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WO2012004658A3 - Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof - Google Patents

Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof Download PDF

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Publication number
WO2012004658A3
WO2012004658A3 PCT/IB2011/001593 IB2011001593W WO2012004658A3 WO 2012004658 A3 WO2012004658 A3 WO 2012004658A3 IB 2011001593 W IB2011001593 W IB 2011001593W WO 2012004658 A3 WO2012004658 A3 WO 2012004658A3
Authority
WO
WIPO (PCT)
Prior art keywords
dibutylamino
propoxy
benzoyl
butyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/001593
Other languages
French (fr)
Other versions
WO2012004658A2 (en
WO2012004658A8 (en
Inventor
Rajiv Kumar
Vijay Tambe
Sanjay Patil
Kishor Chavan
Syed Shawkat Naim
Ramesh Dandala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FRICHEM PRIVATE Ltd
Original Assignee
FRICHEM PRIVATE Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FRICHEM PRIVATE Ltd filed Critical FRICHEM PRIVATE Ltd
Publication of WO2012004658A2 publication Critical patent/WO2012004658A2/en
Publication of WO2012004658A8 publication Critical patent/WO2012004658A8/en
Publication of WO2012004658A3 publication Critical patent/WO2012004658A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of highly pure N- [2- butyl -3- [4- [3- (dibutylamino) propoxy] benzoyl] -5- benzofuranyljmethanesulfonamide and pharmaceutically acceptable salts thereof having HPLC purity greater than 99.5%.
PCT/IB2011/001593 2010-07-09 2011-07-08 Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof Ceased WO2012004658A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1979MU2010 2010-07-09
IN1979/MUM/2010 2010-07-09
IN2716/MUM/2010 2010-09-27
IN2716MU2010 2010-09-27

Publications (3)

Publication Number Publication Date
WO2012004658A2 WO2012004658A2 (en) 2012-01-12
WO2012004658A8 WO2012004658A8 (en) 2012-03-15
WO2012004658A3 true WO2012004658A3 (en) 2012-05-18

Family

ID=44759725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/001593 Ceased WO2012004658A2 (en) 2010-07-09 2011-07-08 Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof

Country Status (1)

Country Link
WO (1) WO2012004658A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9174958B2 (en) 2010-06-18 2015-11-03 Sanofi Process for the preparation of dronedarone
US9174959B2 (en) 2011-03-29 2015-11-03 Sanofi Process for preparation of dronedarone by N-butylation
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9221777B2 (en) 2012-01-20 2015-12-29 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9334254B2 (en) 2010-03-30 2016-05-10 Sanofi Process for preparing sulfonamidobenzofuran derivatives
US9499507B2 (en) 2011-11-29 2016-11-22 Sanofi Method for preparing 5-amino-benzoyl-benzofuran derivatives

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012032545A1 (en) * 2010-09-08 2012-03-15 Cadila Healthcare Limited Processes for preparing dronedarone and its intermediates
WO2012120544A2 (en) * 2011-03-10 2012-09-13 Sun Pharmaceutical Industries Ltd. PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2014203058A1 (en) * 2013-06-17 2014-12-24 Aurobindo Pharma Limited An improved process for preparing benzofuran compound

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471609A1 (en) * 1990-08-06 1992-02-19 Sanofi Benzofuran Derivatives, Benzothiophenes, Indoles or Indolizines, Process for Production and Compositions containing them
WO2002048078A1 (en) * 2000-12-11 2002-06-20 Sanofi-Synthelabo 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof
WO2002048132A1 (en) * 2000-12-11 2002-06-20 Sanofi-Synthelabo Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate
WO2011070380A1 (en) * 2009-12-08 2011-06-16 Sanofi-Aventis New process for the preparation of dronedarone
EP2371808A1 (en) * 2010-03-08 2011-10-05 Ratiopharm GmbH Process for preparing dronedarone
EP2371824A1 (en) * 2010-03-08 2011-10-05 Ratiopharm GmbH Crystalline dronedarone salts

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471609A1 (en) * 1990-08-06 1992-02-19 Sanofi Benzofuran Derivatives, Benzothiophenes, Indoles or Indolizines, Process for Production and Compositions containing them
WO2002048078A1 (en) * 2000-12-11 2002-06-20 Sanofi-Synthelabo 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof
WO2002048132A1 (en) * 2000-12-11 2002-06-20 Sanofi-Synthelabo Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate
WO2011070380A1 (en) * 2009-12-08 2011-06-16 Sanofi-Aventis New process for the preparation of dronedarone
EP2371808A1 (en) * 2010-03-08 2011-10-05 Ratiopharm GmbH Process for preparing dronedarone
EP2371824A1 (en) * 2010-03-08 2011-10-05 Ratiopharm GmbH Crystalline dronedarone salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUSLY: "Publication Number IPCOM000193200D : Solid state formsof (N-(2-butyl)-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)methanesulfonamide hydrochloride", IP.COM JOURNAL, vol. 10, no. 2B, 14 February 2010 (2010-02-14), pages 1 - 6, XP002664270 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334254B2 (en) 2010-03-30 2016-05-10 Sanofi Process for preparing sulfonamidobenzofuran derivatives
US9174958B2 (en) 2010-06-18 2015-11-03 Sanofi Process for the preparation of dronedarone
US9174959B2 (en) 2011-03-29 2015-11-03 Sanofi Process for preparation of dronedarone by N-butylation
US9611242B2 (en) 2011-03-29 2017-04-04 Sanofi Process for preparation of dronedarone by N-butylation
US9499507B2 (en) 2011-11-29 2016-11-22 Sanofi Method for preparing 5-amino-benzoyl-benzofuran derivatives
US9221777B2 (en) 2012-01-20 2015-12-29 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9708281B2 (en) 2012-01-20 2017-07-18 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9701654B2 (en) 2012-02-13 2017-07-11 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction

Also Published As

Publication number Publication date
WO2012004658A2 (en) 2012-01-12
WO2012004658A8 (en) 2012-03-15

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