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WO2012090073A3 - Methods and compositions for predicting chemotherapy sensitivity - Google Patents

Methods and compositions for predicting chemotherapy sensitivity Download PDF

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Publication number
WO2012090073A3
WO2012090073A3 PCT/IB2011/003338 IB2011003338W WO2012090073A3 WO 2012090073 A3 WO2012090073 A3 WO 2012090073A3 IB 2011003338 W IB2011003338 W IB 2011003338W WO 2012090073 A3 WO2012090073 A3 WO 2012090073A3
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WO
WIPO (PCT)
Prior art keywords
patient
methods
compositions
breast cancer
chemotherapy sensitivity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/003338
Other languages
French (fr)
Other versions
WO2012090073A2 (en
Inventor
Sven ROTTENBERG
Jos JONKERS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Netherlands Cancer Institute
Original Assignee
Netherlands Cancer Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Netherlands Cancer Institute filed Critical Netherlands Cancer Institute
Publication of WO2012090073A2 publication Critical patent/WO2012090073A2/en
Publication of WO2012090073A3 publication Critical patent/WO2012090073A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The instant application provides methods and related compositions pertaining to the identification of chemosensitivity in a patient. In a particular embodiment, the invention provides biomarkers for the identification of chemosensitivity in a breast cancer patient, wherein a reduced expression of an X-linked gene, such as XIST, in the breast cancer cells of the patient indicates that the breast cancer cells in the patient may be successfully treated with a platinum-based compound, such as cisplatin.
PCT/IB2011/003338 2010-12-30 2011-12-30 Methods and compositions for predicting chemotherapy sensitivity Ceased WO2012090073A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201061428674P 2010-12-30 2010-12-30
US61/428,674 2010-12-30
US201161429364P 2011-01-03 2011-01-03
US61/429,364 2011-01-03

Publications (2)

Publication Number Publication Date
WO2012090073A2 WO2012090073A2 (en) 2012-07-05
WO2012090073A3 true WO2012090073A3 (en) 2012-11-29

Family

ID=45873186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/003338 Ceased WO2012090073A2 (en) 2010-12-30 2011-12-30 Methods and compositions for predicting chemotherapy sensitivity

Country Status (1)

Country Link
WO (1) WO2012090073A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2787084A1 (en) * 2013-04-05 2014-10-08 Les Laboratoires Servier Biomarkers for the identification of chemosensitivity
RU2551232C1 (en) * 2014-07-04 2015-05-20 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Method of predicting efficiency of chemotherapy in treatment of mammary gland cancer
CN110438222B (en) * 2018-05-04 2023-08-18 中国科学院分子细胞科学卓越创新中心 A detection kit for early diagnosis of aggressive lymphoma
CN110438221B (en) * 2018-05-04 2023-06-06 中国科学院分子细胞科学卓越创新中心 A detection kit for predicting and evaluating the curative effect of lymphoma on chemotherapeutic drugs
CN109771668A (en) * 2019-02-03 2019-05-21 隋新兵 Use of KDM6A gene or KDM6A mRNA
US20250082600A1 (en) * 2022-01-07 2025-03-13 Pharma& Schweiz Gmbh Treating haematological malignancies by means of satraplatin

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