[go: up one dir, main page]

WO2012159632A1 - Verre fritté destiné à la libération de nutriments ou d'autres agents - Google Patents

Verre fritté destiné à la libération de nutriments ou d'autres agents Download PDF

Info

Publication number
WO2012159632A1
WO2012159632A1 PCT/DK2011/050176 DK2011050176W WO2012159632A1 WO 2012159632 A1 WO2012159632 A1 WO 2012159632A1 DK 2011050176 W DK2011050176 W DK 2011050176W WO 2012159632 A1 WO2012159632 A1 WO 2012159632A1
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
pores
water
glass
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2011/050176
Other languages
English (en)
Inventor
Jean-Luc Madier de Champvermeil
Daniel Frauchiger
Mikkel Vestergaard Frandsen
David Michael Healy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vestergaard Frandsen SA
Original Assignee
Vestergaard Frandsen SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestergaard Frandsen SA filed Critical Vestergaard Frandsen SA
Priority to PCT/DK2011/050176 priority Critical patent/WO2012159632A1/fr
Priority to TW101118174A priority patent/TW201311577A/zh
Publication of WO2012159632A1 publication Critical patent/WO2012159632A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C02F1/685—Devices for dosing the additives
    • C02F1/688—Devices in which the water progressively dissolves a solid compound
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • B01F21/20—Dissolving using flow mixing
    • B01F21/22—Dissolving using flow mixing using additional holders in conduits, containers or pools for keeping the solid material in place, e.g. supports or receptacles
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C14/00—Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix
    • C03C14/008—Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix the non-glass component being in molecular form
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0035—Compositions for glass with special properties for soluble glass for controlled release of a compound incorporated in said glass
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C2214/00—Nature of the non-vitreous component
    • C03C2214/17—Nature of the non-vitreous component in molecular form (for molecular composites)

Definitions

  • the present invention relates to a device and method for controlled release of a material into an aqueous medium.
  • the device comprises a porous matrix of sintered, water- soluble glass particles having pores between the sintered glass particles, and comprising material partly or entirely filling the pores.
  • the invention also relates to use of such a device, to a method for controlled release of material from the pores of a sintered, par- ticulate, water-soluble glass, and to a method for production of the matrix.
  • Soluble glass is well known as a medium for provision of nutrients to humans and animals.
  • Kendall et al published in Animal Science 2001, 73, pp. 163-169, the article "The effect of a zinc, cobalt and selenium soluble glass bolus on the trace element status of extensively grazed sheep over winter" describes nutritional additives for sheep in sintered soluble glass.
  • British patent application GB2030559 discloses soluble glass with Se and Zn for cattle and sheep. Slow release of Se over years is reported in US5049139. The company Telsol delivers soluble glass with Se and Zn for sheep and cattle, see http://www.telsol.co.uk/sel_def.html.
  • Glass is also used for release of antimicrobials.
  • US6555491 is concerned with water-soluble glasses, particularly glass fibres, containing small amounts of alkali metal compounds, with suggested uses being the sustained release of inorganic metals and anti-corrosion agents.
  • US5792360 concerns water soluble glass with antimicrobial copper, silver and/or zinc submerged in a water tank in order to prevent fouling, corrosion and scaling, where zinc is primarily applied to prevent corrosion.
  • Slow-dissolving glasses also known as controlled release glasses, include the range of products from Giltech Ltd (Ayr, UK; www.giltech.biz) under the trade name CORGLAESTM.
  • Addition of vitamins to filtered water in a personal drinking straw is discussed in international patent application WO2008/067816. Adding nutrients to filtered or otherwise purified water is discussed in International patent application WO03/011769 disclosing a water purifier for personal or domestic use and containing disinfectants and slow release nutrients, for example for use in rural areas of developing countries; the purifier includes a combination of (i) a primary coagulant, (ii) a microbicidal disinfectant, (iii) an oxidant, and optionally a food additive or nutrient source either as separate compositions in unit dosage form or incorporated directly into the water-purification compo- sition itself.
  • US6855252 discloses a tubular filter inside which a dispenser is centrally provided, the dispenser containing a solid or granular substance to be dissolved by liquid inside the dispenser.
  • the dispenser has a fluid intake and a fluid outlet, and fluid flowing through the filter creates a differential pressure between the intake and the outlet, which draws saturated liquid out of the fluid dispenser and into the filtered water.
  • Slipstream arrangements for dispensers in water filters are further disclosed in US4059522, US5897770, and US6485641.
  • This objective is achieved with a device and a method for controlled release of a material into an aqueous medium according to the following.
  • the objective is also achieved with a method for production according to the following.
  • the device comprises
  • the material has a lower dissolution rate in the aqueous medium than the glass.
  • the material is entirely filling the pores.
  • the pores are partly filled by the material.
  • the dissolution rate is typically dependent on the temperature, and the ratio between the dissolution rate of the glass and the dissolution rate of the material can vary with temperature as well.
  • the aspect of the dissolution rate of the material being lower than that of the glass has to be understood as being determined at a temperature or in a temperature range, at which the device has its normal operation temperature.
  • the dissolution rate is determined at a fixed temperature of 20°C, 25°C, 30°C or 35°C, or for a range of temperature, for example between 1°C- 50°C or 20°C and 25°C degrees. If no specific temperature is emphasized, the dissolution rates are determined at 25°C.
  • the device comprises only the glass matrix and the material that is provided in the pores of the glass matrix.
  • the device can be provided according to various embodiments with additional features.
  • the matrix When an aqueous medium is provided in contact with the matrix, the matrix is dissolved into the aqueous medium, and the material released into the aqueous medium.
  • the dissolution rate of the material is less that the dissolution rate of the glass
  • a high degree of control is achieved for the release of the material, because the dissolution rate of the glass determines how fast the material is released.
  • the device is particularly advantageous when the dissolution rate of the material is substantially less than the dissolution rate of the glass.
  • Such a device is much less sensitive with respect to the pore size than of the device described in US4587267, where the release of the material from the pores is determined by the diffusion rate of the material.
  • the material has a dissolution rate in the aqueous medium, for example water, at least 5 times lower than the glass, for example at least 10 times lower, or at least 50 times lower, or even at least 100 times lower at a given temperature, for example 25°C or at one of the other temperatures or temperature ranges given above.
  • the material is insoluble in water at 25°C or at one of the other temperatures or temperature ranges given above.
  • the matrix is provided in a bulk state which is then placed in an aqueous medium, for example water, in which the glass will slowly dissolve. As the material has a lower dissolution rate, the glass will dissolve more readily than the material, and will only free the material from the matrix once the glass around a pore is dissolved.
  • the material in a pore may be partly dissolved during the dissolution of the glass around that specific pore.
  • the material from pores remote from the surface of the glass will be protected from dissolution. This way, the material is only released from the surface layer of the glass matrix, which gives a high degree of control for the release of the material.
  • a surface layer has a thickness in the order of the size of the pores, because only the outermost pores release the material.
  • the material comprises nutrients, pharmaceuticals, nutraceuticals, nutricosmetics, biocides, and/or flavours, these are released to the aqueous medium upon dissolution of the glass.
  • Open pores in the glass mean that the volumes of neighbouring pores are in direct mutual contact and not closed by the glass.
  • a glass matrix with open pores can be easily filled, for example by one of the following methods, where the volumes of the pores are filled or partially filled with the material.
  • the porous matrix soaks up liquid material by capillary force.
  • the material may be an oil but can also be a material that solidifies or semi-solidifies after having entered the pores, for example by solidification (hardening) of a molten material during cooling. If the solidification is accompanied by contraction of the material, at least some of the pores in the end product may only be partially filled.
  • the material is dissolved in a solvent, and the material solidifies by evaporation of a solvent. Also in this case, at least some of the pores may end up not being entirely filled with the material due to the evaporation of solvent from the pores.
  • porous matrix of sintered, particulate, water-soluble glass containing a material can be achieved by the following methods.
  • the method comprises providing a porous matrix of sintered, water-soluble glass particles having empty pores between the glass particles, placing the matrix in contact with a liquid material and drawing the liquid material into the pores throughout the matrix.
  • empty pores we mean that the pores contain only ambient air.
  • the method comprises placing one part of the matrix, for example one end or side or edge of the matrix, in contact with a liquid material and an opposite part of the matrix outside the liquid material and drawing the liquid material into the pores throughout the matrix by capillary forces.
  • one part of the matrix for example one end or side or edge of the matrix
  • the method comprises placing the matrix with the empty pores in contact with a liquid material and applying a vacuum to the matrix to remove air from the pores and filling the pores with the liquid material as substitution for the air.
  • a part of the matrix for example a side or end or edge, is placed in the liquid material, and the vacuum is applied to another part of the matrix.
  • Another method comprises filling the pores of the matrix with a solvent, placing the matrix in a liquid material, causing the solvent to evaporate and drawing the liquid material into the pores by the evaporation of the solvent and substitution of the solvent by the liquid material.
  • a part of the matrix for example a side or end or edge, is placed in the liquid material, and another part of the matrix is outside the liquid material; evaporation of the solvent will draw the liquid material into the pores.
  • a further method of filling is achieved by the use of compression in which pressure is applied to the liquid to fill the sinter.
  • pressure is applied to the liquid to fill the sinter.
  • hydraulic pressure is applied to the matrix for filing of the matrix with creams and pastes that are more viscous that typical oil.
  • liquid material is oil containing an agent.
  • the liquid material contains a solvent and an agent, whereby the agent is then trapped in the pores upon evaporation of the solvent.
  • liquid material include the liquid material being a solution of solid material in a solvent or a dispersion of a solid material in a solvent.
  • the solvent for the liquid material need not be the same as a solvent that is used to fill the pores prior to drawing the liquid material into the pores.
  • the solvent provided in the pores as a prior step may evaporate easier and faster than the solvent of the liquid material.
  • the liquid material is a molten material, which solidifies after its location into the pores.
  • the methods for filling the pores in the matrix can be applied successfully for producing a matrix according to the foregoing.
  • the method for filling the matrix may be applied to porous, sintered, soluble-glass matrices in general, for example, also for filling a matrix according to US4587267.
  • the methods for filling a matrix are independent of the feature of the material having a lower dissolution rate in the aqueous medium than the glass, although the use of the filling methods for especially such a matrix is highly useful.
  • References to the pores being "filled with the material" mean that the material extends across the pore from a glass particle on one side of a pore to a glass particle on an opposite side of the pore.
  • This definition differentiates the invention from the example of having a very thin layer of material coating the surface of the pores but otherwise having empty pores that are not filled with the material.
  • suitable glass particle sizes can be selected from the following ranges: 10 - 150 ⁇ , 150 - 300 ⁇ , 300 - 500 ⁇ , 500 - 710 ⁇ , 710 - 1.0mm, 1.0 - 1.4mm, 1.4 - 2.0mm, 2.0 - 3.15mm, and 3.15 - 4.0mm.
  • the glass particles of the matrix have a size of 0.05 to 0.5 mm. If the glass particles are not spherical or approximately spherical, the size is to be measured as an average dimension of the particle, that is, the diameter of a sphere having the same volume than the glass particle.
  • a useful example of a type of glass is phosphate glass, although silicon glass can be used as well, such as a glass using borosilicate as a glass former.
  • the glass can comprise phosphorous pentoxide as the principal glass former together with one or more glass modifying materials including at least one of the following oxides, sodium oxide, potassium oxide, magnesium oxide, zinc oxide, and calcium oxide. Production of the glass itself is explained in the prior art, for example in international patent application W096/24364.
  • the dissolution rate of the glass material may be strongly or weakly dependent on the pH of the aqueous medium.
  • the dissolution rate may be dependent on other factors as well, for example the presence of material dissolved in the aqueous medium.
  • hard water versus soft water may influence the dissolution rate.
  • the matrix can be formed into any suitable shape, including, for example spherical, ellipsoidal, cubic, rectangular, elongate, tubular, or cylindrical.
  • the matrix may be in the form of a thin long slab. This shape has the advantage that the surface area of the slab does not change significantly even with a substantial change of volume during dissolution.
  • Non- limiting examples of sizes suitable for the sintered matrix are: a length of 20-200 mm, a width of 5-100 mm, and a thickness of 1-20 mm.
  • Alternative examples of sizes for the sintered matrix are: a length of 50-150 mm, a width of 10-50 mm, and a thickness of 2-10 mm.
  • the thickness is at least 5 or 10 times smaller than the length.
  • the matrix is provided in the form of a slab having a thickness at least a factor of 10 less than a length of the slab.
  • a non limiting example of slab di- mensions are 30 mm x 120 mm x 5 mm.
  • the matrix is a block with a constant or approximately constant cross section along a length of the block and with a plane surface at one end of the block or with two plane surfaces at opposite ends of the block.
  • the one or two plane surfaces have a shape of the cross section, and the block is covered with the sealant apart from the one or two plane surfaces leaving only the plane surface(s) in contact with the aqueous media.
  • the block is covered with the sealant apart from the one or two plane surfaces leaving only the plane surface(s) in contact with the aqueous media.
  • 4 or 5 sides are covered with a sealant for prevention of dissolution of the glass from these sides.
  • the matrix is elongate and rod-shaped with only one or two ends of the rod being exposed to water, as the remaining part is covered with the sealant.
  • the material is a hydrophobic material, although also amphiphilic materials may be used.
  • the material can comprises lipid.
  • Non limiting examples are various viscosities of oils, greases, fats or waxes.
  • the material comprises an agent distributed in the material. Examples of such an agent are nutrients, pharmaceuticals, nutraceuticals, nutricosmetics, biocides, and flavours or mixtures of at least two thereof.
  • the agent has a higher dissolution rate in oil than in water, for example a dissolution rate in oil that is at least 10 times higher than its dissolution rate in water.
  • An example of an oil soluble agents is carotene, for example the vitamin A precursor beta carotene.
  • lipid vesicles containing an agent lipid vesicles containing an agent or microcapsules containing an agent.
  • microcapsules can be based on starch or other materi- als that have a slow dissolution rate in water. This way, the agent, for example a nutrient, may be supplied to the consumer in a protected form. In case of consumption of the enriched water by drinking, such microcapsules should be digestible.
  • the agent may be encapsulated by using amphiphilic materials, which contributes to a controlled release.
  • amphiphilic materials which contributes to a controlled release.
  • lipid and a surfactant are mixed to obtain a dispersion, for example homogenous size dispersion, of globules containing water-soluble agents, for example vitamins from the B complex group or vitamin C.
  • concentration of the surfactant would then allow a control of the average hydrophobic globule size, yielding an additional control for the release rate of the hydrophilic active agent, which contrib- utes to a controlled release.
  • the material comprises the agent as outlined above; it is also possible that the glass itself comprises some agent in addition.
  • the material may comprise one agent and the glass comprises another agent.
  • a non limiting example is the material comprising an agent that is more lipophilic than hydrophilic, for example at least 5 or 10 times more lipophilic than hydrophilic, whereas the glass contains an agent that is more hydrophilic than lipophilic, for example at least 5 or 10 times more hydrophilic than lipophilic.
  • One option is the device for use as a water purification unit, where material with the agent inside the porous matrix is released to the water; alternatively or in addition, the agent is contained in the material and released directly to the water, for example by seeping out or diffusing out of the material.
  • the material or agent in the material is released into the water in small amounts, optionally as small portions, in order to obtain a long-lasting enrichment device.
  • a possibility in this respect is the enclosure of agent in lipid vesicles or microcap- sules.
  • the agent for enriching the water may comprise nutrients, pharmaceuticals, nutraceuticals, nutricosmetics, flavours, biocides or a combination thereof.
  • the matrix is useful for enriching drinking water with nutrients and/or flavours.
  • Other examples are water purification devices for medical or cosmetic use, where the water is enriched by pharmaceuticals, nutraceuticals, and/or nutricosmetics.
  • Non limiting examples of nutrients are iodine, zinc, selenium, iron, magnesium, calcium, vitamins and folic acid, which can also be used in combination.
  • vitamins are vitamin A, vitamin Bl, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenate, biotin, vitamin C, vitamin D, and vitamin K.
  • the material in the device comprises a carotinoid or a suspension of carot- inoid as disclosed in international patent application WO2010/112406 assigned to BASF.
  • the material in the pores of the matrix is a hydrophobic material comprising a pro-retinol, especially beta-carotene.
  • the beta-carotene itself is an antioxidant, which counteracts destructive oxidisation, resulting in a longer preservation in the ma- trix as well as outside the matrix when released into the water. This way, a self preserving system is provided.
  • DL-alpha-tocopherol(vitamin E active) can be added to the material in the pores acting as an anti-oxidant
  • Zn ion release is combined with the release of other agents, for example pro-retinol.
  • a source of Zn ions is incorporated in the material in the pores, but may alternatively be incorporated in the sintered glass itself.
  • minute amounts of Zn ions would be released from the glass and into the material, thereby acting antimicrobially during storage before the sintered material is used for release of the agent, for example pro-retinol.
  • the Zn ions would also act as an antimicrobial during use of the matrix in the aqueous medium.
  • the dissolved Zn ions released from the device would act as a nutrient for the consumer.
  • Zn ions are important in connection with the conversion of the pro-retinol beta carotene into vitamin A.
  • a combination of especially pro- retinol and Zn works synergistically in different directions, including antimicrobial ac- tion and nutritional action, especially in connection with enhancement of the nutritional action of Vitamin A.
  • a combination of pro-retinol, for example beta-carotene, in the material and a source of Zn ions in the water soluble glass composition is not only beneficial for a matrix as described above but also for sintered matrices an general, thus, also for the matrix as disclosed in US4587267.
  • a device for controlled release of a material into an aqueous medium, wherein the device comprises a porous matrix of sintered water-soluble glass particles having pores between the particles in the sintered matrix, the pores containing the material, wherein the material contains a pro-retinol, for example beta-carotene, and wherein the water-soluble glass contains a source of Zn ions.
  • the material has a lower dissolution rate in the aqueous medium than the glass. Whilst this independent device is particularly advantageous even when considered alone, the device can be combined with any of the features as described above for any of the other objectives.
  • Non limiting pharmaceuticals include orally administrable pharmaceuticals in general; generic drugs, non-generic drugs, for example analgesics, as well as pharmaceuticals that are not regarded as drugs, such as caffeine.
  • Specific non- limiting examples of pharmaceuticals include:
  • Antipyretics reducing fever (pyrexia/pyresis), for example Quinine
  • Analgesics reducing pain (painkillers)
  • Antimalarial drugs treating malaria, for example Quinine Antibiotics: inhibiting germ growth
  • Antiseptics prevention of germ growth near burns, cuts and wounds
  • useful pharmaceuticals include the following non limiting examples:
  • useful pharmaceuticals include the following non limiting examples:
  • ⁇ -receptor blockers (“beta blockers”), calcium channel blockers, diuretics, cardiac glycosides, antiarrhythmics, nitrate, antianginals, vasoconstrictors, vasodilators, peripheral activators
  • Affecting blood pressure (antihypertensive drugs): ACE inhibitors, angiotensin receptor blockers, a blockers, calcium channel blockers
  • Coagulation anticoagulants, heparin, antiplatelet drugs, fibrinolytics, anti-hemophilic factors, haemostatic drugs
  • Atherosclerosis/cholesterol inhibitors hypolipidaemic agents, statins.
  • useful pharmaceuticals include the following non limiting examples:
  • hypnotics anaesthetics, antipsychotics, antidepressants (including tricyclic antidepressants, monoamine oxidase inhibitors, lithium salts, and selective serotonin reuptake inhibitors (SSRIs)), antiemetics, anticonvulsants/antiepileptics, anxiolytics, barbiturates, movement disorder (e.g., Parkinson's disease) drugs, stimulants (including amphetamines), benzodiazepines, cyclopyrrolones, dopamine antagonists, antihistamines, cho- linergics, anticholinergics, emetics, cannabinoids, and 5-HT (serotonin) antagonists.
  • antidepressants including tricyclic antidepressants, monoamine oxidase inhibitors, lithium salts, and selective serotonin reuptake inhibitors (SSRIs)
  • antiemetics anticonvulsants/antiepileptics
  • anxiolytics
  • useful pharmaceuticals include the following non limiting examples: NSAIDs, opioids, and various orphans such as paracetamol, tricyclic antidepressants, and anticonvulsants.
  • useful pharmaceuticals include the following non limiting examples: NSAIDs (including COX-2 selective inhibitors), muscle relaxants, neuromuscular drugs, and anticholinesterases.
  • useful pharmaceuticals include the following non limiting examples:
  • Anti-bacterial antibiotics, topical antibiotics, sulfa drugs, aminoglycosides, fluoroquinolones
  • Anti-fungal imidazoles, polyenes
  • Anti-inflammatory NSAIDs, corticosteroids
  • Anti-glaucoma adrenergic agonists, beta-blockers, carbonic anhydrase inhibi- tors/hyperosmotics, cholinergics, miotics, parasympathomimetics, prostaglandin ago- nists/prostaglandin inhibitors, nitroglycerin
  • useful pharmaceuticals include the following non limiting examples: sympathomimetics, antihistamines, anticholinergics, NSAIDs, ster- oids, antiseptics, local anesthetics, antifungals, cerumenolyti.
  • useful pharmaceuticals include the following non limiting examples:
  • bronchodilators NSAIDs, anti-allergics, antitussives, mucolytics, decongestants corticosteroids, Beta2-adrenergic agonists, anticholinergics, steroids.
  • useful pharmaceuticals include the following non limiting examples: androgens, antiandrogens, gonadotropin, corticosteroids, human growth hormone, insulin, antidiabetics (sulfonylureas, biguanides/metformin, thiazolidinediones, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin analogues.
  • useful pharmaceuticals include the following non limiting examples:
  • antifungal alkalising agents, quinolones, antibiotics, cholinergics, anticholinergics, anticholinesterases, antispasmodics, 5 -alpha reductase inhibitor, selective alpha- 1 blockers, sildenafils, fertility medications.
  • useful pharmaceuticals include the following non limiting examples: Hormonal contraception, Ormeloxifene
  • useful pharmaceuticals include the following non limit- ing examples:
  • NSAIDs anticholinergics, haemostatic drugs, antifibrinolytics, Hormone Replacement Therapy (HRT), bone regulators, beta-receptor agonists, follicle stimulating hormone, luteinising hormone, LHRH, gamolenic acid, gonadotropin release inhibitor, progestogen, dopamine agonists, oestrogen, prostaglandins, gonadorelin, clomiphene, ta- moxifen, Diethylstilbestrol.
  • HRT Hormone Replacement Therapy
  • useful pharmaceuticals include the following non limiting examples:
  • emollients emollients, anti-pruritics, antifungals, disinfectants, scabicides, pediculicides, tar products, vitamin A derivatives, vitamin D analogues, keratolytics, abrasives, systemic anti- biotics, topical antibiotics, hormones, desloughing agents, exudate absorbents, fibrinolytics, proteolytics, sunscreens, antiperspirants, corticosteroids.
  • useful pharmaceuticals include the following non limiting examples: antibiotics, antifungals, antileprotics, antituberculous drugs, antima- larials, anthelmintics, amoebicides, antivirals, antiprotozoals.
  • useful pharmaceuticals include the following non limiting examples: vaccines, immunoglobulins, immunosuppressants, interferons, monoclonal antibodies
  • useful pharmaceuticals include the following non limiting examples: anti-allergics, antihistamines, NSAIDs
  • Hormones for example insulin or progesterone.
  • useful pharmaceuticals include the following non limiting examples: tonics, iron preparations, electrolytes, parenteral nutritional supplements, vitamins, anti-obesity drugs, anabolic drugs, haematopoietic drugs, food product drugs
  • useful pharmaceuticals include the following non limiting ex- amples: cytotoxic drugs, therapeutic antibodies, sex hormones, aromatase inhibitors, somatostatin inhibitors, recombinant interleukins, G-CSF, erythropoietin
  • nutraceuticals include (but are not limited to):
  • nutraceutical chemicals examples include probiotics, antioxidants, and phytochemi- cals:
  • Antioxidants resveratrol from red grape products; fiavonoids inside citrus, tea, wine, and dark chocolate foods; anthocyanins found in berries
  • soluble dietary fiber products such as psyllium seed husk
  • Botanical, herbal and spices extracts such as ginseng, garlic oil, etc.
  • Neutraceutical are products which typically claim to prevent chronic diseases, improve health, delay the aging process, and increase life expectancy.
  • Preferable nutricosmetics include (but are not limited to):
  • Antioxydants Vitamin C, Omega-3 fatty acids, Carotenes, Flavonoids
  • nutricosmetics refers to nutritional supplements which can support the function and the structure of the skin. Many micronutrients have this effect. Vitamin C, for example, has a well established anti-oxidant effect that reduces the impact of free radicals in the skin. It also has a vital function in the production of collagen in the dermis. Other micronutrients, for example, some omega-3 fatty acids, carotenes, and flavonoids protect the skin from the damaging effects of Ultraviolet (UV) light exposure, which may lead to accelerated skin ageing and wrinkle formation.
  • UV Ultraviolet
  • a practical embodiment includes a device comprising a water purification unit with a purification medium for providing a stream of purified water.
  • the device comprises a supply chamber containing the matrix.
  • the supply chamber is in fluid flow connection to a water purification unit for guiding the stream or part of the stream along the matrix.
  • water is purified by the water purification unit after which the water contacts the matrix resulting in dissolution, for example slow dissolution, of the material contained within the pores
  • a stream of purified water from the purification medium is divided into a main stream and a side stream, and only the side stream is guided along a surface of the matrix before the side stream is combined again with the main stream. This way, small amounts of the material can be provided to a relatively large volume of water in a controlled manner.
  • the device comprises a supply chamber containing the matrix.
  • the supply chamber is separate or even remote from the water purification unit.
  • the supply chamber is separate or remote from the water purifica- tion unit and has a first fluid flow connection to the water purification unit for receiving part of the stream and a second fluid flow connection to the water purification unit for delivering treated water back to the water purification unit.
  • Differential pressure may be provided between the first and the second fluid flow connection if the spacing between the first and the second fluid flow connection is along the direction of the main stream. In this case the side stream is received through the first fluid flow connection and guided along the matrix before returning the enriched side stream back to the main stream through the second fluid flow connection.
  • the water purification unit can comprise a downstream side of the purification medium, for example a membrane filter or chemical purification medium or a combination thereof.
  • the downstream side can comprise a water outlet for consumption of purified water from the downstream side.
  • the downstream side comprises a stream of purified water from the purification medium to the water outlet.
  • the first and the second connections from the supply chamber are to the downstream side and are dimensioned to guide only part of the stream into and through the supply chamber, thereby dividing the stream of purified water into a main stream in the downstream side and a smaller side stream through the supply chamber.
  • the purifying medium is a membrane filter, for example a ceramic filter or a polymer membrane.
  • a membrane filter for example a ceramic filter or a polymer membrane.
  • polymer membranes are well known in the art and made from various polymers, including polyethersulfone (PES) and polyvinylporrylidone (PVP).
  • PES polyethersulfone
  • PVP polyvinylporrylidone
  • the membrane is a bundle of hollow fibre membranes. Examples are described in international patent applications W098/15342.
  • the device is a portable device.
  • the term "portable device” means that the device can easily be carried by an adult human.
  • the device has a largest dimension of less than 1 meter.
  • the device also has a weight of less than 30 kg, more preferably less than 20 kg, or less than 10 kg when containing no water, or even less than 2 kg for a small model.
  • the device is a portable device with dimensions less than 60 cm in all three orthogonal directions.
  • Another example is a portable device being less than 50 cm in one dimension and less than 20 cm in the other two orthogonal dimensions.
  • weights and dimensions given above also apply for the device having a water purification unit as explained above.
  • Examples of small size and portable water purification devices are published in International patent applications WO2008/067816, WO2008/067817, WO2008/110165 or WO2008/110172.
  • Products on the market include personal water filter straws with the registered trademark LifeStraw® or gravity feeded filters of the trademark LifeStraw Family® marketed by the company Vester- gaard-Frandsen with the internet site www.vestergaard-frandsen.com.
  • a target value for production of purified water is 10,000 litres of drinking water over two years. This corresponds largely to a water purification device in the form of the above-mentioned LifeStraw Family®. Therefore in a further embodiment, the de- vice is configured for water purification of 10,000 litres before exhaustion.
  • the device may contain between 100 mg and 1000 mg of Retinol Equivalent (RE) to pure Vitamin A, for example between 350 mg and 1000 mg. With such a device, it is possible to fulfil a target of delivery of 350 mg per annum of Retinol Equivalent (RE) to pure Vitamin A.
  • RE Retinol Equivalent
  • the device contains between lg and 10 g of zinc, for example between 3.5g and lOg.
  • the zinc can be in the form of metallic zinc or zinc ions.
  • the Zn is contained in the glass as part of the molecular structure of the glass and will be released as zinc ions upon dissolution of the glass by aqueous media, although it could have been incorporated in the material as well.
  • a target can be reached of delivering 3.5 grams per annum of Zinc ions through the 10,000 litres of drinking water. This equates to 35 ⁇ g RE/1 and 0.35mg/l zinc ions for a 12 month period.
  • an RE Vitamin A is formulated and incorporated into the material in the pores of the water-soluble sintered glass.
  • the glass itself contains a source of zinc (Zn) ions to form a composite material that will slowly release the required levels of Vitamin A and zinc ions for a year or longer.
  • the reference to Zn or to a source of Zn ions includes various zinc compositions that are able to release zinc in a proper form, for example in a biologically suitable form when used for nutrition and in a biocidally active form when used as a biocide.
  • Such forms include salts of Zn
  • Vitamin A is not used in its pure form, but a natural or synthetic dietary pro-retinol is used, such as beat- carotene, because it is not possible to overdose this precursor form.
  • a natural or synthetic dietary pro-retinol such as beat- carotene
  • the matrix contains 1 to 12 g of beta carotene, for example 3.5 to 12 g of beta-carotene.
  • the amount of pro-retinol can be further reduced, possibly to 1 g or even less, if delivered in an oil base, because lipids have the potential to improve dietary bioavailability and its subsequent conversion to retinol.
  • a lipid formulation for the material in the pores can be based on various materials, for example taken from the following non-limiting list comprising cottonseed oil, sunflower seed oil, rape seed oil, other vegetable oil, coconut oil, cocoa butter, shea butter, vegetable fats, Carnauba wax, beeswax.
  • the lipid material should be an edible material, where the term "edible” means that the material can be ingested by a human or animal without harm.
  • FIG. 1 is a schematic sketch of a glass matrix, with 1A) showed a detailed sketch, IB) showing a cylindrical matrix, and 1C) showing an elongate rectangular matrix;
  • FIG. 2 illustrates a device with in the form of a water purification unit and a supply chamber.
  • FIG. 1A is a sketch of a device with a glass matrix 1 comprising glass particles 2 that are sintered together into a solid, porous matrix.
  • the particles 2 are illustrated as spheres, which is normally not the case after sintering but which is used here for simple illustration.
  • a material 3 containing an agent for example nutrients, pharmaceuticals, nutraceuticals, nutricosmetics, flavours, biocides, or combinations thereof.
  • agents can be part of a composition that is included in the material 3 before filling into the pores.
  • FIG. IB shows a cylindrical matrix IB and FIG. 1C an elongate rectangular matrix 1C.
  • the matrices IB, 1C have a constant or approximately constant cross section along a length of the matrix and a plane surface 4B, 4C at one end of the matrix.
  • the wall 29B, 29C of the matrix, apart from the plane surface 4B, 4C, is covered with a sealant 30B, 30C, leaving only the plane surface 4B, 4C in contact with the aqueous medium.
  • the opposite ends of the matrices IB, 1C may optionally be covered in order only to expose one end 4B, 4C to the aqueous medium, or may be free of sealant in order to double the exposed surface.
  • FIG. 2 illustrates the principle of a device 6 for purifying and enriching water.
  • the device 6 contains a water-soluble matrix 1 containing releasable material, for example as illustrated in FIG. 1.
  • the device comprises a fluid inlet side 7, a fluid inlet 8 into the fluid inlet side 7, and a filter 9, for example comprising a plurality of microporous hol- low fibre membranes.
  • the device further comprises a fluid outlet side 10 and a first fluid outlet 11 from the fluid outlet side 10.
  • it comprises a side-stream outlet 12 from the fluid outlet side 10, the side-stream outlet 12 being in tubular connection to an inlet 13 of a supply chamber 14 in order to provide water from the outlet side 10 to the supply chamber 14.
  • An outlet 15 of the supply chamber 14 is in tubular connection to a side stream return 16 for returning water from the supply chamber 14 to the fluid outlet side 10.
  • the device 6 comprises a separate filtering unit 17 and a remote supply chamber 14, which are mutually connected by tubing 18 from side stream outlet 12 to chamber inlet 13 and by tubing 19 from chamber outlet 15 to side stream return 16.
  • the device 6 has a first and a second fluid flow paths between the fluid inlet 8 and the first fluid outlet 11.
  • the first fluid flow path is from the fluid inlet 8 into the fluid inlet side 7, through the filter 9 to the fluid outlet side 10 and to the first fluid outlet 11.
  • the second fluid flow path is from the fluid inlet 8 to the fluid inlet side 7, through the filter 9 to the fluid outlet side 10, to the side-stream outlet 12, through the chamber inlet 13, into the inner volume 20 of the supply chamber 14 and along the matrix 1, which is illustrated by arrows 28, then, through the chamber outlet 15 through the side-stream return 16, into the fluid outlet side 10 and through first fluid outlet 11.
  • the second fluid flow is a side stream relative to the first fluid flow, which is the main steam.
  • the side stream is typically of much smaller volume than the main stream and has the purpose to transport minor amounts of agent, for example nutrients, from the supply chamber 14 into the main stream in the fluid outlet side 10.
  • agent for example nutrients
  • Such agents are supplied from a soluble matrix 1 inside the inner volume 20 of chamber 14 providing the side stream with the agent upon slow dissolution of the matrix 1.
  • the driving force for the side stream is the differential pressure in the fluid outlet side 10 between the side-stream outlet 12 and the side-stream return 16.
  • the soluble matrix 1 is provided as a slab, although it can have various shapes, including rods or tubes.
  • the device 6 further comprises a second fluid outlet 24 out of the fluid inlet side 2 de- fining a third fluid flow path between the fluid inlet 3 and the second fluid outlet 24.
  • the third flow path is from the fluid inlet 8 into the fluid inlet side 7 to the second fluid outlet 24.
  • the first fluid outlet 11 and the second fluid outlet 21 have valves 22, 23, respectively, for controlling the flow of fluid therethrough.
  • the valves 22, 23 each have valve fluid outlets 24, 25 for dispensing fluid therefrom.
  • the filter 9 is typically cylindrical in shape.
  • the filter 9 is a ceramic membrane or a polymer membrane, for example a porous PES/PVP ultra-filtration or micro-filtration membrane.
  • the wall 26 is typically cylindrical in shape but could have many other tubular shapes, if convenient.
  • the filter 9 is provided such that fluid cannot pass from the fluid inlet side 7 to the fluid outlet side 10 without passing through the filter 9, thereby ensuring that all water dispensed from the valve fluid outlet 25 has been filtered.
  • Valve 23 can be opened for allowing water to flow from the fluid inlet 8 along the in- ner surface of the filter 9 and out of the valve fluid outlet 24. This acts to flush out the filter 9 and remove any residue trapped in or on the filter 9 which then leaves device 6 through valve fluid outlet 21.
  • the device 6 is preferably oriented in use such that the second fluid outlet 21 is dis- posed below the fluid inlet 8, for example vertically, approximately vertically or inclined to not more than 45 degrees. This allows a good flow-rate of water from the fluid inlet 8 to the valve fluid outlet 24 when flushing out the device.
  • the side stream return 16 is disposed above the side stream outlet 12, allowing improved circulation of water through the supply chamber 14.
  • valves 22, 23 are closed to prevent water from leaving the device 6 uninten- tially.
  • Fluid inlet 8 is connected to a supply of untreated water (not shown), for example a container suitable for storing untreated water and positioned higher than the fluid inlet 8, such that untreated water can flow to the fluid inlet 8 by gravity. This saves a user from the need to pump water through the device 6.
  • the device is arranged to be driven by a pump.
  • the container may contain a coarse filter for filtration of larger particles.
  • the outlet of the container is in fluid flow communication with the fluid inlet 8 of the device 6.
  • Valve 22 is to be opened in order to dispense water. Once, air has cleared from the device 6, treated water flows from the valve fluid outlet 25.
  • agent 2 has arrows indicating the direction of fluid flow through the device 6. It shows the agent dispensed by supply chamber 14 as zinc ions (Zn2+), but the invention is not limited thereto.
  • agent covers nutrients, pharmaceuticals, nutraceuticals, nutricosmetics, or flavours, but the principle could as well serve for adding other chemicals, for example biocides.
  • the supply chamber 14 is provided outside and remote from the purifier housing 27.
  • the supply chamber 14 could also be provided outside the purifier housing 27 but abutting the purifier housing 27.
  • the supply chamber 14 could share a common housing with the purification medium, for example a filter 9, although, a separating wall between the fluid outlet side 10 and inner volume 20 of the supply chamber 14 would be needed in order to use the principle.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Materials Engineering (AREA)
  • Toxicology (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Dispersion Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Hydrology & Water Resources (AREA)
  • Environmental & Geological Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une matrice en verre fritté, contenant des nutriments ou d'autres agents dans ses pores, utilisée pour la libération contrôlée de l'agent dans l'eau, par exemple en tant que partie d'un dispositif de filtration de l'eau. Le matériau dans les pores présente une solubilité plus faible dans le milieu aqueux que le verre de sorte que la dissolution du verre détermine la libération du matériau à partir des pores.
PCT/DK2011/050176 2011-05-26 2011-05-26 Verre fritté destiné à la libération de nutriments ou d'autres agents Ceased WO2012159632A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/DK2011/050176 WO2012159632A1 (fr) 2011-05-26 2011-05-26 Verre fritté destiné à la libération de nutriments ou d'autres agents
TW101118174A TW201311577A (zh) 2011-05-26 2012-05-22 供釋出營養物或其他藥劑之燒結玻璃

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK2011/050176 WO2012159632A1 (fr) 2011-05-26 2011-05-26 Verre fritté destiné à la libération de nutriments ou d'autres agents

Publications (1)

Publication Number Publication Date
WO2012159632A1 true WO2012159632A1 (fr) 2012-11-29

Family

ID=47216621

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2011/050176 Ceased WO2012159632A1 (fr) 2011-05-26 2011-05-26 Verre fritté destiné à la libération de nutriments ou d'autres agents

Country Status (2)

Country Link
TW (1) TW201311577A (fr)
WO (1) WO2012159632A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015132283A1 (fr) * 2014-03-05 2015-09-11 Danmarks Tekniske Universitet Appareil comprenant un dosage d'élément en trace, et procédé de traitement d'eau brute dans un biofiltre
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
CN114477735A (zh) * 2022-02-21 2022-05-13 衡水伟业水准仪器有限公司 水平仪玻璃水泡灌装封堵装置

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202106923D0 (en) * 2021-05-14 2021-06-30 Bimeda Animal Health Ltd A water soluble or water dispersible bolus article containing bromoform

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517006A (en) * 1981-11-18 1985-05-14 Itt Industries, Inc. Composite materials comprising water-soluble glass particles
US4587267A (en) * 1983-09-15 1986-05-06 Standard Telephones And Cables, Plc Controlled release system
EP0220928A1 (fr) * 1985-10-23 1987-05-06 Stc Plc Verre fritté
US4866097A (en) * 1983-09-15 1989-09-12 Standard Telephones And Cables Public Limited Company (Stc) Controlled release system
WO1990011756A1 (fr) * 1989-04-12 1990-10-18 Aberdeen University Systeme vitre a liberation lente
WO1996026364A2 (fr) * 1995-02-14 1996-08-29 Ocean Power Technologies, Inc. Generation d'energie electrique par des elements piezoelectriques elastiques a poids
US5897770A (en) * 1997-10-23 1999-04-27 Plymouth Products, Inc. Center core cartridge feeder insert
WO1999055461A1 (fr) * 1998-04-27 1999-11-04 Corning Incorporated Reservoir capillaire etire pour imagerie
WO2001018174A2 (fr) * 1999-09-07 2001-03-15 Giltech Limited Substrat de croissance pour des cellules
US6267886B1 (en) * 2000-02-20 2001-07-31 Brandreth, Iii John B. Uni-directional flow chemical dispenser
US6325926B1 (en) * 1999-11-18 2001-12-04 Austin Hansen Liquid treatment apparatus
WO2005087274A1 (fr) * 2004-03-05 2005-09-22 Xl Sci-Tech, Inc. Materiaux pulverulents et compositions de radiotherapie
WO2007011612A2 (fr) * 2005-07-15 2007-01-25 Tyco Healthcare Group Lp Pansement et procedes pour sa fabrication et son utilisation
US20070104949A1 (en) * 2003-06-20 2007-05-10 Misapor Ag Granulate made of sintered or cellular broken glass

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517006A (en) * 1981-11-18 1985-05-14 Itt Industries, Inc. Composite materials comprising water-soluble glass particles
US4587267A (en) * 1983-09-15 1986-05-06 Standard Telephones And Cables, Plc Controlled release system
US4866097A (en) * 1983-09-15 1989-09-12 Standard Telephones And Cables Public Limited Company (Stc) Controlled release system
EP0220928A1 (fr) * 1985-10-23 1987-05-06 Stc Plc Verre fritté
WO1990011756A1 (fr) * 1989-04-12 1990-10-18 Aberdeen University Systeme vitre a liberation lente
WO1996026364A2 (fr) * 1995-02-14 1996-08-29 Ocean Power Technologies, Inc. Generation d'energie electrique par des elements piezoelectriques elastiques a poids
US5897770A (en) * 1997-10-23 1999-04-27 Plymouth Products, Inc. Center core cartridge feeder insert
WO1999055461A1 (fr) * 1998-04-27 1999-11-04 Corning Incorporated Reservoir capillaire etire pour imagerie
EP0955084A1 (fr) * 1998-04-27 1999-11-10 Corning Incorporated Réservoir capillaire refilé
WO2001018174A2 (fr) * 1999-09-07 2001-03-15 Giltech Limited Substrat de croissance pour des cellules
US6325926B1 (en) * 1999-11-18 2001-12-04 Austin Hansen Liquid treatment apparatus
US6267886B1 (en) * 2000-02-20 2001-07-31 Brandreth, Iii John B. Uni-directional flow chemical dispenser
US20070104949A1 (en) * 2003-06-20 2007-05-10 Misapor Ag Granulate made of sintered or cellular broken glass
WO2005087274A1 (fr) * 2004-03-05 2005-09-22 Xl Sci-Tech, Inc. Materiaux pulverulents et compositions de radiotherapie
WO2007011612A2 (fr) * 2005-07-15 2007-01-25 Tyco Healthcare Group Lp Pansement et procedes pour sa fabrication et son utilisation

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039619B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11464232B2 (en) 2014-02-19 2022-10-11 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11470847B2 (en) 2014-02-19 2022-10-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11751570B2 (en) 2014-02-19 2023-09-12 Corning Incorporated Aluminosilicate glass with phosphorus and potassium
US12121030B2 (en) 2014-02-19 2024-10-22 Corning Incorporated Aluminosilicate glass with phosphorus and potassium
WO2015132283A1 (fr) * 2014-03-05 2015-09-11 Danmarks Tekniske Universitet Appareil comprenant un dosage d'élément en trace, et procédé de traitement d'eau brute dans un biofiltre
CN114477735A (zh) * 2022-02-21 2022-05-13 衡水伟业水准仪器有限公司 水平仪玻璃水泡灌装封堵装置
CN114477735B (zh) * 2022-02-21 2022-08-23 衡水伟业水准仪器有限公司 水平仪玻璃水泡灌装封堵装置

Also Published As

Publication number Publication date
TW201311577A (zh) 2013-03-16

Similar Documents

Publication Publication Date Title
WO2012159632A1 (fr) Verre fritté destiné à la libération de nutriments ou d'autres agents
DE69632067T2 (de) Orale verabreichung von nützlichen wirkstoffen
US9663691B2 (en) Production of highly ionized alkaline water using a combination of reducing metals and reductive minerals
CN104768879B (zh) 膳食补充剂配给装置
WO2014110580A1 (fr) Rinçage nasal au miel
CN110279678A (zh) 含大麻素的固体组合物及其制备方法和应用
CN102429073A (zh) 一种姜糖
US20090082738A1 (en) Natural Anti-Inflammatory Agents for Reducing Pain
KR101910694B1 (ko) 철분 보충 조성물
CN103571704A (zh) 沉香保健酒制备方法及其沉香酒
US20100322961A1 (en) Intranasal Drug Delivery System
WO2019002933A1 (fr) Composition de granulés vétérinaires contenant un extrait de chanvre
White et al. The herbal drugstore: the best natural alternatives to over-the-counter and prescription medicines!
TW201300328A (zh) 用於淨化水及以例如養分的試劑濃化水之裝置及方法
CN103330813B (zh) 治疗脚气的中药组合物
CN103432044A (zh) 一种西瓜霜牙膏及其制备方法
EP2676555A1 (fr) Utilisation d'un polymère de masse moléculaire élevée et composition en contenant
CN100364498C (zh) 用于减轻或消除鼾声的口腔喷雾剂及其制备方法
JP2006232833A (ja) 栄養補給剤調合品及び栄養補給剤調合品セット
WO1999055171A1 (fr) Pierre a lecher
JPS59157018A (ja) 新規なる被覆含油カプセル剤形
DE202013000774U1 (de) Miniaturisiertes Inhalationsgerät zur Privatanwendung
JPS63258820A (ja) 止瀉剤含有内用懸濁剤
CN102600320B (zh) 一种用于镇静促眠的中药及制备方法
EP1563743B1 (fr) Composition comprenant une substance contenant de la caféine, en particulier guarana

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11866398

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 11866398

Country of ref document: EP

Kind code of ref document: A1