[go: up one dir, main page]

WO2012098560A3 - Procédé de préparation de l'antagoniste du récepteur muscarinique - Google Patents

Procédé de préparation de l'antagoniste du récepteur muscarinique Download PDF

Info

Publication number
WO2012098560A3
WO2012098560A3 PCT/IN2012/000039 IN2012000039W WO2012098560A3 WO 2012098560 A3 WO2012098560 A3 WO 2012098560A3 IN 2012000039 W IN2012000039 W IN 2012000039W WO 2012098560 A3 WO2012098560 A3 WO 2012098560A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
receptor antagonist
muscarinic receptor
phenylisobutyrate
diisopropylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2012/000039
Other languages
English (en)
Other versions
WO2012098560A2 (fr
Inventor
Manne Satyanarayana Reddy
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Suraparaju Raghuram
Peri Seetha Rama Sarma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of WO2012098560A2 publication Critical patent/WO2012098560A2/fr
Publication of WO2012098560A3 publication Critical patent/WO2012098560A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux procédés améliorés de préparation de (r)-2-(3-(diisopropylamino)-1-phénylpropyl)-4-(hydroxyméthyl)phénylisobutyrate représenté par la formule structurale suivante 1, et les sels pharmaceutiquement acceptables de ce composé.
PCT/IN2012/000039 2011-01-17 2012-01-16 Procédé de préparation de l'antagoniste du récepteur muscarinique Ceased WO2012098560A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN154/CHE/2011 2011-01-17
IN154CH2011 2011-01-17
IN3555/CHE/2011 2011-10-17
IN3555CH2011 2011-10-17

Publications (2)

Publication Number Publication Date
WO2012098560A2 WO2012098560A2 (fr) 2012-07-26
WO2012098560A3 true WO2012098560A3 (fr) 2012-11-22

Family

ID=46516179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000039 Ceased WO2012098560A2 (fr) 2011-01-17 2012-01-16 Procédé de préparation de l'antagoniste du récepteur muscarinique

Country Status (1)

Country Link
WO (1) WO2012098560A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6234999B2 (ja) 2012-05-04 2017-11-22 クリスタル ファルマ、エセ、ア、ウＣｒｙｓｔａｌ Ｐｈａｒｍａ，Ｓ．Ａ．Ｕ． 光学的に活性な３，３−ジフェニルプロピルアミンを調製するための方法
ITMI20121232A1 (it) * 2012-07-16 2014-01-17 Cambrex Profarmaco Milano Srl Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
CN116685578A (zh) * 2021-02-01 2023-09-01 帝斯曼知识产权资产管理有限公司 新的丁酸酯化合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713464B1 (en) * 1998-05-12 2004-03-30 Schwarz Pharma Ag Derivatives of 3,3-diphenylpropylamines
US6858650B1 (en) * 1999-11-16 2005-02-22 Schwarz Pharma Ag Stable salts of novel derivatives of 3,3-diphenylpropylamines
WO2007147547A1 (fr) * 2006-06-20 2007-12-27 Lek Pharmaceuticals D.D. Procédé de préparation de 3-(2-hydroxy-5-(phényle substitué))-n-alkyl-3-phénylpropylamines
WO2010018484A1 (fr) * 2008-08-14 2010-02-18 Pfizer Limited Nouvelles utilisations de dérivés de diisopropylamine
EP2251317A1 (fr) * 2009-05-15 2010-11-17 CHEMI S.p.A. Méthode pour la préparation de fésotéridine et/ou de fumarate de fésotéridine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713464B1 (en) * 1998-05-12 2004-03-30 Schwarz Pharma Ag Derivatives of 3,3-diphenylpropylamines
US6858650B1 (en) * 1999-11-16 2005-02-22 Schwarz Pharma Ag Stable salts of novel derivatives of 3,3-diphenylpropylamines
WO2007147547A1 (fr) * 2006-06-20 2007-12-27 Lek Pharmaceuticals D.D. Procédé de préparation de 3-(2-hydroxy-5-(phényle substitué))-n-alkyl-3-phénylpropylamines
WO2010018484A1 (fr) * 2008-08-14 2010-02-18 Pfizer Limited Nouvelles utilisations de dérivés de diisopropylamine
EP2251317A1 (fr) * 2009-05-15 2010-11-17 CHEMI S.p.A. Méthode pour la préparation de fésotéridine et/ou de fumarate de fésotéridine

Also Published As

Publication number Publication date
WO2012098560A2 (fr) 2012-07-26

Similar Documents

Publication Publication Date Title
CA2826751C (fr) Procedes de synthese de quinoleines et compositions pharmaceutiques les incluant
WO2013098833A3 (fr) Procédés et intermédiaires destinés à la préparation de rivaroxaban
WO2012088038A3 (fr) Antagonistes de mch-1 consistant en tétrahydro-carbolines substituées par pipérazinone, leurs procédés de fabrication et utilisations
WO2012025944A3 (fr) Sitagliptine, sels et polymorphes de celle-ci
WO2011121418A9 (fr) Dérivés de 4-aminopyrimidine et leur utilisation en tant qu'antagonistes des récepteurs de l'adénosine a2a
MX351305B (es) Antagonistas del receptor de mineralocorticoides.
WO2010092090A3 (fr) Nouveaux sels de la sitagliptine
WO2014072961A3 (fr) Formes polymorphes du suvorexant
WO2013121436A3 (fr) Procédé de préparation de rivaroxaban et de ses intermédiaires
WO2012015999A3 (fr) Procédé de préparation de mésylate d'imatinib
WO2012135615A3 (fr) Enopeptines, utilisations de celles-ci, et procédés de synthèse de celles-ci
WO2013014665A8 (fr) Composés intermédiaires et procédé pour la préparation de lurasidone et de sels de celle-ci
WO2013042135A8 (fr) Composés hétéroaryles convenant comme ligands du récepteur 5-ht4
WO2013128379A3 (fr) Formes polymorphes cristallines de linagliptine
WO2012131707A3 (fr) Nouvelle forme cristalline de bortezomib, son procédé de préparation et composition pharmaceutique l'utilisant
WO2015068175A3 (fr) Procédé perfectionné de préparation de pazopanib ou d'un sel de qualité pharmaceutique de celui-ci
MX339858B (es) Compuestos novedosos como ligandos del receptor h3 de la histamina.
WO2011008666A3 (fr) Composés 3-phénoxyméthylpyrrolidines
WO2013111162A3 (fr) Procédé pour la préparation de fingolimod
WO2014014794A3 (fr) Antagonistes des récepteurs aux minéralocorticoïdes
WO2012098560A3 (fr) Procédé de préparation de l'antagoniste du récepteur muscarinique
WO2013017910A8 (fr) Compositions pharmaceutiques à libération prolongée contenant de la palipéridone
WO2014049612A3 (fr) Procédés et polymorphes de 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-pipérazinyl]-2-benzofuran carboxamide et ses sels
WO2012018791A3 (fr) Préparation de chlorhydrate de prasugrel
SI2532651T1 (sl) Postopek sinteze in kristalinična oblika 4-(3-(cis-heksahidrociklopenta(c)pirol-2(1H)-il)propoksi) benzamid hidroklorida ter njegova prosta baza, pa tudi farmacevtski sestavki, ki ju vsebujejo

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12736102

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12736102

Country of ref document: EP

Kind code of ref document: A2