce the risk of getting metabolic disorders.
• composition of the present invention may be for use in the support of weight management.
• compositions are administered in an amount sufficient to at least partially cure or arrest the symptoms of a disease and/or its complications.
• An amount adequate to accomplish this is defined as "a therapeutically effective dose”. Amounts effective for this purpose will depend on a number of factors known to those of skill in the art such as the severity of the disease and the weight and general state of the patient.
• compositions according to the invention are administered to a patient susceptible to or otherwise at risk of a particular disease in an amount that is sufficient to at least partially reduce the risk of developing a disease.
• a prophylactic effective dose Such an amount is defined to be "a prophylactic effective dose”.
• the precise amounts depend on a number of patient specific factors such as the patient's state of health and weight.
• compositions of the present invention are effective following a dose-response curve. They may be administered in a therapeutically effective dose or a prophylactic effective dose. Skilled artesians will be able to determine such dosages appropriately .
• composition of the present invention may be to be administered in a daily dose corresponding to at least 0.04 g, 0.6 g, 3 g, 6 g, 10 g, or 80 g kudzu and at least 2.5 mg, 10 mg, 15 mg, 25 mg, or 40 mg phytosterols per kg body weight per day.
• composition of the present invention may comprise at least 0.04 g kudzu and at least 2.5 mg phytosterols per kg body weight per day.
• composition of the present invention may comprise at least 3 g kudzu and at least 15 mg phytosterols per kg body weight per day.
• composition of the present invention may comprise at least 6 g kudzu and at least 40 mg phytosterols per kg body weight per day.
• the dosages should be kept at a reasonably low level.
• the dosages of kudzu may not exceed 6 g per kg body weight per day and the dosage of phytosterols may not exceed 40 mg per kg body weight per day.
• Kudzu may be provided in any form suitable for administration to humans or animals.
• kudzu may be provided as kudzu root, kudzu leaf, kudzu flower, dried kudzu or as an extract thereof.
• the extract may be for example a watery extracts.
• Watery extracts have the advantage that no solvents must be removed from the extract before the extract can be used for human or animal consumption.
• Typical phytosterols that may be used for the purpose of the present invention may be selected from the group consisting of plant sterols, stands, or combinations thereof.
• Examples are ⁇ -sitosterol , campesterol and/or stigmasterol .
• Phytosterols may be provided as chemically pure compounds. As such they may be purified from plant sources or synthesized chemically. This allows a very precise dosing. It may also be preferred to provide phytosterols from natural sources or extracts thereof. As such the phytosterols may be dietary phytosterols. They may be provided as vegetable oils, nuts, cereal products, vegetables, fruit, berries or as extracts thereof.
• the composition may be any composition that is suitable for human or animal consumption.
• composition may be selected from the group consisting of a food product, a drink, a functional food, a nutraceutical , a food additive, a nutritional formula, and a pet food product.
• composition of the present invention may be to be administered to humans or animals, for example companion animals such as cats or dogs.
• composition of the present invention may be consumed briefly before, with or briefly after the consumption of a high-fat meal.
• the composition may be to be administered in the time frame from 1 hour before to 1 hour after a high fat meal.
• Figure 2 shows that the combination treatment of Kudzu and plant sterols at the same dose significantly and synergistically caused a robust reduction in abdominal fat gain in HFD hamsters .
• Examples Golden Syrian hamsters weighing about 120-130g were purchased from Beijing Vital River Laboratory Animal Co., Ltd. Animals were housed in a controlled environment (22-24°C and 12h light-12h dark) with free access to tap water and food. After 1 week of acclimatization, hamsters were randomly allocated to different test groups. Hyperlipidemia was induced by feeding the animals a diet high in cholesterol and determined by the elevated plasma TC, TG and HDL-C level. The diet was prepared by mixing the following ingredients (g/kg) : Formula High-fat Diet (g/kg)
• the ingredient powders were mixed with a gelatin solution (20g/L) in a ratio of 200g diet per liter of solution. Once the gelatin had set, the diets were cut into pieces of approximately lOg cubes and stored frozen at -80C until use.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
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• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
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• General Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Diabetes (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Obesity (AREA)
• Hematology (AREA)
• Polymers & Plastics (AREA)
• Food Science & Technology (AREA)
• Nutrition Science (AREA)
• Mycology (AREA)
• Epidemiology (AREA)
• Child & Adolescent Psychology (AREA)
• Botany (AREA)
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• Medicines Containing Plant Substances (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

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• 2012
  • 2012-07-23 WO PCT/CN2012/079048 patent/WO2014015467A1/fr not_active Ceased
• 2013
  • 2013-07-22 WO PCT/EP2013/065450 patent/WO2014016266A1/fr not_active Ceased

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