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WO2013190509A3 - Preparation of intermediates of boceprevir - Google Patents

Preparation of intermediates of boceprevir Download PDF

Info

Publication number
WO2013190509A3
WO2013190509A3 PCT/IB2013/055096 IB2013055096W WO2013190509A3 WO 2013190509 A3 WO2013190509 A3 WO 2013190509A3 IB 2013055096 W IB2013055096 W IB 2013055096W WO 2013190509 A3 WO2013190509 A3 WO 2013190509A3
Authority
WO
WIPO (PCT)
Prior art keywords
boceprevir
preparation
intermediates
processes
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2013/055096
Other languages
French (fr)
Other versions
WO2013190509A2 (en
Inventor
Sekhar Munaswamy Nariyam
Dinesh Shivaji BHALERAO
Vilas Hareshwar Dahanukar
Srinivas ORUGANTI
Rajesh Kumar Rapolu
Bhaskar KANDAGATLA
Javed Iqbal
Sandip Ramdas KHOBARE
Srinivasa Reddy KALLAM
Malavika BANDA
Vikas Sadashiv GARARE
Vishnuvardhana vema Reddy EDA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of WO2013190509A2 publication Critical patent/WO2013190509A2/en
Publication of WO2013190509A3 publication Critical patent/WO2013190509A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Processes for preparing intermediates of Boceprevir and their use in preparation of Boceprevir or its pharmaceutically acceptable salts are provided.
PCT/IB2013/055096 2012-06-22 2013-06-21 Preparation of intermediates of boceprevir Ceased WO2013190509A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2493CH2012 2012-06-22
IN2493/CHE/2012 2012-06-22
IN56CH2013 2013-01-07
IN56/CHE/2013 2013-01-07

Publications (2)

Publication Number Publication Date
WO2013190509A2 WO2013190509A2 (en) 2013-12-27
WO2013190509A3 true WO2013190509A3 (en) 2014-03-13

Family

ID=49769628

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/055096 Ceased WO2013190509A2 (en) 2012-06-22 2013-06-21 Preparation of intermediates of boceprevir

Country Status (1)

Country Link
WO (1) WO2013190509A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105001145B (en) * 2015-07-14 2017-06-20 华南理工大学 A kind of synthetic method of bicyclic cyclopropane compound
CN114544810A (en) * 2022-02-16 2022-05-27 汉瑞药业(荆门)有限公司 HPLC detection method for chiral purity of paluvird starting material and enantiomer thereof
CN114539125B (en) * 2022-03-07 2024-02-09 杭州国瑞生物科技有限公司 Synthesis method of paciclovir intermediate
CN114957087A (en) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 Preparation method of intermediate of palovaried
CN115947679B (en) * 2022-12-16 2024-06-07 杭州澳赛诺生物科技有限公司 Synthesis method of 6, 6-dimethyl-3-hetero-nitrogen-bicyclo [3.1.0] hexane-2-carboxylic acid methyl ester

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60155967A (en) * 1984-01-25 1985-08-16 Sumitomo Chem Co Ltd Gas chromatography stationary phase and analysis of enantiomer mixture using the same
WO2008064066A1 (en) * 2006-11-16 2008-05-29 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2009039361A2 (en) * 2007-09-20 2009-03-26 Virobay, Inc. Process for the preparation of (s)-2-(3-tert-butylureido)-3,3-dimethylbutanoic acid
US20100256416A1 (en) * 2007-11-16 2010-10-07 Kaneka Corporation Process for production of n-carbamoyl-tert-leucine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60155967A (en) * 1984-01-25 1985-08-16 Sumitomo Chem Co Ltd Gas chromatography stationary phase and analysis of enantiomer mixture using the same
WO2008064066A1 (en) * 2006-11-16 2008-05-29 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2009039361A2 (en) * 2007-09-20 2009-03-26 Virobay, Inc. Process for the preparation of (s)-2-(3-tert-butylureido)-3,3-dimethylbutanoic acid
US20100256416A1 (en) * 2007-11-16 2010-10-07 Kaneka Corporation Process for production of n-carbamoyl-tert-leucine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AVDEENKO,A. P. ET AL.: "Synthesis and Structure ofN-Alkyl(aryl)aminocarbonyl-1,4- benzoquinone Imines.", RUSSIAN JOUMAL OF ORGANIC CHEMISTRY, vol. 44, no. 12, December 2008 (2008-12-01), pages 1765 - 1772 *
DANOPOULOS,ANDREAS ET AL.: "Synthesis of Isocyanates by the Reaction of Certain Primary Amines with Benzyl Carbonochloridate", SYNTHESIS, 1985, pages 682 *
SAYLIK, DILEK ET AL.: "Preparation of Isocyanates from Primary Amines and Carbon Dioxide Using Mitsunobu Chemistry.", J. ORG. CHEM., vol. 64, no. 11, 7 May 1999 (1999-05-07), pages 3940 - 3946 *

Also Published As

Publication number Publication date
WO2013190509A2 (en) 2013-12-27

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