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WO2013118759A1 - Bactéricide - Google Patents

Bactéricide Download PDF

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Publication number
WO2013118759A1
WO2013118759A1 PCT/JP2013/052701 JP2013052701W WO2013118759A1 WO 2013118759 A1 WO2013118759 A1 WO 2013118759A1 JP 2013052701 W JP2013052701 W JP 2013052701W WO 2013118759 A1 WO2013118759 A1 WO 2013118759A1
Authority
WO
WIPO (PCT)
Prior art keywords
honey
porphyromonas gingivalis
royal jelly
disinfectant
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2013/052701
Other languages
English (en)
Japanese (ja)
Inventor
藤井　彰
功治 平尾
山口　喜久二
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Royal Jelly Co Ltd
Original Assignee
Japan Royal Jelly Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Royal Jelly Co Ltd filed Critical Japan Royal Jelly Co Ltd
Priority to JP2013557541A priority Critical patent/JP6047105B2/ja
Publication of WO2013118759A1 publication Critical patent/WO2013118759A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Definitions

  • the present invention relates to a disinfectant for periodontal disease-causing bacteria and a preventive or ameliorating agent for periodontal disease.
  • the main causative bacterium of periodontal disease is Porphyromonas gingivalis, and it is considered that the progression of periodontal disease can be suppressed by suppressing this bacterium.
  • the present invention provides a disinfectant for periodontal disease-causing bacteria and a preventive or ameliorating agent for periodontal disease.
  • the present inventors examined anti-porphyromonas gingivalis activity using yah honey and / or royal jelly.
  • the present invention provides the following: 1. Porphyromonas gingivalis disinfectant containing Yahashi honey and / or royal jelly, 2. A preventive or ameliorating agent for periodontal disease, including yah honey and / or royal jelly, About.
  • the Porphyromonas gingivalis disinfectant of the present invention has an excellent disinfecting action against Porphyromonas gingivalis and is a natural substance, so it is highly safe and has problems such as the appearance of resistant bacteria. At the same time, it can be applied without the help of a dentist. Therefore, it is very useful for eradication of Porphyromonas gingivalis and prevention or improvement of diseases related to Porphyromonas gingivalis.
  • FIG. 1 shows the antibacterial effect of honey on Porphyromonas gingivalis.
  • the Porphyromonas gingivalis disinfectant means a composition capable of suppressing the growth of Porphyromonas gingivalis.
  • the disinfectant of the present invention can be used for prevention or amelioration of diseases associated with Porphyromonas gingivalis.
  • Yahashi honey is a unique honey that is harvested from Elsholtzia rugulosa flowers that grow naturally in the relatively high grounds of Yunnan, China. It is also sold in Japan (Japan Royal Jelly Co., Ltd., Honey (registered trademark)).
  • Royal jelly is a secreted product produced by the reaction of different components secreted from the pharyngeal glands of the upper and lower jaws of a young worker bee, and a health food made from it.
  • the disinfectant of the present invention can be added to any food material, for example, milk, fruit juices such as orange and lemon, dairy products such as yogurt, bread, and other foods.
  • the daily intake amount of yah honey per adult is usually 0.01 to 10.0 g.
  • concentration of honey honey in the disinfectant varies depending on the form, but in the case of solid forms such as tablets (tablets), troches, granules, and gums, it is in the range of 10 to 100% by weight based on the total mass. It is. In the case of a paste or liquid, it is in the range of 10 to 80% by weight with respect to the total weight.
  • the final concentration in saliva is 5 to 10 mg / ml.
  • Examples of the disinfectant of the present invention include dentifrices, oral ointments, mouth washes, gargles, troches, tablets (tablets and mouth tablets), and granules.
  • the disinfectant of the present invention includes various additives such as various nutrients, various vitamins, minerals, dietary fiber, polyunsaturated fatty acids, stabilizers such as dispersants and emulsifiers, sweeteners, taste ingredients, flavors. Etc. can be blended.
  • a liquid it may be prepared from the beginning as a liquid, but it can be prepared in a powder or paste form and dissolved in a predetermined amount of an aqueous liquid.
  • the disinfectant of the present invention can remove Porphyromonas gingivalis in the oral cavity, it can be used to prevent or ameliorate diseases related to Porphyromonas gingivalis.
  • diseases related to Porphyromonas gingivalis there is periodontal disease (alveolar pyorrhea) as a typical one in the oral cavity.
  • periodontal disease alveolar pyorrhea
  • diabetes, cardiovascular disease and the like which are considered to be strongly associated with periodontal disease.
  • Method 1 Preparation of honey and royal jelly solution
  • the honey solution is 20% w / v (200 mg / ml) in phosphate buffered saline (PBS) or Brain Heart Infusion for Porphyromonas gingivalis ( (BHI)
  • PBS phosphate buffered saline
  • BHI Brain Heart Infusion for Porphyromonas gingivalis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Insects & Arthropods (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Animal Husbandry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Cosmetics (AREA)
PCT/JP2013/052701 2012-02-10 2013-02-06 Bactéricide Ceased WO2013118759A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013557541A JP6047105B2 (ja) 2012-02-10 2013-02-06 除菌剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012027328 2012-02-10
JP2012-027328 2012-02-10

Publications (1)

Publication Number Publication Date
WO2013118759A1 true WO2013118759A1 (fr) 2013-08-15

Family

ID=48947520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2013/052701 Ceased WO2013118759A1 (fr) 2012-02-10 2013-02-06 Bactéricide

Country Status (2)

Country Link
JP (1) JP6047105B2 (fr)
WO (1) WO2013118759A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021187840A (ja) * 2020-05-29 2021-12-13 株式会社山田養蜂場本社 蜂蜜の抗菌活性低下抑制方法及び抗菌剤の製造方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005314266A (ja) * 2004-04-28 2005-11-10 Sangi Co Ltd 口腔用組成物
JP2007277210A (ja) * 2006-04-04 2007-10-25 Masami Kanda マヌカハニーを主成分とする歯周炎治療用剤およびサプリメント
WO2008133098A1 (fr) * 2007-04-16 2008-11-06 Kikuji Yamaguchi Agent éradiquant l'helicobacter pylori

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005314266A (ja) * 2004-04-28 2005-11-10 Sangi Co Ltd 口腔用組成物
JP2007277210A (ja) * 2006-04-04 2007-10-25 Masami Kanda マヌカハニーを主成分とする歯周炎治療用剤およびサプリメント
WO2008133098A1 (fr) * 2007-04-16 2008-11-06 Kikuji Yamaguchi Agent éradiquant l'helicobacter pylori

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOMED. RES., vol. 32, no. 4, 2011, pages 285 - 291 *
HORM. METAB. RES., vol. 21, no. 6, 1989, pages 338 - 340 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021187840A (ja) * 2020-05-29 2021-12-13 株式会社山田養蜂場本社 蜂蜜の抗菌活性低下抑制方法及び抗菌剤の製造方法
JP7776849B2 (ja) 2020-05-29 2025-11-27 株式会社山田養蜂場本社 蜂蜜の抗菌活性低下抑制方法及び抗菌剤の製造方法

Also Published As

Publication number Publication date
JP6047105B2 (ja) 2016-12-21
JPWO2013118759A1 (ja) 2015-05-11

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