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WO2014052040A3 - Noninvasive absolute oximetry of brain tissue - Google Patents

Noninvasive absolute oximetry of brain tissue Download PDF

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Publication number
WO2014052040A3
WO2014052040A3 PCT/US2013/059610 US2013059610W WO2014052040A3 WO 2014052040 A3 WO2014052040 A3 WO 2014052040A3 US 2013059610 W US2013059610 W US 2013059610W WO 2014052040 A3 WO2014052040 A3 WO 2014052040A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
optical
optical signal
parameters characterizing
oximetry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/059610
Other languages
French (fr)
Other versions
WO2014052040A2 (en
Inventor
Bertan HALLACOGLU
Sergio Fantini
Angelo SASSAROLI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts University filed Critical Tufts University
Publication of WO2014052040A2 publication Critical patent/WO2014052040A2/en
Publication of WO2014052040A3 publication Critical patent/WO2014052040A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Determining tissue properties by optical sensing includes applying an optical signal to input locations on a surface a body; sensing transmission through the body of the optical signal at an output location on the surface of the body, each input location being separated from the output location by a separation distance along the surface of the body; determining a transmission characteristic from each of the input locations to the output location of the optical signal; applying a computer implemented procedure to process the determined transmission characteristic to determine parameters characterizing two tissue layers below the surface of the body, the layers including an inner and an outer layer between the inner layer and the surface of the body, the parameters characterizing optical properties of the inner layer; and using the parameters characterizing the optical properties of the inner layer to determine a metabolic characteristic of tissue in the layer.
PCT/US2013/059610 2012-09-27 2013-09-13 Noninvasive absolute oximetry of brain tissue Ceased WO2014052040A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261706275P 2012-09-27 2012-09-27
US61/706,275 2012-09-27

Publications (2)

Publication Number Publication Date
WO2014052040A2 WO2014052040A2 (en) 2014-04-03
WO2014052040A3 true WO2014052040A3 (en) 2014-10-09

Family

ID=50389114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/059610 Ceased WO2014052040A2 (en) 2012-09-27 2013-09-13 Noninvasive absolute oximetry of brain tissue

Country Status (1)

Country Link
WO (1) WO2014052040A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040664A1 (en) * 2000-01-12 2003-02-27 Suresh Thennadil Method and apparatus for path normalization of light transport in tissue
US20100056928A1 (en) * 2008-08-10 2010-03-04 Karel Zuzak Digital light processing hyperspectral imaging apparatus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040664A1 (en) * 2000-01-12 2003-02-27 Suresh Thennadil Method and apparatus for path normalization of light transport in tissue
US20100056928A1 (en) * 2008-08-10 2010-03-04 Karel Zuzak Digital light processing hyperspectral imaging apparatus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FANTINI ET AL.: "Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy.", PHYS. MED. BIOL., vol. 44, 1999, pages 1543 - 1563, Retrieved from the Internet <URL:http://www.nmr.mgh.harvard.edulPMI/PDF/Fantini_PMB_44_1543_1999.pdf> *
ISS, INC.: "OxiplexTS. ISS, Inc.", 2001, Retrieved from the Internet <URL:http://www.iss.com/resources/pdf/brochures/ISS_OxiplexTS_Brochure.pdf> [retrieved on 20140202] *

Also Published As

Publication number Publication date
WO2014052040A2 (en) 2014-04-03

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