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WO2012033353A3 - 세스터터핀 화합물 및 이들 물질의 용도 - Google Patents

세스터터핀 화합물 및 이들 물질의 용도 Download PDF

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Publication number
WO2012033353A3
WO2012033353A3 PCT/KR2011/006638 KR2011006638W WO2012033353A3 WO 2012033353 A3 WO2012033353 A3 WO 2012033353A3 KR 2011006638 W KR2011006638 W KR 2011006638W WO 2012033353 A3 WO2012033353 A3 WO 2012033353A3
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Prior art keywords
functional
relates
alcoholic
sesterterpene compounds
present
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PCT/KR2011/006638
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English (en)
French (fr)
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WO2012033353A9 (ko
WO2012033353A2 (ko
Inventor
강헌중
원동환
양인호
김은오
김정아
가젠드라 기리아워두트
레디 말레팔리뱅킷
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SNU R&DB Foundation
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SNU R&DB Foundation
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Priority to JP2013528120A priority Critical patent/JP2013542183A/ja
Priority to RU2013115395/04A priority patent/RU2013115395A/ru
Priority to US13/821,482 priority patent/US20130274212A1/en
Priority to EP11823786.6A priority patent/EP2615094A4/en
Priority to CN201180053679.5A priority patent/CN103517908A/zh
Priority to CA2811145A priority patent/CA2811145A1/en
Priority to BR112013005425-5A priority patent/BR112013005425A2/ko
Priority to AU2011299703A priority patent/AU2011299703A1/en
Publication of WO2012033353A2 publication Critical patent/WO2012033353A2/ko
Publication of WO2012033353A9 publication Critical patent/WO2012033353A9/ko
Publication of WO2012033353A3 publication Critical patent/WO2012033353A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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Abstract

본 발명은 세스터터핀 화합물, 생체 내에서 가수분해 가능한 그의 전구체 또는 약제학적으로 허용 가능한 그의 염 및 세스터터핀 화합물이 갖는 인슐린 비의존성 당뇨병, 당뇨합병증(당뇨병에 의한 신부전증 및 족부궤양증), 알콜성, 비알콜성 및 바이러스성 지방간 질환, 비만, 고지혈증, 동맥경화증(atherosclerosis), 동맥경화성 중품과 같은 심혈관계 질환, 뇌질환(파킨슨병, 조울증, 정신분열증 및 알츠하이머병)에 대한 예방 및 치료 효능에 관한 것이다. 또한 본 발명은 이들 물질의 기능성 식품, 기능성 음료, 기능성 화장품 및 기능성 사료의 조성물 제공에 관한 것이다.
PCT/KR2011/006638 2010-09-07 2011-09-07 세스터터핀 화합물 및 이들 물질의 용도 Ceased WO2012033353A2 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2013528120A JP2013542183A (ja) 2010-09-07 2011-09-07 セスタテルペン化合物およびこれらの物質の用途
RU2013115395/04A RU2013115395A (ru) 2010-09-07 2011-09-07 Сестертерпеновое соединение и его применение
US13/821,482 US20130274212A1 (en) 2010-09-07 2011-09-07 Sesterterpene Compounds and Use Thereof
EP11823786.6A EP2615094A4 (en) 2010-09-07 2011-09-07 SESTERTERPENE COMPOUNDS AND USE THEREOF
CN201180053679.5A CN103517908A (zh) 2010-09-07 2011-09-07 二倍半萜化合物及其用途
CA2811145A CA2811145A1 (en) 2010-09-07 2011-09-07 Sesterterpene compound and use thereof
BR112013005425-5A BR112013005425A2 (ko) 2010-09-07 2011-09-07 Three master teopin compounds and uses of these materials
AU2011299703A AU2011299703A1 (en) 2010-09-07 2011-09-07 Sesterterpene compounds and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2010-0087552 2010-09-07
KR20100087552 2010-09-07
KR10-2011-0020118 2011-03-07
KR20110020118 2011-03-07

Publications (3)

Publication Number Publication Date
WO2012033353A2 WO2012033353A2 (ko) 2012-03-15
WO2012033353A9 WO2012033353A9 (ko) 2012-06-07
WO2012033353A3 true WO2012033353A3 (ko) 2012-07-26

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PCT/KR2011/006638 Ceased WO2012033353A2 (ko) 2010-09-07 2011-09-07 세스터터핀 화합물 및 이들 물질의 용도

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Country Link
US (1) US20130274212A1 (ko)
EP (1) EP2615094A4 (ko)
JP (1) JP2013542183A (ko)
KR (1) KR101901741B1 (ko)
CN (1) CN103517908A (ko)
AU (1) AU2011299703A1 (ko)
BR (1) BR112013005425A2 (ko)
CA (1) CA2811145A1 (ko)
RU (1) RU2013115395A (ko)
WO (1) WO2012033353A2 (ko)

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CN103858820A (zh) * 2014-03-11 2014-06-18 广西大学 一种小型猪2型糖尿病模型的制备方法
EP3347486A4 (en) * 2015-09-09 2019-06-19 The Trustees of Columbia University in the City of New York REDUCTION OF ER-MAM-LOCALIZED APP-C99 AND METHOD FOR THE TREATMENT OF ALZHEIMER DISEASE
US11166949B2 (en) 2016-04-27 2021-11-09 The Board Of Regents Of The University Of Texas System NURR1 activation in the treatment of metabolic disorders and as an exercise mimetic
KR101674622B1 (ko) * 2016-07-07 2016-11-09 국민대학교산학협력단 세스퀴테르펜 유도체의 신규한 용도
CA3252482A1 (en) * 2022-03-18 2023-09-21 The University Of British Columbia ALOTACETAL COMPOUNDS AND THEIR DERIVATIVES USED AS ANTIVIRAL AGENTS

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US20130274212A1 (en) 2013-10-17
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