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WO2012016266A3 - Tetrahydro-anthracenone derivative - Google Patents

Tetrahydro-anthracenone derivative Download PDF

Info

Publication number
WO2012016266A3
WO2012016266A3 PCT/AT2011/000334 AT2011000334W WO2012016266A3 WO 2012016266 A3 WO2012016266 A3 WO 2012016266A3 AT 2011000334 W AT2011000334 W AT 2011000334W WO 2012016266 A3 WO2012016266 A3 WO 2012016266A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetrahydro
anthracenone
derivative
talaromanin
octahydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AT2011/000334
Other languages
German (de)
French (fr)
Other versions
WO2012016266A2 (en
Inventor
Alexander Pretsch
Heinz Burgmann
Apostolos Georgopoulos
Peter Proksch
Abdessamad Debbab
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sealife Pharma GmbH
Original Assignee
Sealife Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sealife Pharma GmbH filed Critical Sealife Pharma GmbH
Publication of WO2012016266A2 publication Critical patent/WO2012016266A2/en
Publication of WO2012016266A3 publication Critical patent/WO2012016266A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the novel chemical compound 6,6'-dimethyl-2,2',3,3',6,6',9,9'-octahydroxy-5,5',6,6'-tetrahydro-1,1'-bianthracenyl-8,8'(7H,7'H)-dione ("talaromanin"), to the use thereof as an anti-infective agent and to a method for producing same (formula (A)).
PCT/AT2011/000334 2010-08-04 2011-08-03 Tetrahydro-anthracenone derivative Ceased WO2012016266A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0130310A AT509716B1 (en) 2010-08-04 2010-08-04 NEW TETRAHYDROANTHRACENONE DERIVATIVES
ATA1303/2010 2010-08-04

Publications (2)

Publication Number Publication Date
WO2012016266A2 WO2012016266A2 (en) 2012-02-09
WO2012016266A3 true WO2012016266A3 (en) 2012-04-26

Family

ID=44653045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2011/000334 Ceased WO2012016266A2 (en) 2010-08-04 2011-08-03 Tetrahydro-anthracenone derivative

Country Status (2)

Country Link
AT (1) AT509716B1 (en)
WO (1) WO2012016266A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108485987B (en) * 2018-03-14 2020-10-09 扬州大学 Dibenzoxepanone compounds and preparation method and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT507298A4 (en) * 2009-05-29 2010-04-15 Sealife Pharma Gmbh New acetoxy-tetrahydroxy-7-methoxy-2-methyl-tetrahydroanthracen-9,10-dione and 8-(trihydroxy-7-methyl-2-methoxy-9,10-dioxo-anthracen-1-yl)-pentahydroxy-7-methoxy-2-methyl-tetrahydro-anthracen-9,10-dione, useful e.g. as antitumor agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT5072B (en) 1900-08-03 1901-08-26 Siemens Ag
JPS5655334A (en) * 1979-10-12 1981-05-15 Suntory Ltd Dimeric tetrahydroanthracene compound
JP2001031564A (en) * 1999-05-19 2001-02-06 Mitsubishi Chemicals Corp Telomerase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT507298A4 (en) * 2009-05-29 2010-04-15 Sealife Pharma Gmbh New acetoxy-tetrahydroxy-7-methoxy-2-methyl-tetrahydroanthracen-9,10-dione and 8-(trihydroxy-7-methyl-2-methoxy-9,10-dioxo-anthracen-1-yl)-pentahydroxy-7-methoxy-2-methyl-tetrahydro-anthracen-9,10-dione, useful e.g. as antitumor agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
INE DEWI INDRIANI: "Biodiversity of marine-derived fungi and identification of their metabolites", 1 January 2007 (2007-01-01), Düsseldorf, pages 1 - 338, XP055019174, Retrieved from the Internet <URL:http://docserv.uni-duesseldorf.de/servlets/DerivateServlet/Derivate-7551/Indriani-Diss.pdf> [retrieved on 20120213] *

Also Published As

Publication number Publication date
AT509716B1 (en) 2011-11-15
AT509716A4 (en) 2011-11-15
WO2012016266A2 (en) 2012-02-09

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