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WO2012003003A3 - Compositions et procédés de préparation de nanoformulations et systèmes de nanodélivrance utilisant l'énergie acoustique focalisée - Google Patents

Compositions et procédés de préparation de nanoformulations et systèmes de nanodélivrance utilisant l'énergie acoustique focalisée Download PDF

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Publication number
WO2012003003A3
WO2012003003A3 PCT/US2011/001171 US2011001171W WO2012003003A3 WO 2012003003 A3 WO2012003003 A3 WO 2012003003A3 US 2011001171 W US2011001171 W US 2011001171W WO 2012003003 A3 WO2012003003 A3 WO 2012003003A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
approximately
formulation
focused
particle size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/001171
Other languages
English (en)
Other versions
WO2012003003A2 (fr
Inventor
Carl Beckett
James A Laugharn, Jr.
Srikanth Kakumanu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covaris LLC
Original Assignee
Covaris LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covaris LLC filed Critical Covaris LLC
Priority to JP2013518374A priority Critical patent/JP2013530223A/ja
Priority to EP11738844.7A priority patent/EP2588222B1/fr
Priority to HK13113096.1A priority patent/HK1185829B/xx
Priority to CN201180041736.8A priority patent/CN103124592B/zh
Publication of WO2012003003A2 publication Critical patent/WO2012003003A2/fr
Publication of WO2012003003A3 publication Critical patent/WO2012003003A3/fr
Priority to US13/724,796 priority patent/US9776149B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/87—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations transmitting the vibratory energy by means of a fluid, e.g. by means of air shock waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0454—Numerical frequency values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0477—Numerical time values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00932—Sonic or ultrasonic vibrations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Le traitement acoustique ultrasonore focalisé est utilisé pour préparer des formulations de particules dans la plage d'approximativement 10 nm à approximativement 50 microns (par exemple, de 1 micron à 20 microns), ou d'approximativement 10 nm à approximativement 400 nm (par exemple, de 10 nm à 100 nm). Les formulations (par exemple, les nanoformulations) peuvent comprendre une suspension (par exemple, une nanosuspension), une émulsion (par exemple, une nanoémulsion) ou tout autre système à petites particules. Les formulations peuvent être utilisées en tant que systèmes de délivrance d'agents thérapeutiques. Une formulation peut également inclure une suspension de particules de la taille du micron ou d'une taille inférieure au micron dispersées dans un solvant. Il est également possible qu'une formulation inclue un agent bioactif et un composé vecteur tel qu'un surfactant qui encapsule l'agent bioactif (par exemple, un liposome/une micelle contenant un produit pharmaceutique, un polynucléotide, etc.). Dans certains cas, l'indice de polydispersité de la distribution de la taille de particules dans une formulation est inférieur à 0,1. Les formulations peuvent être préparées de manière adaptée en utilisant l'énergie acoustique focalisée qui résulte en une réduction de la taille moyenne de particules d'un mélange. En variante, des formulations adaptées peuvent être préparées en utilisant l'énergie acoustique focalisée d'une manière qui ne réduit pas la taille moyenne de particules du mélange.
PCT/US2011/001171 2010-07-01 2011-07-01 Compositions et procédés de préparation de nanoformulations et systèmes de nanodélivrance utilisant l'énergie acoustique focalisée Ceased WO2012003003A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2013518374A JP2013530223A (ja) 2010-07-01 2011-07-01 集束音響を用いたナノ製剤を調製するための組成物および方法並びにナノ送達用のシステム
EP11738844.7A EP2588222B1 (fr) 2010-07-01 2011-07-01 Procédé de préparation de nanoformulations utilisant l'énergie acoustique focalisée
HK13113096.1A HK1185829B (en) 2010-07-01 2011-07-01 Compositions and methods for preparing nanoformulations and systems for nano - delivery using focused acoustics
CN201180041736.8A CN103124592B (zh) 2010-07-01 2011-07-01 使用聚焦声制备用于纳米递送之纳米制剂和系统的组合物和方法
US13/724,796 US9776149B2 (en) 2010-07-01 2012-12-21 Compositions and methods for preparing nanoformulations and systems for nano-delivery using focused acoustics

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36070010P 2010-07-01 2010-07-01
US61/360,700 2010-07-01
US201161434941P 2011-01-21 2011-01-21
US61/434,941 2011-01-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/724,796 Continuation US9776149B2 (en) 2010-07-01 2012-12-21 Compositions and methods for preparing nanoformulations and systems for nano-delivery using focused acoustics

Publications (2)

Publication Number Publication Date
WO2012003003A2 WO2012003003A2 (fr) 2012-01-05
WO2012003003A3 true WO2012003003A3 (fr) 2012-04-05

Family

ID=44629399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/001171 Ceased WO2012003003A2 (fr) 2010-07-01 2011-07-01 Compositions et procédés de préparation de nanoformulations et systèmes de nanodélivrance utilisant l'énergie acoustique focalisée

Country Status (5)

Country Link
US (1) US9776149B2 (fr)
EP (1) EP2588222B1 (fr)
JP (1) JP2013530223A (fr)
CN (1) CN103124592B (fr)
WO (1) WO2012003003A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130026669A1 (en) * 2011-07-14 2013-01-31 Covaris, INC Systems and methods for preparing nanocrystalline compositions using focused acoustics
US9320995B2 (en) * 2013-09-17 2016-04-26 Covaris, Inc. Method and apparatus for processing sample material
CA3002989C (fr) 2013-10-14 2021-03-16 Nanosphere Health Sciences, Llc Compositions de nanoparticules et procedes utilises en tant que supports de facteurs nutraceutiques a travers des membranes cellulaires et des barrieres biologiques
US20160030344A1 (en) * 2014-08-04 2016-02-04 Covaris, Inc. Compositions including apolipoprotein and methods using focused acoustics for preparation thereof
CA3050535C (fr) 2014-12-15 2021-11-09 Richard Clark Kaufman Methodes de traitement de troubles inflammatoires et d'inflammation generale au moyen de compositions renfermant des encapsulations de nanoparticules phospholipides de nutraceutiques anti-inflammatoires
EP3268043A4 (fr) 2015-03-10 2018-12-19 Nanosphere Health Sciences, LLC Compositions et méthodes à base de nanoparticules lipidiques en tant que support de cannabinoïdes sous des formes posologiques dosées avec précision
CN106422930A (zh) * 2016-08-31 2017-02-22 无锡东恒新能源科技有限公司 一种高固含量浆料自动化预混系统
JP7326445B2 (ja) 2018-12-11 2023-08-15 ディスラプション・ラブズ・インコーポレイテッド 治療剤の送達のための組成物並びにその使用及び製造方法
KR102645443B1 (ko) * 2018-12-21 2024-03-11 (주)아모레퍼시픽 공진 주파수를 이용하여 화장료 조성물을 제조하는 방법
CN112426943A (zh) * 2020-11-30 2021-03-02 深圳达远辰光科技有限公司 一种采用聚焦超声分散微生物的方法及样品处理系统
CN115069319A (zh) * 2022-06-29 2022-09-20 深圳达远辰光科技有限公司 聚焦超声制备液滴的方法、系统、检测设备及存储介质
CN117482961B (zh) * 2022-07-26 2025-11-21 重庆融海超声医学工程研究中心有限公司 一种改性钯铜合金纳米粒子的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6719449B1 (en) * 1998-10-28 2004-04-13 Covaris, Inc. Apparatus and method for controlling sonic treatment
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
EP1925359A1 (fr) * 2006-11-22 2008-05-28 Covaris, Inc. Procédé et appareil pour traiter des échantillons avec de l'énergie acoustique pour former des particules et des substances particulaires

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US1734975A (en) * 1927-09-02 1929-11-12 Alfred L Loomis Method and apparatus for forming emulsions and the like
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4908154A (en) 1981-04-17 1990-03-13 Biotechnology Development Corporation Method of forming a microemulsion
US4452747A (en) * 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
CN100388971C (zh) * 2002-05-20 2008-05-21 严卓理 一种利用超声技术制备纳米材料的方法
EP1615959B1 (fr) * 2003-04-10 2013-06-05 Evonik Corporation Procede de production de microparticules a base d'emulsion
CA2526965C (fr) * 2003-05-16 2011-10-11 Velocys Inc. Procede pour former une emulsion par la technique de traitement en microcanal
JP2007533647A (ja) * 2003-10-24 2007-11-22 アルザ・コーポレーシヨン 脂質粒子の調製
CN1546219A (zh) * 2003-11-28 2004-11-17 戴露雯 一种超声聚焦处理装置
CN100467117C (zh) * 2005-09-05 2009-03-11 鸿富锦精密工业（深圳）有限公司 纳米粉体制备装置及制备方法
US20070134332A1 (en) * 2005-11-21 2007-06-14 Medivas, Llc Polymer particles for delivery of macromolecules and methods of use
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CA2719803A1 (fr) 2008-03-28 2009-10-01 University Of Massachusetts Compositions et procedes de preparation de nanoemulsions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6719449B1 (en) * 1998-10-28 2004-04-13 Covaris, Inc. Apparatus and method for controlling sonic treatment
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
EP1925359A1 (fr) * 2006-11-22 2008-05-28 Covaris, Inc. Procédé et appareil pour traiter des échantillons avec de l'énergie acoustique pour former des particules et des substances particulaires

Also Published As

Publication number Publication date
HK1185829A1 (en) 2014-02-28
CN103124592A (zh) 2013-05-29
JP2013530223A (ja) 2013-07-25
EP2588222B1 (fr) 2016-09-07
US20130155802A1 (en) 2013-06-20
CN103124592B (zh) 2015-05-27
US9776149B2 (en) 2017-10-03
WO2012003003A2 (fr) 2012-01-05
EP2588222A2 (fr) 2013-05-08

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