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WO2012070569A1 - Procédé de mesure et dispositif de mesure de réceptivité endométriale, et procédé de fonctionnement du dispositif de mesure - Google Patents

Procédé de mesure et dispositif de mesure de réceptivité endométriale, et procédé de fonctionnement du dispositif de mesure Download PDF

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Publication number
WO2012070569A1
WO2012070569A1 PCT/JP2011/076900 JP2011076900W WO2012070569A1 WO 2012070569 A1 WO2012070569 A1 WO 2012070569A1 JP 2011076900 W JP2011076900 W JP 2011076900W WO 2012070569 A1 WO2012070569 A1 WO 2012070569A1
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Prior art keywords
impedance
subject
endometrial
value
endometrium
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English (en)
Japanese (ja)
Inventor
中村　仁美
木村　正
剛良 細野
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University of Osaka NUC
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Osaka University NUC
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Priority to JP2012545764A priority Critical patent/JP5923760B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4318—Evaluation of the lower reproductive system
    • A61B5/4325—Evaluation of the lower reproductive system of the uterine cavities, e.g. uterus, fallopian tubes, ovaries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0012—Ovulation-period determination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0537—Measuring body composition by impedance, e.g. tissue hydration or fat content
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0012—Ovulation-period determination
    • A61B2010/0016—Ovulation-period determination based on measurement of electric currents, e.g. conductivity tests

Definitions

  • the present invention uses a method for measuring the maternal receptive ability (uterine implantation ability) by which a fertilized egg is implanted in the uterus (also referred to as “uterine implantation ability measurement method” in the present invention), and this method is used.
  • the present invention relates to a measuring device (in the present invention, this is also referred to as “uterine implantation ability measuring device”) and a method of operating the measuring device.
  • a measuring device in the present invention, this is also referred to as “uterine implantation ability measuring device”
  • infertility In the case of humans, infertility is defined as having no sexual intercourse without contraception for one year. Currently, it is said that 10-15% of all reproductive age couples suffer from infertility. In recent years, with the advancement of women into society, it is considered that there is an increasing trend in the future due to late marriage, late birth and the spread of sexually transmitted diseases.
  • infertility There are some causes of infertility on the female side, one with ovary (ovulation), one with oviduct (ovum transport), and one with unknown cause. Of these, many infertility with unknown causes are thought to be due to implantation failure. “Implantation” refers to the process by which a fertilized egg (embryo) adheres to and infiltrates the endometrium and is medically defined as having become pregnant at this point. In this implantation process, there is a problem with the endometrium on the receiving side, and as a result, no implantation is called “implantation failure”. That is, “implantation failure” refers to a state in which an embryo that has been successfully developed upon fertilization moves to the uterine lumen but does not normally implant.
  • Non-patent Document 1 the vaginal mucosal impedance has been put to practical use as a parameter indicating the breeding time. It has also been reported that this shows a high value in the mouse estrus. However, there is no attempt to evaluate uterine implantation using this parameter.
  • An object of the present invention is to provide a method for measuring the uterine implantation ability of a mother. Furthermore, an object of the present invention is to provide a uterine implantation ability measuring apparatus useful for simply measuring the uterine implantation ability of a mother and an operating method of the measurement apparatus.
  • the present inventors were diligently examining parameters serving as indicators of uterine implantation ability using human implantation failure model mice produced by Nakamura et al., The present inventors.
  • the potential difference of the endometrium, endometrial impedance and vaginal mucosa impedance it is measured forward-looking whether the uterine implantation ability is good, in other words, whether the uterus is ready for implantation. I found that I can do it.
  • an electrode that can contact the vaginal mucosa epithelium, or that can be inserted into the uterine vagina and can contact the endometrium can measure the potential emitted from the endometrium or the vaginal mucosa epithelium.
  • the potential difference and impedance can be measured in real time, and as a result, it is considered that efficient embryo transfer can be performed. We were convinced that this would significantly improve the efficiency of current infertility treatment.
  • the present invention has been completed based on the above findings and includes the following aspects.
  • Method of measuring uterine implantation ability (1-1) Using at least one selected from the group consisting of endometrial potential difference, endometrial impedance, and vaginal mucosal impedance obtained from the subject as an index Of measuring the endometrial implantation ability of the rat.
  • the method described in (1-1) having the following steps: (A) At least one value (test value) selected from the group consisting of an endometrial potential difference obtained from a subject, endometrial impedance, and vaginal mucosa impedance is set as the above test value for a fertile woman.
  • control value selected from the group consisting of a corresponding endometrial potential difference, endometrial impedance, and vaginal mucosal impedance
  • (1-3) The method described in (1-1) having the following steps: (A ′) comparing at least one value (test value) selected from the group consisting of an endometrial potential difference obtained from a subject, endometrial impedance, and vaginal mucosal impedance with a corresponding threshold value; And (b ′) if the test value is higher than the corresponding threshold value, the subject's implantation ability is determined to be poor, and if the test value is equal to or lower than the threshold value, The process of determining the floor ability as good. (1-4) The method described in (1-2) or (1-3), which further comprises the following steps: (C) A step of determining that embryo transfer is to be performed on a subject in the menstrual cycle evaluated as having good implantation ability.
  • test value selected from the group consisting of an endometrial potential difference obtained from a subject, endometrial impedance, and vaginal mucosal impedance with a corresponding threshold value
  • test value selected from the group consisting of an end
  • Measuring device for uterine implantation ability (2-1) An apparatus for measuring the implantation ability of the subject's endometrium, which can contact the endometrium or vaginal mucosa epithelium of the subject; Measuring means for measuring an endometrial potential difference generated at the interface between the electrode and endometrium, or an endometrial impedance or vaginal mucosa impedance generated between the electrode and the endometrium or vaginal mucosa epithelium And measuring means for measuring the endometrial implantation ability of the subject using as an index at least one selected from the group consisting of a potential difference of the endometrium obtained from the subject, endometrial impedance, and vaginal mucosal impedance A device comprising: (2-2) at least one value (test value) selected from the group consisting of an endometrial potential difference obtained from the subject, endometrial impedance, and vaginal mucosal impedance, a predetermined threshold value corresponding there
  • test value is higher than the corresponding threshold value or control value as a result of the comparison by the comparison means, the subject's implantation ability in the menstrual cycle is determined to be poor, and the test value corresponds to the corresponding threshold value or A determination means for determining that the implantation ability of the subject in the menstrual cycle is good when the value is equal to or lower than the control value.
  • test value at least one value selected from the group consisting of the measured potential difference of the endometrium of the subject, endometrial impedance, and vaginal mucosa impedance, and a predetermined threshold corresponding thereto, or , At least one value selected from the group consisting of endometrial potential difference, endometrial impedance, and vaginal mucosal impedance corresponding to the test value for a fertile woman measured in advance (control value) And a step of comparing (B) If the test value is higher than the corresponding threshold value or control value according to the comparison result, the subject's implantation ability in the menstrual cycle is determined to be poor, and the test value is the corresponding threshold value or control value.
  • test value selected from the group consisting of the measured potential difference of the endometrium of the subject, endometrial impedance, and vaginal mucosa impedance, and a predetermined threshold corresponding thereto, or , At least one value selected from the group consisting of endometri
  • infertility treatment can be succeeded with a high probability, the cost of medical care is high and the number of times of ovarian stimulation and egg collection with a heavy burden on the mother can be reduced. Furthermore, if the pregnancy rate per embryo transfer improves, the number of transplanted embryos can be limited to one, and iatrogenic multiple pregnancies derived from infertility treatment, which are considered problematic in current perinatal medicine, can be eliminated It is expected.
  • Example 3 The result of measuring the pH change of the endometrium of female mice over time after mating ICR mice is shown (Experimental Example 1).
  • Example 2 The result of having measured the change in the potential difference of the endometrium of female mice over time after mating ICR mice is shown (Experimental Example 2).
  • Example 3 The result of contrasting the potential difference between the endometrium of the human implantation failure model mouse and the potential difference of the endometrium of the control mouse on the 2.5th day after the mating (immediately before the implantation period) is shown (Experimental Example 3).
  • (A) shows the results of daily measurement of changes in vaginal impedance in vivo in the early pregnancy of untreated ICR mice.
  • (B) shows the results of a comparative study of vaginal impedance in human implantation failure model mice and control mice on day 2.5 after mating (immediately before implantation). It is a block diagram which shows schematic structure of the uterine implantation ability measuring apparatus of one Embodiment of this invention. It is a block diagram which shows schematic structure of the uterine implantation ability measuring apparatus of other embodiment of this invention.
  • the method for measuring uterine implantation ability according to the present invention is characterized by using the potential difference of the endometrium obtained from the subject or the impedance of the endometrium or vaginal mucosa as an index. .
  • the potential difference of the endometrium is measured with a known potentiometer, for example, by contacting an electrode made of a glass electrode or a glass-coated antimony electrode with the endometrium, and the contact potential generated between the electrode and the endometrium Can be measured.
  • the electrode is a probe-type electrode so that it can be inserted into the uterine cavity.
  • the impedance (AC electrical resistance value) of the vagina and endometrium is such that at least two electrodes, such as platinum electrodes or tungsten electrodes, are brought into contact with the vaginal mucosa epithelium or endometrium, and a predetermined frequency is set between the electrodes.
  • An alternating current is applied by applying an alternating voltage.
  • the current value of the current flowing between each electrode and the vaginal mucosa epithelium or endometrium and the potential generated in the vaginal mucosa epithelium or endometrium (potential difference (voltage value) between the electrodes) are measured.
  • the impedance of the vagina and endometrium can be detected based on the current value and the voltage value.
  • the electrode preferably has a shape (probe type) that can be inserted into the vagina or uterine cavity.
  • a shape probe type
  • either the two-terminal method in which two electrodes are arranged on the vaginal mucosa epithelium or the endometrium or the four-terminal method in which four electrodes are arranged may be used.
  • the “Vaginal Impedance Checker” IMPEDANCE CHECKER FOR RATS MK-11
  • the impedance (AC electrical resistance value) of the film may be measured.
  • the measurement method of the present invention is a method for measuring the potential difference of the subject's endometrium, the endometrial impedance, or the vaginal mucosa impedance (collectively referred to as “test value”). ) Values of endometrial potential, endometrial impedance, or vaginal mucosal impedance obtained from a fertile woman (hereinafter referred to as “control”) (collectively these values are referred to as “control values”). ").
  • control a fertile woman
  • control values collectively these values are referred to as “control values”.
  • the measurement can be performed by selecting at least one of the above-described endometrial potential difference, endometrial impedance, and vaginal mucosal impedance values. Although it does not restrict
  • Implantation failure means that in vitro fertility embryo transfer has become one of the most common treatment methods for infertility, so there are problems in the process of (i) ovulation and (ii) fertilization pregnancy. It is only a concept of the pathology that indicates the situation in which the situation does not lead to pregnancy despite the fact that there is no problem in (i) and (ii) in the situation that can be clearly made. This is because there is currently no diagnostic method for implantation failure.
  • the subject targeted by the measurement method of the present invention is a woman who wishes to raise a child.
  • women who are treated for in vitro fertilization and embryo transfer are considered effective as subjects.
  • test value is higher than the corresponding control value, the implantation ability of the subject in the uterus during the menstrual cycle is not sufficient for embryo implantation, that is, “poor implantation ability”
  • test value is the same or lower than the corresponding control value, the implantation ability of the subject in the uterus during the menstrual cycle is sufficient for embryo implantation. That is, it can be judged and determined as “good landing ability”.
  • the measurement method of the present invention can also compare each test value (the potential difference of the subject's endometrium, the endometrial impedance, or the vaginal mucosa impedance) with each preset threshold value. Can be implemented.
  • test value is higher than the corresponding threshold value, the implantation ability of the subject in the uterus during the menstrual cycle is not sufficient for the implantation of the embryo, that is, “poor implantation ability”
  • test value is equal to or lower than the corresponding threshold value, the subject's implantation ability in the uterus during the menstrual cycle is sufficient for embryo implantation, that is, Can be judged / decided as “good landing ability”.
  • FIG. 5 is a block diagram showing the configuration of a measuring device (uterine implantation ability measuring device) 1 according to an embodiment of the present invention.
  • the uterine implantation ability measuring apparatus 1 includes a measuring electrode 2 inserted into a uterine vagina of a subject, an impedance measuring instrument 10, a control device 6, and an output device 7.
  • the measurement electrode 2 is formed in a needle shape (probe type) as a whole so that it can be inserted into the uterine vagina of the subject.
  • the distal end portion of the needle-like (probe type) body portion 20 is formed.
  • two electrodes 21 made of a platinum electrode, a tungsten electrode or the like are arranged at a predetermined interval.
  • the distal end portion of the body portion 20 is rounded to prevent rounding of the subject's uterine vagina.
  • a current path is formed between each electrode 21 and the endometrium.
  • a voltage is applied between the electrodes 21, a current corresponding to an impedance (endometrial impedance) generated between each electrode 21 and the endometrium flows through the current path.
  • the impedance measuring instrument 10 includes a power source 3, an ammeter 4 that measures a current flowing through the current path, a voltmeter 9 that measures a potential difference (voltage value) between the electrodes 21, and an impedance measuring unit 5. Yes.
  • the power source 3, ammeter 4 and voltmeter 5 and each electrode 21 of the measurement electrode 2 are electrically connected via lead wires.
  • the power source 3 is a power source for applying an alternating voltage of a predetermined frequency between the electrodes 21, and ON / OFF control of voltage application to the electrodes 21 is performed by the switching element 8.
  • the switching element 8 is controlled to be turned on and off by the impedance measuring means 5.
  • Impedance measuring means 5 performs energization control to each electrode 21 and control of ammeter 4 and voltmeter 9.
  • the impedance measuring means 5 receives an operation signal from the subject side, performs ON-OFF control of the switching element 8 to control energization of each electrode 21, and uses the voltage value measured by the voltmeter 5 and the ammeter 4.
  • the endometrial impedance is obtained from the measured current value.
  • the impedance measurement method described above is based on a conventionally known method.
  • a “vagina impedance checker” IMPEDANCE CHECKER FOR RATS MK-11 manufactured by Muromachi Kikai Co., Ltd. it can.
  • the control device 6 uses the endometrial impedance measured by the impedance measuring instrument 10 to perform measurement processing of the subject's uterine implantation ability.
  • the control device 6 includes a microcomputer, and includes a storage unit such as a ROM 61 and a RAM 62 in addition to the CPU 60 that is a main body of control and calculation.
  • the ROM 61 stores measurement values (control values) of endometrial impedance of fertile women.
  • the RAM 62 temporarily stores the endometrial impedance of the subject measured by the impedance measuring device 10.
  • the CPU 60 reads the test value of the subject stored in the RAM 62 and compares it with the control value of the fertile woman stored in the ROM 61. If the test value is higher than the corresponding control value, the subject's implantation ability in the menstrual cycle is determined to be poor. On the other hand, when the test value is the same or lower than the corresponding control value, a process for determining that the subject's implantation ability in the menstrual cycle is good is performed.
  • the output device 7 is composed of a display device such as a liquid crystal display, for example, and the measured value (test value) of the endometrial impedance measured by the impedance measuring instrument 10 or the uterine implantation ability of the subject determined by the control device 6. Display measurement results. Note that the output device 7 is not necessarily limited to the display device, and the measured value (test value) of the endometrial impedance measured by the impedance measuring instrument 10 or the uterine implantation of the subject determined by the control device 6. Various modes can be used as long as the measurement results of performance can be output to the outside.
  • the potential generated in the endometrium of the subject is detected by bringing the electrode 21 into contact with the endometrium of the subject, and this is detected.
  • the implantation ability of the uterus can be evaluated in real time. This evaluation makes it possible to evaluate the implantation ability of the uterus in front of each menstrual cycle and to treat it.
  • the uterine implantation ability measurement device of the present invention As mentioned above, although one embodiment of the uterine implantation ability measuring device and the operation method of the measurement device of the present invention was described, the uterine implantation ability measurement device of the present invention and the operation method of the measurement device are limited to this. is not.
  • the test value (measured value of endometrial impedance) is compared with the measured value (control value) of fertile female endometrial impedance (control value).
  • control value the measured value of fertile female endometrial impedance
  • the measured value of endometrial impedance is used as a test value
  • the impedance value of the vaginal mucosa By measuring the vaginal mucosal impedance and comparing this vaginal mucosal impedance measurement to a fertile female vaginal mucosal impedance measurement (control value) or a predetermined threshold, subjects in a menstrual cycle It is possible to measure the uterine implantation ability.
  • FIG. 6 shows an impedance measuring instrument 10 ′ according to another embodiment.
  • the measurement electrode 2 ′ shown in FIG. 6 is formed in a needle shape (probe type) as a whole so that it can be inserted into the uterine vagina of the subject.
  • Four electrodes 21A to 21D made of a platinum electrode, a tungsten electrode, or the like are arranged at a predetermined interval at the distal end of a body (probe type) body 20.
  • the distal end portion of the body portion 20 is rounded to prevent rounding of the subject's uterine vagina.
  • the electrodes 21A to 21D are electrically connected to the impedance measuring instrument 10 'by lead wires. In this embodiment, it is divided into two electrodes for passing current and two electrodes for measuring voltage, whereas the electrodes 21A, 21D at both ends are electrically connected to the ammeter 4, whereas The remaining electrodes 21B and 21C are electrically connected to the voltmeter 9.
  • the impedance measuring means 5 performs energization control to the electrodes 21A to 21D and control of the ammeter 4 and voltmeter 9.
  • the impedance measuring means 5 receives the operation signal from the subject side, performs ON / OFF control of the switching element 8 to control energization of the electrodes 21A, 21D, and each of the electrodes 21A, 21D as in the above embodiment.
  • the impedance measuring instrument 10 that measures impedance by the above four-terminal method, “body composition analyzer MLT-50” manufactured by Sekisui Medical Electronics Co., Ltd. can be preferably used.
  • the uterine implantation ability of the subject can also be measured by using the endometrial potential difference as the test value.
  • an electrode made of, for example, a glass electrode or a glass-coated antimony electrode as an electrode is brought into contact with the endometrium of the subject, and a contact potential generated between the electrode and the endometrium Is measured by a known potentiometer to measure the potential difference of the subject's endometrium.
  • the potential difference of the endometrium is compared with a measured value (control value) of the potential difference of the endometrium of a fertile woman or a predetermined threshold value, thereby determining the uterine implantation ability of the subject in a certain menstrual cycle. It becomes possible to measure.
  • the pH of the in vivo endometrium in the early pregnancy was measured every day using ICR mice (CLEA Japan).
  • the pH of the endometrium in vivo was determined by opening the mouse under anesthesia, inserting a probe into the uterine cavity from the vagina, and using a laboratory precision digital pH / mV meter (MODEL: CL-9D01, CHEMICAL INS LTD.) was used to measure the pH of the in vivo endometrium.
  • the mouse is a human implantation failure model animal that well reproduces the pathology often seen in human infertility.
  • (B) Control Mouse A control mouse for a human implantation failure model mouse was prepared according to the description in FEBS Lett. 2006, Vol. 580, 2717-2722 (Non-patent Document 2).
  • the mouse is a mouse that has been gene transferred as a scramble decoy that is a double-stranded DNA having the same length as the STAT-3 decoy and that does not bind to a specific gene sequence. After gene transfer, it has been confirmed that this gene transfer does not affect pregnancy in terms of normal implantation, maintenance of pregnancy, parturition, number of pups, birth weight, etc. (Nakamura, H. et. al., Mol. Hum. Reprod. 2003, 9: 603-609.).
  • the AC electrical resistance value (vaginal impedance) of the vaginal mucosa after mating was measured every day in the early stage of pregnancy and compared.
  • FIG. 4 (A) shows the results of tracking changes in vaginal impedance in the early stage of pregnancy for untreated mice over time.
  • FIG. 4 (B) shows the results of examining vaginal mucosal impedance on the 2.5th day after mating, which is just before the implantation period, in human implantation failure model mice and control mice.
  • the impedance tends to decrease as the number of days of pregnancy progresses from the early pregnancy stage to the implantation stage (3.5-5.5 days after mating). Admitted. Further, as shown in FIG. 4 (B), it was confirmed that the vaginal impedance of the human implantation failure model mouse was significantly higher than that of the control mouse at 2.5 days after mating immediately before the implantation period. It was.
  • vaginal impedance showed a significantly high value when the uterine implantation ability was not appropriate. This suggests that the vaginal impedance can be a parameter that can evaluate the implantation ability of the uterus in a forward view.
  • infertility is not an irreversible condition like a gene-deficient mouse, but is a condition that is temporarily out of balance, so it can be said that it is a treatable condition. Therefore, a forward-looking diagnosis for each menstrual cycle and a treatment adapted thereto are effective. If the uterine implantation ability can be measured in real time in a forward view, it can be reflected in infertility treatment. Specifically, if it is determined that the implantation ability of the uterus is good (the preparation for implantation of the uterus is sufficient) as a result of the measurement, an embryo transfer using a fresh embryo or a cryopreserved embryo is performed.
  • the cycle is cryopreserved without embryo transfer, and no embryo transfer is performed during that cycle. .
  • embryo transfer is performed at a cycle determined to be suitable for uterine implantation, it is possible to provide highly efficient infertility treatment. In other words, since wasteful embryo transfer is reduced, the number of ovarian overstimulations and egg collections that have been repeatedly performed can be reduced.

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Abstract

L'invention porte sur un procédé de mesure de la réceptivité du corps d'une mère à l'implantation d'un embryon dans l'utérus (à savoir, la réceptivité endométriale) ; et sur un dispositif de mesure destiné à être utilisé dans le procédé (à savoir, un dispositif de mesure de réceptivité endométriale). Ce procédé est caractérisé en ce qu'il emploie au moins un élément choisi dans le groupe constitué d'une différence de potentielles endométriales, d'une impédance endométriale et d'une impédance de muqueuse vaginale dans un corps vivant, qui sont obtenues dans un sujet, en tant que mesure.
PCT/JP2011/076900 2010-11-22 2011-11-22 Procédé de mesure et dispositif de mesure de réceptivité endométriale, et procédé de fonctionnement du dispositif de mesure Ceased WO2012070569A1 (fr)

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JP2012545764A JP5923760B2 (ja) 2010-11-22 2011-11-22 子宮着床能の測定装置

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
WO2015146172A1 (fr) * 2014-03-28 2015-10-01 国立大学法人大阪大学 Dispositif d'évaluation du vagin et dispositifs d'évaluation de l'utérus
WO2020202108A1 (fr) * 2019-04-05 2020-10-08 Julius Georgiou Procédé et appareil de surveillance et de stimulation directes, in vivo, électriques et chimiques de la cavité de l'endomètre
WO2024242172A1 (fr) * 2023-05-23 2024-11-28 国立大学法人大阪大学 Dispositif et procédé de prédiction de capacité d'implantation dans l'utérus et d'estimation de synchronisation d'administration

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JP2006525099A (ja) * 2003-05-02 2006-11-09 ザ ジョンズ ホプキンス ユニバーシティ 子宮頚部組織のバイオインピーダンス測定のためのデバイス、システムおよび方法、並びにヒト子宮頚部の診断および処置のための方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000237197A (ja) * 1999-02-19 2000-09-05 Erutekku Kk 哺乳動物の排卵時期測定装置並びに排卵時期測定方法
JP2006525099A (ja) * 2003-05-02 2006-11-09 ザ ジョンズ ホプキンス ユニバーシティ 子宮頚部組織のバイオインピーダンス測定のためのデバイス、システムおよび方法、並びにヒト子宮頚部の診断および処置のための方法

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015146172A1 (fr) * 2014-03-28 2015-10-01 国立大学法人大阪大学 Dispositif d'évaluation du vagin et dispositifs d'évaluation de l'utérus
JPWO2015146172A1 (ja) * 2014-03-28 2017-04-13 国立大学法人大阪大学 膣評価装置及び子宮評価装置
US10271760B2 (en) 2014-03-28 2019-04-30 Osaka University Vagina evaluation device and uterus evaluation device
US10602955B2 (en) 2014-03-28 2020-03-31 Osaka University Vagina evaluation device and uterus evaluation device
US11826131B2 (en) 2014-03-28 2023-11-28 Osaka University Vagina evaluation device and uterus evaluation device
WO2020202108A1 (fr) * 2019-04-05 2020-10-08 Julius Georgiou Procédé et appareil de surveillance et de stimulation directes, in vivo, électriques et chimiques de la cavité de l'endomètre
US12102303B2 (en) 2019-04-05 2024-10-01 Gynetronics Ltd. Method and apparatus for direct in-vivo, electrical and chemical monitoring and stimulation of the endometrial cavity
WO2024242172A1 (fr) * 2023-05-23 2024-11-28 国立大学法人大阪大学 Dispositif et procédé de prédiction de capacité d'implantation dans l'utérus et d'estimation de synchronisation d'administration

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