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WO2013093114A3 - Procédé de spectrométrie de masse en tandem - Google Patents

Procédé de spectrométrie de masse en tandem Download PDF

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Publication number
WO2013093114A3
WO2013093114A3 PCT/EP2012/076874 EP2012076874W WO2013093114A3 WO 2013093114 A3 WO2013093114 A3 WO 2013093114A3 EP 2012076874 W EP2012076874 W EP 2012076874W WO 2013093114 A3 WO2013093114 A3 WO 2013093114A3
Authority
WO
WIPO (PCT)
Prior art keywords
ions
mass
mass spectrometry
segments
tandem mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/076874
Other languages
English (en)
Other versions
WO2013093114A2 (fr
Inventor
Alexander Alekseevich Makarov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific Bremen GmbH
Original Assignee
Thermo Fisher Scientific Bremen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Fisher Scientific Bremen GmbH filed Critical Thermo Fisher Scientific Bremen GmbH
Priority to GB1409655.6A priority Critical patent/GB2511239B/en
Priority to US14/367,857 priority patent/US9748083B2/en
Priority to DE112012005396.6T priority patent/DE112012005396B4/de
Publication of WO2013093114A2 publication Critical patent/WO2013093114A2/fr
Publication of WO2013093114A3 publication Critical patent/WO2013093114A3/fr
Anticipated expiration legal-status Critical
Priority to US15/684,163 priority patent/US10224193B2/en
Priority to US16/274,463 priority patent/US10541120B2/en
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

L'invention concerne un procédé de spectrométrie de masse en tandem. Un flux quasi continu d'ions provenant d'une source d'ion (20) et comprenant une gamme relativement large d'ions de ratio de masse sur charge est segmenté de manière temporelle en une pluralité de segments. Chaque segment est soumis à un degré de fragmentation indépendamment sélectionné, de telle sorte que, par exemple, certains segments de la gamme de masse large sont fragmentés alors que d'autres ne le sont pas. La population d'ions résultante, contenant à la fois des ions précurseurs et des ions fragmentés, est analysée dans un cycle d'acquisition unique à l'aide d'un analyseur de masse à haute résolution (150). La technique permet à l'analyse de la population d'ions initiale d'être optimisée pour des limitations analytiques.
PCT/EP2012/076874 2011-12-22 2012-12-24 Procédé de spectrométrie de masse en tandem Ceased WO2013093114A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB1409655.6A GB2511239B (en) 2011-12-22 2012-12-24 Method of tandem mass spectrometry
US14/367,857 US9748083B2 (en) 2011-12-22 2012-12-24 Method of tandem mass spectrometry
DE112012005396.6T DE112012005396B4 (de) 2011-12-22 2012-12-24 Verfahren zur Tandem-Massenspektrometrie und Tandem-Massenspektrometer
US15/684,163 US10224193B2 (en) 2011-12-22 2017-08-23 Method of tandem mass spectrometry
US16/274,463 US10541120B2 (en) 2011-12-22 2019-02-13 Method of tandem mass spectrometry

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1122178.5 2011-12-22
GBGB1122178.5A GB201122178D0 (en) 2011-12-22 2011-12-22 Method of tandem mass spectrometry

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/367,857 A-371-Of-International US9748083B2 (en) 2011-12-22 2012-12-24 Method of tandem mass spectrometry
US15/684,163 Continuation US10224193B2 (en) 2011-12-22 2017-08-23 Method of tandem mass spectrometry

Publications (2)

Publication Number Publication Date
WO2013093114A2 WO2013093114A2 (fr) 2013-06-27
WO2013093114A3 true WO2013093114A3 (fr) 2014-01-09

Family

ID=45572926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/076874 Ceased WO2013093114A2 (fr) 2011-12-22 2012-12-24 Procédé de spectrométrie de masse en tandem

Country Status (4)

Country Link
US (3) US9748083B2 (fr)
DE (1) DE112012005396B4 (fr)
GB (2) GB201122178D0 (fr)
WO (1) WO2013093114A2 (fr)

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DE102022128278A1 (de) 2021-10-29 2023-05-04 Thermo Fisher Scientific (Bremen) Gmbh Verfahren zum Bestimmen eines Maßes für eine Abfallrate und Massenspektrometriesystem
GB2621393B (en) 2022-08-12 2024-12-25 Thermo Fisher Scient Bremen Gmbh Methods and mass spectrometry systems for acquiring mass spectral data
GB2621395B (en) 2022-08-12 2025-02-05 Thermo Fisher Scient Bremen Gmbh Methods and mass spectrometry systems for acquiring mass spectral data
GB2621394B (en) 2022-08-12 2024-12-04 Thermo Fisher Scient Bremen Gmbh Methods and Mass Spectrometry Systems for Acquiring Mass Spectral Data
DE202023102071U1 (de) 2023-04-20 2023-06-12 Thermo Fisher Scientific (Bremen) Gmbh Massenspektrometriesystem zur Bestimmung eines Maßes für eine Abfallrate

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Also Published As

Publication number Publication date
US10224193B2 (en) 2019-03-05
US10541120B2 (en) 2020-01-21
US20190180994A1 (en) 2019-06-13
US9748083B2 (en) 2017-08-29
DE112012005396B4 (de) 2019-03-14
US20140346345A1 (en) 2014-11-27
DE112012005396T5 (de) 2014-09-11
GB2511239B (en) 2018-03-28
GB2511239A (en) 2014-08-27
US20170372882A1 (en) 2017-12-28
GB201122178D0 (en) 2012-02-01
WO2013093114A2 (fr) 2013-06-27
GB201409655D0 (en) 2014-07-16

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