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WO2014002114A3 - Process for preparation of saxagliptin and hydrates thereof - Google Patents

Process for preparation of saxagliptin and hydrates thereof Download PDF

Info

Publication number
WO2014002114A3
WO2014002114A3 PCT/IN2013/000375 IN2013000375W WO2014002114A3 WO 2014002114 A3 WO2014002114 A3 WO 2014002114A3 IN 2013000375 W IN2013000375 W IN 2013000375W WO 2014002114 A3 WO2014002114 A3 WO 2014002114A3
Authority
WO
WIPO (PCT)
Prior art keywords
saxagliptin
preparation
hydrates
monohydrate
imolar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2013/000375
Other languages
French (fr)
Other versions
WO2014002114A2 (en
Inventor
Shekhar Bhaskar Bhirud
Kumar Hari Bhushan
Hiremath Veerabhadra Swamy
Dilipkumar Jibhau PATIL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glenmark Pharmaceuticals Ltd
Original Assignee
Glenmark Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Ltd filed Critical Glenmark Pharmaceuticals Ltd
Publication of WO2014002114A2 publication Critical patent/WO2014002114A2/en
Publication of WO2014002114A3 publication Critical patent/WO2014002114A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the preparation of saxagliptin monohydrate is provided, comprising: a) reacting saxagliptin salt, b) adding more than 4 Imolar equivalent of water, and c) isolating saxagliptin monohydrate.
PCT/IN2013/000375 2012-06-29 2013-06-17 Process for the preparation of saxagliptin and hydrates thereof Ceased WO2014002114A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN1883MU2012 2012-06-29
IN1883/MUM/2012 2012-06-29
IN2232/MUM/2012 2012-08-02
IN2232MU2012 2012-08-02
US201261702857P 2012-09-19 2012-09-19
US61/702,857 2012-09-19

Publications (2)

Publication Number Publication Date
WO2014002114A2 WO2014002114A2 (en) 2014-01-03
WO2014002114A3 true WO2014002114A3 (en) 2014-02-20

Family

ID=49783963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000375 Ceased WO2014002114A2 (en) 2012-06-29 2013-06-17 Process for the preparation of saxagliptin and hydrates thereof

Country Status (1)

Country Link
WO (1) WO2014002114A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013175297A1 (en) 2012-05-24 2013-11-28 Apotex Pharmachem India Pvt. Ltd Salts of saxagliptin with organic acids
CN110940757B (en) * 2019-12-21 2022-07-29 尚科生物医药（上海）有限公司 High performance liquid chromatography detection method for saxagliptin intermediate and isomer thereof
CN114113419B (en) * 2020-08-26 2024-07-30 尚科生物医药（上海）有限公司 Chromatographic separation method of saxagliptin and isomer thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131149A2 (en) * 2007-04-20 2008-10-30 Bristol-Myers Squibb Company Crystal forms of saxagliptin and processes for preparing same
WO2012017028A1 (en) * 2010-08-06 2012-02-09 Sandoz Ag A novel crystalline compound comprising saxagliptin and phosphoric acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131149A2 (en) * 2007-04-20 2008-10-30 Bristol-Myers Squibb Company Crystal forms of saxagliptin and processes for preparing same
WO2012017028A1 (en) * 2010-08-06 2012-02-09 Sandoz Ag A novel crystalline compound comprising saxagliptin and phosphoric acid

Also Published As

Publication number Publication date
WO2014002114A2 (en) 2014-01-03

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