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WO2013165051A1 - Implant de titane ultra-hydrophile et ses procédés de traitement de surface et de stockage - Google Patents

Implant de titane ultra-hydrophile et ses procédés de traitement de surface et de stockage Download PDF

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Publication number
WO2013165051A1
WO2013165051A1 PCT/KR2012/005490 KR2012005490W WO2013165051A1 WO 2013165051 A1 WO2013165051 A1 WO 2013165051A1 KR 2012005490 W KR2012005490 W KR 2012005490W WO 2013165051 A1 WO2013165051 A1 WO 2013165051A1
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WO
WIPO (PCT)
Prior art keywords
implant
titanium
titanium implant
surface treatment
ultra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/005490
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English (en)
Korean (ko)
Inventor
김수경
장일석
박기태
강은정
송주동
엄태관
최규옥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osstem Implant Co Ltd
Original Assignee
Osstem Implant Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osstem Implant Co Ltd filed Critical Osstem Implant Co Ltd
Publication of WO2013165051A1 publication Critical patent/WO2013165051A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A61C8/0015—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating being a conversion layer, e.g. oxide layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14—Plasma, i.e. ionised gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Definitions

  • the present invention is a superoleophilic titanium or titanium alloy material (hereinafter,
  • the present invention relates to a surface treatment method that gives such superhydrophilicity and a storage method capable of preserving the superhydrophilicity imparted by the surface treatment method for a long time.
  • a surface treatment method that gives such superhydrophilicity and a storage method capable of preserving the superhydrophilicity imparted by the surface treatment method for a long time.
  • RBM or SLA which is widely used as a method
  • it provides superhydrophilicity to the surface of titanium implants through dry cleaning method using room temperature plasma or ultraviolet rays, and immediately transfers titanium implants to organic zwitterionic buffer.
  • the present invention relates to a titanium implant having a superhydrophilic property to preserve superhydrophilic properties for a long time by supporting the same, and a surface treatment and storage method thereof.
  • the surface treatment method of the implant As an important determinant in bone fusion, the surface treatment method of the implant has been pointed out.
  • the smooth surface treatment method by lathe processing has the longest history and the long term history due to the excellent biocompatibility and tissue stability with bone. Has been used.
  • efforts have been made to improve the surface in order to improve the success rate in bones with low bone density.
  • Predecki et al. Reported that irregularly-imposed implants were able to observe rapid bone growth and good mechanical bonding.
  • Buser et al. Reported that implants with irregular and rough surfaces showed more bone contact rates than those with smooth surfaces in animal experiments.
  • first-generation implants have smooth surfaces
  • second-generation implants are coated surfaces
  • the blasting technique is used as an absorbent medium. It is divided into RBMC Resorbable Blasted Media blasting, which increases the roughness of the implant, Titanium Plasma Spray (TPS), and sandblast large grit acid etch (SLA) with high biocompatibility. can see.
  • Implants with a hydroxyapatite (HA) coating surface belong to the third generation. The surface area is increased by the effect of particles and coatings sprayed on the surface, which increases the interfacial bond strength of the implant and activates the reaction of cells on the rough surface. Has the advantage of being.
  • an oxide layer grows on the surface of the product when the product is exposed to air vapor after the surface treatment process, as shown in FIG. Adsorption of contaminants occurs and hydrophobizes while changing to a chemically stable state. Since the surface of the hydrophobized implant has low wettability to body fluids and blood, it has a disadvantage of prolonging the period of stabilization of the implant by preventing the overall process of fusion with bone after implant implantation.
  • Prior art according to EP 1,150,620 describes an implant having a hydrophilic surface after SLA surface treatment.
  • the manufacturing method in this document shows that i) mechanically roughening the titanium surface through various methods. Ii) cleaning the surface with pure water, which may contain additives, and iii) packaging the titanium surface in a container containing inert gas without further processing.
  • the wettability of the titanium surface is described as maintaining a hydrophilic surface exhibiting a contact angle of 20 to 50 ° with respect to water.
  • water containing salts is mentioned as an alternative to an inert gas, and in the case of salt concentration, 100 to 200 mEq / Mg for monovalent salts such as Na and K and 1 to 1 for divalent salts such as Ca. A concentration range of 20 mEq / is described.
  • EP1, 150 In the case of the prior art according to No. 620, a method of cleaning titanium surface using pure water is applied, and when applying such a wet method such as ultrasonic method in surface cleaning, it is possible to remove 1 or less fine surface contaminants present on the surface. Not only is it difficult to remove, but there are disadvantages in that it is difficult to clean the minute irregularities that ultrasonic waves cannot reach.
  • the concentration of the applied salt is sufficient at a concentration of 100 200 mEq / i for the monovalent salt, whereas for the divalent salt, 1-20 mEq
  • concentration is too low in the / i range when applied to the actual dental implant abutment there is a problem that the amount is too small to cover the entire surface of the abutment.
  • the present invention is to improve the body fluid and blood affinity through the super-hydrophilicity secured by the above method to finally provide an implant having an excellent initial bone formation effect and a short bone fusion period after the implant procedure The purpose.
  • the present invention provides ultra-hydrophilic properties through precise dry surface cleaning, without changing the physical shape of the titanium surface. It is related to the method of modifying the surface and the method of storing it to maintain its superhydrophilicity for a long time. By securing the superhydrophilicity of the implant surface for a long time, it improves the fluid and blood affinity, and finally the excellent initial bone formation effect after the implant procedure. And a short bone fusion period, and to provide such superhydrophilized implants.
  • the present invention comprises the steps of modifying the macro-micromorphology to a superhydrophilic surface having a contact angle of 10 ⁇ or less through dry cleaning of room temperature full-lasma or ultraviolet irradiation in a timed manner to sufficiently remove the microcontamination present on the structured titanium surface. And, after the contaminant cleaning, the implant surface is immersed in a concentration of organic amphoteric bilayer complete solution so that the surface of the implant is not hydrophobized and the superhydrophilicity of 10 ° or less is continuously maintained.
  • the first step of the present invention is a dry cleaning method that decomposes a fine contaminant layer on the surface of an implant by reaction of an ionized component by room temperature plasma or ultraviolet light in a vacuum or atmosphere without using a solvent. It is the step of changing the surface contact angle to less than 10 ⁇ superhydrophilicity without changing the physical shape.
  • the second step of the present invention in order to maintain the superhydrophilic for a long time is to support in a buffer containing a salt based on organic amphoteric material, the salt concentration of the titanium surface even if stored for a long period of about 3 years It is characterized by being protected by an aqueous solution containing a salt in a layered amount capable of maintaining hydrophilicity of 10 ° or less without being hydrophobized.
  • the organic zwitterionic material include, for example, ACE, BES, CHES, HEPES, MOPS, PIPES, TES, etc., and it was confirmed that the salt concentration is preferably in the range of 0.1M to 1M.
  • organic zwitterionic buffer having a sulfonic acid group and removing contaminants adsorbed on the metal surface by pretreatment such as plasma or light irradiation. It is possible to maintain superhydrophilicity for a long period of time by being supported on the base material so that hydrophobicity as in conventional titanium surfaces does not occur.
  • the superhydrophilic titanium implant of the present invention has a surface that not only effectively prevents the adsorption and stabilization of pollutants in the air, but also uniformly surrounds the surface.
  • Superhydrophilicity of the surface is maintained by the solution; Excellent blood affinity, excellent bone formation effect and has an effect of shortening the bone fusion period.
  • 1 is a view schematically showing the surface treatment and storage method of the super-hydrophilic titanium implant of the present invention.
  • Figure 3 is a photograph showing the contact angle of the titanium disk stored on the organic zwitterionic complete layer liquid having a titanium disk and sulfonic acid group hydrophobized by surface contamination.
  • FIG. 4 is a view showing a change in contact angle with a change in the irradiation time of ultraviolet rays during dry cleaning.
  • FIG. 5 shows changes in implant-bone interface binding force at 4 months accelerated aging conditions.
  • Figure 6 shows the change in implant-bone interface binding force under three-year accelerated aging conditions.
  • FIG. 7 shows the change in implant-bone interface binding force with concentration of organic zwitterionic buffer at 3 years accelerated aging conditions.
  • Machined titanium disks are blasted for 1 to 60 seconds with blast pressure of 1 to 10 atm using A1 2 Q 3 powder with particle size of 1mm or less, and then macro acid is applied to titanium disk surface by acid treatment with mixed acid aqueous solution.
  • Micromorphology was assigned (hereinafter referred to as 'SA treatment' or 'SA').
  • the acid-treated titanium disc was ultrasonically cleaned for 30 minutes with ethanol and for 30 minutes with distilled water and then dried.
  • RFGD Radio-Frequency Glow Discharge
  • Organic zwitterionic materials with sulfonic acid groups that can be used in addition to HEPES include ACES, BES, CHES, MOPS, PIPES, TES, etc.
  • Titanium discs prepared through the above process were used in Examples 2 and 3 below.
  • the surface of the negative control group (SA) is the same as the SA-treated basic shape, but the surface component is present only titanium, in the case of the experimental group has a shape that the SA surface is covered with the supporting solution and the surface component of the supporting solution Ingredients S, 0, and C were detected with titanium.
  • the sample was washed three times or more with distilled water for 10 minutes, and then dried by spraying with nitrogen. From the side after The contact angle was measured by close-up photography.
  • the negative control group used a titanium disk in which the pollutant was adsorbed on the surface by exposure to the air after the SA treatment and dry cleaning using plasma or ultraviolet light at room temperature.
  • the negative control group was hydrophobized, and the contact angle showed a large value of 107 °, while the contact angle of the experimental group was 0 ° and it was confirmed that superhydrophilicity was maintained.
  • Figure 4 is a graph showing the change in contact angle with the time change of the dry cleaning process using ultraviolet light. As shown, it can be seen that when irradiated with ultraviolet rays for a time of 2 minutes or more, it is possible to secure a superhydrophilic surface having a contact angle of 0 °.
  • the SA surface is treated with SA, wet cleaning, and drying, followed by dry cleaning for 1 minute with room temperature plasma or at least 2 minutes with ultraviolet light to remove pollutants adsorbed and stabilized on the surface. It was confirmed in this example that the superhydrophilic titanium surface having a contact angle of 0 ° may be maintained when supported on the complete layer solution.
  • the machined dental titanium implant is blasted for 1 to 60 seconds with a blast pressure of 1 to 10 atm using A1 2 0 3 powder with a particle size of 1 mm or less.
  • Macro-micromorphology was imparted to the titanium disc surface by acid treatment with aqueous solution (SA treatment).
  • SA treatment aqueous solution
  • the acid-treated titanium disc was ultrasonically washed with ethanol for 30 minutes and distilled water for 30 minutes and then dried.
  • the implant was removed by a dry cleaning treatment of at least one minute of plasma at room temperature or at least two minutes of ultraviolet light to remove contaminants adsorbed and stabilized on the surface, and was supported in an organic amphoteric buffer (HEPES) having 0.02M sulfonic acid group on the surface.
  • HEPES organic amphoteric buffer
  • the titanium implant prepared as above was used in Examples 5, 6 and 7 below.
  • Example 5 Animal Experiment for Measurement of Bone Interfacial Adhesion of Organic Amphiphilic Complete Serum with Dental Accelerated Sulfonate Group (1)
  • the micro-pig After placing the HEPES-supported dental titanium implant prepared in Example 4 for 2 weeks under accelerated aging conditions (about 55 ° C.) for 4 months, the micro-pig (to check the implant-bone interface strength) was established. micropig) The implant was placed in the tibia and after 16 days of bone formation, the removal torque was measured.
  • a titanium implant without a contaminant was removed as a negative control, and a titanium implant (pretreatment) without undergoing accelerated aging conditions was used as a positive control after dry removal of the contaminant.
  • the bond-bone interface coupling force decreased by about 20% due to accelerated aging conditions. It was also confirmed that the removal ability of the skid was improved by about 5%.
  • the HEPES-supported dental titanium implant prepared in Example 4 was left for 18 weeks under accelerated aging conditions (about 55 ° C) to create a three-year storage period, followed by micro-implantation to check the implant-bone interface.
  • the implant was placed in the pig tibia and measured for removal torque after 16 days of bone formation.
  • a titanium implant that did not remove the contaminant was used as a negative control group, and a titanium implant that was subjected to a pretreatment process to remove the contaminant as a negative control group was not supported in the HEPES solution and was not subjected to accelerated aging conditions.
  • the implant-bone interface binding force of the experimental group that underwent the accelerated aging condition of 3 years of storage period was maintained at the same level as the implant-bone interface binding force of the positive control group which did not undergo any accelerated aging condition. It is confirmed that the storage of implant in ionic complete layer solution is very effective in maintaining superhydrophilicity of implant surface.
  • the HEPES-supported dental titanium implant described in Example 4 was varied in the concentration of HEPES and left for 18 weeks under accelerated aging conditions (approximately 55 0 C) to create a condition for one year of storage, and then implants—
  • the implant was placed in the micropig tibia to check the bone interface binding force, and the removal torque was measured after 16 days of bone formation period.
  • the negative control group was used as a titanium implant that did not remove the contaminant, and the positive control group was subjected to a pretreatment process but not carried out in the HEPES solution and subjected to accelerated aging conditions.
  • the source was dry-removed and used as an implant supported in distilled water instead of HEPES buffer. .
  • the removal ability of Birlin was increased by about 50% in the positive control group compared to the negative control group.
  • the concentration of HEPES buffer exceeds 1M, the HEPES buffer itself is toxic, but considering that the actual amount of HEPES buffer remaining on the implant surface is not too high, the concentration of HEPES buffer is set to 1M or less. It can also be evaluated that the level of safety is secured.
  • the concentration of the HEPES buffer supporting the implant is set in the range of 0.1M ⁇ 1M it was confirmed that the effect of the impingement bone interface binding strength is clearly maintained.
  • the embodiment is intended to help the description of the present invention is not limited by the embodiment, the person skilled in the art of the present invention within the scope of the technical idea of the present invention Various modifications and equivalent other embodiments are possible based on the claims and the content of the invention.
  • the first invention can be applied widely throughout the first half of the implant of titanium or titanium alloy material which lip expression in human bone tissue in the field of medicine dealing with the human bone, such as orthopedic medicine or dentistry.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ceramic Engineering (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un procédé pour modifier une surface de titane en une surface ultra-hydrophile par nettoyage de surface à sec précis sans changer la forme physique de la surface de titane, sans traitements de surface supplémentaires tels que le RBM et le SLA, et un procédé de stockage pour conserver sa propriété ultra-hydrophile pendant une longue période de temps. L'affinité pour un fluide corporel et le sang est améliorée par fixation de la propriété ultra-hydrophile de la surface d'un implant pendant une longue période de temps, permettant ainsi en fin de compte une excellente ostéogenèse initiale et une courte durée d'ostéo-intégration après l'implantation. De plus, un implant hydrophilisé est ainsi fourni.
PCT/KR2012/005490 2012-04-30 2012-07-11 Implant de titane ultra-hydrophile et ses procédés de traitement de surface et de stockage Ceased WO2013165051A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020120045351A KR101248785B1 (ko) 2012-04-30 2012-04-30 초친수성을 갖는 티타늄 임플란트, 그 표면처리 및 보관 방법
KR10-2012-0045351 2012-04-30

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WO2013165051A1 true WO2013165051A1 (fr) 2013-11-07

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CN115041462A (zh) * 2022-07-15 2022-09-13 江苏创英医疗器械有限公司 一种牙种植体表面清洗工艺

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KR101404632B1 (ko) 2013-05-02 2014-06-27 오스템임플란트 주식회사 임플란트의 표면처리방법
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KR101460974B1 (ko) 2014-07-11 2014-11-13 오스템임플란트 주식회사 표면이 코팅되어 생체 적합성이 향상된 치과용 임플란트 및 이의 제조 방법
WO2016006889A1 (fr) * 2014-07-11 2016-01-14 오스템임플란트 주식회사 Implant dentaire à revêtement de surface présentant une bioaffinité et une biocompatibilité améliorées et procédé de fabrication associé
KR101460973B1 (ko) 2014-07-11 2014-11-13 오스템임플란트 주식회사 표면이 코팅되어 생체 친화성과 생체 적합성이 향상된 치과용 임플란트 및 이의 제조 방법
KR101460976B1 (ko) 2014-07-11 2014-11-13 오스템임플란트 주식회사 표면이 코팅되어 생체 친화성이 향상된 치과용 임플란트 및 이의 제조 방법
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