[go: up one dir, main page]

WO2012033291A3 - 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법 - Google Patents

자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법 Download PDF

Info

Publication number
WO2012033291A3
WO2012033291A3 PCT/KR2011/006105 KR2011006105W WO2012033291A3 WO 2012033291 A3 WO2012033291 A3 WO 2012033291A3 KR 2011006105 W KR2011006105 W KR 2011006105W WO 2012033291 A3 WO2012033291 A3 WO 2012033291A3
Authority
WO
WIPO (PCT)
Prior art keywords
fine particles
separating fine
magnetophoresis
same
separating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2011/006105
Other languages
English (en)
French (fr)
Other versions
WO2012033291A2 (ko
Inventor
한기호
이환용
한송이
김선영
최인학
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Inje University
Original Assignee
Industry Academic Cooperation Foundation of Inje University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of Inje University filed Critical Industry Academic Cooperation Foundation of Inje University
Priority to EP11823724.7A priority Critical patent/EP2615463B1/en
Priority to US13/821,477 priority patent/US10253309B2/en
Publication of WO2012033291A2 publication Critical patent/WO2012033291A2/ko
Priority to KR1020120063111A priority patent/KR101622342B1/ko
Publication of WO2012033291A3 publication Critical patent/WO2012033291A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0335—Component parts; Auxiliary operations characterised by the magnetic circuit using coils
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/32—Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1023—Microstructural devices for non-optical measurement

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Electrochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

본 발명은 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법에 관한 것으로서, 미세 입자에 결합된 입자의 자성이 미약할 경우에도 우수한 효율로 신속하게 분리가 가능한 패턴화된 자성체 미세 구조물을 포함하는 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법을 제공하는 것을 목적으로 한다.
PCT/KR2011/006105 2010-09-10 2011-08-19 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법 Ceased WO2012033291A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP11823724.7A EP2615463B1 (en) 2010-09-10 2011-08-19 Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same
US13/821,477 US10253309B2 (en) 2010-09-10 2011-08-19 Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same
KR1020120063111A KR101622342B1 (ko) 2011-06-13 2012-06-13 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20100088957 2010-09-10
KR10-2010-0088957 2010-09-10
KR10-2011-0057095 2011-06-13
KR1020110057095A KR20120026959A (ko) 2010-09-10 2011-06-13 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법

Publications (2)

Publication Number Publication Date
WO2012033291A2 WO2012033291A2 (ko) 2012-03-15
WO2012033291A3 true WO2012033291A3 (ko) 2012-06-14

Family

ID=46132614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/006105 Ceased WO2012033291A2 (ko) 2010-09-10 2011-08-19 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법

Country Status (4)

Country Link
US (1) US10253309B2 (ko)
EP (1) EP2615463B1 (ko)
KR (1) KR20120026959A (ko)
WO (1) WO2012033291A2 (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101810941B1 (ko) 2012-11-26 2017-12-20 한국전자통신연구원 다중 분리 장치 및 이의 제조 방법
US9535036B2 (en) * 2012-06-19 2017-01-03 Electronics And Telecommunications Research Institute Multiple discrimination device and method of manufacturing the device
CN104540594B (zh) * 2012-06-25 2019-07-02 通用医疗公司 使用高梯度磁场对粒子进行分类
US10202577B2 (en) 2013-10-18 2019-02-12 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
KR20160120416A (ko) * 2015-04-08 2016-10-18 인제대학교 산학협력단 분리 가능한 복수의 패널을 포함하는 미세 입자 분리 장치 어셈블리
US10145906B2 (en) 2015-12-17 2018-12-04 Analog Devices Global Devices, systems and methods including magnetic structures
SG11201903247VA (en) * 2016-10-18 2019-05-30 Menarini Silicon Biosystems Spa Microfluidic device, microfluidic system and method for the isolation of particles
IT201600104601A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico
KR101888636B1 (ko) 2017-06-02 2018-08-14 지트로닉스 주식회사 자기 영동 바이오 칩
KR20190017389A (ko) 2017-08-11 2019-02-20 경희대학교 산학협력단 자성입자 분리 장치 및 방법
EP3821226A4 (en) * 2018-07-13 2022-04-13 The Governing Council of the University of Toronto MICROFLUID DEVICES AND METHODS OF USE
KR102050685B1 (ko) * 2019-01-21 2019-11-29 인제대학교 산학협력단 분리 가능한 복수의 패널을 포함하는 미세 입자 분리 장치 어셈블리
CN113680524A (zh) * 2021-09-23 2021-11-23 大连海事大学 一种基于Fe-PDMS复合材料的油液磨粒分离装置及其制作方法
CN115846048B (zh) * 2022-11-25 2025-01-24 大连交通大学 循环磁场动态磁泳分离装置和方法
CN120662446A (zh) * 2025-07-30 2025-09-19 上海迪化科技股份有限公司 一种磁珠连续分离装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044832A1 (en) * 1996-09-04 2003-03-06 Scandinavian Micro Biodevices A/S Microflow system for particle separation and analysis
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
KR100907213B1 (ko) * 2007-12-07 2009-07-10 한국과학기술원 등자기영동 기술을 이용한 미세입자 분리 장치 및등자기영동 기술을 이용한 미세입자 분리 방법
KR20100079045A (ko) * 2008-12-30 2010-07-08 한국과학기술원 밀도차영동 현상을 이용한 미세유체 제어소자 및 미세유체 분석 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US105019A (en) * 1870-07-05 Improvement in distilling pine wood
AU2593192A (en) 1992-09-14 1994-04-12 Oystein Fodstad Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
KR100791036B1 (ko) 2006-07-07 2008-01-03 한국과학기술원 연속적인 자기영동을 이용한 순수한 탄소나노튜브와 금속 불순물을 함유한 탄소나노튜브의 분리방법 및 이에 사용되는 자기영동 미세 유체 제어소자
US7807454B2 (en) * 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
IT1392999B1 (it) * 2009-02-12 2012-04-02 Ct De Investigacion Cooperativa En Nanociencias Cic Nanogune Asoc Manipolazione di particelle magnetiche in circuiti per la propagazione di pareti di dominio magnetiche.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044832A1 (en) * 1996-09-04 2003-03-06 Scandinavian Micro Biodevices A/S Microflow system for particle separation and analysis
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
KR100907213B1 (ko) * 2007-12-07 2009-07-10 한국과학기술원 등자기영동 기술을 이용한 미세입자 분리 장치 및등자기영동 기술을 이용한 미세입자 분리 방법
KR20100079045A (ko) * 2008-12-30 2010-07-08 한국과학기술원 밀도차영동 현상을 이용한 미세유체 제어소자 및 미세유체 분석 방법

Also Published As

Publication number Publication date
US10253309B2 (en) 2019-04-09
US20130189755A1 (en) 2013-07-25
WO2012033291A2 (ko) 2012-03-15
EP2615463A2 (en) 2013-07-17
EP2615463B1 (en) 2016-10-12
EP2615463A4 (en) 2013-09-25
KR20120026959A (ko) 2012-03-20

Similar Documents

Publication Publication Date Title
WO2012033291A3 (ko) 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법
EP2671065A1 (en) Particle sorting apparatus and method
WO2012158196A3 (en) Core-shell magnetic particles and related methods
EP2576070A4 (en) Method and apparatus for separating low density particles from feed slurries
EP2667817A1 (en) Method and apparatus for image-based navigation
EP2669045A4 (en) Fine abrasive particles and process for producing same
EP2667818A1 (en) Method and apparatus for image-based navigation
EP2599048A4 (en) METHOD AND DEVICE FOR SORTING SURVEY RESULTS
PL2580380T3 (pl) Aparat do separacji cząstek i sposób jego użycia
EP3043903A4 (en) New process and system for magnetic separation
EP3384991A4 (en) Magnetic separator, magnetic separation method, and method for manufacturing iron source
IL241479B (en) A method for separating cells by using immunorosts and magnetic particles
TWI561014B (en) Method and apparatus for separating the reference current from the input signal in sigma-delta converter
EP2666120A1 (en) Signal processing method and apparatus
EP3008203A4 (en) Magnetic separation process using carboxyl-functionalized superparamagnetic nanoclusters
EP3010074A4 (en) Device for preparing core-shell particles and method for preparing core-shell particles by using same
GB2502215B (en) Structure and method for hard mask removal on an soi substrate without using CMP process
ZA201409026B (en) Methods for separating and dewatering fine particles
WO2015075563A3 (en) Magnetic separation
EP2579973A4 (en) Apparatus and method for the production of particles
ZA201307586B (en) Method and apparatus for particle separation
GB2510535B (en) Method and magnetic separator for separating magnetic and/or magnetizable particles from a fluid
EP3248955A4 (en) Method for producing -eucryptite fine particles
ZA201401131B (en) Method for solid waste separation and processing
EP3020721A4 (en) Purification method for virus-like particles

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11823724

Country of ref document: EP

Kind code of ref document: A2

REEP Request for entry into the european phase

Ref document number: 2011823724

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2011823724

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13821477

Country of ref document: US