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WO2012063269A3 - Procédé de préparation d'iloperidone - Google Patents

Procédé de préparation d'iloperidone Download PDF

Info

Publication number
WO2012063269A3
WO2012063269A3 PCT/IN2011/000785 IN2011000785W WO2012063269A3 WO 2012063269 A3 WO2012063269 A3 WO 2012063269A3 IN 2011000785 W IN2011000785 W IN 2011000785W WO 2012063269 A3 WO2012063269 A3 WO 2012063269A3
Authority
WO
WIPO (PCT)
Prior art keywords
iloperidone
relates
preparation
preparing
preparing iloperidone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2011/000785
Other languages
English (en)
Other versions
WO2012063269A2 (fr
Inventor
Shriprakash Dhar DWIVEDI
Dhimant Jasubhai Patel
Alpesh Pravinchandra Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of WO2012063269A2 publication Critical patent/WO2012063269A2/fr
Publication of WO2012063269A3 publication Critical patent/WO2012063269A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne l'iloperidone et son procédé de préparation, et notamment un procédé amélioré de préparation de l'iloperidone sous forme cristalline. L'invention concerne des compositions pharmaceutiques comprenant l'iloperidone cristalline sensiblement exempte d'impuretés telles que N-oxyde, desfluoro et dimère.
PCT/IN2011/000785 2010-11-12 2011-11-11 Procédé de préparation d'iloperidone Ceased WO2012063269A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN3103MU2010 2010-11-12
IN3103/MUM/20 2010-11-12
IN3131MU2010 2010-11-16
IN3131/MUM/2010 2010-11-16
IN1518MU2011 2011-05-18
IN1518/MUM/2011 2011-05-18

Publications (2)

Publication Number Publication Date
WO2012063269A2 WO2012063269A2 (fr) 2012-05-18
WO2012063269A3 true WO2012063269A3 (fr) 2013-03-14

Family

ID=45607322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000785 Ceased WO2012063269A2 (fr) 2010-11-12 2011-11-11 Procédé de préparation d'iloperidone

Country Status (1)

Country Link
WO (1) WO2012063269A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012164516A1 (fr) * 2011-06-03 2012-12-06 Lupin Limited Procédé pour la préparation d'ilopéridone
CN102796090B (zh) * 2012-08-30 2015-03-25 天津华津制药有限公司 一种伊潘立酮的制备方法
CN103880828A (zh) * 2012-12-24 2014-06-25 凌沛学 一种苯并异噁唑类化合物的氧化物
CN106831742B (zh) * 2016-12-28 2019-08-23 北京医药集团有限责任公司 一种伊潘立酮中间体的制备方法
CN111285862A (zh) * 2018-12-07 2020-06-16 江苏恩华药业股份有限公司 一种丙酰胺类衍生物的结晶形式及其制备方法
CN109438443A (zh) * 2018-12-24 2019-03-08 浙江工业大学上虞研究院有限公司 利培酮的制备方法
CN112624992A (zh) * 2021-01-19 2021-04-09 浙江华海药业股份有限公司 一种6-氟-3-（4-哌啶基）-1,2-苯并异噁唑盐酸盐的纯化方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402644B1 (fr) * 1989-05-19 1995-08-16 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)hétéroarylpipéridines et -hétéroarylpipérazines, leur procédé de préparation et leur application comme médicaments
WO2008128166A1 (fr) * 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Dérivés deutériés de composés 4-(6-fluoro-1,2-benzisoxazol-3-yl) pipéridine
WO2011055188A1 (fr) * 2009-11-05 2011-05-12 Orchid Chemicals And Pharmaceuticals Limited Amélioration de procédé d'élaboration d'ilopéridone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355307A (en) 1976-11-26 1982-10-19 Beck Darrel R Safety stress shutdown switch
FR2654104B1 (fr) 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5365866A (en) 1992-12-08 1994-11-22 Southdown, Inc. Method and apparatus for treating exhaust gases from preheater and preheater/precalciner kilns burning hazardous waste fuels
AU734331B2 (en) 1997-06-18 2001-06-14 Ciba Specialty Chemicals Water Treatments Limited Irrigation method
ATE518845T1 (de) 2001-08-31 2011-08-15 Novartis Pharma Gmbh Optische isomere eines iloperidon-metaboliten
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
WO2010031497A1 (fr) 2008-09-19 2010-03-25 Miklos Vertessy Nouveau procédé de préparation d’ilopéridone
CN102395582A (zh) 2009-09-19 2012-03-28 浙江华海药业股份有限公司 伊潘立酮的一种制备方法及结晶方法
US20120220776A1 (en) 2009-11-19 2012-08-30 Symed Labs Limited Process for the preparation of iloperidone using a novel intermediate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402644B1 (fr) * 1989-05-19 1995-08-16 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)hétéroarylpipéridines et -hétéroarylpipérazines, leur procédé de préparation et leur application comme médicaments
WO2008128166A1 (fr) * 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Dérivés deutériés de composés 4-(6-fluoro-1,2-benzisoxazol-3-yl) pipéridine
WO2011055188A1 (fr) * 2009-11-05 2011-05-12 Orchid Chemicals And Pharmaceuticals Limited Amélioration de procédé d'élaboration d'ilopéridone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STRUPCZEWSKI J T ET AL: "3- not not (ARYLOXY)ALKYL 3/4 PIPERIDINYL 3/4 -1,2-BENZISOXAZOLES AS D2/5-HT2 ANTAGONISTS WITH POTENTIAL ATYPICAL ANTIPSYCHOTIC ACTIVITY: ANTIPSYCHOTIC PROFILE OF ILOPERIDONE (HP 873)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 38, no. 7, 1 January 1995 (1995-01-01), pages 1119 - 1131, XP000941571, ISSN: 0022-2623, DOI: 10.1021/JM00007A009 *

Also Published As

Publication number Publication date
WO2012063269A2 (fr) 2012-05-18

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