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WO2012097368A3 - Her3 and her4 primers and probes for detecting her3 and her4 mrna expression - Google Patents

Her3 and her4 primers and probes for detecting her3 and her4 mrna expression Download PDF

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Publication number
WO2012097368A3
WO2012097368A3 PCT/US2012/021546 US2012021546W WO2012097368A3 WO 2012097368 A3 WO2012097368 A3 WO 2012097368A3 US 2012021546 W US2012021546 W US 2012021546W WO 2012097368 A3 WO2012097368 A3 WO 2012097368A3
Authority
WO
WIPO (PCT)
Prior art keywords
her3
her4
detecting
primers
probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/021546
Other languages
French (fr)
Other versions
WO2012097368A2 (en
Inventor
Craig Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Response Genetics Inc
Original Assignee
Response Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Response Genetics Inc filed Critical Response Genetics Inc
Publication of WO2012097368A2 publication Critical patent/WO2012097368A2/en
Anticipated expiration legal-status Critical
Publication of WO2012097368A3 publication Critical patent/WO2012097368A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to methods, primers and probes useful for detecting the presence of HER1, HER 2, HER3 and/or HER 4 sequences or a combination thereof, in a sample, specifically for measuring the expression levels in the sample. The invention provides oligonucleotide primer pairs and methods comprising their use for detecting levels of HER1, HER 2, HER3 and/or HER 4 mRNA.
PCT/US2012/021546 2011-01-14 2012-01-17 Her3 and her4 primers and probes for detecting her3 and her4 mrna expression Ceased WO2012097368A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161432933P 2011-01-14 2011-01-14
US61/432,933 2011-01-14

Publications (2)

Publication Number Publication Date
WO2012097368A2 WO2012097368A2 (en) 2012-07-19
WO2012097368A3 true WO2012097368A3 (en) 2014-04-10

Family

ID=46507705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/021546 Ceased WO2012097368A2 (en) 2011-01-14 2012-01-17 Her3 and her4 primers and probes for detecting her3 and her4 mrna expression

Country Status (1)

Country Link
WO (1) WO2012097368A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020192652A1 (en) * 2001-06-11 2002-12-19 Danenberg Kathleen D. Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates
US20040157255A1 (en) * 2003-02-06 2004-08-12 David Agus Gene expression markers for response to EGFR inhibitor drugs
US20070065845A1 (en) * 2002-03-13 2007-03-22 Baker Joffre B Gene expression profiling in biopsied tumor tissues
US20080026393A1 (en) * 2006-05-25 2008-01-31 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
US20100008975A1 (en) * 2007-03-02 2010-01-14 Amler Lukas C Predicting response to a HER inhibitor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020192652A1 (en) * 2001-06-11 2002-12-19 Danenberg Kathleen D. Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates
US20070065845A1 (en) * 2002-03-13 2007-03-22 Baker Joffre B Gene expression profiling in biopsied tumor tissues
US20040157255A1 (en) * 2003-02-06 2004-08-12 David Agus Gene expression markers for response to EGFR inhibitor drugs
US20080026393A1 (en) * 2006-05-25 2008-01-31 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
US20100008975A1 (en) * 2007-03-02 2010-01-14 Amler Lukas C Predicting response to a HER inhibitor

Also Published As

Publication number Publication date
WO2012097368A2 (en) 2012-07-19

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