[go: up one dir, main page]

WO2012076000A3 - Method for detecting anti-nmda receptor autoantibodies for use in diagnostic procedures - Google Patents

Method for detecting anti-nmda receptor autoantibodies for use in diagnostic procedures Download PDF

Info

Publication number
WO2012076000A3
WO2012076000A3 PCT/DE2011/002078 DE2011002078W WO2012076000A3 WO 2012076000 A3 WO2012076000 A3 WO 2012076000A3 DE 2011002078 W DE2011002078 W DE 2011002078W WO 2012076000 A3 WO2012076000 A3 WO 2012076000A3
Authority
WO
WIPO (PCT)
Prior art keywords
nmda receptor
diagnostic procedures
detecting anti
receptor autoantibodies
autoantibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2011/002078
Other languages
German (de)
French (fr)
Other versions
WO2012076000A2 (en
Inventor
Winfried STÖCKER
Klaus-Peter Wandinger
Lars Komorowski
Christian Probst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroimmun Medizinische Labordiagnostika AG
Original Assignee
Euroimmun Medizinische Labordiagnostika AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroimmun Medizinische Labordiagnostika AG filed Critical Euroimmun Medizinische Labordiagnostika AG
Priority to EP11846070.8A priority Critical patent/EP2649448A2/en
Priority to CN2011800586351A priority patent/CN103282776A/en
Publication of WO2012076000A2 publication Critical patent/WO2012076000A2/en
Publication of WO2012076000A3 publication Critical patent/WO2012076000A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a method for detecting IgA and/or IgM anti-NMDA receptor antibodies, and also to a method and an assay kit for the diagnosis of an autoimmune neuropathy, dementia, borderline personality disorder or primary psychosis.
PCT/DE2011/002078 2010-12-06 2011-12-05 Method for detecting anti-nmda receptor autoantibodies for use in diagnostic procedures Ceased WO2012076000A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11846070.8A EP2649448A2 (en) 2010-12-06 2011-12-05 Method for detecting anti-nmda receptor autoantibodies for use in diagnostic procedures
CN2011800586351A CN103282776A (en) 2010-12-06 2011-12-05 Method for detection of anti-NMDA receptor autoantibodies for use in diagnostic procedures

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE201010053432 DE102010053432A1 (en) 2010-12-06 2010-12-06 Method for detection of anti-NMDA receptor autoantibodies for use in diagnostic procedures
DE102010053432.3 2010-12-06

Publications (2)

Publication Number Publication Date
WO2012076000A2 WO2012076000A2 (en) 2012-06-14
WO2012076000A3 true WO2012076000A3 (en) 2013-01-24

Family

ID=45815454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2011/002078 Ceased WO2012076000A2 (en) 2010-12-06 2011-12-05 Method for detecting anti-nmda receptor autoantibodies for use in diagnostic procedures

Country Status (4)

Country Link
EP (1) EP2649448A2 (en)
CN (1) CN103282776A (en)
DE (1) DE102010053432A1 (en)
WO (1) WO2012076000A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014160431A1 (en) 2013-03-13 2014-10-02 Health Diagnostic Laboratory, Inc. Method of determining prior history of ischemic stroke for current risk evaluation and therapy guidance
EP3026434B1 (en) 2014-11-25 2022-01-05 Euroimmun Medizinische Labordiagnostika AG A novel diagnostically relevant autoantibody
CN111320684B (en) * 2018-12-13 2022-10-14 中国科学院脑科学与智能技术卓越创新中心 Expression and application of GluN1/GluN2A tetramer of human N-methyl-D-aspartate receptor
WO2021008890A1 (en) 2019-07-16 2021-01-21 Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) Nmda receptor constructs to detect and isolate nmdar autoantibodies
CN110606887A (en) * 2019-08-12 2019-12-24 陕西脉元生物科技有限公司 Detection material for anti-NMDAR autoantibody in human body fluid, preparation method and application
EP4028769A1 (en) * 2019-09-13 2022-07-20 Euroimmun Medizinische Labordiagnostika AG Improved detection of nmda receptor autoantibodies
CN113755443B (en) * 2020-06-05 2025-07-15 陈向军 Transient and stable detection methods of autoimmune encephalitis antibodies and their applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5529898A (en) * 1993-08-19 1996-06-25 Duke University Methods of detecting disorders of the central nervous system by detecting autoantibodies which specifically bind ionotropic glutamate receptors
WO2008021408A2 (en) * 2006-08-15 2008-02-21 The Trustees Of The University Of Pennsylvania Methods and compositions for treatment and diagnosis of autoimmune encephalitis or epilepsy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5666087B2 (en) * 2005-04-06 2015-02-12 アダマス・ファーマシューティカルズ・インコーポレーテッド Methods and compositions for the treatment of CNS related diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5529898A (en) * 1993-08-19 1996-06-25 Duke University Methods of detecting disorders of the central nervous system by detecting autoantibodies which specifically bind ionotropic glutamate receptors
WO2008021408A2 (en) * 2006-08-15 2008-02-21 The Trustees Of The University Of Pennsylvania Methods and compositions for treatment and diagnosis of autoimmune encephalitis or epilepsy

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BOKESCH P M ET AL: "NMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients", STROKE, vol. 37, no. 6, June 2006 (2006-06-01), pages 1432 - 1436, XP002677906, ISSN: 0039-2499, DOI: 10.1161/01.STR.0000221295.14547.C8 *
DALMAU ET AL.: "Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies", 1 December 2008 (2008-12-01), pages 1091 - 1098+Webtables +Webappendix, XP002677903, Retrieved from the Internet <URL:http://ac.els-cdn.com/S1474442208702242/1-s2.0-S1474442208702242-main.pdf?_tid=98850bd52f430a20254393881537b67c&acdnat=1340006300_2635140f4d34ead31d7e853dc05bd056> [retrieved on 20120614] *
DALMAU JOSEP ET AL: "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma", ANNALS OF NEUROLOGY, JOHN WILEY AND SONS, BOSTON, US, vol. 61, no. 1, 1 January 2007 (2007-01-01), pages 25 - 36, XP009122766, ISSN: 0364-5134, DOI: 10.1002/ANA.21050 *
ERDEM TÃ Â 1/4 ZÃ Â 1/4 N ET AL: "Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma", ACTA NEUROPATHOLOGICA, vol. 118, no. 6, 14 August 2009 (2009-08-14), SPRINGER, BERLIN, DE, pages 737 - 743, XP019759697, ISSN: 1432-0533, DOI: 10.1007/S00401-009-0582-4 *
FRANCESC GRAUS ET AL: "Antibodies and neuronal autoimmune disorders of the CNS", JOURNAL OF NEUROLOGY, vol. 257, no. 4, 25 December 2009 (2009-12-25), STEINKOPFF-VERLAG, DA, pages 509 - 517, XP019802732, ISSN: 1432-1459 *
HANLY JOHN G ET AL: "Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus", JOURNAL OF RHEUMATOLOGY, vol. 33, no. 8, 1 August 2006 (2006-08-01), pages 1553 - 1558, XP009160151, ISSN: 0315-162X *
MOSCAVITCH S D ET AL: "Autoimmune pathology accounts for common manifestations in a wide range of neuro-psychiatric disorders: The olfactory and immune system interrelationship", CLINICAL IMMUNOLOGY, vol. 130, no. 3, 1 March 2009 (2009-03-01), ACADEMIC PRESS, US, pages 235 - 243, XP025915058, ISSN: 1521-6616, [retrieved on 20090206], DOI: 10.1016/J.CLIM.2008.10.010 *
TAKAHASHI ET AL.: "Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua", 1 October 2003 (2003-10-01), pages 891 - 896+Supp. Material, XP002677902, Retrieved from the Internet <URL:http://www.neurology.org/content/61/7/891.full.html> [retrieved on 20120614] *

Also Published As

Publication number Publication date
CN103282776A (en) 2013-09-04
WO2012076000A2 (en) 2012-06-14
DE102010053432A1 (en) 2012-06-06
EP2649448A2 (en) 2013-10-16

Similar Documents

Publication Publication Date Title
WO2012076000A3 (en) Method for detecting anti-nmda receptor autoantibodies for use in diagnostic procedures
ZA201203717B (en) Assays for the detection of anti-tnf drugs autoantibodies
WO2009128963A3 (en) Cross-neutralizing human monoclonal antibodies to sars-cov and methods of use thereof
WO2012038012A3 (en) Method for connecting components
WO2012047618A3 (en) Mesothelioma biomarkers and uses thereof
WO2010042562A3 (en) Muc1* antibodies
WO2010065929A3 (en) Method for diagnosing allergic reactions
WO2014165082A3 (en) Antibodies and methods of detection
WO2013064701A3 (en) Specific antibodies and their isolation with anti-idiotypic antibodies
WO2011056606A8 (en) Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis
IL222359A0 (en) Monoclonal antibodies against her2 antigens, and uses therefor
BR112013013573A2 (en) method for producing antibodies specific for an antigen of interest, isolated or recombinant b-cell, antibody population, and antibody
WO2010115745A3 (en) Biomarkers, methods and kits for the diagnosis of rheumatoid arthritis
WO2012058220A3 (en) Anti-sod1 antibodies and uses thereof
WO2012154983A3 (en) Systems and methods for anti-pax8 antibodies
WO2012170206A3 (en) Color-producing diagnostic systems, reagents and methods
EP2536817A4 (en) Immunoassay device for detecting antibodies and antigens
WO2012175602A3 (en) Elisa for calprotectin
EP2475383A4 (en) SPECIFIC HUMANIZED ANTIBODIES OF PEPTIDE-6 DERIVED FROM HSP65, METHODS AND USES THEREOF
MX343873B (en) Diagnostic antibody assay.
WO2011130647A3 (en) Compositions and methods for characterizing a myopathy
WO2011003598A3 (en) Detection of antigens
WO2012075321A3 (en) Trichomonas vaginalis testing using tv5.8s as a target
WO2012032512A3 (en) Methods and kits for the detection of an infection in subjects with low specific antibody levels
WO2011031472A3 (en) Detection of auto-antibodies to specific glycans as diagnostic tests for autoimmune diseases

Legal Events

Date Code Title Description
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2011846070

Country of ref document: EP