WO2012152966A1 - Cosmetic composition for couperosis care - Google Patents

Abstract

The present invention relates to the use of a cosmetic composition in the form of a cream, which comprises a cosmetically effective amount of stearyl glycyrrhetinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter, for the preparation of a cosmetic composition for the care and treatment of couperosis, and to the method for the administration thereof.

Description

 COMPOSTCT N C SMFTT A PAR A FT CTTTDAD DF T A CTTPFROSTS

D E S f R I P n Ó N

OBJECT OF THE INVENTION

The present invention relates to the use of a cosmetic composition comprising a cosmetically effective amount of stearyl glycyrrheinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter for the preparation of a cosmetic composition for the care and treatment of couperose. The present invention also relates to the method of application on the facial skin of said composition which comprises the steps of taking a sample of the cosmetic composition with an application device and applying it locally on the couperose and optionally applying heat on said couperose.

BACKGROUND OF THE INVENTION

Cuperosis is an alteration in the form of dilation of the superficial capillaries of the skin of the face, mainly in the central area (cheeks, nose), whose origin is multifactorial. Among the causes that cause this disorder include a genetic predisposition, prior involvement with acne and / or rosacea, whose outbreaks subsequently lead to the presence of permanent superficial capillary dilations, as well as hormonal and environmental changes.

It is therefore an alteration that involves permanent reddening of the face, which is worsened by vasodilation with the sudden changes in ambient temperature (hot-cold, closed premises, etc.) leading to concern, insecurity and decreased self-esteem of people who suffer {Balkrishnan R, McMichael Aj, Hu JY et al. Correlates of health-related quality oflife in women with severe facial blemishes. Int Soc Dermatol. 2006; 45: 111-115).

Exact incidence figures are not available because there is no uniform definition of the clinical picture presenting this type of condition. The difficulty lies in defining the point at which a patient with pink cheeks presents a dermatological problem, rosacea type. However, a Swedish study published an incidence of 10%, which is a reasonable percentage to take into account the treatment and care of such patients {Berg M, Liden S. An epidemiological study of rosacea. Dermatovenerol Act. 1989; 69: 419-23).

Currently, there are different treatments to alleviate or eliminate these alterations, which can be summarized as follows:

- Cosmetic treatments - These are topical products such as creams, tonics and makeup, aimed at alleviating the burning sensation and redness that is usually linked to couperose, and that cover, camouflaging venous dilations. These cosmetic products are not included in the European Pharmacopoeia, and due to their cost-benefit balance, only a small part of the population is willing to use them.

- Surgical treatments - There are several procedures that are useful for removing capillaries that constitute couperose. Until a few years ago, electrocoagulation of the facial veins was used, one at a time, which involved pain and often residual scars. Currently, the laser / IPL technology (Intense Pulsed Light Laser) is used successfully for the treatment of couperose. Both pulsed dye lasers and Neodymium: Yag (laser generally 1064 nm) and intense pulsed light (IPL) achieve, gradually acting on the venous paths, their gradual decrease and elimination. They are techniques that do not require anesthesia or analgesic medication, but several sessions are necessary, and the Cost is high. They are avant-garde technologies, which need to be carried out by an expert doctor, and there is still a risk of hypopigmented residual lesions, therefore, although it is the current treatment of choice to treat couperose, its cost limits its usefulness to a portion reduced patient

There is therefore a need to find a non-invasive, safe, effective, rapid and effective alternative for the care and / or cosmetic treatment of couperose that leads to a real decrease in facial emotion, which facilitates the patient the correct and comfortable administration of the same, without involving a health risk because it is a corrective and reparative product of topical administration on the skin.

In this way the present invention solves the drawbacks of the state of the art by referring to a cosmetic composition of topical administration located on the couperose (non-invasive) that allows the patient the controlled administration thereof without the safety and toxicity problems they pose. surgical treatments as well as cosmetic treatments known in the state of the art.

DESCRIPTION OF THE INVENTION

Currently, the problems of couperose are frequent, with the consequent discomfort that this entails for the affected patients, in their physical state, in addition to the limitations that it gives rise, in many cases restricting the activity, with impediment even for the development of certain functions of work, sport, etc.

In this sense, to alleviate as much as possible these inconveniences and harmful consequences of couperose, especially due to the unsightly effect, in accordance with the purpose of the The present invention proposes a topical cream of cosmetic action that is very advantageous to reduce the aforementioned effects as well as the unsightly problems caused by couperose. The composition object of the present invention has the advantage that it also lacks corticosteroids which also makes it possible for its continued use without causing side effects, such as skin winding and the appearance of stretch marks and fissures. A first important aspect of the present invention is that it refers to the use of a cosmetic composition comprising a cosmetically effective amount of stearyl glycyrrheinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter for the preparation of a cosmetic composition for the Cuperosis care and treatment. Additional aspects of the present invention protect the use of the aforementioned cosmetic composition topically in the form of a cream and / or emulsion, as well as the use of said composition to make up and disguise couperose.

The present invention also relates to the use of said composition topically by an application device selected from the group consisting of: a brush, a spatula, a cotton pad, gauze and a swab, sponge, tube with applicator.

The present invention also protects the method of application on the facial skin of said composition comprising the steps of taking a sample of the cosmetic composition with an application device and applying it locally on the couperose and optionally applying heat on said couperose.

The composition cited above is obtained with the following method: Aqueous PHASE (A):

 In a beaker, weigh the distilled water, with the help of a magnetic stirrer add the maltitol and stir with magnetic stirring until completely dissolved. Add NIKKOSOME OS (squalene + glycerin + hydrogenated lecithin), and optionally hydrolyzed silk and stir until completely dispersed. Cover and store until used.

PHASE (B) ALCOHOLIC:

 In a beaker weigh 96 ° ethanol, weigh propylene glycol, diethylene glycol monoethyl ether add and stir on a magnetic stirrer until dissolved. Weigh the rest of the components (preservatives and silicone) and add one by one until completely dissolved. Keep covered until use.

PHASE (C) INSOLUBLE PHASE:

Weigh each of the components (dye, talc and titanium dioxide) and transfer them to a mortar. Mix homogeneously and pass the mixture through a 0.600 mm light mesh screen. Return the mixture to the mortar, homogenize and keep covered until used. PHASE (D) tocopheryl nicotinate:

 Weigh in a tocopheryl nicotinate watch glass. Preserve from light and air. Save until use.

OLEOUS (O) PHASE:

Weigh the petroleum jelly in a 250 ml beaker and melt in a bath Weigh the rest of the components of this phase one by one (liquid paraffin, pentamer cyclomethicone, stearyl glycyrrhecinate, tribehenine, dicaprilat propylene glycol, cholesterol esters and lanoesterol , sip laurate and shea butter) and add to the glass that contains petroleum jelly. Heat up to 80 ° C (± 2 ° C) to total fusion of all components. Keep the molten mixture at 80 ° C (± 2 ° C).

The beneficial properties of this cream are due to the selection and proportion of each of the components of the cream.

For example, glycyretinic acid is a complex triterpene that is used locally in preparations for the treatment of non-infectious inflammatory disorders of the skin, it is also a potent inhibitor of the 11-b-hydroxysteroid dehydrogenase enzyme that inactivates cortisol. In fact it has been shown that the concomitant application of glycyrrhizinic acid together with hydrocortisone enhances the activity of the latter in the skin. Another property of glycyrrhizinic acid is that it can be esterified with stearyl alcohol, which favors its absorption through the skin, acting as stearyl alcohol as a vehicle, conferring an emollient, moisturizing and surfactant action.

Stearyl glycyrrheinate, a derivative of glycyrrhizinic acid is involved in skin whitening, therefore being used in sunscreen preparations because it has an inhibitory effect of melanogenesis. In this sense for the present invention, stearyl glycyrrheinate has been selected as an active compound because it increases lipid solubility and has anti-inflammatory properties at low concentrations.

Tocopheryl nicotinate is a substance with lipid-lowering and vasodilatory properties, which is why it is commonly used in the treatment of hyperlipidemias, in peripheral vasculopathies (atherosclerotic or occlusive vasculopathy, as well as venous disorders resulting from atherosclerosis, a vasospasm or a thromboembolism) as well as Cerebrovascular diseases.

For the purpose of the present invention, tocopheryl nicotinate favors oxygenation of the hair bulb and skin microcirculation, it also has an antioxidant and conditioning function of the skin, not being an irritating or sensitizing compound. The purified talc, used topically, relieves irritation and prevents chafing. It is usually mixed with starch and zinc oxide, to increase moisture absorption. The purified talc is also used as a lubricant and diluent excipient in the manufacture of tablets and capsules, and for bleaching liquids. Talc is also used as a sclerosant in malignant effusions and in recurrent spontaneous pneumothorax.

For the cosmetic field, talc is used to facilitate application and dispersion as well as offers slip and adhesion properties. Its coverage power and moisture absorption capacity are relatively low. Therefore, it is frequently combined with other products such as kaolin and zinc oxide.

Titanium dioxide is one of the whitest chemical substances that exist: It reflects practically all the visible radiation that comes to it and keeps the color permanently. It is one of the substances with the highest refractive index, even pulverized or mixed with other substances. And for the same reason, it is very opaque and that is why it serves to protect from sunlight. Titanium dioxide pigments are also used in cosmetics as ultraviolet absorbers in cosmetic products. Titanium dioxide also has the advantages of being harmless, of being compatible with mucous membranes and skin and having good dispersibility in organic solutions. That is why in the field of cosmetics titanium dioxide is commonly used as an ingredient. In addition, titanium dioxide has an action on the skin similar to that of zinc oxide and is used together with titanium peroxide and titanium salicylate in the treatment of diaper rash.

It has been demonstrated in the topical use of titanium dioxide that it is not absorbed, that is, the titanium dioxide pigments when analyzed were only found in the stratum corneum of the skin.

Shea butter, has a protective action against dry skin, being moisturizing for both skin and hair. It also has a protective action against solar erythema, prevents and treats skin aging, stimulates the metabolism of cells and prevents wrinkles.

Shea butter also has a healing action of wounds, suitable for the treatment of squamous dermis, for dry and cracked hands, for the treatment of ulcers, eczema and stretch marks on the skin.

CREAM FORMATION:

 Melt phase (O) in an appropriate container and in the same bath, heat phase (A) to 80 ° C (± 2 ° C). With phases (O) and (A) at the same temperature, manually stir the phase (O) and add slowly and while stirring the phase (A). While stirring, remove the mixture from the bath.

When the mixture reaches 50 ° C and while stirring, add phase (D) (tocopheryl nicotinate), until fully incorporated.

Then, while stirring, add phase (B), until fully incorporated. At this point you should obtain a well-emulsified white fluid cream base. Pass the base obtained to the mortar where phase (C) is and work with the mortar hand until obtaining a cream with a homogeneous texture and color. Pass the obtained cream to a container and cover well.

RTFMPT.OS DF RF.A T.T7. Action

The following specific examples provided herein serve to illustrate the nature of the present invention. These examples are included for illustrative purposes only and should not be construed as limitations on the invention claimed herein.

A homogeneous flesh-colored cream is obtained. After 24 h of its preparation, the consistency of the cream increases until a paste is obtained that applied on top of the skin forms a consistent and well adhered layer, resistant to water (slips when it falls from the tap on the skin) but easily removable by rubbing with Water and shower gel.

The cream obtained is suitable for topical application, presenting good organoleptic, covering, bioadhesive and water resistance characteristics.

Claims

RFIVTNDTC TO CTONF.S 1. - Use of a cosmetic composition comprising a cosmetically effective amount of stearyl glycinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter for the preparation of a cosmetic composition for the care and treatment of couperose. 2. - Use of the cosmetic composition according to claim 1, characterized in that it is topically applied as a cream and / or emulsion. 3. - Use of the cosmetic composition according to claim 1 to make up and conceal the couperose. 4. - Use of the cosmetic composition according to claim 1 and 2, characterized in that it is applied topically by means of an application device selected from the group consisting of: a brush, a spatula, a cotton pad, gauze and a swab, sponge, tube with applicator 5. - Method of administration of the composition of claim 1 characterized in that it comprises the steps of taking a sample of the cosmetic composition with the application device, applying it locally on the couperose and optionally applying heat on said couperose.