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WO2012116289A3 - Microbial signatures as indicators of radiation exposure - Google Patents

Microbial signatures as indicators of radiation exposure Download PDF

Info

Publication number
WO2012116289A3
WO2012116289A3 PCT/US2012/026541 US2012026541W WO2012116289A3 WO 2012116289 A3 WO2012116289 A3 WO 2012116289A3 US 2012026541 W US2012026541 W US 2012026541W WO 2012116289 A3 WO2012116289 A3 WO 2012116289A3
Authority
WO
WIPO (PCT)
Prior art keywords
nuclear
exposure
radiation
indicators
microbiomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/026541
Other languages
French (fr)
Other versions
WO2012116289A2 (en
Inventor
John Edward Baker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TRICORDER DIAGNOSTICS LLC
Original Assignee
TRICORDER DIAGNOSTICS LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TRICORDER DIAGNOSTICS LLC filed Critical TRICORDER DIAGNOSTICS LLC
Priority to US13/499,256 priority Critical patent/US20130330728A1/en
Publication of WO2012116289A2 publication Critical patent/WO2012116289A2/en
Publication of WO2012116289A3 publication Critical patent/WO2012116289A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/40—Disorders due to exposure to physical agents, e.g. heat disorders, motion sickness, radiation injuries, altitude sickness, decompression illness

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of Radiation (AREA)

Abstract

The present disclosure defines a method for identifying and characterizing radiation exposure after, for example, a nuclear event such as detonation of a nuclear weapon or a nuclear meltdown of a nuclear power plant, using changes in microbiomes. The present disclosure demonstrates that microbiomes are reproducibly and detectably altered by exposure to radiation. As described herein, microbial signatures can be used to characterize components of microbiomes that are altered by exposure to radiation.
PCT/US2012/026541 2011-02-25 2012-02-24 Microbial signatures as indicators of radiation exposure Ceased WO2012116289A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/499,256 US20130330728A1 (en) 2011-02-25 2012-02-24 Microbial signatures as indicators of radiation exposure

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201161446696P 2011-02-25 2011-02-25
US61/446,696 2011-02-25
US201161451930P 2011-03-11 2011-03-11
US61/451,930 2011-03-11
US201161479786P 2011-04-27 2011-04-27
US61/479,786 2011-04-27
US201161491452P 2011-05-31 2011-05-31
US61/491,452 2011-05-31

Publications (2)

Publication Number Publication Date
WO2012116289A2 WO2012116289A2 (en) 2012-08-30
WO2012116289A3 true WO2012116289A3 (en) 2012-11-01

Family

ID=46000317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/026541 Ceased WO2012116289A2 (en) 2011-02-25 2012-02-24 Microbial signatures as indicators of radiation exposure

Country Status (3)

Country Link
AR (1) AR085409A1 (en)
TW (1) TW201247875A (en)
WO (1) WO2012116289A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
EP2953472A4 (en) 2012-11-23 2017-03-01 Seres Therapeutics, Inc. Synergistic bacterial compositions and methods of production and use thereof
WO2014121298A2 (en) 2013-02-04 2014-08-07 Seres Health, Inc. Methods of populating a gastrointestinal tract
EP3904502A3 (en) 2013-02-04 2022-02-23 Seres Therapeutics, Inc. Compositions and methods
JP2016519664A (en) 2013-03-15 2016-07-07 セレス セラピューティクス インコーポレイテッド Microbial composition and method based on network
MX367109B (en) 2013-11-25 2019-08-05 Seres Therapeutics Inc Synergistic bacterial compositions and methods of production and use thereof.
WO2015095241A2 (en) 2013-12-16 2015-06-25 Seres Health, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
EP3209803A4 (en) 2014-10-21 2018-06-13 Ubiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics
WO2016193846A2 (en) * 2015-05-29 2016-12-08 Koninklijke Philips N.V. Degenerate primer sets
CN106991265B (en) * 2016-01-20 2019-12-24 华北电力大学 Inverse method for surface source radiation source strength in nuclear power plant and surface source radiation source intensity inversion system
US11701394B2 (en) 2017-08-14 2023-07-18 Seres Therapeutics, Inc. Compositions and methods for treating cholestatic disease
US20200202979A1 (en) * 2017-09-06 2020-06-25 Psomagen, Inc. Nasal-related characterization associated with the nose microbiome
US12214002B2 (en) 2017-10-30 2025-02-04 Seres Therapeutics, Inc. Compositions and methods for treating antibiotic resistance
CN109738929B (en) * 2018-12-03 2022-10-21 中国辐射防护研究院 Dose estimation method and system based on maximum consumption of resident food
WO2022032282A1 (en) * 2020-08-06 2022-02-10 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Methods and reagents for microbiome analysis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
"Novel Biomarkers Reveal Evidence of Radiation Exposure", 1 May 2012 (2012-05-01), XP002681319, Retrieved from the Internet <URL:http://www.mcw.edu/Releases/2012-Releases/-Novel-Biomarkers-Reveal-Evide.htm> [retrieved on 20120803] *
BALISH E ET AL: "Irradiated humans: microbial flora, immunoglobulins, complement (C'3), transferrin, agglutinins, and bacteriocidins.", RADIATION RESEARCH SEP 1970 LNKD- PUBMED:4196098, vol. 43, no. 3, September 1970 (1970-09-01), pages 729 - 756, XP008154348, ISSN: 0033-7587 *
F W FURTH ET AL: "Bacteriologic studies of the X-radiated dog a", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 28, no. 2, 1 March 1952 (1952-03-01), pages 171 - 183, XP055034768 *
HOWARD E. NOYES ET AL: "EFFECTS OF A NUCLEAR DETONATION ON SWINE - BACTERIOLOGIC STUDIES", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 105, no. 11, 1 October 1963 (1963-10-01), pages 653 - 665, XP055034735, ISSN: 0077-8923, DOI: 10.1111/j.1749-6632.1963.tb42955.x *
J G VINCENT ET AL: "Relation of the indigenous flora of the small intestine of the rat to post-irradiation bacteremia", JOURNAL OF BACTERIOLOGY, vol. 69, no. 1, 1 January 1955 (1955-01-01), pages 38 - 44, XP055034736 *
JEAN-PIERRE FURET ET AL: "Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR", FEMS MICROBIOLOGY ECOLOGY, vol. 68, no. 3, 1 June 2009 (2009-06-01), pages 351 - 362, XP055034776, ISSN: 0168-6496, DOI: 10.1111/j.1574-6941.2009.00671.x *
KENT T H ET AL: "Intestinal flora in whole-body and intestinal X-irradiated rats", RADIATION RESEARCH 1968 LNKD- DOI:10.2307/3572521, vol. 35, no. 3, 1968, pages 635 - 651, XP008154333, ISSN: 0033-7587 *
LAM VY ET AL: "Intestinal Microbiota as Novel Biomarkers of Prior Radiation Exposure", RADIATION RESEARCH, vol. 177, no. 5, May 2012 (2012-05-01), pages 573 - 583, XP008154295 *
O. PALIY ET AL: "High-Throughput Quantitative Analysis of the Human Intestinal Microbiota with a Phylogenetic Microarray", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 75, no. 11, 1 June 2009 (2009-06-01), pages 3572 - 3579, XP055020698, ISSN: 0099-2240, DOI: 10.1128/AEM.02764-08 *

Also Published As

Publication number Publication date
WO2012116289A2 (en) 2012-08-30
AR085409A1 (en) 2013-10-02
TW201247875A (en) 2012-12-01

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