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WO2014044674A3 - Verfarhen zur isomerisierung von (r)-3-hydroxycarbonsäuren zu 2-hydroxy-2-methylcarbonsäuren - Google Patents

Verfarhen zur isomerisierung von (r)-3-hydroxycarbonsäuren zu 2-hydroxy-2-methylcarbonsäuren Download PDF

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Publication number
WO2014044674A3
WO2014044674A3 PCT/EP2013/069272 EP2013069272W WO2014044674A3 WO 2014044674 A3 WO2014044674 A3 WO 2014044674A3 EP 2013069272 W EP2013069272 W EP 2013069272W WO 2014044674 A3 WO2014044674 A3 WO 2014044674A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
acids
isomerizing
methylcarboxylic
hydroxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2013/069272
Other languages
English (en)
French (fr)
Other versions
WO2014044674A2 (de
Inventor
Thore Rohwerder
Roland H. MÜLLER
Nadya Yaneva
Judith Schuster
Martin Sajfutdinow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Umweltforschung GmbH UFZ
Original Assignee
Helmholtz Zentrum fuer Umweltforschung GmbH UFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Zentrum fuer Umweltforschung GmbH UFZ filed Critical Helmholtz Zentrum fuer Umweltforschung GmbH UFZ
Publication of WO2014044674A2 publication Critical patent/WO2014044674A2/de
Publication of WO2014044674A3 publication Critical patent/WO2014044674A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur enzymatischen Isomerisierung von (R)- 3-Hydroxycarbonsäuren zu den entsprechenden 2-Hydroxy-2-methylcarbonsäuren. Die Umwandlung erfolgt in einer wässrigen Reaktionslösung in einem Temperaturbereich von 20 bis 80°C, wobei Mikroorganismen bzw. Zellextrakte oder ein Rohextrakt davon, die eine Cobalamin-abhängige (R)-3-Hydroxycarbonyl-CoA-Mutase zur Isomerisierung von (R)-3- Hydroxycarbonyl-CoA- und 2-Hydroxy-2-methylcarbonyl-CoA-Estern aufweisen oder die mit der genannten Mutase transfiziert sind, kultiviert werden. Die entsprechende 2-Hydroxy-2-methylcarbonsäure wird ins Medium abgegeben und als Säure oder in Form ihrer Salze gewonnen.
PCT/EP2013/069272 2012-09-20 2013-09-17 Verfarhen zur isomerisierung von (r)-3-hydroxycarbonsäuren zu 2-hydroxy-2-methylcarbonsäuren Ceased WO2014044674A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012216904.0A DE102012216904A1 (de) 2012-09-20 2012-09-20 Verfahren zur Isomerisierung von (R)-3-Hydroxycarbonsäuren zu 2-Hydroxy-2-methylcarbonsäuren
DE102012216904.0 2012-09-20

Publications (2)

Publication Number Publication Date
WO2014044674A2 WO2014044674A2 (de) 2014-03-27
WO2014044674A3 true WO2014044674A3 (de) 2014-10-09

Family

ID=49385220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/069272 Ceased WO2014044674A2 (de) 2012-09-20 2013-09-17 Verfarhen zur isomerisierung von (r)-3-hydroxycarbonsäuren zu 2-hydroxy-2-methylcarbonsäuren

Country Status (2)

Country Link
DE (1) DE102012216904A1 (de)
WO (1) WO2014044674A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014212069B4 (de) 2014-06-24 2018-01-25 Helmholtz-Zentrum Für Umweltforschung Gmbh - Ufz Verfahren zur Herstellung organischer Verbindungen
DE102014218121A1 (de) 2014-09-10 2016-03-10 Helmholtz-Zentrum Für Umweltforschung Gmbh - Ufz Verfahren zur enzymatischen Herstellung von 2-Hydroxycarbonsäuren
EP3746559A4 (de) 2018-02-01 2021-12-22 INVISTA Textiles (U.K.) Limited Verfahren und materialien zur biosynthese von beta-hydroxyfettsäureanionen und / oder deren derivaten und davon abgeleiteten verbindungen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006017760A1 (de) * 2006-03-24 2007-09-27 Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren
WO2009156214A1 (de) * 2008-06-27 2009-12-30 Evonik Röhm Gmbh 2-hydroxyisobuttersäure produzierende rekombinante zelle
WO2011057871A2 (de) * 2009-11-11 2011-05-19 Evonik Röhm Gmbh Verwendung eines zu einem meab-protein homologen proteins zur erhöhung der enzymatischen aktivität einer 3-hydroxycarbonsäure-coa-mutase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006017760A1 (de) * 2006-03-24 2007-09-27 Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren
WO2009156214A1 (de) * 2008-06-27 2009-12-30 Evonik Röhm Gmbh 2-hydroxyisobuttersäure produzierende rekombinante zelle
WO2011057871A2 (de) * 2009-11-11 2011-05-19 Evonik Röhm Gmbh Verwendung eines zu einem meab-protein homologen proteins zur erhöhung der enzymatischen aktivität einer 3-hydroxycarbonsäure-coa-mutase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HANS-PETER KLENK ET AL: "Complete genome sequence of the thermophilic, hydrogen-oxidizing Bacillus tusciae type strain (T2T) and reclassification in the new genus, Kyrpidia gen. nov. as Kyrpidia tusciae comb. nov. and emendation of the family Alicyclobacillaceae da Costa and Rainey, 2010.", STANDARDS IN GENOMIC SCIENCES, vol. 5, no. 1, 23 September 2011 (2011-09-23), pages 121 - 134, XP055119507, ISSN: 1944-3277, DOI: 10.4056/sigs.2144922 *
N. YANEVA ET AL: "Bacterial Acyl-CoA Mutase Specifically Catalyzes Coenzyme B12-dependent Isomerization of 2-Hydroxyisobutyryl-CoA and (S)-3-Hydroxybutyryl-CoA", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 19, 4 May 2012 (2012-05-04), pages 15502 - 15511, XP055036888, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.314690 *
ROHWERDER THORE ET AL: "Biosynthesis of 2-hydroxyisobutyric acid (2-HIBA) from renewable carbon", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, LONDON, NL, vol. 9, no. 1, 25 February 2010 (2010-02-25), pages 13, XP021067683, ISSN: 1475-2859 *

Also Published As

Publication number Publication date
WO2014044674A2 (de) 2014-03-27
DE102012216904A1 (de) 2014-03-20

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