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WO2014084650A1 - Biotissue sampling apparatus - Google Patents

Biotissue sampling apparatus Download PDF

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Publication number
WO2014084650A1
WO2014084650A1 PCT/KR2013/010963 KR2013010963W WO2014084650A1 WO 2014084650 A1 WO2014084650 A1 WO 2014084650A1 KR 2013010963 W KR2013010963 W KR 2013010963W WO 2014084650 A1 WO2014084650 A1 WO 2014084650A1
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
syringe
needle assembly
housing
biological tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2013/010963
Other languages
French (fr)
Korean (ko)
Inventor
강현귀
김광기
양나리
이상봉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Cancer Center Japan
National Cancer Center Korea
Original Assignee
National Cancer Center Japan
National Cancer Center Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020130079977A external-priority patent/KR20140070333A/en
Application filed by National Cancer Center Japan, National Cancer Center Korea filed Critical National Cancer Center Japan
Priority to US14/648,685 priority Critical patent/US10695039B2/en
Priority to KR1020147010915A priority patent/KR101463867B1/en
Priority to CN201380062814.1A priority patent/CN104955403B/en
Publication of WO2014084650A1 publication Critical patent/WO2014084650A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe

Definitions

  • the present invention relates to an apparatus for collecting biological tissues and a method of using the same, and more particularly, to an apparatus for collecting biological tissues and a method of using the same, which can simultaneously perform tissue collection and drug injection.
  • Accurate diagnosis is essential before treatment because various types of tumors in the human body may differ from each other.
  • the diagnosis of the tumor is diagnosed by detecting tumor cells in the tumor tissue. Since several types of tumors may occur even in the same region of the human body, it is necessary to confirm the type of tumor before treatment through a cell test.
  • Methods for collecting tissue from tumor lesions include incision biopsies, which are taken directly after the incision of the skin, fine needle aspiration with a syringe, and total biopsy with a needle launch gun device (Gun Biopsy).
  • the incision biopsy can obtain sufficient tissues, which can lead to high diagnostic accuracy, but it requires a lot of time and money for anesthesia and skin incision, and there is a problem that tumor cells are more likely to be contaminated around the incision without accurate and meticulous surgical techniques.
  • the fine needle aspiration test using a syringe has a problem in that it is insufficient to make an accurate diagnosis because the patient is less uncomfortable and painless, or because the amount of tissue collected is very small.
  • Total biopsy is a widely used method for diagnosing various cancers because more tissues can be obtained using a needle having a cutting surface, and thus the accuracy of the biopsy methods is relatively high.
  • Figure 1 shows a perspective view showing a device 100 for biological tissue collection according to the conventional total histology.
  • the apparatus 100 for collecting biological tissues according to the conventional biopsy technique includes a housing 110, a tube 120 extended by being coupled to the front end of the housing 110, and a biological tissue collected by being coupled to the front end of the tube 120. It consists of a needle assembly (130).
  • the needle assembly 130 includes a front end 132 and a storage unit 134 in which tissue formed at the rear of the front end 132 is stored.
  • the rear end of the housing 110 is provided with a firing button 112 to move the needle assembly 130 to the biopsy site and to advance the tube 120 along the moved needle.
  • the tip portion of the tube 120 is provided with a cutting portion 122 for cutting the tissue.
  • FIG. 2A to 2C illustrate a tissue collection process of the apparatus 100 for collecting biological tissues according to the prior art.
  • tissue collection Penetrates the needle assembly 130 to the desired tissue site, and the tissue to be collected in the tissue is seated in the reservoir 134 of the needle assembly 130 (see arrow A in FIG. 2A).
  • the firing button 112 provided at the rear end of the housing 110 is pressed once more, and as shown in FIG. 2B, the tube 120 is moved to the needle assembly 130. It moves up to the tip 132, whereby tissue is cut and stored in the reservoir 134 (see arrow B in FIG. 2B).
  • the apparatus 100 for collecting the biological tissue of the prior art having such a configuration may cause bleeding from the insertion hole when the needle assembly 130 is inserted into the human body, thereby causing a bruise or blood accumulation of hematoma. There was a problem that could occur.
  • the tissue is a malignant tumor
  • the bleeding portion and the hematoma are considered to be contaminated with malignant tumor cells, and there is a problem that the range of excision during surgery or the limbs should be cut.
  • cystic tumors containing only liquids and liquid and solid substances mixed heterogeneously inside the tumors of the human body there are cystic tumors containing only liquids and liquid and solid substances mixed heterogeneously inside the tumors of the human body, and in the case of liquid tumors, it is recommended to collect the biological tissues according to the prior art. There was a problem that it was not easy.
  • the present invention has been made to solve the above-mentioned problems of the prior art, and provided with a storage unit for storing the cut tissue in the needle assembly of the apparatus for collecting biological tissue, and a suction hole for collecting liquid tissue, By providing an injection hole for injecting the drug into the wounded tissue at the lower end, it is possible to provide a biological tissue harvesting device capable of administering the drug to the site where the bleeding can occur while collecting the tissue with a single device.
  • the lower end of the tube is provided with an injection hole for administering the drug into the wounded tissue in the longitudinal direction to allow for simultaneous tissue collection and drug injection in the human body, thereby preventing the spread of tumor or tissue cells, tissue It is to provide a biological tissue collection device that is easy to remove during surgery that can mark the test track (path for tissue collection into the human body) and the tumor site.
  • the tissue to be collected is collected in a storage unit when the solid to be collected, the liquid tissue is to provide a biological tissue harvesting device that can be easily collected with a suction hole.
  • the present invention to achieve this object is a housing; A firing button provided at the rear end of the housing; A tube extending from the front end of the housing and equipped with an injection hole for injecting the drug into the tissue along the length of the bottom; And a needle assembly which is installed to be movable to the histological examination site in the tube by a button, and cuts and stores solid tissue or sucks the liquid tissue.
  • the cutting portion for cutting the tissue is formed at the front end of the needle assembly, characterized in that formed.
  • the needle assembly is formed of one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy.
  • the tip end of the needle assembly is characterized in that the coating with one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy.
  • the cutting portion for cutting the tissue is formed at the tip of the tube, characterized in that formed.
  • the present invention extends from the leading end of the needle assembly, characterized in that the reservoir for storing the cut tissue is formed.
  • the needle assembly is characterized in that the suction hole is connected to the reservoir to suck the liquid tissue.
  • the vertical cross section of the injection hole is characterized in that it is formed to have a circular, elliptical or inverted triangle shape.
  • a plurality of side holes are formed on the outer surface of the injection hole.
  • the drug injection syringe connected to the injection hole and the tissue suction syringe connected to the suction hole is characterized in that it is detachably provided inside the housing.
  • the drug injection syringe and the tissue suction syringe is characterized by consisting of a hollow syringe body and a piston moving inside the syringe body.
  • the slide button is coupled to the piston so that the drug injection syringe and the tissue suction syringe are slidable, respectively.
  • the drug injection syringe and the tissue suction syringe is characterized by having a dose of 1 ⁇ 3cc.
  • one or more fixing grooves are continuously formed on one surface of the housing in which the slide button is moved to slide the piston to a unit length, and then stop not moving in the direction of the firing button by pressure. do.
  • a space portion formed in the housing, and one end is connected to the injection hole, characterized in that it comprises an extension tube accommodated in the space portion.
  • the other end of the extension tube is exposed to the outside of the space portion to form a fastening portion.
  • the cover which opens and closes a space part is characterized by the above-mentioned.
  • the space portion formed in the housing, and one end is connected to the suction hole, characterized in that it comprises an extension tube accommodated in the space portion.
  • the other end of the extension tube is exposed to the outside of the space portion to form a fastening portion.
  • the cover which opens and closes a space part is characterized by the above-mentioned.
  • the needle assembly of the biological tissue collecting device is provided with a storage unit for storing the cut tissue, and a suction hole for collecting liquid tissue, and the lower end of the tube contains a drug into the wounded tissue.
  • the injection hole is provided, and the bleeding generated from the tumor and the histological track due to the tissue collection is administered by the injection hole in the site of the tumor cell contamination, so that the tissue collection and drug administration can be performed simultaneously with a single instrument.
  • the tissue to be collected may be collected in a storage unit when the tissue to be collected is solid, and the liquid tissue may be easily collected by a suction hole.
  • FIG. 1 is a perspective view showing a device for collecting biological tissue according to the prior art
  • Figures 2a to 2c is a view showing the use of the apparatus for collecting biological tissue according to the prior art
  • FIG. 3 is a perspective view showing a device for collecting biological tissue in one embodiment of the present invention.
  • Figure 4 is a perspective view showing a device for collecting biological tissue according to another embodiment of the present invention.
  • FIG. 5 is a perspective view showing a biological tissue collection device according to an embodiment of the present invention.
  • FIG. 6 is a perspective view showing the action of the needle assembly according to FIG. 5;
  • FIG. 7 to 12 is a perspective view showing a tissue collection process of the apparatus for collecting biological tissues according to the present invention.
  • FIG. 13A to 13C are schematic views showing various shapes of the apparatus injection hole for collecting biological tissue of FIG. 7;
  • FIG. 14A to 14D are schematic views showing various shapes of the device storage unit for collecting the biological tissue of FIG. 12;
  • FIG. 15 is a perspective view of a biological tissue collection device according to another embodiment of the present invention.
  • FIG. 16 is a plan view showing the action of the needle assembly according to FIG. 15;
  • FIG. 17 is a perspective view showing a device for biological tissue collection according to another embodiment of the present invention.
  • FIG. 18 is a perspective view showing an apparatus for collecting biological tissues according to another embodiment of the present invention.
  • FIG. 19 is a perspective view illustrating a method for mounting the extension tube in FIG.
  • FIG 3 is a perspective view showing a biological tissue collection device 200 according to the present invention.
  • the biological tissue collecting device 200 includes a housing 210, a tube 220 coupled to an extended end of the housing 210, and a needle assembly 230 coupled to the tube 220 to collect biological tissue. It is composed of
  • the rear end of the housing 210 has a firing button 212 for moving the tube 220 and the needle assembly 230, a first syringe 214 containing liquid tissue, a second syringe 216 containing a drug
  • the first slide 215 is slidably coupled to the first syringe 214
  • the second slide 217 is slidably coupled to the second syringe 216.
  • Launch button 212 is formed of a two-stage button, a detailed description thereof will be described below.
  • the first syringe 214 and the second syringe 216 are composed of hollow syringe bodies 214a and 216a and pistons 214b and 216b that move in the syringe bodies 214a and 216a. It is provided side by side inside the 210.
  • a first slide coupled to one end of pistons 214b and 216b of the first syringe 214 and the second syringe 216 so that the first syringe 214 and the second syringe 216 are slidable.
  • the 215 and the second slide 217 are detachably provided side by side inside the housing 210.
  • the housing 210 is a portion that the user grips by hand, and the capacity of the first syringe 214 and the second syringe 216 preferably has a capacity of 1 kW or more.
  • first syringe 214 and the second syringe 216 are as follows.
  • the operation of the first syringe 214, the initial state of the first syringe 214 is the front end of the piston 214b of the first syringe 214 the syringe of the first syringe 214
  • the piston 214b of the first syringe 214 is in contact with the tip of the body 214a.
  • the tip and the tip of the syringe body 214a of the first syringe 214 are spaced apart from each other, so that liquid tissue is sucked into the syringe body 214a of the first syringe 214 (see FIG. 5). ).
  • one or more fixing grooves 218 are continuously formed on one surface of the housing 210 in which the first slide 215 and the second slide 217 slide to slide the piston in the front-rear direction and then stop. After the pressure can be stopped so as not to move in the direction of the firing button, it can be operated in unit length.
  • the shape of the fixing groove 218 is not particularly limited as long as it can prevent the piston (214b, 216b) from moving excessively in the direction of the needle assembly 230, in one preferred example, shown in the enlarged view of FIG.
  • the fixing groove 218a may have a rack gear shape, which may prevent the pistons 214b and 216b of the syringes 214 and 216 from moving in the direction of the needle assembly 230.
  • a plurality of fixing grooves 218b on one surface of the sliding housing 210 may be formed in a projection shape in the longitudinal direction, the projection shape fixed
  • a fixing hole 219 that may be coupled to the groove 218b may be formed at the rear end of the first slide 215 or the second slide 217.
  • the protrusion-shaped fixing groove 218b may be formed in a row or two rows according to the moving directions of the first syringe 215 and the second syringe 217, and may flow upward and downward when an external force is applied.
  • the pistons 214b and 216b of the syringes 214 and 216 can move in the horizontal direction.
  • the initial state of the second syringe 216 is the front end of the piston 216b of the second syringe 216 and the syringe body of the second syringe 216 ( 216a) the tips are spaced apart from each other, and the second slide 217 moves the tip of the piston 216b of the second syringe 216 to the tip of the syringe body 216a of the second syringe 216.
  • the drug in the syringe body 216a of the second syringe 216 is a tissue extraction site of the tumor through the injection hole 222 by the pushing force of the piston 216b of the second syringe 216. And the bleeding portion of the biopsy track (see FIG. 6).
  • 17 and 18 as another example of the apparatus for collecting biological tissue, may have a structure including at least one extension tube in place of the first and second syringes.
  • the apparatus for collecting biological tissue is connected to the end of the space portion 412, one end of the suction hole 436 and / or injection hole 422 formed in the housing 410 and is received in the space portion It may be configured to include an extension tube (440, 440 ').
  • one end of the extension tube 440 and 440' is connected to the end of the suction hole 436 and / or injection hole 422, respectively, the other end Fastening portions 442 and 442 ′ for exposing the syringe 460 or the general syringe 461 that are commonly used at the other end of the space 412 and exposed to the other end thereof may be formed.
  • the integrated syringe 460 may be connected to the fastening portion 442, and by fastening the general syringe 461 to another fastening portion 442 ', suction or through the extension tube (440, 440') Drug injection may be possible.
  • the extension tubes 440 and 440 ' are stored and stored in the space 412, and when the suction of liquid is required, the general syringe 461 is provided through the fastening portion 442'.
  • the integrated syringe 460 loaded with drugs may be injected into the fastening part 440.
  • extension tubes 440 and 440 ' may be connected to the end of the suction hole 436 or the injection hole 422 according to the intended use, and at the same time the ends of the suction hole 436 and the injection hole 422 Of course, you can connect and use.
  • the type of drug injected into the integrated syringe 460 may vary, for example, may be an anticancer agent or a hemostatic agent, and the hemostatic agent is separately stored in the integrated syringe 460 and stored in a liquid state. If you coalesce with each other to coagulate can exhibit a hemostatic effect.
  • fastening parts 442 and 442 'used in the present invention are universal connectors to which all types of syringes can be mounted, a variety of syringes can be easily and easily attached to the fastening parts 442 and 442'. I can attach it.
  • the extension tube 440 is stored in the space 412 formed in the housing 410, the space The cover 450 coupled to the portion 412 may be stored inside the biological tissue collection device.
  • the cover 450 is not particularly limited as long as it is a shape capable of opening and closing the space 412, but as a preferred example, may be formed integrally with the housing 410, the tip of the cover 450 The locking protrusion 452 having a predetermined size of the groove 454 is formed, and the locking protrusion 452 may be inserted into the hook 414 formed on one side of the space 412 to be closed.
  • the space 412 is not particularly limited as long as it can have a predetermined depth and size to accommodate the extension tubes 440 and 440 '.
  • FIG. 7 shows a perspective view of a biological tissue collection device 200 according to an embodiment of the present invention
  • Figure 8 shows a plan view showing the action of the needle assembly 230 according to FIG.
  • FIG. 7 to 8 is a biological tissue harvesting apparatus 200 according to an embodiment of the present invention shown in Figure 3, the housing 210, the tube 220 is coupled to the front end of the housing 210 and extended, and It is composed of a needle assembly 230 coupled to the tube 220 to collect biological tissue.
  • the needle assembly 230 is formed at the front end portion 232, the rear end portion 232 of the storage portion 234 to store tissue, and the storage portion 234 connected to the first syringe 214 in liquid tissue.
  • the suction hole 236 is collected.
  • the tip portion 232 of the needle assembly 230 is not particularly limited as long as it is a needle shape having a cut surface, but preferably, the tip portion 232 of the needle assembly 230 may have a triangular pyramid shape.
  • the needle assembly 230 may be formed of one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloys, in one preferred example, In another preferred example, it may be coated with one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloys.
  • the formation recovery temperature varies according to the weight composition ratio of nickel and titanium. For example, when the shape recovery temperature is higher than room temperature, the shape memory effect appears at room temperature, and the shape recovery temperature is If it is lower than room temperature, there is a characteristic that the super elastic effect appears at room temperature.
  • the superelastic alloy is deformed by applying a large deformation force such that plastic deformation is normal metal material, and when the deformation force is removed, it is restored to its original shape like rubber. Therefore, since there is a characteristic of maintaining the original shape even after collection without deformation or breakage due to the force collected during tissue collection, safety can be improved.
  • the weight composition ratio of nickel and titanium is preferably 55:45 to 99: 1, and more preferably 55:45 to 65:35.
  • the composition may be dissolved in a melt in a vacuum arc furnace to coat only the tip portion 232 of the needle assembly 230 to form the needle assembly 230 of the present invention.
  • the molten nickel-titanium melt may be solidified into a plate shape and then processed to form the needle assembly 230 of the present invention.
  • the tube 220 is composed of an injection hole 222 through which the drug flows and a cutting portion 224 for cutting the tissue, the injection hole 222 through which the drug flows in the longitudinal direction at the lower end of the tube 220 It is provided with.
  • the vertical cross-sectional shape of the injection hole 222 may be variously formed as necessary, but preferably, as shown in FIGS. 7 and 13A to 13C, a circular, elliptical, or inverse may be used to facilitate the flow of drugs. It may be formed in a triangular shape, the size of the hole 223 is preferably determined in a smaller range than the cutting portion 224 due to the nature of the mechanism to be inserted into the living body.
  • a plurality of side holes 221 may be formed on the outer surface of the injection hole 222.
  • a plurality of side holes 221 are formed on the whole or part of the outer surface of the injection hole 222, through the holes 223 and the plurality of side holes 221 of the injection hole in the wound site generated due to tissue collection Drugs can be accurately administered, there is an effect that can be easily administered to a large wound area.
  • the side hole 221 may be formed at the tip of the injection hole 222 with a length of 10 to 20% based on the entire length of the injection hole 222 in the longitudinal direction.
  • the cutting portion 224 for cutting the tissue is sharply formed at the tip of the tube 220, that is, the tube 220 position leading from the reservoir 234 of the needle assembly 230.
  • the launch button 212 of the housing 210 may be installed as a two-stage button, and the user may launch the button 212. Press once to release the needle assembly 230 to the location of the tissue to be collected (see arrow C in FIG. 7), and once again to press the fire button 212, the tube 220 covers the needle assembly 230. Move to tip 232 of needle assembly 230 (see arrow D in FIG. 8).
  • the tissue is cut and collected in the storage portion 234 by the cutting portion 224 provided at the tip portion of the tube 220.
  • FIGS. 9 to 12 are views illustrating a sampling process of the apparatus 200 for collecting biological tissues according to the present invention.
  • FIGS. 9 to 12 examples of the solid tissue will be described.
  • a tube 220 and a needle assembly 230 coupled within the tube 220 are loaded into the housing 210 using a loading device (not shown) coupled to the housing 210, and then ultrasonic or computer monolayer.
  • the tube 220 is inserted into the tumor tissue while viewing an imaging device (not shown) such as a photographing.
  • the firing button 212 provided at the rear end of the housing 210 is pressed once, as shown in FIG. 10, the needle assembly 230 is fired and positioned on the tissue 240 to be collected.
  • the tissue 240 to be collected may be solid or liquid. Therefore, in the case of liquid tissue, when the first slide 215 is slid toward the firing button 212, the liquid tissue flows into the first syringe 214 through the suction hole 236.
  • the tissue 240 to be collected becomes solid.
  • the cutting unit 224 cuts the tissue 240 positioned in the storage unit 234, and the cut tissue 240 is stored in the storage unit 234.
  • the storage unit 234 of the cutting unit 224 is not particularly limited as long as the cut tissue 240 is a shape that can be stored well without leaking to the outside, but preferably shown in FIGS. 14A to 14D. It can be formed as.
  • the second slide 217 Since the tissue is cut in the body, bleeding occurs around the tissue. Accordingly, when the second slide 217 is slid toward the tube 220, the second slide 217 is connected to the second slide 217.
  • the drug 250 is administered to the bleeding portion through the injection hole 222, and as shown in FIG. 11, the drug 250 administered through the injection hole 222 is applied to the tissue collection portion and the bleeding portion.
  • hemostatic agents tissue coalescing agents, tissue marking fluorescent and contrast materials, bone cement, tumor treatment drugs, and other tissue treatment materials may be used. .
  • the collected tissue 240 is stored in the storage unit 234, and the stored tissue 240 is sent to a laboratory for examination. Perform.
  • the needle assembly 230 is positioned on the tissue portion to be collected, and then the first slide 215 is slid toward the firing button 212. Liquid tissue flows into the first syringe 214 through 236.
  • the first syringe 214 can be attached and detached, the first syringe 214 can be detached from the housing 210 and sent to the examination room to perform the inspection.
  • Figure 16 is a plan view showing the operation of the needle assembly 330 according to FIG.
  • the biological tissue collecting device 300 to which the needle assembly is applied according to another embodiment of the present invention is coupled to the front end of the housing 310 and the housing 310 as shown in FIGS. 3 and 7.
  • a needle assembly 330 coupled to the tube 320 and collecting the biological tissue, and a cutting portion 338 for cutting the tissue is provided at the tip 332 of the needle assembly 330. It is characterized by being.
  • the configuration and shape of the housing 310, tube 320 and needle assembly 330 are as described in the detailed description of FIGS. 3 and 7 and will be omitted.
  • the cutting portion 338 for cutting tissue is sharply formed at the tip 332 of the needle assembly 330, ie, from the reservoir 334 to the tip 332.
  • the launch button of the housing 310 is installed as a two-stage button. 330 is fired to the location of the tissue to be harvested (see arrow E in FIG. 15), and once again the firing button is pressed, the needle assembly 330 moves into the tube 320 (see arrow F in FIG. 16). .
  • the tissue is cut and collected in the reservoir 334 by the cutting portion 338 provided at the tip portion 332 of the needle assembly 330.
  • the biological tissue collecting device 200 As described above, the biological tissue collecting device 200 according to the embodiment of the present invention, the needle assembly 230 of the biological tissue collecting device, the storage unit 234 for storing the cut tissue, and collecting the liquid tissue
  • the suction hole 236 is provided, the lower end of the tube 210 is provided with an injection hole 222 for injecting the drug into the wounded tissue, the injection hole 222 in the wounded portion of the human body due to tissue collection
  • tissue collection and drug administration can be performed at the same time with one apparatus, thereby preventing bleeding and tumor cell contamination after tissue collection.
  • the resection site can be marked, so that the biological tissue collection that can remove not only the tumor tissue during surgery, but also the areas where the drug may be contaminated with the tumor cells.
  • a device can be provided.
  • the tissue to be collected may be collected from the storage unit 234, and the liquid tissue may be easily collected into the suction hole 236.

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Abstract

The present invention relates to a biotissue sampling apparatus and to a method for using same. More particularly, provided is a biotissue sampling apparatus comprising: a housing; a shoot button arranged at the rear end of the housing; a tube which is extended from the front end of the housing and which has an injection hole formed in the lower end thereof in the lengthwise direction so as to inject drugs into tissues; and a needle assembly which is arranged to be movable in the tube by a button, and which cuts and stores solid tissues or suctions liquid tissues.

Description

생체 조직 채취 장치Biological tissue collection device

본 발명은 생체 조직 채취용 장치 및 그 사용 방법에 관한 것으로, 더욱 상세하게는 조직 채취와 약물 주입이 동시에 이루어질 수 있는 생체 조직 채취용 장치 및 그 사용 방법에 관한 것이다.The present invention relates to an apparatus for collecting biological tissues and a method of using the same, and more particularly, to an apparatus for collecting biological tissues and a method of using the same, which can simultaneously perform tissue collection and drug injection.

인체에서 발생하는 다양한 종류의 종양들은 치료약과 방법이 서로 다를 수 있기 때문에 치료 전에 정확한 진단이 필수적이다. 종양의 확진은 종양 조직에서 종양세포를 검출하여 진단하게 되는데 인체 내 같은 부위에서조차도 여러 종류의 종양이 발생할 수 있기 때문에 세포 검사를 통해 치료 전에 종양의 종류를 확인하는 것이 필요하다.Accurate diagnosis is essential before treatment because various types of tumors in the human body may differ from each other. The diagnosis of the tumor is diagnosed by detecting tumor cells in the tumor tissue. Since several types of tumors may occur even in the same region of the human body, it is necessary to confirm the type of tumor before treatment through a cell test.

종양 병소에서 조직을 채취하는 방법은 피부를 절개 한 후 직접 채취하는 절개 생검, 주사기를 이용한 세침 흡인 검사, 및 바늘 발사건 장치를 이용한 총 조직 검사(Gun Biopsy)가 있다.Methods for collecting tissue from tumor lesions include incision biopsies, which are taken directly after the incision of the skin, fine needle aspiration with a syringe, and total biopsy with a needle launch gun device (Gun Biopsy).

절개 생검은 충분한 조직을 얻을 수 있어 진단 정확도는 높을 수 있으나 마취와 피부 절개에 따른 시간과 비용이 많이 들어가며 정확하고 세심한 수술 기술이 없다면 절개 주변에 종양세포가 오염될 가능성이 크다는 문제점이 있다.The incision biopsy can obtain sufficient tissues, which can lead to high diagnostic accuracy, but it requires a lot of time and money for anesthesia and skin incision, and there is a problem that tumor cells are more likely to be contaminated around the incision without accurate and meticulous surgical techniques.

주사기를 이용한 세침 흡인 검사는 환자가 덜 불편하고 통증이 덜한 방법이나 채취되는 조직의 양이 아주 적기 때문에 정확한 진단을 하는데 부족하다는 문제점이 있다.The fine needle aspiration test using a syringe has a problem in that it is insufficient to make an accurate diagnosis because the patient is less uncomfortable and painless, or because the amount of tissue collected is very small.

총 조직 검사는 절단면을 가진 바늘을 이용하여 더욱 많은 조직의 획득이 가능하여 생검 방법들 중 비교적 정확도가 높기 때문에 여러 암의 진단 시 널리 사용되는 검사법이다.Total biopsy is a widely used method for diagnosing various cancers because more tissues can be obtained using a needle having a cutting surface, and thus the accuracy of the biopsy methods is relatively high.

도 1은 종래 총 조직검사 기술에 따른 생체 조직 채취용 장치(100)를 도시한 사시도를 나타낸다.Figure 1 shows a perspective view showing a device 100 for biological tissue collection according to the conventional total histology.

종래 조직검사 기술에 따른 생체 조직 채취용 장치(100)는 하우징(110), 하우징(110)의 선단부에 결합되어 연장되는 튜브(120), 및 튜브(120)의 선단부에 결합되어 생체 조직을 채취하는 바늘 조립체(130)로 구성된다.The apparatus 100 for collecting biological tissues according to the conventional biopsy technique includes a housing 110, a tube 120 extended by being coupled to the front end of the housing 110, and a biological tissue collected by being coupled to the front end of the tube 120. It consists of a needle assembly (130).

바늘 조립체(130)는 선단부(132)와, 선단부(132)의 후방에 형성되는 조직이 보관되는 저장부(134)로 구성된다. The needle assembly 130 includes a front end 132 and a storage unit 134 in which tissue formed at the rear of the front end 132 is stored.

하우징(110)의 후단부에는 바늘 조립체(130)를 조직검사부위로 이동시키고 이동된 바늘을 따라 튜브(120)를 전진시키는 발사 버튼(112)이 구비된다.The rear end of the housing 110 is provided with a firing button 112 to move the needle assembly 130 to the biopsy site and to advance the tube 120 along the moved needle.

튜브(120)의 선단부에는 조직을 절단하기 위한 커팅부(122)가 구비된다.The tip portion of the tube 120 is provided with a cutting portion 122 for cutting the tissue.

이와 같이 구성된 종래 기술에 따른 생체 조직 채취용 장치(100)의 사용법을 살펴보면 다음과 같다.Looking at the usage of the apparatus 100 for biological tissue collection according to the prior art configured as described above are as follows.

도 2a 내지 도 2c는 종래 기술의 따른 생체 조직 채취용 장치(100)의 조직 채취 과정을 나타낸다.2A to 2C illustrate a tissue collection process of the apparatus 100 for collecting biological tissues according to the prior art.

먼저, 영상 장치(미도시)를 보면서 종양 조직 내로 튜브(120)를 삽입하고, 하우징(110)의 후단부에 구비된 발사 버튼(112)을 한번 누르면, 도 2a에 도시된 바와 같이, 조직 채취를 원하는 조직 부위에 바늘 조립체(130)를 투과시키며, 바늘 조립체(130)의 저장부(134) 내에 조직 중 채취될 조직이 안착된다(도 2a의 화살표 A 참조).First, while inserting the tube 120 into the tumor tissue while viewing the imaging device (not shown), and pressing the launch button 112 provided at the rear end of the housing 110 once, as shown in Figure 2a, tissue collection Penetrates the needle assembly 130 to the desired tissue site, and the tissue to be collected in the tissue is seated in the reservoir 134 of the needle assembly 130 (see arrow A in FIG. 2A).

조직이 저장부(134) 내에 안착되면, 하우징(110)의 후단부에 구비된 발사 버튼(112)을 한번 더 누르며, 도 2b에 도시된 바와 같이, 튜브(120)가 바늘 조립체(130)의 선단부(132)까지 이동하게 되고, 이에 조직이 절단되어 저장부(134) 내에 저장된다(도 2b의 화살표 B 참조).When the tissue is seated in the reservoir 134, the firing button 112 provided at the rear end of the housing 110 is pressed once more, and as shown in FIG. 2B, the tube 120 is moved to the needle assembly 130. It moves up to the tip 132, whereby tissue is cut and stored in the reservoir 134 (see arrow B in FIG. 2B).

마지막으로, 튜브(120)가 바늘 조립체(130)의 선단부(132)까지 이동한 상태(도 2b)에서 피부 밖으로 빼낸 후에 튜브(120)를 후방으로 이동시키게되면, 바늘 조립체(130)의 저장부(134)에 채취된 조직을 얻을 수 있다. 도 2c에 도시된 바와 같이 조직 채취가 완료된다.Finally, when the tube 120 is moved out of the skin in the state where the tube 120 is moved up to the tip 132 of the needle assembly 130 (FIG. 2B) and the tube 120 is moved backward, the reservoir of the needle assembly 130 is moved. The tissue collected at 134 can be obtained. Tissue collection is complete as shown in FIG. 2C.

그러나 이러한 구성을 갖는 종래 기술의 생체 조직 채취용 장치(100)는 바늘 조립체(130)가 인체 내로 삽입되었다 인체 외부로 뺄 때, 삽입구로부터 출혈이 생길 수 있고, 이로 인하여 멍이 들거나 혈액이 고여 혈종이 생길 수 있다는 문제점이 있었다.However, the apparatus 100 for collecting the biological tissue of the prior art having such a configuration may cause bleeding from the insertion hole when the needle assembly 130 is inserted into the human body, thereby causing a bruise or blood accumulation of hematoma. There was a problem that could occur.

또한, 조직이 악성 종양일 경우, 출혈이 생긴 부분 및 혈종은 악성 종양 세포에 오염이 된 것으로 간주되어 수술시 절제 범위가 넓어지거나 또는 사지절단을 해야만 하는 문제점이 있었다.In addition, when the tissue is a malignant tumor, the bleeding portion and the hematoma are considered to be contaminated with malignant tumor cells, and there is a problem that the range of excision during surgery or the limbs should be cut.

또한, 인체의 종양 내부에 액체성 및 고체성 물질이 이질적으로 혼합되어 있는 경우와 액체만을 함유한 낭성 종양이 있으며, 이러한 액체성 종양일 경우에는 종래 기술에 따른 생체 조직 채취용 장치로 채취하는 것이 용이하지 않다는 문제점이 있었다.In addition, there are cystic tumors containing only liquids and liquid and solid substances mixed heterogeneously inside the tumors of the human body, and in the case of liquid tumors, it is recommended to collect the biological tissues according to the prior art. There was a problem that it was not easy.

본 발명은 상술한 종래 기술의 문제점을 해결하기 위하여 창안한 것으로, 생체 조직 채취용 장치의 바늘 조립체에 절단된 조직을 보관하는 저장부, 및 액체성 조직을 채취하는 흡인홀이 구비되고, 튜브의 하단부에 상처가 생긴 조직 내로 약물을 주입하는 주입홀이 구비됨으로써, 하나의 기구로 조직을 채취할 수 있는 동시에 출혈이 생길 수 있는 부위에 약물 투여가 가능한 생체 조직 채취 장치를 제공하는 것이다.The present invention has been made to solve the above-mentioned problems of the prior art, and provided with a storage unit for storing the cut tissue in the needle assembly of the apparatus for collecting biological tissue, and a suction hole for collecting liquid tissue, By providing an injection hole for injecting the drug into the wounded tissue at the lower end, it is possible to provide a biological tissue harvesting device capable of administering the drug to the site where the bleeding can occur while collecting the tissue with a single device.

또한, 튜브의 하단부에 길이 방향으로 상처가 생긴 조직 내로 약물을 투여할 수 있는 주입홀을 구비하여 인체 내 조직 채취와 약물 주입이 동시에 이루어질 수 있게 함으로써, 종양 또는 조직 세포의 퍼짐을 예방하고, 조직 검사 트랙(조직 채취용 장치가 인체 내로 들어간 경로) 및 종양 부위를 표시해 놓을 수 있는 수술시 절제가 용이한 생체 조직 채취 장치를 제공하는 것이다.In addition, the lower end of the tube is provided with an injection hole for administering the drug into the wounded tissue in the longitudinal direction to allow for simultaneous tissue collection and drug injection in the human body, thereby preventing the spread of tumor or tissue cells, tissue It is to provide a biological tissue collection device that is easy to remove during surgery that can mark the test track (path for tissue collection into the human body) and the tumor site.

또한, 생체 조직 채취 시, 채취하고자 하는 조직이 고체성일 경우에는 저장부에서 채취하고, 액체성 조직은 흡인홀로 용이하게 채취할 수 있는 생체 조직 채취 장치를 제공하는 것이다.In addition, when biological tissue is collected, the tissue to be collected is collected in a storage unit when the solid to be collected, the liquid tissue is to provide a biological tissue harvesting device that can be easily collected with a suction hole.

이러한 목적을 달성하기 위하여 본 발명은 하우징; 하우징의 후단부에 구비되는 발사버튼; 하우징의 선단부에서 연장되며, 하단의 길이 방향을 따라 조직 내로 약물을 주입하는 주입홀이 장착되는 튜브; 및 버튼에 의해 튜브 내에서 조직검사부위로 이동가능하게 설치되어, 고체성 조직을 절단하여 보관하거나 액체성 조직을 흡인하는 바늘 조립체;를 포함하는 것을 특징으로 하는 생체 조직 채취 장치를 제공한다.The present invention to achieve this object is a housing; A firing button provided at the rear end of the housing; A tube extending from the front end of the housing and equipped with an injection hole for injecting the drug into the tissue along the length of the bottom; And a needle assembly which is installed to be movable to the histological examination site in the tube by a button, and cuts and stores solid tissue or sucks the liquid tissue.

또한, 본 발명에 있어서, 바늘 조립체의 선단부에 조직을 절단하기 위한 커팅부가 형성되는 것을 특징으로 한다.In addition, in the present invention, the cutting portion for cutting the tissue is formed at the front end of the needle assembly, characterized in that formed.

또한, 본 발명에 있어서, 바늘조립체는 Ti, Ni, Fe, Cr, Ta, 스테인레스 스틸, 및 형상기억합금으로 구성되는 군으로부터 선택되는 하나 또는 둘 이상의 금속으로 형성되는 것을 특징으로 한다.In addition, in the present invention, the needle assembly is formed of one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy.

또한, 본 발명에 있어서, 바늘 조립체의 선단부는 Ti, Ni, Fe, Cr, Ta, 스테인레스 스틸, 및 형상기억합금으로 구성되는 군으로부터 선택되는 하나 또는 둘 이상의 금속으로 코팅되는 것을 특징으로 한다.In addition, in the present invention, the tip end of the needle assembly is characterized in that the coating with one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy.

또한, 본 발명에 있어서, 튜브의 선단부에 조직을 절단하기 위한 커팅부가 형성되는 것을 특징으로 한다.In addition, in the present invention, the cutting portion for cutting the tissue is formed at the tip of the tube, characterized in that formed.

또한, 본 발명에 있어서, 바늘 조립체의 선단부에서 연장되어, 절단된 조직을 보관하는 저장부가 형성되는 것을 특징으로 한다.In addition, in the present invention, it extends from the leading end of the needle assembly, characterized in that the reservoir for storing the cut tissue is formed.

또한, 본 발명에 있어서, 바늘 조립체에는 저장부와 연결되어 액체성 조직을 흡입하는 흡인홀이 형성되는 것을 특징으로 한다.In addition, in the present invention, the needle assembly is characterized in that the suction hole is connected to the reservoir to suck the liquid tissue.

또한, 본 발명에 있어서, 주입홀의 수직 단면은 원형, 타원형 또는 역삼각형 모양을 갖도록 형성되는 것을 특징으로 한다.In addition, in the present invention, the vertical cross section of the injection hole is characterized in that it is formed to have a circular, elliptical or inverted triangle shape.

또한, 본 발명에 있어서, 주입홀의 외면에 다수의 사이드 홀이 형성되는 것을 특징으로 한다.In the present invention, a plurality of side holes are formed on the outer surface of the injection hole.

또한, 본 발명에 있어서, 주입홀과 연결되는 약물 주입 실린지 및 흡인홀과 연결되는 조직 흡인 실린지가 하우징의 내부에 탈착 가능하게 구비되는 것을 특징으로 한다.In addition, in the present invention, the drug injection syringe connected to the injection hole and the tissue suction syringe connected to the suction hole is characterized in that it is detachably provided inside the housing.

또한, 본 발명에 있어서, 약물 주입 실린지 및 조직 흡인 실린지는 중공의 실린지 바디 및 실린지 바디 내부를 이동하는 피스톤으로 구성되는 것을 특징으로 한다.In addition, in the present invention, the drug injection syringe and the tissue suction syringe is characterized by consisting of a hollow syringe body and a piston moving inside the syringe body.

또한, 본 발명에 있어서, 약물 주입 실린지 및 조직 흡인 실린지가 슬라이드 가능하도록 각각 슬라이드 버튼이 피스톤과 결합하는 것을 특징으로 한다.In addition, in the present invention, the slide button is coupled to the piston so that the drug injection syringe and the tissue suction syringe are slidable, respectively.

또한, 본 발명에 있어서, 약물 주입 실린지 및 조직 흡인 실린지는 1㏄ 내지 3cc의 용량을 갖는 것을 특징으로 한다.In addition, in the present invention, the drug injection syringe and the tissue suction syringe is characterized by having a dose of 1 ~ 3cc.

또한, 본 발명에 있어서, 슬라이드 버튼이 이동하는 하우징의 일면에 하나 또는 둘 이상의 고정홈이 연속적으로 형성되어 단위길이로 피스톤을 슬라이드 시킨 후 압력에 의해 발사버튼 방향으로 이동되지 않게 정지시키는 것을 특징으로 한다.In addition, in the present invention, one or more fixing grooves are continuously formed on one surface of the housing in which the slide button is moved to slide the piston to a unit length, and then stop not moving in the direction of the firing button by pressure. do.

또한, 본 발명에 있어서, 하우징에 형성되는 공간부, 및 일단이 주입홀과 연결되고, 공간부에 수납되는 연장튜브를 포함하는 것을 특징으로 한다.In addition, in the present invention, a space portion formed in the housing, and one end is connected to the injection hole, characterized in that it comprises an extension tube accommodated in the space portion.

또한, 본 발명에 있어서, 연장튜브의 타단이 공간부의 외부로 노출되어 체결부를 형성하는 것을 특징으로 한다.In addition, in the present invention, the other end of the extension tube is exposed to the outside of the space portion to form a fastening portion.

또한, 본 발명에 있어서, 공간부를 개폐하는 커버를 형성하는 것을 특징으로 한다.Moreover, in this invention, the cover which opens and closes a space part is characterized by the above-mentioned.

또한, 본 발명에 있어서, 하우징에 형성되는 공간부, 및 일단이 흡인홀과 연결되고, 공간부에 수납되는 연장튜브를 포함하는 것을 특징으로 한다.Further, in the present invention, the space portion formed in the housing, and one end is connected to the suction hole, characterized in that it comprises an extension tube accommodated in the space portion.

또한, 본 발명에 있어서, 연장튜브의 타단이 공간부의 외부로 노출되어 체결부를 형성하는 것을 특징으로 한다.In addition, in the present invention, the other end of the extension tube is exposed to the outside of the space portion to form a fastening portion.

또한, 본 발명에 있어서, 공간부를 개폐하는 커버를 형성하는 것을 특징으로 한다.Moreover, in this invention, the cover which opens and closes a space part is characterized by the above-mentioned.

본 발명의 생체 조직 채취 장치에 따르면, 생체 조직 채취 장치의 바늘 조립체에는 절단된 조직을 보관하는 저장부, 및 액체성 조직을 채취하는 흡인홀이 구비되고, 튜브의 하단부에는 상처가 생긴 조직 내로 약물을 주입하는 주입홀이 구비되며, 조직 채취로 인해 종양 및 조직 검사 트랙에서 발생되는 출혈과 종양 세포 오염 부위에는 주입홀에 의해 약물이 투여됨으로써, 하나의 기구로 조직 채취와 약물 투여가 동시에 이루어질 수 있기 때문에, 조직 채취 후 출혈과 종양 세포 오염을 예방할 수 있는 생체 조직 채취 장치를 제공할 수 있다.According to the biological tissue collecting device of the present invention, the needle assembly of the biological tissue collecting device is provided with a storage unit for storing the cut tissue, and a suction hole for collecting liquid tissue, and the lower end of the tube contains a drug into the wounded tissue. The injection hole is provided, and the bleeding generated from the tumor and the histological track due to the tissue collection is administered by the injection hole in the site of the tumor cell contamination, so that the tissue collection and drug administration can be performed simultaneously with a single instrument. As a result, it is possible to provide a biological tissue collection device that can prevent bleeding and tumor cell contamination after tissue collection.

또한, 조직 검사 트랙 및 종양의 조직 채취 부위에 약물을 도포하여 절단 부분을 표시함으로써, 수술 시 종양 조직뿐만 아니라 약물이 도포된 부분까지 절제할 수 있는 생체 조직 채취 장치를 제공할 수 있다.In addition, by applying the drug to the biopsy track and the tissue extraction site of the tumor to mark the cut portion, it is possible to provide a biological tissue harvesting device that can remove not only tumor tissue but also the drug applied portion during surgery.

또한, 생체 조직 채취 시, 채취하고자 하는 조직이 고체성일 경우에는 저장부에서 채취하고, 액체성 조직은 흡인홀로 용이하게 채취할 수 있는 생체 조직 채취 장치를 제공할 수 있다.In addition, when biological tissue is collected, the tissue to be collected may be collected in a storage unit when the tissue to be collected is solid, and the liquid tissue may be easily collected by a suction hole.

도 1은 종래 기술에 따른 생체 조직 채취용 장치를 도시한 사시도이다;1 is a perspective view showing a device for collecting biological tissue according to the prior art;

도 2a 내지 도 2c는 종래 기술의 따른 생체 조직 채취용 장치의 사용법을 도시한 도이다;Figures 2a to 2c is a view showing the use of the apparatus for collecting biological tissue according to the prior art;

도 3은 본 발명의 일실시예에 생체 조직 채취용 장치를 도시한 사시도이다;3 is a perspective view showing a device for collecting biological tissue in one embodiment of the present invention;

도 4는 본 발명의 또다른 일실시예에 따른 생체 조직 채취용 장치를 도시한 사시도이다;Figure 4 is a perspective view showing a device for collecting biological tissue according to another embodiment of the present invention;

도 5는 본 발명의 실시예에 따른 생체 조직 채취 장치를 나타낸 사시도이다; 5 is a perspective view showing a biological tissue collection device according to an embodiment of the present invention;

도 6은 도 5에 따른 바늘 조립체의 작용을 나타낸 사시도이다;6 is a perspective view showing the action of the needle assembly according to FIG. 5;

도 7 내지 도 12는 본 발명에 따른 생체 조직 채취용 장치의 조직 채취 과정을 도시한 사시도이다;7 to 12 is a perspective view showing a tissue collection process of the apparatus for collecting biological tissues according to the present invention;

도 13a 내지 도 13c는 도 7의 생체 조직 채취용 장치 주입홀의 다양한 형상을 나타내는 개략도이다;13A to 13C are schematic views showing various shapes of the apparatus injection hole for collecting biological tissue of FIG. 7;

도 14a 내지 도 14d는 도 12의 생체 조직 채취용 장치 저장부의 다양한 형상을 나타내는 개략도이다;14A to 14D are schematic views showing various shapes of the device storage unit for collecting the biological tissue of FIG. 12;

도 15는 본 발명의 다른 실시예에 따른 생체 조직 채취 장치의 사시도; 및 15 is a perspective view of a biological tissue collection device according to another embodiment of the present invention; And

도 16는 도 15에 따른 바늘 조립체의 작용을 도시한 평면도이다;16 is a plan view showing the action of the needle assembly according to FIG. 15;

도 17은 본 발명의 또다른 일실시예에 따른 생체 조직 채취용 장치를 도시한 사시도이다;17 is a perspective view showing a device for biological tissue collection according to another embodiment of the present invention;

도 18은 본 발명의 또다른 일실시예에 따른 생체 조직 채취용 장치를 도시한 사시도이다;18 is a perspective view showing an apparatus for collecting biological tissues according to another embodiment of the present invention;

도 19는 도 17에 따른 연장튜브를 개폐장치가 있는 공간부 내 장착 방법을 도시한 사시도이다.19 is a perspective view illustrating a method for mounting the extension tube in FIG.

이하, 첨부한 도면들 및 후술되어 있는 내용을 참조하여 본 발명의 바람직한 실시예를 상세히 설명한다. 그러나 본 발명은 여기서 설명되는 실시예에 한정되지 않고 다른 형태로 구체화될 수도 있다. 오히려, 여기서 소개되는 실시예는 개시된 내용이 철저하고 완전해질 수 있도록 그리고 당업자에게 본 발명의 사상이 충분히 전달될 수 있도록 하기 위해 제공되는 것이다. 명세서 전체에 걸쳐서 동일한 참조 번호들은 동일한 구성 요소들을 나타낸다.Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings and the contents described below. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosure may be made thorough and complete, and to fully convey the spirit of the invention to those skilled in the art. Like reference numerals refer to like elements throughout.

도 3은 본 발명에 따른 생체 조직 채취 장치(200)를 도시한 사시도를 나타낸다.3 is a perspective view showing a biological tissue collection device 200 according to the present invention.

도 3에 따른 생체 조직 채취 장치(200)는 하우징(210), 하우징(210)의 선단부에 결합되어 연장되는 튜브(220), 및 튜브(220) 내에 결합되어 생체 조직을 채취하는 바늘 조립체(230)로 구성된다.The biological tissue collecting device 200 according to FIG. 3 includes a housing 210, a tube 220 coupled to an extended end of the housing 210, and a needle assembly 230 coupled to the tube 220 to collect biological tissue. It is composed of

하우징(210)의 후단부에는 튜브(220) 및 바늘 조립체(230)를 이동시키는 발사 버튼(212), 액체성 조직을 담는 제1실린지(214), 약물을 담는 제2실린지(216), 제1실린지(214)와 슬라이드 가능하게 결합하는 제1슬라이드(215), 제2실린지(216)와 슬라이드 가능하게 결합하는 제2슬라이드(217)로 구성된다.The rear end of the housing 210 has a firing button 212 for moving the tube 220 and the needle assembly 230, a first syringe 214 containing liquid tissue, a second syringe 216 containing a drug The first slide 215 is slidably coupled to the first syringe 214, and the second slide 217 is slidably coupled to the second syringe 216.

발사 버튼(212)은 2단 버튼으로 형성되며, 이에 대한 자세한 설명은 하기에서 설명하도록 한다.Launch button 212 is formed of a two-stage button, a detailed description thereof will be described below.

제1실린지(214)와 제2실린지(216)는 중공의 실린지 바디(214a, 216a)와 실린지 바디(214a, 216a) 내를 이동하는 피스톤(214b, 216b)으로 구성되어, 하우징(210)의 내부에 나란히 구비된다.The first syringe 214 and the second syringe 216 are composed of hollow syringe bodies 214a and 216a and pistons 214b and 216b that move in the syringe bodies 214a and 216a. It is provided side by side inside the 210.

또한, 제1실린지(214) 및 제2실린지(216)가 슬라이드 가능하도록 제1실린지(214) 및 제2실린지(216)의 피스톤(214b, 216b) 일단에 결합되는 제1슬라이드(215) 및 제2슬라이드(217)가 하우징(210)의 내부에서 나란히 탈부착 가능하게 구비된다.In addition, a first slide coupled to one end of pistons 214b and 216b of the first syringe 214 and the second syringe 216 so that the first syringe 214 and the second syringe 216 are slidable. The 215 and the second slide 217 are detachably provided side by side inside the housing 210.

여기서, 하우징(210)은 사용자가 손으로 파지하는 부분으로, 제1실린지(214)와 제2실린지(216)의 용량은 1㏄ 이상의 용량을 구비하는 것이 바람직하다. Here, the housing 210 is a portion that the user grips by hand, and the capacity of the first syringe 214 and the second syringe 216 preferably has a capacity of 1 kW or more.

제1실린지(214)와 제2실린지(216)의 작동 방법을 살펴보면 다음과 같다.Looking at the operation of the first syringe 214 and the second syringe 216 are as follows.

먼저, 제1실린지(214)의 작동을 설명하면, 제1실린지(214)의 초기 상태는 제1실린지(214)의 피스톤(214b) 선단이 제1실린지(214)의 실린지 바디(214a) 선단에 닿아 있으며, 제1슬라이드(215)가 제1실린지(214)의 피스톤(214b)을 발사 버튼(212) 방향으로 이동시키면, 제1실린지(214)의 피스톤(214b) 선단과 제1실린지(214)의 실린지 바디(214a) 선단이 서로 이격되고, 이에 따라 제1실린지(214)의 실린지 바디(214a) 내에 액체성 조직이 흡인된다(도 5 참조).First, the operation of the first syringe 214, the initial state of the first syringe 214 is the front end of the piston 214b of the first syringe 214 the syringe of the first syringe 214 When the first slide 215 moves the piston 214b of the first syringe 214 toward the firing button 212, the piston 214b of the first syringe 214 is in contact with the tip of the body 214a. ) The tip and the tip of the syringe body 214a of the first syringe 214 are spaced apart from each other, so that liquid tissue is sucked into the syringe body 214a of the first syringe 214 (see FIG. 5). ).

이때, 제1실린지(214)가 액체성 조직을 흡인하는 경우, 제1실린지(214)의 피스톤(214b)에는 발사 버튼(212) 방향으로 압력이 발생된다. 제1실린지(214)의 실린지 바디(214a) 내로 흡인되는 액체성 조직은 점성을 가지고 있기 때문에 제1실린지(214)의 피스톤(214b)과는 반대 방향으로 압력이 발생하게 되고, 이에 발사 버튼(212) 방향으로 이동하던 실린지(214, 216)의 피스톤(214b, 216b)이 바늘 조립체(230) 방향으로 이동하는 경우가 발생한다.At this time, when the first syringe 214 sucks liquid tissue, pressure is generated in the piston 214b of the first syringe 214 in the direction of the firing button 212. Since the liquid tissue sucked into the syringe body 214a of the first syringe 214 is viscous, pressure is generated in a direction opposite to the piston 214b of the first syringe 214. The pistons 214b and 216b of the syringes 214 and 216 that have moved in the direction of the firing button 212 may move in the direction of the needle assembly 230.

따라서, 제1슬라이드(215) 및 제2슬라이드(217)가 슬라이드하는 하우징(210)의 일면에 하나 또는 둘 이상의 고정홈(218)이 연속적으로 형성되어 전후방향으로 상기 피스톤을 슬라이드 시킨 후 정지시킨 후 압력에 의해 발사버튼 방향으로 이동되지 않게 정지시킬 수 있으며, 이를 단위길이로 작동시킬 수 있다.Accordingly, one or more fixing grooves 218 are continuously formed on one surface of the housing 210 in which the first slide 215 and the second slide 217 slide to slide the piston in the front-rear direction and then stop. After the pressure can be stopped so as not to move in the direction of the firing button, it can be operated in unit length.

상기 고정홈(218)의 형상은 피스톤(214b, 216b)이 바늘 조립체(230) 방향으로 지나치게 이동하는 것을 방지할 수 있다면 특별히 제한되는 것은 아니나, 하나의 바람직한 예에서, 도 3의 확대도에 도시된 바와 같이, 상기 고정홈(218a)은 래크기어 형상일 수 있으며, 이는 실린지(214, 216)의 피스톤(214b, 216b)이 바늘 조립체(230) 방향으로 이동하는 것을 방지할 수 있다. The shape of the fixing groove 218 is not particularly limited as long as it can prevent the piston (214b, 216b) from moving excessively in the direction of the needle assembly 230, in one preferred example, shown in the enlarged view of FIG. As shown, the fixing groove 218a may have a rack gear shape, which may prevent the pistons 214b and 216b of the syringes 214 and 216 from moving in the direction of the needle assembly 230.

생체 조직 채취용 장치의 또다른 바람직한 예에서, 도 4와 같이, 슬라이드하는 하우징(210)의 일면에 다수의 고정홈(218b)이 길이방향으로 돌기 형상으로 형성될 수 있으며, 상기 돌기 형상의 고정홈(218b)과 체결될 수 있는 고정홀(219)이 제1슬라이드(215) 또는 제2슬라이드(217)의 후단부에 형성될 수 있다. 구체적으로, 도 4의 확대도와 같이, 상기 제1슬라이드(215) 또는 제2슬라이드(217)가 길이방향으로 이동하다가 고정홈(218b)이 고정홀(219)에 삽입되어 걸림 고정되면, 피스톤(214b, 216b)이 바늘 조립체(230) 방향으로 이동하는 것을 방지할 수 있다. 경우에 따라서, 돌기 형상의 고정홈(218b)은 제1실린지(215)와 제2실린지(217)의 이동방향에 따라 일렬 또는 이열로 형성될 수 있으며, 외력을 가하면 상하방향으로 유동되어 실린지(214, 216)의 피스톤(214b, 216b) 수평방향으로 이동할 수 있다.In another preferred example of the apparatus for collecting biological tissue, as shown in Figure 4, a plurality of fixing grooves 218b on one surface of the sliding housing 210 may be formed in a projection shape in the longitudinal direction, the projection shape fixed A fixing hole 219 that may be coupled to the groove 218b may be formed at the rear end of the first slide 215 or the second slide 217. Specifically, as shown in the enlarged view of FIG. 4, when the first slide 215 or the second slide 217 moves in the longitudinal direction, and the fixing groove 218b is inserted into the fixing hole 219 and locked, the piston ( 214b and 216b may be prevented from moving in the direction of the needle assembly 230. In some cases, the protrusion-shaped fixing groove 218b may be formed in a row or two rows according to the moving directions of the first syringe 215 and the second syringe 217, and may flow upward and downward when an external force is applied. The pistons 214b and 216b of the syringes 214 and 216 can move in the horizontal direction.

제2실린지(216)의 작동을 설명하면, 제2실린지(216)의 초기 상태는 제2실린지(216)의 피스톤(216b) 선단과 제2실린지(216)의 실린지 바디(216a) 선단이 서로 최대 이격된 상태로 있으며, 제2슬라이드(217)가 제2실린지(216)의 피스톤(216b) 선단을 제2실린지(216)의 실린지 바디(216a) 선단으로 이동시키면, 제2실린지(216)의 실린지 바디(216a) 내에 있던 약물은 제2실린지(216)의 피스톤(216b)의 밀어내는 힘에 의해 주입홀(222)을 통하여 종양의 조직 채취 부위 및 조직 검사 트랙의 출혈 부분에 투여된다(도 6 참조).Referring to the operation of the second syringe 216, the initial state of the second syringe 216 is the front end of the piston 216b of the second syringe 216 and the syringe body of the second syringe 216 ( 216a) the tips are spaced apart from each other, and the second slide 217 moves the tip of the piston 216b of the second syringe 216 to the tip of the syringe body 216a of the second syringe 216. In other words, the drug in the syringe body 216a of the second syringe 216 is a tissue extraction site of the tumor through the injection hole 222 by the pushing force of the piston 216b of the second syringe 216. And the bleeding portion of the biopsy track (see FIG. 6).

도 17 및 도 18은, 생체 조직 채취용 장치의 또다른 예로서, 상기의 제1실린지 및 제2실린지를 대신하여 적어도 하나의 연장튜브를 포함하는 구조일 수 있다.17 and 18, as another example of the apparatus for collecting biological tissue, may have a structure including at least one extension tube in place of the first and second syringes.

일 실시예에 따르면, 생체 조직 채취용 장치는 하우징(410)에 형성되는 공간부(412), 일단이 흡인홀(436) 및/또는 주입홀(422)의 끝단과 연결되고 공간부에 수납되는 연장튜브(440, 440')를 포함하여 구성될 수 있다.According to one embodiment, the apparatus for collecting biological tissue is connected to the end of the space portion 412, one end of the suction hole 436 and / or injection hole 422 formed in the housing 410 and is received in the space portion It may be configured to include an extension tube (440, 440 ').

구체적으로, 연장튜브(440, 440')를 사용할 경우에는, 상기 연장튜브(440, 440')의 일단은 흡인홀(436) 및/또는 주입홀(422)의 끝단에 각각 연결되고, 타단은 공간부(412)의 외부로 노출되고, 그 타단에 통상에서 사용되는 일체형 주사기(460)또는 일반 주사기(461)를 체결하기 위한 체결부(442, 442')가 형성될 수 있다. Specifically, in the case of using the extension tubes 440 and 440 ', one end of the extension tube 440 and 440' is connected to the end of the suction hole 436 and / or injection hole 422, respectively, the other end Fastening portions 442 and 442 ′ for exposing the syringe 460 or the general syringe 461 that are commonly used at the other end of the space 412 and exposed to the other end thereof may be formed.

바람직하게는, 체결부(442)에 일체형 주사기(460)를 연결하고, 또 다른 체결부(442')에 일반 주사기(461)를 체결함으로써, 상기 연장튜브(440, 440')를 통해 흡인이나 약물 주입이 가능할 수 있다. 구체적으로, 조직 검사만 진행할 경우에는, 공간부(412) 내에 연장튜브(440, 440')를 수납하여 보관하고, 액체의 흡인이 필요한 경우에는 체결부(442')를 통해 일반 주사기(461)로 흡인하고, 약물주입이 필요한 경우에는 약물이 장전된 일체형 주사기(460)를 체결부(440)에 결합하여 주입할 수 있다.Preferably, by connecting the integrated syringe 460 to the fastening portion 442, and by fastening the general syringe 461 to another fastening portion 442 ', suction or through the extension tube (440, 440') Drug injection may be possible. Specifically, when only the biopsy is performed, the extension tubes 440 and 440 'are stored and stored in the space 412, and when the suction of liquid is required, the general syringe 461 is provided through the fastening portion 442'. When aspirated and drug injection is required, the integrated syringe 460 loaded with drugs may be injected into the fastening part 440.

즉, 연장튜브(440, 440')는 사용 용도에 따라 흡인홀(436) 또는 주입홀(422)의 끝단에 연결하여 사용할 수 있으며, 흡인홀(436) 및 주입홀(422)의 끝단에 동시에 연결하여 사용할 수 있음은 물론이다.That is, the extension tubes 440 and 440 'may be connected to the end of the suction hole 436 or the injection hole 422 according to the intended use, and at the same time the ends of the suction hole 436 and the injection hole 422 Of course, you can connect and use.

상기 일체형 주사기(460)에 주입되는 약물의 종류는 다양할 수 있으며, 예를 들어, 항암제 또는 지혈제 등일 수 있으며, 상기 지혈제는 일체형 주사기(460)에 각각 분리되어 액체 상태로 보관되어 있다가, 주입할 경우 서로 합체되어 응고되면서 지혈 효과를 나타낼 수 있다.The type of drug injected into the integrated syringe 460 may vary, for example, may be an anticancer agent or a hemostatic agent, and the hemostatic agent is separately stored in the integrated syringe 460 and stored in a liquid state. If you coalesce with each other to coagulate can exhibit a hemostatic effect.

또한, 본 발명에서 사용되는 체결부(442, 442')는 모든 형태의 주사기를 장착할 수 있는 유니버셜한 커넥터(universal connector)이므로, 체결부(442, 442')에 다양한 주사기를 간단하고 용이하게 장착할 수 있다. In addition, since the fastening parts 442 and 442 'used in the present invention are universal connectors to which all types of syringes can be mounted, a variety of syringes can be easily and easily attached to the fastening parts 442 and 442'. I can attach it.

한편, 상기 연장튜브를 사용하지 않을 경우에는, 도 19에서와 같이, 일체형 주사기 또는 일반 주사기를 제거하여, 하우징(410)에 형성된 공간부(412) 내부에 연장튜브(440)를 수납하고, 공간부(412)와 결합된 덮개(450)를 통해 생체 조직 채취용 장치 내부에 보관할 수 있다.On the other hand, when not using the extension tube, as shown in Figure 19, by removing the integrated syringe or a general syringe, the extension tube 440 is stored in the space 412 formed in the housing 410, the space The cover 450 coupled to the portion 412 may be stored inside the biological tissue collection device.

구체적으로, 상기 덮개(450)는 공간부(412)를 개폐할 수 있는 형상이면 특별히 제한되는 것은 아니나, 하나의 바람직한 예로서, 하우징(410)과 일체형으로 형성될 수 있으며, 덮개(450) 선단에는 일정 크기의 홈(454)을 가진 걸림돌기(452)가 형성되어, 공간부(412)의 일측에 형성된 걸고리(414)에 상기 걸림돌기(452)가 끼워져 폐쇄되는 구조로 형성될 수 있다. 또한, 상기 공간부(412)는 연장튜브(440, 440')가 수납될 수 있도록 일정 깊이와 크기를 가질 수 있으면, 특별히 제한되는 것은 아니다.Specifically, the cover 450 is not particularly limited as long as it is a shape capable of opening and closing the space 412, but as a preferred example, may be formed integrally with the housing 410, the tip of the cover 450 The locking protrusion 452 having a predetermined size of the groove 454 is formed, and the locking protrusion 452 may be inserted into the hook 414 formed on one side of the space 412 to be closed. In addition, the space 412 is not particularly limited as long as it can have a predetermined depth and size to accommodate the extension tubes 440 and 440 '.

도 7은 본 발명의 실시예에 따른 생체 조직 채취 장치(200)의 사시도를 나타내며, 도 8은 도 7에 따른 바늘 조립체(230)의 작용을 도시한 평면도를 나타낸다.7 shows a perspective view of a biological tissue collection device 200 according to an embodiment of the present invention, Figure 8 shows a plan view showing the action of the needle assembly 230 according to FIG.

도 7 내지 도 8에 도시된 본 발명의 일 실시예에 따른 생체 조직 채취 장치(200)는 도 3과 같이 하우징(210), 하우징(210)의 선단부에 결합되어 연장되는 튜브(220), 및 튜브(220) 내에 결합되어 생체 조직을 채취하는 바늘 조립체(230)로 구성된다. 7 to 8 is a biological tissue harvesting apparatus 200 according to an embodiment of the present invention shown in Figure 3, the housing 210, the tube 220 is coupled to the front end of the housing 210 and extended, and It is composed of a needle assembly 230 coupled to the tube 220 to collect biological tissue.

하우징(210)의 구성 및 형상은 도 3의 상세한 설명에 기술된 바와 같으므로 생략하도록 한다.Configuration and shape of the housing 210 is as described in the detailed description of Figure 3 will be omitted.

바늘 조립체(230)는 선단부(232), 선단부(232)의 후방에 형성되어 조직이 보관되는 저장부(234), 및 저장부(234)에서 제1실린지(214)와 연결되어 액체성 조직이 채취되는 흡인홀(236)로 구성된다.The needle assembly 230 is formed at the front end portion 232, the rear end portion 232 of the storage portion 234 to store tissue, and the storage portion 234 connected to the first syringe 214 in liquid tissue. The suction hole 236 is collected.

상기 바늘 조립체(230)의 선단부(232)는 절단면을 가진 바늘 형상이면 특별히 제한하는 것은 아니지만, 바람직하게는 바늘 조립체(230)의 선단부(232)는 삼각뿔 형태를 가질 수도 있다.The tip portion 232 of the needle assembly 230 is not particularly limited as long as it is a needle shape having a cut surface, but preferably, the tip portion 232 of the needle assembly 230 may have a triangular pyramid shape.

또한, 바늘 조립체(230)는, 하나의 바람직한 예에서, Ti, Ni, Fe, Cr, Ta, 스테인레스 스틸, 및 형상기억합금으로 구성되는 군으로부터 선택되는 하나 또는 둘 이상의 금속으로 형성될 수 있으며, 또다른 바람직한 예에서, Ti, Ni, Fe, Cr, Ta, 스테인레스 스틸, 및 형상기억합금으로 구성되는 군으로부터 선택되는 하나 또는 둘 이상의 금속으로 코팅될 수 있다.Further, the needle assembly 230 may be formed of one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloys, in one preferred example, In another preferred example, it may be coated with one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloys.

바람직하게는, 인체에 유해하여 염증 등을 유발시킬 수 있는 요소가 거의 없고 내식성과 기계적 특성이 우수한 형상기억합금의 니켈-티타늄 합금일 수 있다. 상기 니켈-티타늄 합금은, 니켈 및 티타늄의 무게 조성비에 따라 형성회복 온도가 달라지며, 예를 들어, 형상회복온도가 실온보다 높으면 실온에서 형상기억효과(Shape Memory Effect)가 나타나며, 형상회복온도가 실온보다 낮으면 실온에서 초탄성효과(Super Elastic Effect)가 나타나는 특성이 있다.Preferably, it may be a nickel-titanium alloy of a shape memory alloy that is harmful to the human body and causes little or no inflammation and has excellent corrosion resistance and mechanical properties. In the nickel-titanium alloy, the formation recovery temperature varies according to the weight composition ratio of nickel and titanium. For example, when the shape recovery temperature is higher than room temperature, the shape memory effect appears at room temperature, and the shape recovery temperature is If it is lower than room temperature, there is a characteristic that the super elastic effect appears at room temperature.

초탄성 합금은 보통의 금속재료라면 소성 변형(plastic deformation)이 될 정도의 큰 변형력을 가하여 변형시키고 변형력을 제거하면 고무와 같이 원래의 모양으로 회복된다. 따라서, 조직 채취시 채취하는 힘에 의한 변형이나 부러짐이 생기지 않고 채취 후에도 원래 형상을 유지하는 특성이 있으므로, 안전성이 향상될 수 있다.The superelastic alloy is deformed by applying a large deformation force such that plastic deformation is normal metal material, and when the deformation force is removed, it is restored to its original shape like rubber. Therefore, since there is a characteristic of maintaining the original shape even after collection without deformation or breakage due to the force collected during tissue collection, safety can be improved.

니켈-티타늄 합금이 본 발명이 소망하는 효과를 나타내기 위해서는, 니켈 및 티타늄의 중량 조성비는 55:45 내지 99:1인 것이 바람직하며, 보다 바람직하게는 55:45 내지 65:35일 수 있다. 하나의 바람직한 예로서, 상기 조성물을 진공아크용해로에서 용융물로 용해하여 바늘 조립체(230)의 선단부(232)에만 코팅하여 본 발명의 바늘 조립체(230)를 형성할 수 있다. 또 다른 바람직한 예로서, 용해된 니켈-티타늄 용융물을 판재 형상으로 응고시킨 뒤, 가공하여 본 발명의 바늘 조립체(230)을 형성할 수 있다.In order for the nickel-titanium alloy to exhibit the desired effect of the present invention, the weight composition ratio of nickel and titanium is preferably 55:45 to 99: 1, and more preferably 55:45 to 65:35. As one preferred embodiment, the composition may be dissolved in a melt in a vacuum arc furnace to coat only the tip portion 232 of the needle assembly 230 to form the needle assembly 230 of the present invention. As another preferred example, the molten nickel-titanium melt may be solidified into a plate shape and then processed to form the needle assembly 230 of the present invention.

한편, 튜브(220)는 약물이 유동하는 주입홀(222) 및 조직을 절단하기 위한 커팅부(224)로 구성되며, 약물이 유동하는 주입홀(222)은 튜브(220)의 하단부에서 길이방향으로 구비된다.On the other hand, the tube 220 is composed of an injection hole 222 through which the drug flows and a cutting portion 224 for cutting the tissue, the injection hole 222 through which the drug flows in the longitudinal direction at the lower end of the tube 220 It is provided with.

상기 주입홀(222)의 수직단면 형상은 필요에 따라 다양하게 형성될 수 있으나, 바람직하게는, 도 7 및 13a 내지 13c에 도시된 바와 같이, 약물의 유동이 용이할 수 있도록 원형, 타원형 또는 역삼각형 형상으로 형성될 수 있으며, 홀(223)의 크기는 생체 내에 삽입되는 기구의 특성상 커팅부(224) 보다 작은 범위에서 결정되는 것이 바람직하다.The vertical cross-sectional shape of the injection hole 222 may be variously formed as necessary, but preferably, as shown in FIGS. 7 and 13A to 13C, a circular, elliptical, or inverse may be used to facilitate the flow of drugs. It may be formed in a triangular shape, the size of the hole 223 is preferably determined in a smaller range than the cutting portion 224 due to the nature of the mechanism to be inserted into the living body.

경우에 따라서는, 도 13a 및 도 13c에 도시된 바와 같이, 주입홀(222)의 외면에 다수의 사이드홀(221)이 형성될 수 있다. 구체적으로, 주입홀(222)의 외면 전체 또는 일부에 다수의 사이드홀(221)이 형성되어, 주입홀의 홀(223) 및 다수의 사이드홀(221)을 통해 조직 채취로 인해 발생된 상처 부위에 약물이 정확하게 투여될 수 있으며, 넓은 상처 부위에도 약물을 용이하게 투여할 수 있는 효과가 있다. 바람직하게는, 주입홀(222) 길이방향의 전체 길이를 기준으로 10 내지 20%의 길이로 주입홀(222)의 선단에 사이드홀(221)이 형성될 수 있다.In some cases, as shown in FIGS. 13A and 13C, a plurality of side holes 221 may be formed on the outer surface of the injection hole 222. Specifically, a plurality of side holes 221 are formed on the whole or part of the outer surface of the injection hole 222, through the holes 223 and the plurality of side holes 221 of the injection hole in the wound site generated due to tissue collection Drugs can be accurately administered, there is an effect that can be easily administered to a large wound area. Preferably, the side hole 221 may be formed at the tip of the injection hole 222 with a length of 10 to 20% based on the entire length of the injection hole 222 in the longitudinal direction.

또한, 조직을 절단하는 커팅부(224)는 튜브(220)의 선단부, 즉 바늘 조립체(230)의 저장부(234)에서 이어지는 튜브(220) 위치에 날카롭게 형성된다.In addition, the cutting portion 224 for cutting the tissue is sharply formed at the tip of the tube 220, that is, the tube 220 position leading from the reservoir 234 of the needle assembly 230.

도 8을 참조하여 일 실시예에 따른 생체 조직 채취 장치(200)의 사용 방법을 간략하게 살펴보면, 하우징(210)의 발사 버튼(212)은 2단 버튼으로 설치되어, 사용자가 발사 버튼(212)을 한번 누르면 바늘 조립체(230)가 채취될 조직의 위치로 발사되고(도 7의 화살표 C 참조), 다시 한번 발사 버튼(212)을 누르게 되면, 튜브(220)가 바늘 조립체(230)를 덮도록 바늘 조립체(230)의 선단부(232)까지 이동한다(도 8의 화살표 D 참조).Referring to FIG. 8, a method of using the biological tissue collecting device 200 according to an exemplary embodiment will be described in brief. The launch button 212 of the housing 210 may be installed as a two-stage button, and the user may launch the button 212. Press once to release the needle assembly 230 to the location of the tissue to be collected (see arrow C in FIG. 7), and once again to press the fire button 212, the tube 220 covers the needle assembly 230. Move to tip 232 of needle assembly 230 (see arrow D in FIG. 8).

튜브(220)가 바늘 조립체(230)의 선단부(232)까지 이동하면서, 튜브(220)의 선단부에 구비된 커팅부(224)에 의하여 조직이 절단되어 저장부(234)에 채취된다.As the tube 220 moves up to the tip portion 232 of the needle assembly 230, the tissue is cut and collected in the storage portion 234 by the cutting portion 224 provided at the tip portion of the tube 220.

상술한 바와 같이 구성된 생체 조직 채취용 장치의 조직 채취 과정을 다음 도면을 참조하여 더욱 상세히 설명하도록 한다.The tissue collection process of the apparatus for collecting biological tissues configured as described above will be described in more detail with reference to the following drawings.

도 9 내지 도 12는 본 발명에 따른 생체 조직 채취용 장치(200)의 채취 과정을 도시한 도면을 나타내며, 도 9 내지 도 12에서는 고체성 조직일 경우를 실시예로 설명하도록 한다.9 to 12 are views illustrating a sampling process of the apparatus 200 for collecting biological tissues according to the present invention. In FIGS. 9 to 12, examples of the solid tissue will be described.

먼저, 하우징(210)에 결합된 장전 장치(미도시)를 이용하여 튜브(220), 및 튜브(220) 내에 결합되는 바늘 조립체(230)를 하우징(210)에 장전시킨 후, 초음파 또는 컴퓨터 단층 촬영 등의 영상 장치(미도시)를 보면서 종양 조직 내로 튜브(220)를 삽입한다.First, a tube 220 and a needle assembly 230 coupled within the tube 220 are loaded into the housing 210 using a loading device (not shown) coupled to the housing 210, and then ultrasonic or computer monolayer. The tube 220 is inserted into the tumor tissue while viewing an imaging device (not shown) such as a photographing.

이후, 하우징(210)의 후단부에 구비된 발사 버튼(212)을 한번 누르면, 도 10에 도시된 바와 같이, 바늘 조립체(230)가 발사되어 채취할 조직(240)에 위치된다.Thereafter, when the firing button 212 provided at the rear end of the housing 210 is pressed once, as shown in FIG. 10, the needle assembly 230 is fired and positioned on the tissue 240 to be collected.

이때, 채취해야 할 조직(240)이 고체성이거나 또는 액체성일 경우가 있다. 따라서, 액체성 조직일 경우에는 제1슬라이드(215)를 발사 버튼(212) 방향쪽으로 슬라이드 시키면 흡인홀(236)을 통하여 액체성 조직이 제1실린지(214)로 유입된다. At this time, the tissue 240 to be collected may be solid or liquid. Therefore, in the case of liquid tissue, when the first slide 215 is slid toward the firing button 212, the liquid tissue flows into the first syringe 214 through the suction hole 236.

그러나 제1실린지(214) 내로 유입되는 액체가 없다면 채취해야할 조직(240)은 고체성이 된다. However, if there is no liquid flowing into the first syringe 214, the tissue 240 to be collected becomes solid.

이후, 바늘 조립체(230)가 채취할 조직(240)에 위치되면, 사용자는 발사 버튼(212)을 한 번 더 누르고, 도 10에 도시된 바와 같이, 선단부에 커팅부(224)가 구비된 튜브(220)가 바늘 조립체(230)의 저장부(234)를 덮도록 바늘 조립체(230)의 선단부(232)까지 이동한다.Then, when the needle assembly 230 is positioned on the tissue 240 to be collected, the user presses the firing button 212 once more, and as shown in FIG. 10, the tube having the cutting portion 224 at the tip portion thereof. 220 moves to tip 232 of needle assembly 230 to cover reservoir 234 of needle assembly 230.

이때, 커팅부(224)는 저장부(234)에 위치된 조직(240)을 절단하게 되고, 절단된 조직(240)은 저장부(234) 내에 저장된다. 상기 커팅부(224)의 저장부(234)는 절단된 조직(240)이 외부에 유출되지 않고 잘 저장될 수 있는 형상이라면, 특별히 제한되는 것은 아니나, 바람직하게는 도 14a 내지 도 14d에 도시된 바와 같이 형성될 수 있다.In this case, the cutting unit 224 cuts the tissue 240 positioned in the storage unit 234, and the cut tissue 240 is stored in the storage unit 234. The storage unit 234 of the cutting unit 224 is not particularly limited as long as the cut tissue 240 is a shape that can be stored well without leaking to the outside, but preferably shown in FIGS. 14A to 14D. It can be formed as.

신체 내에는 조직이 절단되었기 때문에 조직 주변에 출혈이 발생하며, 이에 따라 제2슬라이드(217)를 튜브(220) 방향으로 슬라이드 시키면, 제2슬라이드(217)와 연결된 제2실린지(216) 내의 약물(250)이 주입홀(222)을 통하여 출혈 부분에 투여되며, 도 11에 도시된 바와 같이, 주입홀(222)을 통해 투여된 약물(250)이 조직 채취 부분 및 출혈 부분에 도포된다.Since the tissue is cut in the body, bleeding occurs around the tissue. Accordingly, when the second slide 217 is slid toward the tube 220, the second slide 217 is connected to the second slide 217. The drug 250 is administered to the bleeding portion through the injection hole 222, and as shown in FIG. 11, the drug 250 administered through the injection hole 222 is applied to the tissue collection portion and the bleeding portion.

여기서, 주입홀(222)을 통하여 투여될 수 있는 약물로서는 지혈제, 조직 유착제, 조직 표시 형광물질 및 조영 물질, 골 시멘트(bone cement), 종양 치료 약물, 및 기타 조직 치료 물질 등이 사용될 수 있다.Here, as the drug that can be administered through the injection hole 222, hemostatic agents, tissue coalescing agents, tissue marking fluorescent and contrast materials, bone cement, tumor treatment drugs, and other tissue treatment materials may be used. .

마지막으로, 튜브(220)를 신체 내에서 신체 외부로 꺼내면, 도 12에 도시된 바와 같이 저장부(234)에 채취된 조직(240)이 저장되며, 저장된 조직(240)을 검사실로 보내 검사를 수행한다.Finally, when the tube 220 is removed from the body to the outside of the body, as shown in FIG. 12, the collected tissue 240 is stored in the storage unit 234, and the stored tissue 240 is sent to a laboratory for examination. Perform.

만약, 검사할 조직이 액체성 조직일 경우에는 도 9에서와 같이 바늘 조립체(230)를 채취될 조직 부분에 위치시킨 후, 제1슬라이드(215)를 발사 버튼(212) 방향쪽으로 슬라이드 시키면 흡인홀(236)을 통하여 액체성 조직이 제1실린지(214)로 유입된다. If the tissue to be examined is liquid tissue, as shown in FIG. 9, the needle assembly 230 is positioned on the tissue portion to be collected, and then the first slide 215 is slid toward the firing button 212. Liquid tissue flows into the first syringe 214 through 236.

이후, 제1실린지(214) 내로 액체성 조직이 채취되고 난 신체 부분에 출혈이 발생할 수 있기 때문에, 제2슬라이드(217)를 튜브(220) 방향으로 슬라이드 시키면, 제2슬라이드(217)와 연결된 제2실린지(216) 내의 약물(250)이 주입홀(222)을 통하여 출혈 부분에 투여되며, 주입홀(222)을 통해 투여된 약물(250)이 출혈 부분에 도포된다.Thereafter, since the bleeding may occur in the body part after the liquid tissue is collected into the first syringe 214, when the second slide 217 is slid in the direction of the tube 220, the second slide 217 and The drug 250 in the connected second syringe 216 is administered to the bleeding portion through the injection hole 222, and the drug 250 administered through the injection hole 222 is applied to the bleeding portion.

마지막으로, 제1실린지(214)는 탈부착이 가능함으로, 검사할 때에는 제1실린지(214)를 하우징(210)에서 탈착하여 검사실로 보내 검사를 수행하면 된다.Finally, since the first syringe 214 can be attached and detached, the first syringe 214 can be detached from the housing 210 and sent to the examination room to perform the inspection.

도 15는 본 발명의 다른 실시예에 따른 생체 조직 채취 장치(300)의 사시도를 나타내며, 도 16은 도 15에 따른 바늘 조립체(330)의 작용을 도시한 평면도를 나타낸다.15 is a perspective view of a biological tissue collection device 300 according to another embodiment of the present invention, Figure 16 is a plan view showing the operation of the needle assembly 330 according to FIG.

도 15 및 도 16에 도시된 본 발명의 다른 실시예에 따른 바늘 조립체가 적용된 생체 조직 채취 장치(300)는 도 3 및 도 7와 같이 하우징(310), 하우징(310)의 선단부에 결합되어 연장되는 튜브(320), 및 튜브(320) 내에 결합되어 생체 조직을 채취하는 바늘 조립체(330)로 구성되며, 조직을 절단하는 커팅부(338)가 바늘 조립체(330)의 선단부(332)에 구비되는 것에 특징이 있다.15 and 16, the biological tissue collecting device 300 to which the needle assembly is applied according to another embodiment of the present invention is coupled to the front end of the housing 310 and the housing 310 as shown in FIGS. 3 and 7. And a needle assembly 330 coupled to the tube 320 and collecting the biological tissue, and a cutting portion 338 for cutting the tissue is provided at the tip 332 of the needle assembly 330. It is characterized by being.

하우징(310), 튜브(320) 및 바늘 조립체(330)의 구성 및 형상은 도 3 및 도 7의 상세한 설명에 기술된 바와 같으므로 생략하도록 한다.The configuration and shape of the housing 310, tube 320 and needle assembly 330 are as described in the detailed description of FIGS. 3 and 7 and will be omitted.

조직을 절단하는 커팅부(338)는 바늘 조립체(330)의 선단부(332), 즉 저장부(334)에서 선단부(332)로 이어지는 위치에 날카롭게 형성된다.The cutting portion 338 for cutting tissue is sharply formed at the tip 332 of the needle assembly 330, ie, from the reservoir 334 to the tip 332.

도 16을 참조하여 일 실시예에 따른 생체 조직 채취 장치(300)의 사용 방법을 간략하게 살펴보면, 하우징(310)의 발사 버튼은 2단 버튼으로 설치되어, 사용자가 발사 버튼을 한번 누르면 바늘 조립체(330)가 채취될 조직의 위치로 발사되고(도 15의 화살표 E 참조), 다시 한번 발사 버튼을 누르게 되면, 바늘 조립체(330)가 튜브(320)의 내로 이동한다(도 16의 화살표 F 참조).Referring to FIG. 16, a method of using the biological tissue collecting device 300 according to an exemplary embodiment will be described in brief. The launch button of the housing 310 is installed as a two-stage button. 330 is fired to the location of the tissue to be harvested (see arrow E in FIG. 15), and once again the firing button is pressed, the needle assembly 330 moves into the tube 320 (see arrow F in FIG. 16). .

바늘 조립체(330)가 튜브(320) 내로 이동하면서, 바늘 조립체(330)의 선단부(332)에 구비된 커팅부(338)에 의하여 조직이 절단되어 저장부(334)에 채취된다.As the needle assembly 330 moves into the tube 320, the tissue is cut and collected in the reservoir 334 by the cutting portion 338 provided at the tip portion 332 of the needle assembly 330.

이상에서 설명한 바와 같이, 본 발명의 실시예에 따른 생체 조직 채취 장치(200)는 생체 조직 채취 장치의 바늘 조립체(230)에는 절단된 조직을 보관하는 저장부(234), 및 액체성 조직을 채취하는 흡인홀(236)이 구비되고, 튜브(210)의 하단부에는 상처가 생긴 조직 내로 약물을 주입하는 주입홀(222)이 구비되며, 조직 채취로 인해 인체 내 상처가 생긴 부위에는 주입홀(222)에 의해 약물이 투여됨으로써, 하나의 기구로 조직 채취와 약물 투여가 동시에 이루어질 수 있기 때문에, 조직 채취 후 출혈과 종양 세포 오염을 예방할 수 있다.As described above, the biological tissue collecting device 200 according to the embodiment of the present invention, the needle assembly 230 of the biological tissue collecting device, the storage unit 234 for storing the cut tissue, and collecting the liquid tissue The suction hole 236 is provided, the lower end of the tube 210 is provided with an injection hole 222 for injecting the drug into the wounded tissue, the injection hole 222 in the wounded portion of the human body due to tissue collection By administering the drug by), tissue collection and drug administration can be performed at the same time with one apparatus, thereby preventing bleeding and tumor cell contamination after tissue collection.

또한, 조직 검사 트랙 및 종양의 조직 채취 부위에 약물을 도포하여 절제 부위를 표시해 놓을 수 있어, 수술 시 종양 조직뿐만 아니라 종양 세포에 오염 가능성이 있는 약물이 도포된 부분까지 절제할 수 있는 생체 조직 채취 장치를 제공할 수 있다.In addition, by applying the drug to the biopsy track and the tissue collecting site of the tumor, the resection site can be marked, so that the biological tissue collection that can remove not only the tumor tissue during surgery, but also the areas where the drug may be contaminated with the tumor cells. A device can be provided.

또한, 생체 조직 채취 시, 채취하고자 하는 조직이 고체성일 경우에는 저장부(234)에서 채취하고, 액체성 조직은 흡인홀(236)로 용이하게 채취할 수 있다. In addition, at the time of collecting biological tissue, if the tissue to be collected is solid, it may be collected from the storage unit 234, and the liquid tissue may be easily collected into the suction hole 236.

이상에서와 같이, 본 발명의 바람직한 실시예를 중심으로 본 발명의 생체 조직 채취 장치에 대하여 설명하였지만, 본 발명의 사상을 벗어나지 않는 범위 내에서 수정, 변경 및 다양한 변형 실시예가 가능함은 당업자에게 명백하다.As described above, the biological tissue harvesting apparatus of the present invention has been described based on the preferred embodiment of the present invention, but it is apparent to those skilled in the art that modifications, changes, and various modifications can be made without departing from the spirit of the present invention. .

Claims (20)

하우징;housing; 상기 하우징의 후단부에 구비되는 발사버튼;A firing button provided at the rear end of the housing; 상기 하우징의 선단부에서 연장되며, 하단의 길이 방향을 따라 조직 내로 약물을 주입하는 주입홀이 장착되는 튜브; 및A tube extending from the front end of the housing and equipped with an injection hole for injecting the drug into the tissue along the longitudinal direction of the lower end; And 상기 버튼에 의해 상기 튜브 내에서 조직검사부위로 이동가능하게 설치되어, 고체성 조직을 절단하여 보관하거나 액체성 조직을 흡인하는 바늘 조립체;를 포함하는 것을 특징으로 하는 생체 조직 채취 장치.And a needle assembly installed to be movable to the histological examination site in the tube by the button to cut and store solid tissue or to suck up liquid tissue. 제 1 항에 있어서,The method of claim 1, 상기 바늘 조립체의 선단부에 상기 조직을 절단하기 위한 커팅부가 형성되는 것을 특징으로 하는 생체 조직 채취 장치.And a cutting portion for cutting the tissue at a tip end of the needle assembly. 제 2 항에 있어서,The method of claim 2, 상기 바늘조립체는 Ti, Ni, Fe, Cr, Ta, 스테인레스 스틸, 및 형상기억합금으로 구성되는 군으로부터 선택되는 하나 또는 둘 이상의 금속으로 형성되는 것을 특징으로 하는 생체 조직 채취 장치.The needle assembly is a tissue collection device, characterized in that formed of one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy. 제 2 항에 있어서,The method of claim 2, 상기 바늘 조립체의 선단부는 Ti, Ni, Fe, Cr, Ta, 스테인레스 스틸, 및 형상기억합금으로 구성되는 군으로부터 선택되는 하나 또는 둘 이상의 금속으로 코팅되는 것을 특징으로 하는 생체 조직 채취 장치.And a tip portion of the needle assembly is coated with one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy. 제 1 항에 있어서,The method of claim 1, 상기 튜브의 선단부에 상기 조직을 절단하기 위한 커팅부가 형성되는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device characterized in that the cutting portion for cutting the tissue is formed at the front end of the tube. 제 1 항에 있어서,The method of claim 1, 상기 바늘 조립체의 선단부에서 연장되어, 상기 절단된 조직을 보관하는 저장부가 형성되는 것을 특징으로 하는 생체 조직 채취 장치.And a storage portion extending from the tip of the needle assembly to store the cut tissue. 제 6 항에 있어서,The method of claim 6, 상기 바늘 조립체에는 상기 저장부와 연결되어 액체성 조직을 흡입하는 흡인홀이 형성되는 것을 특징으로 하는 생체 조직 채취 장치.And a suction hole is formed in the needle assembly and connected to the reservoir to suck liquid tissue. 제 1 항에 있어서,The method of claim 1, 상기 주입홀의 수직 단면은 원형, 타원형 또는 역삼각형 모양을 갖도록 형성되는 것을 특징으로 하는 생체 조직 채취 장치.The vertical section of the injection hole biological tissue harvesting device, characterized in that formed to have a circular, elliptical or inverted triangle shape. 제 8 항에 있어서,The method of claim 8, 상기 주입홀의 외면에 다수의 사이드 홀이 형성되는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device, characterized in that a plurality of side holes are formed on the outer surface of the injection hole. 제 7 항에 있어서,The method of claim 7, wherein 상기 주입홀과 연결되는 약물 주입 실린지 및 상기 흡인홀과 연결되는 조직 흡인 실린지가 상기 하우징의 내부에 탈착 가능하게 구비되는 것을 특징으로 하는 생체 조직 채취 장치.And a drug injection syringe connected to the injection hole and a tissue suction syringe connected to the suction hole are detachably provided inside the housing. 제 10 항에 있어서,The method of claim 10, 상기 약물 주입 실린지 및 상기 조직 흡인 실린지는 중공의 실린지 바디 및 실린지 바디 내부를 이동하는 피스톤으로 구성되는 것을 특징으로 하는 생체 조직 채취 장치.The drug injection syringe and the tissue suction syringe is a biological tissue collection device, characterized in that consisting of a hollow syringe body and a piston moving inside the syringe body. 제 10 항에 있어서,The method of claim 10, 상기 약물 주입 실린지 및 상기 조직 흡인 실린지가 슬라이드 가능하도록 각각 슬라이드 버튼이 상기 피스톤과 결합하는 것을 특징으로 하는 생체 조직 채취 장치.And a slide button engages the piston so that the drug injection syringe and the tissue suction syringe are slidable, respectively. 제 10 항에 있어서,The method of claim 10, 상기 약물 주입 실린지 및 상기 조직 흡인 실린지는 1㏄ 내지 3㏄의 용량을 갖는 것을 특징으로 하는 생체 조직 채취 장치.And the drug injection syringe and the tissue suction syringe have a capacity of 1 kV to 3 kV. 제 12 항에 있어서,The method of claim 12, 상기 슬라이드 버튼이 이동하는 상기 하우징의 일면에 하나 또는 둘 이상의 고정홈이 연속적으로 형성되어 단위길이로 상기 피스톤을 슬라이드 시킨 후 압력에 의해 발사버튼 방향으로 이동되지 않게 정지시키는 것을 특징으로 하는 생체 조직 채취 장치.One or more fixing grooves are continuously formed on one surface of the housing to which the slide button moves to slide the piston in a unit length, and then stop collecting the living tissue in a direction of the release button by pressure. Device. 제 1 항에 있어서,The method of claim 1, 상기 하우징에 형성되는 공간부; 및A space portion formed in the housing; And 일단이 상기 주입홀과 연결되고, 상기 공간부에 수납되는 연장튜브;An extension tube having one end connected to the injection hole and accommodated in the space part; 를 포함하는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device comprising a. 제 15 항에 있어서,The method of claim 15, 상기 연장튜브의 타단이 상기 공간부의 외부로 노출되어 체결부를 형성하는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device, characterized in that the other end of the extension tube is exposed to the outside of the space to form a fastening portion. 제 15 항에 있어서,The method of claim 15, 상기 공간부를 개폐하는 커버를 형성하는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device, characterized in that to form a cover for opening and closing the space. 제 7 항에 있어서,The method of claim 7, wherein 상기 하우징에 형성되는 공간부; 및A space portion formed in the housing; And 일단이 상기 흡인홀과 연결되고, 상기 공간부에 수납되는 연장튜브;An extension tube having one end connected to the suction hole and accommodated in the space part; 를 포함하는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device comprising a. 제 18 항에 있어서,The method of claim 18, 상기 연장튜브의 타단이 상기 공간부의 외부로 노출되어 체결부를 형성하는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device, characterized in that the other end of the extension tube is exposed to the outside of the space to form a fastening portion. 제 18 항에 있어서,The method of claim 18, 상기 공간부를 개폐하는 커버를 형성하는 것을 특징으로 하는 생체 조직 채취 장치.Biological tissue collection device, characterized in that to form a cover for opening and closing the space.
PCT/KR2013/010963 2012-11-30 2013-11-29 Biotissue sampling apparatus Ceased WO2014084650A1 (en)

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US14/648,685 US10695039B2 (en) 2012-11-30 2013-11-29 Biotissue sampling apparatus
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CN201380062814.1A CN104955403B (en) 2012-11-30 2013-11-29 Biopsy sampling device

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114533142A (en) * 2022-02-23 2022-05-27 上海交通大学医学院附属第九人民医院 Biopsy puncture gun for fast detecting benign and malignant tissues
CN118370561A (en) * 2024-06-24 2024-07-23 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) Gynecological tumor sampling device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020938A1 (en) * 2002-09-25 2005-01-27 B-K Medical A/S Catheter for insertion into the human body
KR20110062386A (en) * 2009-12-03 2011-06-10 주식회사 엠아이텍 Needle device for biopsy
WO2011126898A2 (en) * 2010-03-30 2011-10-13 Sparkmed Research, Llc Drug releasing medical catheters, tubes, and devices
KR20110118603A (en) * 2011-09-23 2011-10-31 박수희 Extractor for biopsy using fine needle
WO2012060968A2 (en) * 2010-11-01 2012-05-10 Devicor Medical Products, Inc. Handheld biopsy device with needle firing

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020938A1 (en) * 2002-09-25 2005-01-27 B-K Medical A/S Catheter for insertion into the human body
KR20110062386A (en) * 2009-12-03 2011-06-10 주식회사 엠아이텍 Needle device for biopsy
WO2011126898A2 (en) * 2010-03-30 2011-10-13 Sparkmed Research, Llc Drug releasing medical catheters, tubes, and devices
WO2012060968A2 (en) * 2010-11-01 2012-05-10 Devicor Medical Products, Inc. Handheld biopsy device with needle firing
KR20110118603A (en) * 2011-09-23 2011-10-31 박수희 Extractor for biopsy using fine needle

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114533142A (en) * 2022-02-23 2022-05-27 上海交通大学医学院附属第九人民医院 Biopsy puncture gun for fast detecting benign and malignant tissues
CN114533142B (en) * 2022-02-23 2023-07-04 上海交通大学医学院附属第九人民医院 Biopsy puncture gun for rapidly detecting benign and malignant tissue
CN118370561A (en) * 2024-06-24 2024-07-23 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) Gynecological tumor sampling device

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