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WO2012013994A3 - COMPOSITION PHARMACEUTIQUE À LIBÉRATION PROLONGÉE DÉPENDANTE DU pH - Google Patents

COMPOSITION PHARMACEUTIQUE À LIBÉRATION PROLONGÉE DÉPENDANTE DU pH Download PDF

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Publication number
WO2012013994A3
WO2012013994A3 PCT/HU2011/000047 HU2011000047W WO2012013994A3 WO 2012013994 A3 WO2012013994 A3 WO 2012013994A3 HU 2011000047 W HU2011000047 W HU 2011000047W WO 2012013994 A3 WO2012013994 A3 WO 2012013994A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
release pharmaceutical
gradual release
composition
dependent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2011/000047
Other languages
English (en)
Other versions
WO2012013994A2 (fr
Inventor
Péter HAJNAL
Péter SZEGŐ
István Nándor ANTAL
Judit DREDÁN
Imre Klebovich
Miléna Bea LENGYEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP11739157.3A priority Critical patent/EP2598116B1/fr
Priority to US13/813,088 priority patent/US9839607B2/en
Publication of WO2012013994A2 publication Critical patent/WO2012013994A2/fr
Publication of WO2012013994A3 publication Critical patent/WO2012013994A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une composition à libération prolongée dépendante du pH destinée à augmenter le pH dans la partie supérieure de l'intestin grêle. Les particules de cette composition sont pourvues d'un revêtement polymère multicouche présentant une structure spécifique qui assure la libération prolongée du principe actif en présence d'un pH compris entre 4,5 et 5,5. Cette invention se rapporte en outre à un procédé pour préparer cette composition.
PCT/HU2011/000047 2010-07-30 2011-05-12 COMPOSITION PHARMACEUTIQUE À LIBÉRATION PROLONGÉE DÉPENDANTE DU pH Ceased WO2012013994A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11739157.3A EP2598116B1 (fr) 2010-07-30 2011-05-12 COMPOSITION PHARMACEUTIQUE À LIBÉRATION PROLONGÉE DÉPENDANTE DU pH
US13/813,088 US9839607B2 (en) 2010-07-30 2011-05-12 pH-dependent gradual release pharmaceutical composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1000407 2010-07-30
HU1000407A HU230560B1 (hu) 2010-07-30 2010-07-30 pH-függő szakaszos és nyújtott hatóanyagleadású gyógyszerkészítmény

Publications (2)

Publication Number Publication Date
WO2012013994A2 WO2012013994A2 (fr) 2012-02-02
WO2012013994A3 true WO2012013994A3 (fr) 2012-03-22

Family

ID=89989862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2011/000047 Ceased WO2012013994A2 (fr) 2010-07-30 2011-05-12 COMPOSITION PHARMACEUTIQUE À LIBÉRATION PROLONGÉE DÉPENDANTE DU pH

Country Status (4)

Country Link
US (1) US9839607B2 (fr)
EP (1) EP2598116B1 (fr)
HU (1) HU230560B1 (fr)
WO (1) WO2012013994A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2919874T3 (es) 2014-09-24 2022-07-28 Vital Beverages Global Inc Composiciones y métodos para el suministro selectivo en el tubo gastrointestinal
JP7336187B2 (ja) * 2017-11-30 2023-08-31 日本ケミファ株式会社 多層構造を有する粒子状医薬組成物
HUP2300183A1 (hu) * 2023-05-31 2024-12-28 Meditop Gyogyszeripari Kft Nátrium-hidrogénkarbonát tartalmú gyomornedv-ellenálló bevont pellet, ennek elõállítása, ezt tartalmazó gyógyszerkészítmény és étrendkiegészítõ készítmény, és ezek alkalmazása
WO2025128724A1 (fr) * 2023-12-12 2025-06-19 Arbert, Llc Sels inorganiques revêtus et leurs utilisations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1172100A1 (fr) * 2000-07-14 2002-01-16 Roberto Valducci Compositions pharmaceutiques solides à usage oral avec libération multiphasique en fonction du pH
EP1514538A1 (fr) * 2002-06-20 2005-03-16 LTT Bio-Pharma Co., Ltd. Composition a liberation prolongee, procede de production de cette composition et preparation contenant cette composition
WO2005051348A2 (fr) * 2003-11-25 2005-06-09 EGIS Gyógyszergyár Rt. Comprimes de pantoprazole a enrobage enterique
WO2010096814A1 (fr) * 2009-02-23 2010-08-26 Eurand, Inc. Compositions à libération contrôlée comportant un inhibiteur de la pompe à protons

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3121663A (en) * 1956-02-09 1964-02-18 Plough Lab Inc Carbon dioxide releasing laxative suppository
US4289750A (en) * 1978-10-16 1981-09-15 Kopp Klaus F Therapy of conditions which may be associated with altered renal function and dosage forms therefor
US5102668A (en) * 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
DE4036757A1 (de) * 1990-11-17 1992-05-21 Bayer Ag Antazida-zubereitung mit verlaengerter magenverweilzeit
WO1995028963A1 (fr) * 1994-04-22 1995-11-02 Yamanouchi Pharmaceutical Co., Ltd. Systeme de liberation de medicament specifique au colon
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
US6897205B2 (en) * 2001-01-31 2005-05-24 Roehm Gmbh & Co. Kg Multi-particulate form of medicament, comprising at least two differently coated forms of pellet

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1172100A1 (fr) * 2000-07-14 2002-01-16 Roberto Valducci Compositions pharmaceutiques solides à usage oral avec libération multiphasique en fonction du pH
EP1514538A1 (fr) * 2002-06-20 2005-03-16 LTT Bio-Pharma Co., Ltd. Composition a liberation prolongee, procede de production de cette composition et preparation contenant cette composition
WO2005051348A2 (fr) * 2003-11-25 2005-06-09 EGIS Gyógyszergyár Rt. Comprimes de pantoprazole a enrobage enterique
WO2010096814A1 (fr) * 2009-02-23 2010-08-26 Eurand, Inc. Compositions à libération contrôlée comportant un inhibiteur de la pompe à protons

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BREITKREUZ JOERG ET AL: "Enteric-coated solid dosage forms containing sodium bicarbonate as a drug substance: an exception from the rule?", JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOCIETY OF GREAT BRITAIN, GB, vol. 59, no. 1, 1 January 2007 (2007-01-01), pages 59 - 65, XP008135631, ISSN: 0022-3573, [retrieved on 20010218], DOI: 10.1211/JPP.59.1.0008 *

Also Published As

Publication number Publication date
US9839607B2 (en) 2017-12-12
HU1000407D0 (en) 2010-10-28
HUP1000407A2 (en) 2012-05-02
US20130195974A1 (en) 2013-08-01
EP2598116B1 (fr) 2018-06-20
EP2598116A2 (fr) 2013-06-05
WO2012013994A2 (fr) 2012-02-02
HU230560B1 (hu) 2016-12-28

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